Lista de obras - David Alan Young - Dominio Público Uruguay

A CD4 T cell gene signature for early rheumatoid arthritis implicates interleukin 6-mediated STAT3 signalling, particularly in anti-citrullinated peptide antibody-negative disease.

artículo científico publicado en 2012

A negative feedback loop mediated by STAT3 limits human Th17 responses.

artículo científico publicado en 2014

Activation of p38 and JNK MAPK pathways abrogates requirement for new protein synthesis for phorbol ester mediated induction of select MMP and TIMP genes.

artículo científico publicado en 2007

An enhancer complex confers both high-level and cell-specific expression of the human type X collagen gene.

artículo científico publicado en 2002

CRELD2 Is a Novel LRP1 Chaperone That Regulates Noncanonical WNT Signaling in Skeletal Development

artículo científico publicado en 2020

Characterization of a gene encoding a single-subunit bacteriophage-type RNA polymerase from maize which is alternatively spliced

artículo científico publicado en 1998

Characterization of the cartilage DNA methylome in knee and hip osteoarthritis

artículo científico publicado en 2014

Class I histone deacetylase inhibition modulates metalloproteinase expression and blocks cytokine-induced cartilage degradation.

artículo científico publicado en 2013

Correlation of Infinium HumanMethylation450K and MethylationEPIC BeadChip arrays in cartilage

scientific article published on 13 December 2019

DNA hypomethylation during MSC chondrogenesis occurs predominantly at enhancer regions

scientific article published on 24 January 2020

Detecting new microRNAs in human osteoarthritic chondrocytes identifies miR-3085 as a human, chondrocyte-selective, microRNA.

artículo científico publicado en 2015

Differential DNA methylation and expression of inflammatory and zinc transporter genes defines subgroups of osteoarthritic hip patients

artículo científico publicado en 2015

Differential Toll-like receptor-dependent collagenase expression in chondrocytes

artículo científico publicado en 2008

Differential gene expression profiling of metalloproteinases and their inhibitors: a comparison between bovine intervertebral disc nucleus pulposus cells and articular chondrocytes.

artículo científico publicado en 2010

Editorial: More evidence for a role of CpG methylation in the pathogenesis of osteoarthritis

artículo científico publicado en 2013

Epigenetic mechanisms and non-coding RNAs in osteoarthritis.

artículo científico

Epigenetic mechanisms in cartilage and osteoarthritis: DNA methylation, histone modifications and microRNAs.

artículo científico publicado en 2012

Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation.

artículo científico publicado en 2011

Expression profiling of metalloproteinases and their inhibitors in cartilage

artículo científico publicado en 2004

Genome-Wide MicroRNA and Gene Analysis of Mesenchymal Stem Cell Chondrogenesis Identifies an Essential Role and Multiple Targets for miR-140-5p

artículo científico publicado en 2015

Glycogen synthase kinase 3 inhibition stimulates human cartilage destruction and exacerbates murine osteoarthritis.

artículo científico publicado en 2014

HDAC-mediated control of ERK- and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes.

artículo científico publicado en 2010

Identification of long non-coding RNAs expressed in knee and hip osteoarthritic cartilage

artículo científico publicado en 2019

Identification of the pathogenic pathways in osteoarthritic hip cartilage: commonality and discord between hip and knee OA

artículo científico publicado en 2012

Interplay between genetics and epigenetics in osteoarthritis

scientific article published on 09 April 2020

Kinetics Analysis of Circulating MicroRNAs Unveils Markers of Failed Myocardial Reperfusion

scientific article published on 31 October 2019

Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases.

artículo científico publicado en 2011

Lipophilic statins prevent matrix metalloproteinase-mediated cartilage collagen breakdown by inhibiting protein geranylgeranylation.

artículo científico publicado en 2010

Lithium protects cartilage from cytokine-mediated degradation by reducing collagen-degrading MMP production via inhibition of the P38 mitogen-activated protein kinase pathway.

artículo científico publicado en 2010

MMP28 gene expression is regulated by Sp1 transcription factor acetylation.

artículo científico publicado en 2010

Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis.

artículo científico publicado en 2010

Matrix metalloproteinase 13 expression in response to double-stranded RNA in human chondrocytes.

artículo científico publicado en 2013

Metalloproteinase and inhibitor expression profiling of resorbing cartilage reveals pro-collagenase activation as a critical step for collagenolysis.

artículo científico publicado en 2006

Methylation quantitative trait locus analysis of osteoarthritis links epigenetics with genetic risk

artículo científico publicado en 2015

Mitochondrial dysfunction in osteoarthritis is associated with down-regulation of superoxide dismutase 2.

artículo científico publicado en 2013

OATargets: a knowledge base of genes associated with osteoarthritis joint damage in animals

artículo científico publicado en 2020

Oncostatin M in combination with tumour necrosis factor {alpha} induces a chondrocyte membrane associated aggrecanase that is distinct from ADAMTS aggrecanase-1 or -2.

artículo científico publicado en 2005

Oxidative changes and signalling pathways are pivotal in initiating age-related changes in articular cartilage.

artículo científico

Pattern recognition receptor expression is not impaired in patients with chronic mucocutanous candidiasis with or without autoimmune polyendocrinopathy candidiasis ectodermal dystrophy

artículo científico publicado en 2009

Protection against murine osteoarthritis by inhibition of the 26S proteasome and lysine-48 linked ubiquitination.

artículo científico publicado en 2014

Proteinases involved in matrix turnover during cartilage and bone breakdown.

artículo científico publicado en 2009

Rac upregulates tissue inhibitor of metalloproteinase-1 expression by redox-dependent activation of extracellular signal-regulated kinase signaling.

artículo científico publicado en 2006

Recent advances in understanding the regulation of metalloproteinases

artículo científico publicado en 2019

Serum snoRNAs as biomarkers for joint ageing and post traumatic osteoarthritis

scientific article published on 02 March 2017

Synergistic collagenase expression and cartilage collagenolysis are phosphatidylinositol 3-kinase/Akt signaling-dependent.

artículo científico publicado en 2008

The comparative role of activator protein 1 and Smad factors in the regulation of Timp-1 and MMP-1 gene expression by transforming growth factor-beta 1

scientific journal article

The expression and function of microRNAs in chondrogenesis and osteoarthritis.

artículo científico publicado en 2011

The first international workshop on the epigenetics of osteoarthritis

artículo científico publicado en 2016

The function of microRNAs in cartilage and osteoarthritis

scientific article published on 01 September 2019

The identification of trans-acting factors that regulate the expression of GDF5 via the osteoarthritis susceptibility SNP rs143383.

artículo científico publicado en 2013

The long non-coding RNA ROCR contributes to SOX9 expression and chondrogenic differentiation of human mesenchymal stem cells.

artículo científico publicado en 2017

The microRNA-29 family in cartilage homeostasis and osteoarthritis

scientific journal article

Understanding CpG methylation in the context of osteoarthritis

artículo científico publicado en 2012

cAMP response element-binding (CREB) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular chondrocytes and osteoarthritis.

artículo científico publicado en 2012

microRNA-seq of cartilage reveals an over-abundance of miR-140-3p which contains functional isomiRs

artículo científico publicado en 2020

Lista de obras de David Alan Young

A CD4 T cell gene signature for early rheumatoid arthritis implicates interleukin 6-mediated STAT3 signalling, particularly in anti-citrullinated peptide antibody-negative disease.

A negative feedback loop mediated by STAT3 limits human Th17 responses.

Activation of p38 and JNK MAPK pathways abrogates requirement for new protein synthesis for phorbol ester mediated induction of select MMP and TIMP genes.

An enhancer complex confers both high-level and cell-specific expression of the human type X collagen gene.

CRELD2 Is a Novel LRP1 Chaperone That Regulates Noncanonical WNT Signaling in Skeletal Development

Characterization of a gene encoding a single-subunit bacteriophage-type RNA polymerase from maize which is alternatively spliced

Characterization of the cartilage DNA methylome in knee and hip osteoarthritis

Class I histone deacetylase inhibition modulates metalloproteinase expression and blocks cytokine-induced cartilage degradation.

Correlation of Infinium HumanMethylation450K and MethylationEPIC BeadChip arrays in cartilage

DNA hypomethylation during MSC chondrogenesis occurs predominantly at enhancer regions

Detecting new microRNAs in human osteoarthritic chondrocytes identifies miR-3085 as a human, chondrocyte-selective, microRNA.

Differential DNA methylation and expression of inflammatory and zinc transporter genes defines subgroups of osteoarthritic hip patients

Differential Toll-like receptor-dependent collagenase expression in chondrocytes

Differential gene expression profiling of metalloproteinases and their inhibitors: a comparison between bovine intervertebral disc nucleus pulposus cells and articular chondrocytes.

Editorial: More evidence for a role of CpG methylation in the pathogenesis of osteoarthritis

Epigenetic mechanisms and non-coding RNAs in osteoarthritis.

Epigenetic mechanisms in cartilage and osteoarthritis: DNA methylation, histone modifications and microRNAs.

Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation.

Expression profiling of metalloproteinases and their inhibitors in cartilage

Genome-Wide MicroRNA and Gene Analysis of Mesenchymal Stem Cell Chondrogenesis Identifies an Essential Role and Multiple Targets for miR-140-5p

Glycogen synthase kinase 3 inhibition stimulates human cartilage destruction and exacerbates murine osteoarthritis.

HDAC-mediated control of ERK- and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes.

Identification of long non-coding RNAs expressed in knee and hip osteoarthritic cartilage

Identification of the pathogenic pathways in osteoarthritic hip cartilage: commonality and discord between hip and knee OA

Interplay between genetics and epigenetics in osteoarthritis

Kinetics Analysis of Circulating MicroRNAs Unveils Markers of Failed Myocardial Reperfusion

Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases.

Lipophilic statins prevent matrix metalloproteinase-mediated cartilage collagen breakdown by inhibiting protein geranylgeranylation.

Lithium protects cartilage from cytokine-mediated degradation by reducing collagen-degrading MMP production via inhibition of the P38 mitogen-activated protein kinase pathway.

MMP28 gene expression is regulated by Sp1 transcription factor acetylation.

Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis.

Matrix metalloproteinase 13 expression in response to double-stranded RNA in human chondrocytes.

Metalloproteinase and inhibitor expression profiling of resorbing cartilage reveals pro-collagenase activation as a critical step for collagenolysis.

Methylation quantitative trait locus analysis of osteoarthritis links epigenetics with genetic risk

Mitochondrial dysfunction in osteoarthritis is associated with down-regulation of superoxide dismutase 2.

OATargets: a knowledge base of genes associated with osteoarthritis joint damage in animals

Oncostatin M in combination with tumour necrosis factor {alpha} induces a chondrocyte membrane associated aggrecanase that is distinct from ADAMTS aggrecanase-1 or -2.

Oxidative changes and signalling pathways are pivotal in initiating age-related changes in articular cartilage.

Pattern recognition receptor expression is not impaired in patients with chronic mucocutanous candidiasis with or without autoimmune polyendocrinopathy candidiasis ectodermal dystrophy

Protection against murine osteoarthritis by inhibition of the 26S proteasome and lysine-48 linked ubiquitination.

Proteinases involved in matrix turnover during cartilage and bone breakdown.

Rac upregulates tissue inhibitor of metalloproteinase-1 expression by redox-dependent activation of extracellular signal-regulated kinase signaling.

Recent advances in understanding the regulation of metalloproteinases

Serum snoRNAs as biomarkers for joint ageing and post traumatic osteoarthritis

Synergistic collagenase expression and cartilage collagenolysis are phosphatidylinositol 3-kinase/Akt signaling-dependent.

The comparative role of activator protein 1 and Smad factors in the regulation of Timp-1 and MMP-1 gene expression by transforming growth factor-beta 1

The expression and function of microRNAs in chondrogenesis and osteoarthritis.

The first international workshop on the epigenetics of osteoarthritis

The function of microRNAs in cartilage and osteoarthritis

The identification of trans-acting factors that regulate the expression of GDF5 via the osteoarthritis susceptibility SNP rs143383.

The long non-coding RNA ROCR contributes to SOX9 expression and chondrogenic differentiation of human mesenchymal stem cells.

The microRNA-29 family in cartilage homeostasis and osteoarthritis

Understanding CpG methylation in the context of osteoarthritis

cAMP response element-binding (CREB) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular chondrocytes and osteoarthritis.

microRNA-seq of cartilage reveals an over-abundance of miR-140-3p which contains functional isomiRs