Lista de obras - James Driscoll - Dominio Público Uruguay

A rational chemical intervention strategy to circumvent bioactivation liabilities associated with a nonpeptidyl thrombopoietin receptor agonist containing a 2-amino-4-arylthiazole motif.

artículo científico publicado en 2007

Biotransformation and bioactivation reactions - 2018 literature highlights

scientific article published on 01 May 2019

Biotransformation and bioactivation reactions of alicyclic amines in drug molecules

artículo científico publicado en 2014

Disposition of GDC-0879, a B-RAF kinase inhibitor in preclinical species.

artículo científico publicado en 2009

Formation of a quinoneimine intermediate of 4-fluoro-N-methylaniline by FMO1: carbon oxidation plus defluorination.

artículo científico publicado en 2010

Going Beyond Common Drug Metabolizing Enzymes: Case Studies of Biotransformation Involving Aldehyde Oxidase, γ-Glutamyl Transpeptidase, Cathepsin B, Flavin-Containing Monooxygenase, and ADP-Ribosyltransferase

artículo científico publicado en 2016

Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model.

artículo científico publicado en 2017

In vitro and in vivo pharmacokinetic characterization of mavacamten, a first-in-class small molecule allosteric modulator of beta cardiac myosin

scientific article published on 01 October 2018

Inhibitory Effects of Trapping Agents of Sulfur Drug Reactive Intermediates against Major Human Cytochrome P450 Isoforms

artículo científico publicado en 2017

Metabolite Profiling and Reaction Phenotyping for the in Vitro Assessment of the Bioactivation of Bromfenac †

scientific article published on 23 December 2019

Novel advances in biotransformation and bioactivation research-2019 year in review

artículo científico publicado en 2020

Novel mechanism for dehalogenation and glutathione conjugation of dihalogenated anilines in human liver microsomes: evidence for ipso glutathione addition

scientific article published on 25 September 2011

Novel quinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV.

artículo científico publicado en 2013

Piperazinyl CCR1 antagonists--optimization of human liver microsome stability.

artículo científico publicado en 2007

Preclinical in vitro and in vivo pharmacokinetic properties of danicamtiv, a new targeted myosin activator for the treatment of dilated cardiomyopathy

artículo científico publicado en 2020

Pyrimidine benzamide-based thrombopoietin receptor agonists.

artículo científico publicado en 2007

Role of Glucuronidation and P450 Oxidation in the Bioactivation of Bromfenac

scientific article published on 02 April 2018

The identification of orally bioavailable thrombopoietin agonists.

artículo científico publicado en 2009

Lista de obras de James Driscoll

A rational chemical intervention strategy to circumvent bioactivation liabilities associated with a nonpeptidyl thrombopoietin receptor agonist containing a 2-amino-4-arylthiazole motif.

Biotransformation and bioactivation reactions - 2018 literature highlights

Biotransformation and bioactivation reactions of alicyclic amines in drug molecules

Disposition of GDC-0879, a B-RAF kinase inhibitor in preclinical species.

Formation of a quinoneimine intermediate of 4-fluoro-N-methylaniline by FMO1: carbon oxidation plus defluorination.

Going Beyond Common Drug Metabolizing Enzymes: Case Studies of Biotransformation Involving Aldehyde Oxidase, γ-Glutamyl Transpeptidase, Cathepsin B, Flavin-Containing Monooxygenase, and ADP-Ribosyltransferase

Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model.

In vitro and in vivo pharmacokinetic characterization of mavacamten, a first-in-class small molecule allosteric modulator of beta cardiac myosin

Inhibitory Effects of Trapping Agents of Sulfur Drug Reactive Intermediates against Major Human Cytochrome P450 Isoforms

Metabolite Profiling and Reaction Phenotyping for the in Vitro Assessment of the Bioactivation of Bromfenac †

Novel advances in biotransformation and bioactivation research-2019 year in review

Novel mechanism for dehalogenation and glutathione conjugation of dihalogenated anilines in human liver microsomes: evidence for ipso glutathione addition

Novel quinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV.

Piperazinyl CCR1 antagonists--optimization of human liver microsome stability.

Preclinical in vitro and in vivo pharmacokinetic properties of danicamtiv, a new targeted myosin activator for the treatment of dilated cardiomyopathy

Pyrimidine benzamide-based thrombopoietin receptor agonists.

Role of Glucuronidation and P450 Oxidation in the Bioactivation of Bromfenac

The identification of orally bioavailable thrombopoietin agonists.