Lista de obras - Paula A Witt-Enderby - Dominio Público Uruguay

2-[(2,3-dihydro-1H-indol-1-yl)methyl]melatonin analogues: a novel class of MT2-selective melatonin receptor antagonists

artículo científico publicado en 2009

A novel calcium aluminate-melatonin scaffold enhances bone regeneration within a calvarial defect.

artículo científico publicado en 2012

Biological effects of melatonin on osteoblast/osteoclast cocultures, bone, and quality of life: Implications of a role for MT2 melatonin receptors, MEK1/2, and MEK5 in melatonin-mediated osteoblastogenesis.

artículo científico publicado en 2017

C-terminal domains within human MT1 and MT2 melatonin receptors are involved in internalization processes.

artículo científico publicado en 2008

Chronic exposure to a β2-adrenoceptor agonist increases the airway response to methacholine

artículo científico publicado en 1993

Could the Fountain of Youth Be All in Your Bones?

scientific article published on 01 February 2013

Desensitization and internalization of the m2 muscarinic acetylcholine receptor are directed by independent mechanisms.

artículo científico publicado en 1995

Determination of the minimal melatonin exposure required to induce osteoblast differentiation from human mesenchymal stem cells and these effects on downstream signaling pathways.

artículo científico publicado en 2010

Down-regulation of mt1 melatonin receptors in rat ovary following estrogen exposure.

artículo científico publicado en 2001

Drug conjugates—an emerging approach to treat breast cancer.

artículo científico publicado en 2018

Dual coupling of MT(1) and MT(2) melatonin receptors to cyclic AMP and phosphoinositide signal transduction cascades and their regulation following melatonin exposure.

artículo científico publicado en 2002

Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release.

artículo científico publicado en 2017

Effects on bone by the light/dark cycle and chronic treatment with melatonin and/or hormone replacement therapy in intact female mice.

artículo científico publicado en 2012

High affinity nuclear and nongenomic estradiol binding sites in the human and mouse lens.

artículo científico publicado en 2013

Knock-down of RGS4 and beta tubulin in CHO cells expressing the human MT1 melatonin receptor prevents melatonin-induced receptor desensitization

artículo científico publicado en 2004

MT1 and MT2 melatonin receptors: ligands, models, oligomers, and therapeutic potential.

artículo científico publicado en 2013

MT1 melatonin receptor internalization underlies melatonin-induced morphologic changes in Chinese hamster ovary cells and these processes are dependent on Gi proteins, MEK 1/2 and microtubule modulation

artículo científico publicado en 2008

Melatonin and breast cancer: cellular mechanisms, clinical studies and future perspectives.

artículo científico publicado en 2009

Melatonin differentially modulates the expression and function of the hMT1 and hMT2 melatonin receptors upon prolonged withdrawal

artículo científico publicado en 2003

Melatonin effects on bone: potential use for the prevention and treatment for osteopenia, osteoporosis, and periodontal disease and for use in bone-grafting procedures.

artículo científico

Melatonin enhances alkaline phosphatase activity in differentiating human adult mesenchymal stem cells grown in osteogenic medium via MT2 melatonin receptors and the MEK/ERK (1/2) signaling cascade.

artículo científico publicado en 2006

Melatonin osteoporosis prevention study (MOPS): a randomized, double-blind, placebo-controlled study examining the effects of melatonin on bone health and quality of life in perimenopausal women

artículo científico publicado en 2012

Melatonin-micronutrients Osteopenia Treatment Study (MOTS): a translational study assessing melatonin, strontium (citrate), vitamin D3 and vitamin K2 (MK7) on bone density, bone marker turnover and health related quality of life in postmenopausal os

artículo científico publicado en 2017

Modulation of melatonin receptors and G-protein function by microtubules

artículo científico publicado en 2006

Morinda citrifolia (Noni) Juice Augments Mammary Gland Differentiation and Reduces Mammary Tumor Growth in Mice Expressing the Unactivated c-erbB2 Transgene.

artículo científico publicado en 2012

N-Acetyl-5-arylalkoxytryptamine analogs: probing the melatonin receptors for MT(1) -selectivity.

artículo científico publicado en 2011

Novel Melatonin, Estrogen, and Progesterone Hormone Therapy Demonstrates Anti-Cancer Actions in MCF-7 and MDA-MB-231 Breast Cancer Cells

artículo científico publicado en 2020

Oxyprenylated Phenylpropanoids Bind to MT1 Melatonin Receptors and Inhibit Breast Cancer Cell Proliferation and Migration.

artículo científico publicado en 2017

Pharmacological, Mechanistic, and Pharmacokinetic Assessment of Novel Melatonin-Tamoxifen Drug Conjugates as Breast Cancer Drugs

scientific article published on 20 June 2019

Physiological Exposure to Melatonin Supersensitizes the Cyclic Adenosine 3′,5′-Monophosphate-Dependent Signal Transduction Cascade in Chinese Hamster Ovary Cells Expressing the Human mt1 Melatonin Receptor* ⬇️

artículo científico publicado el 1 de julio de 1998

Platelet-rich preparations to improve healing. Part I: workable options for every size practice.

artículo científico publicado en 2014

Platelet-rich preparations to improve healing. Part II: platelet activation and enrichment, leukocyte inclusion, and other selection criteria.

artículo científico publicado en 2014

Synthesis and pharmacological evaluation of 1,2,3,4-tetrahydropyrazino[1,2-a]indole and 2-[(phenylmethylamino)methyl]-1H-indole analogues as novel melatoninergic ligands.

artículo científico publicado en 2009

Synthesis and pharmacological evaluation of pentacyclic 6a,7-dihydrodiindole and 2,3-dihydrodiindole derivatives as novel melatoninergic ligands

artículo científico publicado en 2008

Synthesis, NMR conformational analysis and pharmacological evaluation of 7,7a,13,14-tetrahydro-6H-cyclobuta[b]pyrimido[1,2-a:3,4-a']diindole analogues as melatonin receptor ligands.

artículo científico publicado en 2007

The actions of a charged melatonin receptor ligand, TMEPI, and an irreversible MT2 receptor agonist, BMNEP, on mouse hippocampal evoked potentials in vitro

artículo científico publicado en 2004

The effect of estradiol, progesterone, and melatonin on estrous cycling and ovarian aromatase expression in intact female mice

artículo científico publicado en 2013

Therapeutic treatments potentially mediated by melatonin receptors: potential clinical uses in the prevention of osteoporosis, cancer and as an adjuvant therapy

artículo científico publicado en 2006

Lista de obras de Paula A Witt-Enderby

2-[(2,3-dihydro-1H-indol-1-yl)methyl]melatonin analogues: a novel class of MT2-selective melatonin receptor antagonists

A novel calcium aluminate-melatonin scaffold enhances bone regeneration within a calvarial defect.

Biological effects of melatonin on osteoblast/osteoclast cocultures, bone, and quality of life: Implications of a role for MT2 melatonin receptors, MEK1/2, and MEK5 in melatonin-mediated osteoblastogenesis.

C-terminal domains within human MT1 and MT2 melatonin receptors are involved in internalization processes.

Chronic exposure to a β2-adrenoceptor agonist increases the airway response to methacholine

Could the Fountain of Youth Be All in Your Bones?

Desensitization and internalization of the m2 muscarinic acetylcholine receptor are directed by independent mechanisms.

Determination of the minimal melatonin exposure required to induce osteoblast differentiation from human mesenchymal stem cells and these effects on downstream signaling pathways.

Down-regulation of mt1 melatonin receptors in rat ovary following estrogen exposure.

Drug conjugates—an emerging approach to treat breast cancer.

Dual coupling of MT(1) and MT(2) melatonin receptors to cyclic AMP and phosphoinositide signal transduction cascades and their regulation following melatonin exposure.

Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release.

Effects on bone by the light/dark cycle and chronic treatment with melatonin and/or hormone replacement therapy in intact female mice.

High affinity nuclear and nongenomic estradiol binding sites in the human and mouse lens.

Knock-down of RGS4 and beta tubulin in CHO cells expressing the human MT1 melatonin receptor prevents melatonin-induced receptor desensitization

MT1 and MT2 melatonin receptors: ligands, models, oligomers, and therapeutic potential.

MT1 melatonin receptor internalization underlies melatonin-induced morphologic changes in Chinese hamster ovary cells and these processes are dependent on Gi proteins, MEK 1/2 and microtubule modulation

Melatonin and breast cancer: cellular mechanisms, clinical studies and future perspectives.

Melatonin differentially modulates the expression and function of the hMT1 and hMT2 melatonin receptors upon prolonged withdrawal

Melatonin effects on bone: potential use for the prevention and treatment for osteopenia, osteoporosis, and periodontal disease and for use in bone-grafting procedures.

Melatonin enhances alkaline phosphatase activity in differentiating human adult mesenchymal stem cells grown in osteogenic medium via MT2 melatonin receptors and the MEK/ERK (1/2) signaling cascade.

Melatonin osteoporosis prevention study (MOPS): a randomized, double-blind, placebo-controlled study examining the effects of melatonin on bone health and quality of life in perimenopausal women

Melatonin-micronutrients Osteopenia Treatment Study (MOTS): a translational study assessing melatonin, strontium (citrate), vitamin D3 and vitamin K2 (MK7) on bone density, bone marker turnover and health related quality of life in postmenopausal os

Modulation of melatonin receptors and G-protein function by microtubules

Morinda citrifolia (Noni) Juice Augments Mammary Gland Differentiation and Reduces Mammary Tumor Growth in Mice Expressing the Unactivated c-erbB2 Transgene.

N-Acetyl-5-arylalkoxytryptamine analogs: probing the melatonin receptors for MT(1) -selectivity.

Novel Melatonin, Estrogen, and Progesterone Hormone Therapy Demonstrates Anti-Cancer Actions in MCF-7 and MDA-MB-231 Breast Cancer Cells

Oxyprenylated Phenylpropanoids Bind to MT1 Melatonin Receptors and Inhibit Breast Cancer Cell Proliferation and Migration.

Pharmacological, Mechanistic, and Pharmacokinetic Assessment of Novel Melatonin-Tamoxifen Drug Conjugates as Breast Cancer Drugs

Physiological Exposure to Melatonin Supersensitizes the Cyclic Adenosine 3′,5′-Monophosphate-Dependent Signal Transduction Cascade in Chinese Hamster Ovary Cells Expressing the Human mt1 Melatonin Receptor* ⬇️

Platelet-rich preparations to improve healing. Part I: workable options for every size practice.

Platelet-rich preparations to improve healing. Part II: platelet activation and enrichment, leukocyte inclusion, and other selection criteria.

Synthesis and pharmacological evaluation of 1,2,3,4-tetrahydropyrazino[1,2-a]indole and 2-[(phenylmethylamino)methyl]-1H-indole analogues as novel melatoninergic ligands.

Synthesis and pharmacological evaluation of pentacyclic 6a,7-dihydrodiindole and 2,3-dihydrodiindole derivatives as novel melatoninergic ligands

Synthesis, NMR conformational analysis and pharmacological evaluation of 7,7a,13,14-tetrahydro-6H-cyclobuta[b]pyrimido[1,2-a:3,4-a']diindole analogues as melatonin receptor ligands.

The actions of a charged melatonin receptor ligand, TMEPI, and an irreversible MT2 receptor agonist, BMNEP, on mouse hippocampal evoked potentials in vitro

The effect of estradiol, progesterone, and melatonin on estrous cycling and ovarian aromatase expression in intact female mice

Therapeutic treatments potentially mediated by melatonin receptors: potential clinical uses in the prevention of osteoporosis, cancer and as an adjuvant therapy