Lista de obras - Sandor Benyhe - Dominio Público Uruguay

14-O-Methylmorphine: A Novel Selective Mu-Opioid Receptor Agonist with High Efficacy and Affinity

artículo científico publicado en 2017

A monoclonal antibody recognizing kappa- but not mu- and delta-opioid receptors.

artículo científico publicado en 1991

Affinity labelling of frog brain opioid receptors by dynorphin(1-10) chloromethyl ketone

artículo científico publicado en 1997

Agonist-dependent attenuation of mu-opioid receptor-mediated G-protein activation in the dorsal root ganglia of neuropathic rats

artículo científico publicado en 2010

Alkamides and a neolignan from Echinacea purpurea roots and the interaction of alkamides with G-protein-coupled cannabinoid receptors.

artículo científico publicado en 2011

Altered gene expression and functional activity of opioid receptors in the cerebellum of CB1 cannabinoid receptor knockout mice after acute treatments with cannabinoids.

artículo científico publicado en 2007

Antinociceptive effect induced by a combination of opioid and neurotensin moieties vs. their hybrid peptide [Ile(9)]PK20 in an acute pain treatment in rodents.

artículo científico publicado en 2016

Binding characteristics and analgesic activity of D-ALA2-Leu5-enkephalin chloromethyl ketone

artículo científico publicado en 1983

Binding studies of novel, non-mammalian enkephalins, structures predicted from frog and lungfish brain cDNA sequences

artículo científico publicado en 2008

Bioactivity studies on atypical natural opioid hexapeptides processed from proenkephalin (PENK) precursor polypeptides.

artículo científico publicado en 2014

Bioinformatic and biochemical studies on the phylogenetic variability of proenkephalin-derived octapeptides

artículo científico publicado en 2010

Biological evaluation and molecular docking studies of AA3052, a compound containing a μ-selective opioid peptide agonist DALDA and d-Phe-Phe-d-Phe-Leu-Leu-NH2, a substance P analogue.

artículo científico publicado en 2016

Blood-brain transfer and antinociception of linear and cyclic N-methyl-guanidine and thiourea-enkephalins

artículo científico publicado en 2014

CB(2) cannabinoid receptor antagonist SR144528 decreases mu-opioid receptor expression and activation in mouse brainstem: role of CB(2) receptor in pain.

artículo científico publicado en 2008

Changes in the cannabinoid (CB1) receptor expression level and G-protein activation in kainic acid induced seizures ⬇️

artículo científico publicado el 10 de noviembre de 2011

Characterization of [3H] oxymorphone binding sites in mouse brain: Quantitative autoradiography in opioid receptor knockout mice.

artículo científico publicado en 2017

Characterization of [3H]Met-enkephalin-Arg6-Phe7 binding to multiple sites in rat and guinea pig cerebellum

artículo científico publicado en 1999

Characterization of kappa 1 and kappa 2 opioid binding sites in frog (Rana esculenta) brain membrane preparation

artículo científico publicado en 1990

Characterization of rat brain opioid receptors by [Tyr-3,5-3H]1, D-Ala2, Leu5-enkephalin binding

artículo científico publicado en 1985

Cloning and characterization of Xen-dorphin prohormone from Xenopus laevis: a new opioid-like prohormone distinct from proenkephalin and prodynorphin

artículo científico publicado en 2003

Comparative biochemical and pharmacological characterization of a novel, NOP receptor selective hexapeptide, Ac-RYYRIR-ol.

artículo científico publicado en 2009

Covalent labeling of opioid receptors with 3H-D-Ala2-Leu5-enkephalin chloromethyl ketone. II. Binding characteristics in frog brain membranes

artículo científico publicado en 1987

Cyclic Biphalin Analogues Incorporating a Xylene Bridge: Synthesis, Characterization, and Biological Profile.

artículo científico publicado en 2017

Cyclic enkephalins with a diversely substituted guanidine bridge or a thiourea bridge: synthesis, biological and structural evaluations

artículo científico publicado en 2013

Decreased CB receptor binding and cannabinoid signaling in three brain regions of a rat model of schizophrenia

artículo científico publicado en 2016

Design, Synthesis and Biological Evaluation of Two Opioid Agonist and Cav 2.2 Blocker Multitarget Ligands

artículo científico publicado en 2014

Discovery of Novel µ-Opioid Receptor Inverse Agonist from a Combinatorial Library of Tetrapeptides through Structure-Based Virtual Screening

artículo científico publicado en 2019

Effect of alpha-adrenoceptor subtype-selective inverse agonists on non-pregnant and late-pregnant cervical resistance in vitro in the rat.

artículo científico publicado en 2007

Effect of sodium on [3H]ethylketocyclazocine binding to opioid receptors in frog brain membranes

artículo científico publicado en 1989

Endomorphin-2 with a beta-turn backbone constraint retains the potent micro-opioid receptor agonist properties.

artículo científico publicado en 2007

Ethylketocyclazocine and N-cyclopropylmethyl-norazidomorphine are antagonists of morphine-induced analgesia in frog spinal cord

artículo científico publicado en 1988

Evaluation of the analgesic effect of 4-anilidopiperidine scaffold containing ureas and carbamates.

artículo científico publicado en 2016

Exploring the first Rimonabant analog-opioid peptide hybrid compound, as bivalent ligand for CB1 and opioid receptors

artículo científico publicado en 2017

Further Characterization of Hemopressin Peptide Fragments in the Opioid and Cannabinoid Systems

artículo científico publicado en 2015

Homology modeling and phylogenetic relationships of catalases of an opportunistic pathogen Rhizopus oryzae

artículo científico publicado en 2012

Hybrid peptides endomorphin-2/DAMGO: design, synthesis and biological evaluation.

artículo científico publicado en 2013

In vitro and in vivo pharmacological characterization of the nociceptin/orphanin FQ receptor ligand Ac-RYYRIK-ol.

artículo científico publicado en 2006

In vitro binding and functional studies of Ac-RYYRIK-ol and its derivatives, novel partial agonists of the nociceptin/orphanin F/Q receptor

artículo científico publicado en 2006

In vitro binding and signaling profile of the novel mu opioid receptor agonist endomorphin 2 in rat brain membranes

artículo científico publicado en 1998

Inflammatory processes enhance cAMP-mediated uterus relaxation in the pregnant rat: the role of TNF-alpha

artículo científico publicado en 2008

Inhibition of forebrain μ-opioid receptor signaling by low concentrations of rimonabant does not require cannabinoid receptors and directly involves μ-opioid receptors ⬇️

artículo científico publicado el 18 de mayo de 2012

Interactions between the Kynurenine and the Endocannabinoid System with Special Emphasis on Migraine

artículo científico publicado en 2017

Irreversible blockade of the high and low affinity (3H) naloxone binding sites by C-6 derivatives of morphinane-6-ones

artículo científico publicado en 1991

Irreversible labelling of the opioid receptors by a melphalan-substituted [Met5]enkephalin-Arg-Phe derivative

artículo científico publicado en 1999

Kainic acid-induced changes in the opioid/nociceptin system and the stress/toxicity pathways in the rat hippocampus.

artículo científico publicado en 2012

Kainic acid-induced seizure activity alters the mRNA expression and G-protein activation of the opioid/nociceptin receptors in the rat brain cortex

artículo científico publicado en 2013

Kappa-receptor selective binding of opioid ligands with a heterocyclic bicyclo[3.3.1]nonan-9-one structure

artículo científico publicado en 2003

Kinetics and physical parameters of rat brain opioid receptors solubilized by digitonin and CHAPS.

artículo científico publicado en 1986

Kynurenic acid and its analogue can alter the opioid receptor G-protein signaling after acute treatment via NMDA receptor in rat cortex and striatum

artículo científico publicado en 2017

Low dosage of rimonabant leads to anxiolytic-like behavior via inhibiting expression levels and G-protein activity of kappa opioid receptors in a cannabinoid receptor independent manner.

artículo científico publicado en 2015

Micromolar concentrations of rimonabant directly inhibits delta opioid receptor specific ligand binding and agonist-induced G-protein activity.

artículo científico publicado en 2014

Morphine: new aspects in the study of an ancient compound.

artículo científico publicado en 1994

Mu opioid receptor mRNA expression, binding, and functional coupling to G-proteins in human epileptic hippocampus.

artículo científico publicado en 2010

Mu-Opioid (MOP) receptor mediated G-protein signaling is impaired in specific brain regions in a rat model of schizophrenia.

artículo científico publicado en 2016

New opioid receptor antagonist: Naltrexone-14-O-sulfate synthesis and pharmacology.

artículo científico

Nociceptin binding sites in frog (Rana esculenta) brain membranes.

artículo científico publicado en 1999

Nociceptin inhibits uterine contractions in term-pregnant rats by signaling through multiple pathways

scientific journal article

Noladin ether, a putative endocannabinoid, inhibits mu-opioid receptor activation via CB2 cannabinoid receptors.

artículo científico

Non-opioid actions of opioid peptides.

artículo científico publicado en 2004

Novel cyclic biphalin analogue with improved antinociceptive properties.

artículo científico publicado en 2014

Novel diastereomeric opioid tetrapeptides exhibit differing pharmacological activity profiles.

artículo científico publicado en 2007

Novel opioid-neurotensin-based hybrid peptide with spinal long-lasting antinociceptive activity and a propensity to delay tolerance development

scientific article published on 01 May 2020

Opioid Receptor Activity and Analgesic Potency of DPDPE Peptide Analogues Containing a Xylene Bridge.

artículo científico publicado en 2017

Opioid binding profile of morphiceptin, Tyr-MIF-1 and dynorphin-related peptides in rat brain membranes

artículo científico publicado en 1996

Opioid receptor binding characteristics and structure-activity studies of novel tetrapeptides in the TIPP (Tyr-Tic-Phe-Phe) series.

artículo científico publicado en 2005

Opioid receptor labeling with the chloromethyl ketone derivative of [3H]Tyr-D-Ala-Gly-(Me)Phe-Gly-ol (DAMGO) II: Covalent labeling of mu opioid binding site by 3H-Tyr-D-Ala-Gly-(Me)Phe chloromethyl ketone.

artículo científico publicado en 1991

Partial and full agonism in endomorphin derivatives: comparison by null and operational model.

artículo científico publicado en 2006

Pharmacological and functional biochemical properties of D-Ala2-D-Nle5-enkephalin-Arg-Phe

artículo científico publicado en 2004

Phylogenetic diversity and functional efficacy of the C-terminally expressed heptapeptide unit in the opioid precursor polypeptide proenkephalin A.

artículo científico publicado en 2011

Pregnancy-induced decrease in the relaxant effect of terbutaline in the late-pregnant rat myometrium: role of G-protein activation and progesterone

artículo científico publicado en 2005

Promitogenic effects of ethanol, methanol, and ethanolamine in insulin-treated fibroblasts.

artículo científico publicado en 2000

Purification of a kappa-opioid receptor subtype from frog brain

artículo científico publicado en 1987

Receptor binding and G-protein activation by new Met5-enkephalin-Arg6-Phe7 derived peptides

artículo científico publicado en 2000

Receptor constants for endomorphin-1 and endomorphin-1-ol indicate differences in efficacy and receptor occupancy

artículo científico publicado en 2001

Restraint stress and anti-tumor immune response in mice

artículo científico publicado en 2003

Selective and high affinity labeling of neuronal and recombinant nociceptin receptors with the hexapeptide radioprobe [(3)H]Ac-RYYRIK-ol.

artículo científico publicado en 2009

Separation of kappa-opioid receptor subtype from frog brain

artículo científico publicado en 1985

Solubilization and characterization of opioid binding sites from frog (Rana esculenta) brain

artículo científico publicado en 1984

Structurally novel group of ligands selective for kappa opioid receptors

Structure-activity study on the Phe side chain arrangement of endomorphins using conformationally constrained analogues

artículo científico publicado en 2004

Synthesis and binding characteristics of [(3)H]neuromedin N, a NTS2 receptor ligand

artículo científico publicado en 2015

Synthesis and binding characteristics of a novel enkephalin analogue, [3H]Tyr-D-Ala-Gly-Phe-D-Nle-Arg-Phe

artículo científico publicado en 2003

Synthesis and biological studies of nociceptin derivatives containing the DTPA chelating group for further labeling with therapeutic radionuclides

artículo científico publicado en 2005

Synthesis of 3H-Tyr-D-Ala-Gly-N(Me)Phe chloromethyl ketone--an opioid affinity label

artículo científico publicado en 1988

Synthesis of enzymatically resistant nociceptin-related peptides containing a carbamic acid residue

artículo científico publicado en 2006

Temporal lobe epilepsy causes selective changes in mu opioid and nociceptin receptor binding and functional coupling to G-proteins in human temporal neocortex

artículo científico publicado en 2009

Terbutaline increases the cervical resistance of the pregnant rat in vitro

artículo científico publicado en 2005

The effects of estrogen on the α2-adrenergic receptor subtypes in rat uterine function in late pregnancy in vitro

artículo científico publicado en 2016

The effects of female sexual hormones on the expression and function of α1A- and α1D-adrenoceptor subtypes in the late-pregnant rat myometrium

artículo científico publicado en 2015

The effects of progesterone on the alpha2-adrenergic receptor subtypes in late-pregnant uterine contractions in vitro

artículo científico publicado en 2016

Tyr-D-Ala-Gly-(Me)Phe-chloromethyl ketone: a mu specific affinity label for the opioid receptor

artículo científico publicado en 1987

Xendorphin B1, a novel opioid-like peptide determined from a Xenopus laevis brain cDNA library, produces opioid antinociception after spinal administration in amphibians

artículo científico publicado en 2007

[3H]dynorphin1-8 binding sites in frog (Rana esculenta) brain membranes

artículo científico publicado en 1994

Lista de obras de Sandor Benyhe

14-O-Methylmorphine: A Novel Selective Mu-Opioid Receptor Agonist with High Efficacy and Affinity

A monoclonal antibody recognizing kappa- but not mu- and delta-opioid receptors.

Affinity labelling of frog brain opioid receptors by dynorphin(1-10) chloromethyl ketone

Agonist-dependent attenuation of mu-opioid receptor-mediated G-protein activation in the dorsal root ganglia of neuropathic rats

Alkamides and a neolignan from Echinacea purpurea roots and the interaction of alkamides with G-protein-coupled cannabinoid receptors.

Altered gene expression and functional activity of opioid receptors in the cerebellum of CB1 cannabinoid receptor knockout mice after acute treatments with cannabinoids.

Antinociceptive effect induced by a combination of opioid and neurotensin moieties vs. their hybrid peptide [Ile(9)]PK20 in an acute pain treatment in rodents.

Binding characteristics and analgesic activity of D-ALA2-Leu5-enkephalin chloromethyl ketone

Binding studies of novel, non-mammalian enkephalins, structures predicted from frog and lungfish brain cDNA sequences

Bioactivity studies on atypical natural opioid hexapeptides processed from proenkephalin (PENK) precursor polypeptides.

Bioinformatic and biochemical studies on the phylogenetic variability of proenkephalin-derived octapeptides

Biological evaluation and molecular docking studies of AA3052, a compound containing a μ-selective opioid peptide agonist DALDA and d-Phe-Phe-d-Phe-Leu-Leu-NH2, a substance P analogue.

Blood-brain transfer and antinociception of linear and cyclic N-methyl-guanidine and thiourea-enkephalins

CB(2) cannabinoid receptor antagonist SR144528 decreases mu-opioid receptor expression and activation in mouse brainstem: role of CB(2) receptor in pain.

Changes in the cannabinoid (CB1) receptor expression level and G-protein activation in kainic acid induced seizures ⬇️

Characterization of [3H] oxymorphone binding sites in mouse brain: Quantitative autoradiography in opioid receptor knockout mice.

Characterization of [3H]Met-enkephalin-Arg6-Phe7 binding to multiple sites in rat and guinea pig cerebellum

Characterization of kappa 1 and kappa 2 opioid binding sites in frog (Rana esculenta) brain membrane preparation

Characterization of rat brain opioid receptors by [Tyr-3,5-3H]1, D-Ala2, Leu5-enkephalin binding

Cloning and characterization of Xen-dorphin prohormone from Xenopus laevis: a new opioid-like prohormone distinct from proenkephalin and prodynorphin

Comparative biochemical and pharmacological characterization of a novel, NOP receptor selective hexapeptide, Ac-RYYRIR-ol.

Covalent labeling of opioid receptors with 3H-D-Ala2-Leu5-enkephalin chloromethyl ketone. II. Binding characteristics in frog brain membranes

Cyclic Biphalin Analogues Incorporating a Xylene Bridge: Synthesis, Characterization, and Biological Profile.

Cyclic enkephalins with a diversely substituted guanidine bridge or a thiourea bridge: synthesis, biological and structural evaluations

Decreased CB receptor binding and cannabinoid signaling in three brain regions of a rat model of schizophrenia

Design, Synthesis and Biological Evaluation of Two Opioid Agonist and Cav 2.2 Blocker Multitarget Ligands

Discovery of Novel µ-Opioid Receptor Inverse Agonist from a Combinatorial Library of Tetrapeptides through Structure-Based Virtual Screening

Effect of alpha-adrenoceptor subtype-selective inverse agonists on non-pregnant and late-pregnant cervical resistance in vitro in the rat.

Effect of sodium on [3H]ethylketocyclazocine binding to opioid receptors in frog brain membranes

Endomorphin-2 with a beta-turn backbone constraint retains the potent micro-opioid receptor agonist properties.

Ethylketocyclazocine and N-cyclopropylmethyl-norazidomorphine are antagonists of morphine-induced analgesia in frog spinal cord

Evaluation of the analgesic effect of 4-anilidopiperidine scaffold containing ureas and carbamates.

Exploring the first Rimonabant analog-opioid peptide hybrid compound, as bivalent ligand for CB1 and opioid receptors

Further Characterization of Hemopressin Peptide Fragments in the Opioid and Cannabinoid Systems

Homology modeling and phylogenetic relationships of catalases of an opportunistic pathogen Rhizopus oryzae

Hybrid peptides endomorphin-2/DAMGO: design, synthesis and biological evaluation.

In vitro and in vivo pharmacological characterization of the nociceptin/orphanin FQ receptor ligand Ac-RYYRIK-ol.

In vitro binding and functional studies of Ac-RYYRIK-ol and its derivatives, novel partial agonists of the nociceptin/orphanin F/Q receptor

In vitro binding and signaling profile of the novel mu opioid receptor agonist endomorphin 2 in rat brain membranes

Inflammatory processes enhance cAMP-mediated uterus relaxation in the pregnant rat: the role of TNF-alpha

Inhibition of forebrain μ-opioid receptor signaling by low concentrations of rimonabant does not require cannabinoid receptors and directly involves μ-opioid receptors ⬇️

Interactions between the Kynurenine and the Endocannabinoid System with Special Emphasis on Migraine

Irreversible blockade of the high and low affinity (3H) naloxone binding sites by C-6 derivatives of morphinane-6-ones

Irreversible labelling of the opioid receptors by a melphalan-substituted [Met5]enkephalin-Arg-Phe derivative

Kainic acid-induced changes in the opioid/nociceptin system and the stress/toxicity pathways in the rat hippocampus.

Kainic acid-induced seizure activity alters the mRNA expression and G-protein activation of the opioid/nociceptin receptors in the rat brain cortex

Kappa-receptor selective binding of opioid ligands with a heterocyclic bicyclo[3.3.1]nonan-9-one structure

Kinetics and physical parameters of rat brain opioid receptors solubilized by digitonin and CHAPS.

Kynurenic acid and its analogue can alter the opioid receptor G-protein signaling after acute treatment via NMDA receptor in rat cortex and striatum

Low dosage of rimonabant leads to anxiolytic-like behavior via inhibiting expression levels and G-protein activity of kappa opioid receptors in a cannabinoid receptor independent manner.

Micromolar concentrations of rimonabant directly inhibits delta opioid receptor specific ligand binding and agonist-induced G-protein activity.

Morphine: new aspects in the study of an ancient compound.

Mu opioid receptor mRNA expression, binding, and functional coupling to G-proteins in human epileptic hippocampus.

Mu-Opioid (MOP) receptor mediated G-protein signaling is impaired in specific brain regions in a rat model of schizophrenia.

New opioid receptor antagonist: Naltrexone-14-O-sulfate synthesis and pharmacology.

Nociceptin binding sites in frog (Rana esculenta) brain membranes.

Nociceptin inhibits uterine contractions in term-pregnant rats by signaling through multiple pathways

Noladin ether, a putative endocannabinoid, inhibits mu-opioid receptor activation via CB2 cannabinoid receptors.

Non-opioid actions of opioid peptides.

Novel cyclic biphalin analogue with improved antinociceptive properties.

Novel diastereomeric opioid tetrapeptides exhibit differing pharmacological activity profiles.

Novel opioid-neurotensin-based hybrid peptide with spinal long-lasting antinociceptive activity and a propensity to delay tolerance development

Opioid Receptor Activity and Analgesic Potency of DPDPE Peptide Analogues Containing a Xylene Bridge.

Opioid binding profile of morphiceptin, Tyr-MIF-1 and dynorphin-related peptides in rat brain membranes

Opioid receptor binding characteristics and structure-activity studies of novel tetrapeptides in the TIPP (Tyr-Tic-Phe-Phe) series.

Opioid receptor labeling with the chloromethyl ketone derivative of [3H]Tyr-D-Ala-Gly-(Me)Phe-Gly-ol (DAMGO) II: Covalent labeling of mu opioid binding site by 3H-Tyr-D-Ala-Gly-(Me)Phe chloromethyl ketone.

Partial and full agonism in endomorphin derivatives: comparison by null and operational model.

Pharmacological and functional biochemical properties of D-Ala2-D-Nle5-enkephalin-Arg-Phe

Phylogenetic diversity and functional efficacy of the C-terminally expressed heptapeptide unit in the opioid precursor polypeptide proenkephalin A.

Pregnancy-induced decrease in the relaxant effect of terbutaline in the late-pregnant rat myometrium: role of G-protein activation and progesterone

Promitogenic effects of ethanol, methanol, and ethanolamine in insulin-treated fibroblasts.

Purification of a kappa-opioid receptor subtype from frog brain

Receptor binding and G-protein activation by new Met5-enkephalin-Arg6-Phe7 derived peptides

Receptor constants for endomorphin-1 and endomorphin-1-ol indicate differences in efficacy and receptor occupancy

Restraint stress and anti-tumor immune response in mice

Selective and high affinity labeling of neuronal and recombinant nociceptin receptors with the hexapeptide radioprobe [(3)H]Ac-RYYRIK-ol.

Separation of kappa-opioid receptor subtype from frog brain

Solubilization and characterization of opioid binding sites from frog (Rana esculenta) brain

Structurally novel group of ligands selective for kappa opioid receptors