Lista de obras - Robert Layfield - Dominio Público Uruguay

5‐HT6 receptor agonists and antagonists enhance learning and memory in a conditioned emotion response paradigm by modulation of cholinergic and glutamatergic mechanisms ⬇️

artículo científico publicado el 1 de septiembre de 2012

A nonsynonymous TNFRSF11A variation increases NFκB activity and the severity of Paget's disease

artículo científico publicado en 2012

A point mutation in the ubiquitin-associated domain of SQSMT1 is sufficient to cause a Paget's disease-like disorder in mice

artículo científico publicado en 2011

ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling

artículo científico publicado en 2016

Adult Paget's disease of bone: a review.

artículo científico publicado en 2017

Application of formalin fixation to the purification of amyloid proteins

artículo científico publicado en 1997

Assessment of the direct and indirect effects of MPP+ and dopamine on the human proteasome: implications for Parkinson's disease aetiology.

artículo científico publicado en 2007

Autophagy receptor defects and ALS-FTLD.

artículo científico publicado en 2015

Boning up on autophagy: the role of autophagy in skeletal biology

artículo científico publicado en 2014

Capillary electrophoresis assay for ubiquitin carboxyl-terminal hydrolases with chemically synthesized ubiquitin-valine as substrate

artículo científico publicado en 1997

Carbene footprinting accurately maps binding sites in protein-ligand and protein-protein interactions

artículo científico publicado en 2016

Characterisation of faecal protease activity in irritable bowel syndrome with diarrhoea: origin and effect of gut transit

artículo científico publicado en 2013

Characterization of a non-UBA domain missense mutation of sequestosome 1 (SQSTM1) in Paget's disease of bone

artículo científico publicado en 2009

Characterization of biomarkers in polycystic ovary syndrome (PCOS) using multiple distinct proteomic platforms.

artículo científico publicado en 2007

Chemically synthesized ubiquitin extension proteins detect distinct catalytic capacities of deubiquitinating enzymes.

artículo científico publicado en 1999

Cyclisation of Lys48-linked diubiquitin in vitro and in vivo

scientific article published on 17 October 2012

Defective recognition of LC3B by mutant SQSTM1/p62 implicates impairment of autophagy as a pathogenic mechanism in ALS-FTLD.

artículo científico publicado en 2016

Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and Lewy-like inclusions resembling human pale bodies.

artículo científico publicado en 2008

Dimerisation of the UBA domain of p62 inhibits ubiquitin binding and regulates NF-kappaB signalling

artículo científico publicado en 2010

Disruption of ubiquitin-mediated processes in diseases of the brain and bone

artículo científico publicado en 2008

Diverse polyubiquitin chains accumulate following 26S proteasomal dysfunction in mammalian neurones

artículo científico publicado en 2011

Does an inhibition of the ubiquitin/26S proteasome pathway of protein degradation underlie the pathogenesis of non-familial Alzheimer's disease?

artículo científico publicado en 2001

Effects of endotoxaemia on protein metabolism in rat fast-twitch skeletal muscle and myocardium

artículo científico publicado en 2009

Electrophoretic separation of ubiquitin and single amino acid residue ubiquitin extensions using a commercial modified acrylamide gel electrophoresis system: an assay to determine catalytic capacities of deubiquitinating enzymes

artículo científico publicado en 1999

Erratum

scholarly article published in Autophagy

Evaluation of a novel antibody to define histone 3.3 G34R mutant brain tumours

artículo científico publicado en 2017

Evidence for the preservation of native inter- and intra-molecular hydrogen bonds in the desolvated FK-binding protein·FK506 complex produced by electrospray ionization

artículo científico publicado en 2012

Growth-promoting effects of different fractions of extra-embryonic coelomic fluid on embryonic development

artículo científico publicado en 2000

Guidelines for the use and interpretation of assays for monitoring autophagy

artículo científico publicado en 2012

Immunoreactivity to Lys63-linked polyubiquitin is a feature of neurodegeneration

artículo científico publicado en 2009

Impact of p62/SQSTM1 UBA domain mutations linked to Paget's disease of bone on ubiquitin recognition.

artículo científico publicado en 2011

Independent interactions of ubiquitin-binding domains in a ubiquitin-mediated ternary complex

artículo científico publicado en 2011

Induction of a stress response in Lactococcus lactis is associated with a resistance to ribosomally active antibiotics

article

Inhibition of Cullin RING Ligases by Cycle Inhibiting Factor: Evidence for Interference with Nedd8-Induced Conformational Control

article

Inhibition of the ubiquitin-proteasome system in Alzheimer's disease.

scientific article published on August 2000

Insights into the Molecular Composition of Endogenous Unanchored Polyubiquitin Chains

article

Intracellular aggregation of human stefin B: confocal and electron microscopy study.

artículo científico publicado en 2010

Ion mobility-mass spectrometry reveals conformational flexibility in the deubiquitinating enzyme USP5.

artículo científico publicado en 2015

Knockdown of alpha myosin heavy chain disrupts the cytoskeleton and leads to multiple defects during chick cardiogenesis

artículo científico publicado en 2009

Loss of Ubiquitin Binding Is a Unifying Mechanism by Which Mutations of SQSTM1 Cause Paget’s Disease of Bone

artículo científico publicado en 2006

Loss of Ubiquitin-Binding Associated With Paget's Disease of Bone p62 (SQSTM1) Mutations

article

Mass spectrometry insights into a tandem ubiquitin-binding domain hybrid engineered for the selective recognition of unanchored polyubiquitin.

artículo científico

Method for the Purification of Endogenous Unanchored Polyubiquitin Chains

artículo científico publicado en 2016

Mutant p62/SQSTM1 UBA domains linked to Paget's disease of bone differ in their abilities to function as stabilization signals

artículo científico publicado en 2010

Neurofibrillary tangles of Alzheimer's disease brains contain 14-3-3 proteins

artículo científico publicado en 1996

New insights into the role of sequestosome 1/p62 mutant proteins in the pathogenesis of Paget's disease of bone.

artículo científico

Novel UBA domain mutations of SQSTM1 in Paget's disease of bone: genotype phenotype correlation, functional analysis, and structural consequences

artículo científico publicado en 2004

Optimised two-dimensional electrophoresis procedures for the protein characterisation of structural tissues.

artículo científico publicado en 2005

Overlap of proteomics biomarkers between women with pre-eclampsia and PCOS: a systematic review and biomarker database integration

artículo científico publicado en 2014

PPARdelta agonism induces a change in fuel metabolism and activation of an atrophy programme, but does not impair mitochondrial function in rat skeletal muscle

artículo científico publicado en 2007

Paget disease of bone-associated UBA domain mutations of SQSTM1 exert distinct effects on protein structure and function

artículo científico publicado en 2014

Pathogenesis of Paget disease of bone.

artículo científico publicado en 2012

Pathological lesions of Alzheimer's disease and dementia with Lewy bodies brains exhibit immunoreactivity to an ATPase that is a regulatory subunit of the 26S proteasome

artículo científico publicado en 1996

Physical and functional interaction of sequestosome 1 with Keap1 regulates the Keap1-Nrf2 cell defense pathway

artículo científico publicado en 2010

Principles of proteomics and its applications in cancer

artículo científico publicado en 2007

Probing affinity and ubiquitin linkage selectivity of ubiquitin-binding domains using mass spectrometry

artículo científico publicado en 2012

Proteasomal degradation of tau protein

artículo científico publicado en 2002

Proteomic biomarkers for ovarian cancer risk in women with polycystic ovary syndrome: a systematic review and biomarker database integration.

artículo científico publicado en 2012

Proteomic biomarkers for the diagnosis and risk stratification of polycystic ovary syndrome: a systematic review.

artículo científico publicado en 2009

Proteomic biomarkers of endometrial cancer risk in women with polycystic ovary syndrome: a systematic review and biomarker database integration

artículo científico publicado en 2013

Purification of poly-ubiquitinated proteins by S5a-affinity chromatography ⬇️

artículo científico publicado el 1 de junio de 2001

Recent advances in understanding the molecular basis of Paget disease of bone

artículo científico publicado en 2009

Review: the ubiquitin-proteasome system: contributions to cell death or survival in neurodegeneration.

artículo científico publicado en 2010

Review: unchained maladie - a reassessment of the role of Ubb(+1) -capped polyubiquitin chains in Alzheimer's disease.

artículo científico publicado en 2012

Role of ubiquitin-mediated proteolysis in the pathogenesis of neurodegenerative disorders.

artículo científico publicado en 2003

SQSTM1 mutations--bridging Paget disease of bone and ALS/FTLD.

artículo científico publicado en 2014

Second-harmonic generation imaging of collagen in ancient bone

artículo científico publicado en 2017

Selective isopeptide bond formation: coupling ubiquitin(67-76) with histone 2A(114-128) by use of the transfer active ester condensation technique

artículo científico publicado en 1999

Sequestosome 1 mutations in Paget's disease of bone in Australia: prevalence, genotype/phenotype correlation, and a novel non-UBA domain mutation (P364S) associated with increased NF-kappaB signaling without loss of ubiquitin binding.

artículo científico publicado en 2009

Stability and folding kinetics of a ubiquitin mutant with a strong propensity for nonnative beta-hairpin conformation in the unfolded state

artículo científico publicado en 2003

Structural and functional studies of mutations affecting the UBA domain of SQSTM1 (p62) which cause Paget's disease of bone

artículo científico publicado en 2004

Structural insights into interactions between ubiquitin specific protease 5 and its polyubiquitin substrates by mass spectrometry and ion mobility spectrometry

artículo científico publicado en 2015

Structural insights into specificity and diversity in mechanisms of ubiquitin recognition by ubiquitin-binding domains

artículo científico

Structure of the ubiquitin-associated domain of p62 (SQSTM1) and implications for mutations that cause Paget's disease of bone

artículo científico publicado en 2003

Synthesis, structural and biological studies of ubiquitin mutants containing (2S, 4S)-5-fluoroleucine residues strategically placed in the hydrophobic core

artículo científico publicado en 2003

Temporal changes in the involvement of pyruvate dehydrogenase complex in muscle lactate accumulation during lipopolysaccharide infusion in rats.

artículo científico publicado en 2008

The 6(th) East Midlands Proteomics Workshop supported by the BSPR and BMSS 14 November 2007, Nottingham, UK

artículo científico publicado en 2008

The S349T mutation of SQSTM1 links Keap1/Nrf2 signalling to Paget's disease of bone.

artículo científico publicado en 2012

The mechanism of growth-promoting effects of prolactin in embryogenesis--links to growth factors

scientific article published on 01 January 1999

The molecular pathogenesis of Paget disease of bone.

artículo científico publicado en 2007

The ubiquitin proteasome system in human disease

scientific article published on 18 September 2008

The ubiquitin protein catabolic disorders.

artículo científico publicado en 2001

The ubiquitin-binding protein p62 is expressed in breast cancers showing features of aggressive disease

artículo científico publicado en 2007

Ubiquitin recognition by the ubiquitin-associated domain of p62 involves a novel conformational switch

artículo científico publicado en 2008

Ubiquitin superfolds: intrinsic and attachable regulators of cellular activities?

artículo científico publicado en 1998

Ubiquitin-binding domains: mechanisms of ubiquitin recognition and use as tools to investigate ubiquitin-modified proteomes

artículo científico publicado en 2014

Ubiquitin-mediated signalling and Paget's disease of bone

artículo científico publicado en 2007

Validation of proteomic biomarkers previously found to be differentially expressed in women with polycystic ovary syndrome: a cross-sectional study.

artículo científico publicado en 2014

alpha-synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome

artículo científico publicado en 2001

p62 mutations, ubiquitin recognition and Paget's disease of bone

artículo científico publicado en 2006

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

artículo científico publicado en 2016

Lista de obras de Robert Layfield

5‐HT6 receptor agonists and antagonists enhance learning and memory in a conditioned emotion response paradigm by modulation of cholinergic and glutamatergic mechanisms ⬇️

A nonsynonymous TNFRSF11A variation increases NFκB activity and the severity of Paget's disease

A point mutation in the ubiquitin-associated domain of SQSMT1 is sufficient to cause a Paget's disease-like disorder in mice

ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling

Adult Paget's disease of bone: a review.

Application of formalin fixation to the purification of amyloid proteins

Assessment of the direct and indirect effects of MPP+ and dopamine on the human proteasome: implications for Parkinson's disease aetiology.

Autophagy receptor defects and ALS-FTLD.

Boning up on autophagy: the role of autophagy in skeletal biology

Capillary electrophoresis assay for ubiquitin carboxyl-terminal hydrolases with chemically synthesized ubiquitin-valine as substrate

Carbene footprinting accurately maps binding sites in protein-ligand and protein-protein interactions

Characterisation of faecal protease activity in irritable bowel syndrome with diarrhoea: origin and effect of gut transit

Characterization of a non-UBA domain missense mutation of sequestosome 1 (SQSTM1) in Paget's disease of bone

Characterization of biomarkers in polycystic ovary syndrome (PCOS) using multiple distinct proteomic platforms.

Chemically synthesized ubiquitin extension proteins detect distinct catalytic capacities of deubiquitinating enzymes.

Cyclisation of Lys48-linked diubiquitin in vitro and in vivo

Defective recognition of LC3B by mutant SQSTM1/p62 implicates impairment of autophagy as a pathogenic mechanism in ALS-FTLD.

Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and Lewy-like inclusions resembling human pale bodies.

Dimerisation of the UBA domain of p62 inhibits ubiquitin binding and regulates NF-kappaB signalling

Disruption of ubiquitin-mediated processes in diseases of the brain and bone

Diverse polyubiquitin chains accumulate following 26S proteasomal dysfunction in mammalian neurones

Does an inhibition of the ubiquitin/26S proteasome pathway of protein degradation underlie the pathogenesis of non-familial Alzheimer's disease?

Effects of endotoxaemia on protein metabolism in rat fast-twitch skeletal muscle and myocardium

Electrophoretic separation of ubiquitin and single amino acid residue ubiquitin extensions using a commercial modified acrylamide gel electrophoresis system: an assay to determine catalytic capacities of deubiquitinating enzymes

Erratum

Evaluation of a novel antibody to define histone 3.3 G34R mutant brain tumours

Evidence for the preservation of native inter- and intra-molecular hydrogen bonds in the desolvated FK-binding protein·FK506 complex produced by electrospray ionization

Growth-promoting effects of different fractions of extra-embryonic coelomic fluid on embryonic development

Guidelines for the use and interpretation of assays for monitoring autophagy

Immunoreactivity to Lys63-linked polyubiquitin is a feature of neurodegeneration

Impact of p62/SQSTM1 UBA domain mutations linked to Paget's disease of bone on ubiquitin recognition.

Independent interactions of ubiquitin-binding domains in a ubiquitin-mediated ternary complex

Induction of a stress response in Lactococcus lactis is associated with a resistance to ribosomally active antibiotics

Inhibition of Cullin RING Ligases by Cycle Inhibiting Factor: Evidence for Interference with Nedd8-Induced Conformational Control

Inhibition of the ubiquitin-proteasome system in Alzheimer's disease.

Insights into the Molecular Composition of Endogenous Unanchored Polyubiquitin Chains

Intracellular aggregation of human stefin B: confocal and electron microscopy study.

Ion mobility-mass spectrometry reveals conformational flexibility in the deubiquitinating enzyme USP5.

Knockdown of alpha myosin heavy chain disrupts the cytoskeleton and leads to multiple defects during chick cardiogenesis

Loss of Ubiquitin Binding Is a Unifying Mechanism by Which Mutations of SQSTM1 Cause Paget’s Disease of Bone

Loss of Ubiquitin-Binding Associated With Paget's Disease of Bone p62 (SQSTM1) Mutations

Mass spectrometry insights into a tandem ubiquitin-binding domain hybrid engineered for the selective recognition of unanchored polyubiquitin.

Method for the Purification of Endogenous Unanchored Polyubiquitin Chains

Mutant p62/SQSTM1 UBA domains linked to Paget's disease of bone differ in their abilities to function as stabilization signals

Neurofibrillary tangles of Alzheimer's disease brains contain 14-3-3 proteins

New insights into the role of sequestosome 1/p62 mutant proteins in the pathogenesis of Paget's disease of bone.

Novel UBA domain mutations of SQSTM1 in Paget's disease of bone: genotype phenotype correlation, functional analysis, and structural consequences

Optimised two-dimensional electrophoresis procedures for the protein characterisation of structural tissues.

Overlap of proteomics biomarkers between women with pre-eclampsia and PCOS: a systematic review and biomarker database integration

PPARdelta agonism induces a change in fuel metabolism and activation of an atrophy programme, but does not impair mitochondrial function in rat skeletal muscle

Paget disease of bone-associated UBA domain mutations of SQSTM1 exert distinct effects on protein structure and function

Pathogenesis of Paget disease of bone.

Pathological lesions of Alzheimer's disease and dementia with Lewy bodies brains exhibit immunoreactivity to an ATPase that is a regulatory subunit of the 26S proteasome

Physical and functional interaction of sequestosome 1 with Keap1 regulates the Keap1-Nrf2 cell defense pathway

Principles of proteomics and its applications in cancer

Probing affinity and ubiquitin linkage selectivity of ubiquitin-binding domains using mass spectrometry

Proteasomal degradation of tau protein

Proteomic biomarkers for ovarian cancer risk in women with polycystic ovary syndrome: a systematic review and biomarker database integration.

Proteomic biomarkers for the diagnosis and risk stratification of polycystic ovary syndrome: a systematic review.

Proteomic biomarkers of endometrial cancer risk in women with polycystic ovary syndrome: a systematic review and biomarker database integration

Purification of poly-ubiquitinated proteins by S5a-affinity chromatography ⬇️

Recent advances in understanding the molecular basis of Paget disease of bone

Review: the ubiquitin-proteasome system: contributions to cell death or survival in neurodegeneration.

Review: unchained maladie - a reassessment of the role of Ubb(+1) -capped polyubiquitin chains in Alzheimer's disease.

Role of ubiquitin-mediated proteolysis in the pathogenesis of neurodegenerative disorders.

SQSTM1 mutations--bridging Paget disease of bone and ALS/FTLD.

Second-harmonic generation imaging of collagen in ancient bone

Selective isopeptide bond formation: coupling ubiquitin(67-76) with histone 2A(114-128) by use of the transfer active ester condensation technique

Sequestosome 1 mutations in Paget's disease of bone in Australia: prevalence, genotype/phenotype correlation, and a novel non-UBA domain mutation (P364S) associated with increased NF-kappaB signaling without loss of ubiquitin binding.

Stability and folding kinetics of a ubiquitin mutant with a strong propensity for nonnative beta-hairpin conformation in the unfolded state

Structural and functional studies of mutations affecting the UBA domain of SQSTM1 (p62) which cause Paget's disease of bone

Structural insights into interactions between ubiquitin specific protease 5 and its polyubiquitin substrates by mass spectrometry and ion mobility spectrometry

Structural insights into specificity and diversity in mechanisms of ubiquitin recognition by ubiquitin-binding domains

Structure of the ubiquitin-associated domain of p62 (SQSTM1) and implications for mutations that cause Paget's disease of bone

Synthesis, structural and biological studies of ubiquitin mutants containing (2S, 4S)-5-fluoroleucine residues strategically placed in the hydrophobic core

Temporal changes in the involvement of pyruvate dehydrogenase complex in muscle lactate accumulation during lipopolysaccharide infusion in rats.

The 6(th) East Midlands Proteomics Workshop supported by the BSPR and BMSS 14 November 2007, Nottingham, UK

The S349T mutation of SQSTM1 links Keap1/Nrf2 signalling to Paget's disease of bone.

The mechanism of growth-promoting effects of prolactin in embryogenesis--links to growth factors