Lista de obras - Pedro A Sánchez-Murcia - Dominio Público Uruguay

2'-Deoxyribosyltransferase from Leishmania mexicana, an efficient biocatalyst for one-pot, one-step synthesis of nucleosides from poorly soluble purine bases.

artículo científico publicado en 2017

A Series of Enthalpically Optimized Docetaxel Analogues Exhibiting Enhanced Antitumor Activity and Water Solubility

artículo científico publicado en 2018

A Supramolecular Stabilizer of the 14-3-3ζ/ERα Protein-Protein Interaction with a Synergistic Mode of Action

scientific article published on 11 February 2020

A functional BH3 domain in an aquaporin from Leishmania infantum.

artículo científico publicado en 2016

A novel C,D-spirodioxene taxoid synthesized through an unexpected Pd-mediated ring cyclization

artículo científico publicado en 2015

Arginine mimetic appended peptide-based probes for fluorescence turn-on detection of 14-3-3 proteins

scientific article published on 01 April 2019

Cold-induced aldimine bond cleavage by Tris in Bacillus subtilis alanine racemase

artículo científico publicado en 2019

Comparison of hydrocarbon-and lactam-bridged cyclic peptides as dimerization inhibitors of Leishmania infantum trypanothione reductase

scholarly article in RSC Advances, vol. 5 no. 69, 2015

Conservation of antiviral activity and improved selectivity in PMEO-DAPym upon pyrimidine to triazine scaffold hopping

artículo científico publicado en 2015

DNA-binding mechanism of spiropyran photoswitches: the role of electrostatics

artículo científico publicado en 2019

Directional and regioselective hole injection of spiropyran photoswitches intercalated into A/T-duplex DNA

scientific article published on 01 August 2019

Enantioselective oxidation of galactitol 1-phosphate by galactitol-1-phosphate 5-dehydrogenase from Escherichia coli

artículo científico publicado en 2015

Engineering Erg10 Thiolase from Saccharomyces cerevisiae as a Synthetic Toolkit for the Production of Branched-Chain Alcohols.

artículo científico publicado en 2018

Enhanced Rigidity Changes Ultraviolet Absorption: Effect of a Merocyanine Binder on G-Quadruplex Photophysics

artículo científico publicado en 2020

Enzymatic Synthesis of Therapeutic Nucleosides using a Highly Versatile Purine Nucleoside 2’-DeoxyribosylTransferase from Trypanosoma brucei

scholarly article by Elena Pérez et al published 9 August 2018 in ChemCatChem

Exciton Localization on Ru-Based Photosensitizers Induced by Binding to Lipid Membranes.

artículo científico publicado en 2018

First example of peptides targeting the dimer interface of Leishmania infantum trypanothione reductase with potent in vitro antileishmanial activity

artículo científico publicado en 2017

Formal asymmetric enone aminohydroxylation: organocatalytic one-pot synthesis of 4,5-disubstituted oxazolidinones

scientific article published on 16 May 2012

Functional Characterization and Structural Analysis of NADH Oxidase Mutants from Thermus thermophilus HB27: Role of Residues 166, 174, and 194 in the Catalytic Properties and Thermostability

scientific article published on 31 October 2019

Genome mining and characterisation of a novel transaminase with remote stereoselectivity

artículo científico publicado en 2019

Improved proteolytic stability and potent activity against Leishmania infantum trypanothione reductase of α/β-peptide foldamers conjugated to cell-penetrating peptides

artículo científico publicado en 2017

Making sense of the past: hyperstability of ancestral thioredoxins explained by free energy simulations

artículo científico publicado en 2017

Modular Architecture and Unique Teichoic Acid Recognition Features of Choline-Binding Protein L (CbpL) Contributing to Pneumococcal Pathogenesis

artículo científico publicado en 2016

Molecular Interactions and Implications of Aldose Reductase Inhibition by PGA1 and Clinically Used Prostaglandins.

artículo científico publicado en 2015

Molecular Recognition of Epothilones by Microtubules and Tubulin Dimers Revealed by Biochemical and NMR Approaches

scientific article published on 25 February 2014

Orbital-free photophysical descriptors to predict directional excitations in metal-based photosensitizers

scientific article published on 15 May 2020

Photoactivation of channelrhodopsin

artículo científico publicado en 2007

Pro-death activity of a BH3 domain in an aquaporin from the protozoan parasite Leishmania.

artículo científico publicado en 2016

Probing the dimerization interface of Leishmania infantum trypanothione reductase with site-directed mutagenesis and short peptides

artículo científico publicado en 2013

Pyrrolopyrimidine vs Imidazole-Phenyl-Thiazole Scaffolds in Nonpeptidic Dimerization Inhibitors of Leishmania infantum Trypanothione Reductase

scientific article published on 23 April 2019

Reaction mechanism of nucleoside 2'-deoxyribosyltransferases: free-energy landscape supports an oxocarbenium ion as the reaction intermediate

scientific article published on 01 August 2019

Restoration of Microtubule Interaction and Cytotoxicity in D-seco Taxanes upon Incorporation of 20-Hydroxymethyl-4-allyloxy Groups

artículo científico publicado en 2015

Stepwise Simulation of 3,5-Dihydro-5-methylidene-4H-imidazol-4-one (MIO) Biogenesis in Histidine Ammonia-lyase

artículo científico publicado en 2016

Structural Determinants of the Dictyostatin Chemotype for Tubulin Binding Affinity and Antitumor Activity Against Taxane- and Epothilone-Resistant Cancer Cells.

artículo científico publicado en 2016

Structural rationale for the cross-resistance of tumor cells bearing the A399V variant of elongation factor eEF1A1 to the structurally unrelated didemnin B, ternatin, nannocystin A and ansatrienin B.

artículo científico publicado en 2017

Structure-based domain assignment in Leishmania infantum EndoG: characterization of a pH-dependent regulatory switch and a C-terminal extension that largely dictates DNA substrate preferences.

artículo científico publicado en 2017

Synthesis and evaluation of hybrid molecules targeting the vinca domain of tubulin

artículo científico publicado en 2015

Translation Elongation Factor eEF1A2 is a Novel Anticancer Target for the Marine Natural Product Plitidepsin.

artículo científico publicado en 2016

Trypanothione reductase inhibition and anti-leishmanial activity of all-hydrocarbon stapled α-helical peptides with improved proteolytic stability.

artículo científico publicado en 2018

Unravelling the covalent binding of zampanolide and taccalonolide AJ to a minimalist representation of a human microtubule

scientific article published on 31 May 2019

Unveiling the reaction mechanism of novel copper N-alkylated tetra-azacyclophanes with outstanding superoxide dismutase activity

artículo científico publicado en 2020

Lista de obras de Pedro A Sánchez-Murcia

2'-Deoxyribosyltransferase from Leishmania mexicana, an efficient biocatalyst for one-pot, one-step synthesis of nucleosides from poorly soluble purine bases.

A Series of Enthalpically Optimized Docetaxel Analogues Exhibiting Enhanced Antitumor Activity and Water Solubility

A Supramolecular Stabilizer of the 14-3-3ζ/ERα Protein-Protein Interaction with a Synergistic Mode of Action

A functional BH3 domain in an aquaporin from Leishmania infantum.

A novel C,D-spirodioxene taxoid synthesized through an unexpected Pd-mediated ring cyclization

Arginine mimetic appended peptide-based probes for fluorescence turn-on detection of 14-3-3 proteins

Cold-induced aldimine bond cleavage by Tris in Bacillus subtilis alanine racemase

Comparison of hydrocarbon-and lactam-bridged cyclic peptides as dimerization inhibitors of Leishmania infantum trypanothione reductase

Conservation of antiviral activity and improved selectivity in PMEO-DAPym upon pyrimidine to triazine scaffold hopping

DNA-binding mechanism of spiropyran photoswitches: the role of electrostatics

Directional and regioselective hole injection of spiropyran photoswitches intercalated into A/T-duplex DNA

Enantioselective oxidation of galactitol 1-phosphate by galactitol-1-phosphate 5-dehydrogenase from Escherichia coli

Engineering Erg10 Thiolase from Saccharomyces cerevisiae as a Synthetic Toolkit for the Production of Branched-Chain Alcohols.

Enhanced Rigidity Changes Ultraviolet Absorption: Effect of a Merocyanine Binder on G-Quadruplex Photophysics

Enzymatic Synthesis of Therapeutic Nucleosides using a Highly Versatile Purine Nucleoside 2’-DeoxyribosylTransferase from Trypanosoma brucei

Exciton Localization on Ru-Based Photosensitizers Induced by Binding to Lipid Membranes.

First example of peptides targeting the dimer interface of Leishmania infantum trypanothione reductase with potent in vitro antileishmanial activity

Formal asymmetric enone aminohydroxylation: organocatalytic one-pot synthesis of 4,5-disubstituted oxazolidinones

Functional Characterization and Structural Analysis of NADH Oxidase Mutants from Thermus thermophilus HB27: Role of Residues 166, 174, and 194 in the Catalytic Properties and Thermostability

Genome mining and characterisation of a novel transaminase with remote stereoselectivity

Improved proteolytic stability and potent activity against Leishmania infantum trypanothione reductase of α/β-peptide foldamers conjugated to cell-penetrating peptides

Making sense of the past: hyperstability of ancestral thioredoxins explained by free energy simulations

Modular Architecture and Unique Teichoic Acid Recognition Features of Choline-Binding Protein L (CbpL) Contributing to Pneumococcal Pathogenesis

Molecular Interactions and Implications of Aldose Reductase Inhibition by PGA1 and Clinically Used Prostaglandins.

Molecular Recognition of Epothilones by Microtubules and Tubulin Dimers Revealed by Biochemical and NMR Approaches

Orbital-free photophysical descriptors to predict directional excitations in metal-based photosensitizers

Photoactivation of channelrhodopsin

Pro-death activity of a BH3 domain in an aquaporin from the protozoan parasite Leishmania.

Probing the dimerization interface of Leishmania infantum trypanothione reductase with site-directed mutagenesis and short peptides

Pyrrolopyrimidine vs Imidazole-Phenyl-Thiazole Scaffolds in Nonpeptidic Dimerization Inhibitors of Leishmania infantum Trypanothione Reductase

Reaction mechanism of nucleoside 2'-deoxyribosyltransferases: free-energy landscape supports an oxocarbenium ion as the reaction intermediate

Restoration of Microtubule Interaction and Cytotoxicity in D-seco Taxanes upon Incorporation of 20-Hydroxymethyl-4-allyloxy Groups

Stepwise Simulation of 3,5-Dihydro-5-methylidene-4H-imidazol-4-one (MIO) Biogenesis in Histidine Ammonia-lyase

Structural Determinants of the Dictyostatin Chemotype for Tubulin Binding Affinity and Antitumor Activity Against Taxane- and Epothilone-Resistant Cancer Cells.

Structural rationale for the cross-resistance of tumor cells bearing the A399V variant of elongation factor eEF1A1 to the structurally unrelated didemnin B, ternatin, nannocystin A and ansatrienin B.

Structure-based domain assignment in Leishmania infantum EndoG: characterization of a pH-dependent regulatory switch and a C-terminal extension that largely dictates DNA substrate preferences.

Synthesis and evaluation of hybrid molecules targeting the vinca domain of tubulin

Translation Elongation Factor eEF1A2 is a Novel Anticancer Target for the Marine Natural Product Plitidepsin.

Trypanothione reductase inhibition and anti-leishmanial activity of all-hydrocarbon stapled α-helical peptides with improved proteolytic stability.

Unravelling the covalent binding of zampanolide and taccalonolide AJ to a minimalist representation of a human microtubule

Unveiling the reaction mechanism of novel copper N-alkylated tetra-azacyclophanes with outstanding superoxide dismutase activity