Lista de obras - Leen M 't Hart - Dominio Público Uruguay

35th Annual Meeting of the European Association for the Study of Diabetes : Brussels, Belgium, 28 September-2 October 1999

article

A Common Gene Variant in Glucokinase Regulatory Protein Interacts With Glucose Metabolism on Diabetic Dyslipidemia: the Combined CODAM and Hoorn Studies

artículo científico publicado en 2016

A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants

artículo científico publicado en 2017

A SNP panel for identification of DNA and RNA specimens

artículo científico publicado en 2018

A gene variant near ATM is significantly associated with metformin treatment response in type 2 diabetes: a replication and meta-analysis of five cohorts.

artículo científico publicado en 2012

Association of polymorphism in the receptor for advanced glycation end products (RAGE) gene with circulating RAGE levels

artículo científico publicado en 2009

BclI Glucocorticoid Receptor Polymorphism Is Associated With Greater Body Fatness: The Hoorn and CODAM Studies

BclI Glucocorticoid Receptor Polymorphism in Relation to Arterial Stiffening and Cardiac Structure and Function: The Hoorn and CODAM Studies

artículo científico publicado en 2017

BclI glucocorticoid receptor polymorphism in relation to cardiovascular variables: the Hoorn and CODAM studies

artículo científico publicado en 2015

Blood metabolomic measures associate with present and future glycemic control in type 2 diabetes

CONQUER: an interactive toolbox to understand functional consequences of GWAS hits

artículo científico publicado en 2020

Clinical profiles of post-load glucose subgroups and their association with glycaemic traits over time: an IMI-DIRECT study

artículo científico publicado en 2020

Cohort Profile: The Hoorn Studies

artículo científico publicado en 2017

Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk ⬇️

scientific article published on 17 June 2009

Combined gene and protein expression of hormone-sensitive lipase and adipose triglyceride lipase, mitochondrial content, and adipocyte size in subcutaneous and visceral adipose tissue of morbidly obese men.

artículo científico publicado en 2011

Combined risk allele score of eight type 2 diabetes genes is associated with reduced first-phase glucose-stimulated insulin secretion during hyperglycemic clamps

artículo científico publicado en 2009

Common variants in the type 2 diabetes KCNQ1 gene are associated with impairments in insulin secretion during hyperglycaemic glucose clamp

artículo científico publicado en 2012

Correction: Common Variants in the Type 2 Diabetes KCNQ1 Gene Are Associated with Impairments in Insulin Secretion During Hyperglycaemic Glucose Clamp

artículo científico publicado en 2012

Distinct Molecular Signatures of Clinical Clusters in People With Type 2 Diabetes: An IMI-RHAPSODY Study

artículo científico publicado en 2021

Effects of induced hyperinsulinaemia with and without hyperglycaemia on measures of cardiac vagal control

artículo científico publicado en 2013

Evaluation of the importance of maternal history of diabetes and of mitochondrial variation in the development of NIDDM.

artículo científico publicado en 1996

Evidence that the mitochondrial leucyl tRNA synthetase (LARS2) gene represents a novel type 2 diabetes susceptibility gene

artículo científico publicado en 2005

Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes.

artículo científico publicado en 2012

Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell function

artículo científico publicado en 2009

Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study

artículo científico publicado en 2009

Genetic association analysis of LARS2 with type 2 diabetes

artículo científico publicado en 2010

Genetic factors and insulin secretion: gene variants in the IGF genes

artículo científico publicado en 2004

Genetic influences on the insulin response of the beta cell to different secretagogues

artículo científico publicado en 2009

HLA-DQ polymorphism and degree of heteroplasmy of the A3243G mitochondrial DNA mutation in maternally inherited diabetes and deafness

artículo científico publicado en 2000

HbA1c is associated with altered expression in blood of cell cycle- and immune response-related genes.

artículo científico publicado en 2017

Heteroplasmy levels of a mitochondrial gene mutation associated with diabetes mellitus decrease in leucocyte DNA upon aging

article

Identification of biomarkers for glycaemic deterioration in type 2 diabetes

artículo científico publicado en 2023

Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms.

artículo científico publicado en 2007

Inflammation and apoptosis genes and the risk of restenosis after percutaneous coronary intervention.

artículo científico publicado en 2006

Integration of epidemiologic, pharmacologic, genetic and gut microbiome data in a drug-metabolite atlas

scientific article published on 13 January 2020

Integrative network analysis highlights biological processes underlying GLP-1 stimulated insulin secretion: A DIRECT study

artículo científico publicado en 2018

Lack of association between gene variants in the ALMS1 gene and Type 2 diabetes mellitus

artículo científico publicado en 2003

Lessons that can be learned from patients with diabetogenic mutations in mitochondrial DNA: implications for common type 2 diabetes.

artículo científico publicado en 2007

Low mitochondrial DNA content associates with familial longevity: the Leiden Longevity Study

artículo científico publicado en 2014

Maternally inherited diabetes and deafness (MIDD): unusual occult exocrine pancreatic manifestation in an affected German family

artículo científico publicado en 2000

Metabolic Age Based on the BBMRI-NL 1H-NMR Metabolomics Repository as Biomarker of Age-related Disease

artículo científico publicado en 2020

Metabolite ratios as potential biomarkers for type 2 diabetes: a DIRECT study.

artículo científico publicado en 2017

Metformin and statin use associate with plasma protein N-glycosylation in people with type 2 diabetes

artículo científico publicado en 2020

Mitochondrial diabetes and its lessons for common Type 2 diabetes.

artículo científico publicado en 2006

Mitochondrial diabetes: molecular mechanisms and clinical presentation

artículo científico publicado en 2004

Molecular mechanisms of mitochondrial diabetes (MIDD).

artículo científico publicado en 2005

Neuropeptide Y polymorphism significantly magnifies diabetes and cardiovascular disease risk in obesity: the Hoorn Study

artículo científico publicado en 2007

New insights in the molecular pathogenesis of the maternally inherited diabetes and deafness syndrome

artículo científico publicado en 2006

Performance of prediction models for nephropathy in people with type 2 diabetes: systematic review and external validation study

artículo científico publicado en 2021

Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts

scientific article published on 19 June 2020

Progressive sensorineural hearing impairment in maternally inherited diabetes mellitus and deafness (MIDD).

artículo científico publicado en 2006

Replication and cross-validation of type 2 diabetes subtypes based on clinical variables: an IMI-RHAPSODY study ⬇️

artículo científico publicado en 2021

SULF2 strongly prediposes to fasting and postprandial triglycerides in patients with obesity and type 2 diabetes mellitus

artículo científico publicado en 2014

Sex steroids affect triglyceride handling, glucose-dependent insulinotropic polypeptide, and insulin sensitivity: a 1-week randomized clinical trial in healthy young men.

artículo científico publicado en 2010

Sex-specific effects of naturally occurring variants in the dopamine receptor D2 locus on insulin secretion and type 2 diabetes susceptibility.

artículo científico publicado en 2014

The CTRB1/2 locus affects diabetes susceptibility and treatment via the incretin pathway

artículo científico publicado en 2013

The HADHSC gene encoding short-chain L-3-hydroxyacyl-CoA dehydrogenase (SCHAD) and type 2 diabetes susceptibility: the DAMAGE study

artículo científico publicado en 2006

The Hoorn Diabetes Care System (DCS) cohort. A prospective cohort of persons with type 2 diabetes treated in primary care in the Netherlands

artículo científico

The association between the -374T/A polymorphism of the receptor for advanced glycation endproducts gene and blood pressure and arterial stiffness is modified by glucose metabolism status: the Hoorn and CoDAM studies

artículo científico publicado en 2010

The association of mitochondrial content with prevalent and incident type 2 diabetes.

artículo científico publicado en 2010

The endothelial function biomarker soluble E-selectin is associated with nonalcoholic fatty liver disease

scientific article published on 20 January 2020

The heritability of beta cell function parameters in a mixed meal test design

artículo científico publicado en 2011

The impact of genetic variation in the G6PC2 gene on insulin secretion depends on glycemia

artículo científico publicado en 2010

The molecular basis and clinical characteristics of Maternally Inherited Diabetes and Deafness (MIDD), a recently recognized diabetic subtype.

artículo científico publicado en 1996

Tumor necrosis factor-alpha plays an important role in restenosis development

artículo científico publicado en 2005

Variants in Pharmacokinetic Transporters and Glycemic Response to Metformin: A Metgen Meta-Analysis.

artículo científico publicado en 2016

Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps

artículo científico publicado en 2008

Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin

artículo científico publicado en 2016

Variations in insulin secretion in carriers of gene variants in IRS-1 and -2.

artículo científico publicado en 2002

Variations in insulin secretion in carriers of the E23K variant in the KIR6.2 subunit of the ATP-sensitive K(+) channel in the beta-cell

artículo científico publicado en 2002

Lista de obras de Leen M 't Hart

35th Annual Meeting of the European Association for the Study of Diabetes : Brussels, Belgium, 28 September-2 October 1999

A Common Gene Variant in Glucokinase Regulatory Protein Interacts With Glucose Metabolism on Diabetic Dyslipidemia: the Combined CODAM and Hoorn Studies

A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants

A SNP panel for identification of DNA and RNA specimens

A gene variant near ATM is significantly associated with metformin treatment response in type 2 diabetes: a replication and meta-analysis of five cohorts.

Association of polymorphism in the receptor for advanced glycation end products (RAGE) gene with circulating RAGE levels

BclI Glucocorticoid Receptor Polymorphism Is Associated With Greater Body Fatness: The Hoorn and CODAM Studies

BclI Glucocorticoid Receptor Polymorphism in Relation to Arterial Stiffening and Cardiac Structure and Function: The Hoorn and CODAM Studies

BclI glucocorticoid receptor polymorphism in relation to cardiovascular variables: the Hoorn and CODAM studies

Blood metabolomic measures associate with present and future glycemic control in type 2 diabetes

CONQUER: an interactive toolbox to understand functional consequences of GWAS hits

Clinical profiles of post-load glucose subgroups and their association with glycaemic traits over time: an IMI-DIRECT study

Cohort Profile: The Hoorn Studies

Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk ⬇️

Combined gene and protein expression of hormone-sensitive lipase and adipose triglyceride lipase, mitochondrial content, and adipocyte size in subcutaneous and visceral adipose tissue of morbidly obese men.

Combined risk allele score of eight type 2 diabetes genes is associated with reduced first-phase glucose-stimulated insulin secretion during hyperglycemic clamps

Common variants in the type 2 diabetes KCNQ1 gene are associated with impairments in insulin secretion during hyperglycaemic glucose clamp

Correction: Common Variants in the Type 2 Diabetes KCNQ1 Gene Are Associated with Impairments in Insulin Secretion During Hyperglycaemic Glucose Clamp

Distinct Molecular Signatures of Clinical Clusters in People With Type 2 Diabetes: An IMI-RHAPSODY Study

Effects of induced hyperinsulinaemia with and without hyperglycaemia on measures of cardiac vagal control

Evaluation of the importance of maternal history of diabetes and of mitochondrial variation in the development of NIDDM.

Evidence that the mitochondrial leucyl tRNA synthetase (LARS2) gene represents a novel type 2 diabetes susceptibility gene

Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes.

Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell function

Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study

Genetic association analysis of LARS2 with type 2 diabetes

Genetic factors and insulin secretion: gene variants in the IGF genes

Genetic influences on the insulin response of the beta cell to different secretagogues

HLA-DQ polymorphism and degree of heteroplasmy of the A3243G mitochondrial DNA mutation in maternally inherited diabetes and deafness

HbA1c is associated with altered expression in blood of cell cycle- and immune response-related genes.

Heteroplasmy levels of a mitochondrial gene mutation associated with diabetes mellitus decrease in leucocyte DNA upon aging

Identification of biomarkers for glycaemic deterioration in type 2 diabetes

Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms.

Inflammation and apoptosis genes and the risk of restenosis after percutaneous coronary intervention.

Integration of epidemiologic, pharmacologic, genetic and gut microbiome data in a drug-metabolite atlas

Integrative network analysis highlights biological processes underlying GLP-1 stimulated insulin secretion: A DIRECT study

Lack of association between gene variants in the ALMS1 gene and Type 2 diabetes mellitus

Lessons that can be learned from patients with diabetogenic mutations in mitochondrial DNA: implications for common type 2 diabetes.

Low mitochondrial DNA content associates with familial longevity: the Leiden Longevity Study

Maternally inherited diabetes and deafness (MIDD): unusual occult exocrine pancreatic manifestation in an affected German family

Metabolic Age Based on the BBMRI-NL 1H-NMR Metabolomics Repository as Biomarker of Age-related Disease

Metabolite ratios as potential biomarkers for type 2 diabetes: a DIRECT study.

Metformin and statin use associate with plasma protein N-glycosylation in people with type 2 diabetes

Mitochondrial diabetes and its lessons for common Type 2 diabetes.

Mitochondrial diabetes: molecular mechanisms and clinical presentation

Molecular mechanisms of mitochondrial diabetes (MIDD).

Neuropeptide Y polymorphism significantly magnifies diabetes and cardiovascular disease risk in obesity: the Hoorn Study

New insights in the molecular pathogenesis of the maternally inherited diabetes and deafness syndrome

Performance of prediction models for nephropathy in people with type 2 diabetes: systematic review and external validation study

Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts

Progressive sensorineural hearing impairment in maternally inherited diabetes mellitus and deafness (MIDD).

Replication and cross-validation of type 2 diabetes subtypes based on clinical variables: an IMI-RHAPSODY study ⬇️

SULF2 strongly prediposes to fasting and postprandial triglycerides in patients with obesity and type 2 diabetes mellitus

Sex steroids affect triglyceride handling, glucose-dependent insulinotropic polypeptide, and insulin sensitivity: a 1-week randomized clinical trial in healthy young men.

Sex-specific effects of naturally occurring variants in the dopamine receptor D2 locus on insulin secretion and type 2 diabetes susceptibility.

The CTRB1/2 locus affects diabetes susceptibility and treatment via the incretin pathway

The HADHSC gene encoding short-chain L-3-hydroxyacyl-CoA dehydrogenase (SCHAD) and type 2 diabetes susceptibility: the DAMAGE study

The Hoorn Diabetes Care System (DCS) cohort. A prospective cohort of persons with type 2 diabetes treated in primary care in the Netherlands

The association between the -374T/A polymorphism of the receptor for advanced glycation endproducts gene and blood pressure and arterial stiffness is modified by glucose metabolism status: the Hoorn and CoDAM studies

The association of mitochondrial content with prevalent and incident type 2 diabetes.

The endothelial function biomarker soluble E-selectin is associated with nonalcoholic fatty liver disease

The heritability of beta cell function parameters in a mixed meal test design

The impact of genetic variation in the G6PC2 gene on insulin secretion depends on glycemia

The molecular basis and clinical characteristics of Maternally Inherited Diabetes and Deafness (MIDD), a recently recognized diabetic subtype.

Tumor necrosis factor-alpha plays an important role in restenosis development

Variants in Pharmacokinetic Transporters and Glycemic Response to Metformin: A Metgen Meta-Analysis.

Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps

Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin

Variations in insulin secretion in carriers of gene variants in IRS-1 and -2.

Variations in insulin secretion in carriers of the E23K variant in the KIR6.2 subunit of the ATP-sensitive K(+) channel in the beta-cell