Lista de obras - Robin L. Thurmond - Dominio Público Uruguay

A phase 2a study of toreforant, a histamine H4 receptor antagonist, in eosinophilic asthma

A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties

scientific journal article

Agonist/antagonist modulation in a series of 2-aryl benzimidazole H4 receptor ligands

artículo científico publicado en 2010

Alcaftadine, a new antihistamine with combined antagonist activity at histamine H1, H2, and H4 receptors

article

Antagonism of the histamine H4 receptor reduces LPS-induced TNF production in vivo ⬇️

artículo científico publicado el 27 de marzo de 2013

Antigen Presenting Cells as Drug Targets

Antihistamines and itch

artículo científico

Behavioural phenotype of histamine H4 receptor knockout mice: Focus on central neuronal functions

artículo científico publicado en 2016

Cathepsin S inhibitors as novel immunomodulators

artículo científico publicado en 2005

Chapter 3 NMR Studies of Membrane Lipid Properties

Clinical Development of Histamine H4 Receptor Antagonists

artículo científico publicado en 2017

Clinical and preclinical characterization of the histamine H(4) receptor antagonist JNJ-39758979.

artículo científico publicado en 2014

Cloning and pharmacological characterization of the dog histamine H4 receptor

artículo científico publicado en 2008

Cloning, expression, purification, and activity of dog (Canis familiaris) and monkey (Saimiri boliviensis) cathepsin S.

artículo científico publicado en 2003

Conformational energetics of rhodopsin modulated by nonlamellar-forming lipids

artículo científico publicado en 2002

Curvature, order, and dynamics of lipid hexagonal phases studied by deuterium NMR spectroscopy.

artículo científico publicado en 1993

Deuterium NMR study of intermolecular interactions in lamellar phases containing palmitoyllysophosphatidylcholine

article

Diazinones as P2 replacements for pyrazole-based cathepsin S inhibitors

artículo científico publicado en 2010

Discovery and SAR of 6-alkyl-2,4-diaminopyrimidines as histamine H₄ receptor antagonists

artículo científico publicado en 2014

Discovery and SAR of novel pyrazole-based thioethers as cathepsin S inhibitors: part 1.

artículo científico publicado en 2010

Discovery and SAR studies of a novel series of noncovalent cathepsin S inhibitors.

artículo científico publicado en 2005

Elastic deformation of membrane bilayers probed by deuterium NMR relaxation

artículo científico publicado en 2002

Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist

artículo científico publicado en 2005

Functional Profiling of 2-Aminopyrimidine Histamine H4 Receptor Modulators

artículo científico

Gene-Expression - Based Responses to Drug Treatment

artículo científico publicado en 2002

Histamine H 4 receptor antagonists

Histamine H4 receptor activation enhances LPS-induced IL-6 production in mast cells via ERK and PI3K activation

article

Histamine H4 receptor antagonism diminishes existing airway inflammation and dysfunction via modulation of Th2 cytokines

artículo científico publicado en 2010

Histamine H4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus

artículo científico publicado en 2006

Histamine H4 receptor expression is elevated in human nasal polyp tissue

artículo científico publicado en 2007

Histamine H4 receptor mediates chemotaxis and calcium mobilization of mast cells

artículo científico publicado en 2003

Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation

artículo científico publicado en 2004

Histamine H4 receptor optimizes T regulatory cell frequency and facilitates anti-inflammatory responses within the central nervous system

artículo científico publicado en 2011

Histamine H4-receptors inhibit mast cell renin release in ischemia/reperfusion via protein kinase C ε-dependent aldehyde dehydrogenase type-2 activation

artículo científico publicado en 2014

Histamine H4receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation

Histamine Receptors and Signaling

Histamine down-regulates IL-27 production in antigen-presenting cells

artículo científico publicado en 2012

Histamine inflammation. Preface

artículo científico publicado el 1 de enero de 2010

Identification of 2-arylbenzimidazoles as potent human histamine H4 receptor ligands

artículo científico publicado en 2006

Identification of a Potent and Selective Noncovalent Cathepsin S Inhibitor ⬇️

artículo científico publicado el 17 de octubre de 2003

Influences of membrane curvature in lipid hexagonal phases studied by deuterium NMR spectroscopy

article

Inhibitory effects of histamine H4 receptor antagonists on experimental colitis in the rat.

artículo científico publicado en 2005

Kinetics of small molecule inhibitor binding to p38 kinase

artículo científico publicado en 2001

Magnetic alignment and orientational order of dipalmitoylphosphatidylcholine bilayers containing palmitoyllsyophosphatidylcholine

artículo científico publicado en 1990

Membrane Thickness and Molecular Ordering in Acholeplasma laidlawii Strain A Studied by 2H NMR Spectroscopy

artículo científico publicado en 1994

Molecular determinants of ligand binding to H4R species variants

artículo científico publicado en 2010

Nonpeptidic, noncovalent inhibitors of the cysteine protease cathepsin S.

artículo científico publicado en 2004

Organic cation transporter 3 modulates murine basophil functions by controlling intracellular histamine levels

scientific journal article

Peripheral Neuronal Mechanism of Itch

Pharmacological characterization of oxime agonists of the histamine H4 receptor

scholarly article by Robin L. Thurmond published December 2009 in Journal of Receptor, Ligand and Channel Research

Phosphoinositide 3-kinase gamma (PI3Kgamma) inhibitors for the treatment of inflammation and autoimmune disease

artículo científico publicado en 2010

Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists

artículo científico publicado en 2005

Proteases as Drug Targets

Pyrazole-based arylalkyne cathepsin S inhibitors. Part II: optimization of cellular potency

artículo científico publicado en 2009

Pyrazole-based cathepsin S inhibitors with arylalkynes as P1 binding elements

artículo científico publicado en 2009

Pyrazole-based cathepsin S inhibitors with improved cellular potency

scientific article published in 2007

RHAMM, a receptor for hyaluronan-mediated motility, compensates for CD44 in inflamed CD44-knockout mice: a different interpretation of redundancy

artículo científico publicado en 2004

Recent advances in the design of cathepsin S inhibitors

scientific article published on January 2010

Results from a Phase IIA Parallel Group Study of JNJ-40346527, an Oral CSF-1R Inhibitor, in Patients with Active Rheumatoid Arthritis despite Disease-modifying Antirheumatic Drug Therapy

artículo científico

STAT1 phosphorylation and cleavage is regulated by the histamine (H4) receptor in human atopic and non-atopic lymphocytes

Structural requirements for inverse agonism and neutral antagonism of indole-, benzimidazole-, and thienopyrrole-derived histamine H4 receptor ligands

artículo científico publicado en 2010

Structure and packing of phosphatidylcholines in lamellar and hexagonal liquid-crystalline mixtures with a nonionic detergent: a wide-line deuterium and phosphorus-31 NMR study

Subdomains in the F and G helices of bacteriorhodopsin regulate the conformational transitions of the reprotonation mechanism

artículo científico publicado en 2002

TLR7/9 antagonists as therapeutics for immune-mediated inflammatory disorders

artículo científico publicado en 2007

The Histamine H4 Receptor: Drug Discovery in the Post-genomic Era

The Role of Histamine H4 Receptor in Asthma and Atopic Dermatitis

The SAR of 4-substituted (6,6-bicyclic) piperidine cathepsin S inhibitors

artículo científico publicado en 2006

The first potent and selective non-imidazole human histamine H4 receptor antagonists

artículo científico publicado en 2003

The future antihistamines: histamine H3 and H4 receptor ligands

artículo científico publicado en 2010

The histamine H(4) receptor: a novel modulator of inflammatory and immune disorders

artículo científico publicado en 2006

The histamine H4 receptor and potential therapeutic uses for H4 ligands

artículo científico publicado en 2004

The histamine H4 receptor as a new therapeutic target for inflammation

artículo científico publicado en 2005

The histamine H4 receptor in autoimmune disease

artículo científico publicado en 2006

The histamine H4 receptor is a potent inhibitor of adhesion-dependent degranulation in human neutrophils

artículo científico publicado en 2014

The histamine H4 receptor mediates allergic airway inflammation by regulating the activation of CD4+ T cells

artículo científico publicado en 2006

The histamine H4 receptor mediates inflammation and Th17 responses in preclinical models of arthritis

artículo científico publicado en 2013

The histamine H4 receptor mediates inflammation and pruritus in Th2-dependent dermal inflammation

artículo científico publicado en 2009

The histamine H4 receptor: from orphan to the clinic

artículo científico

The histamine H₄ receptor antagonist, JNJ 39758979, is effective in reducing histamine-induced pruritus in a randomized clinical study in healthy subjects

artículo científico publicado en 2014

The mechanism of molecular redundancy in autoimmune inflammation in the context of CD44 deficiency

artículo científico publicado en 2005

The new biology of histamine receptors

artículo científico publicado en 2008

The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines

artículo científico publicado en 2008

Thioether acetamides as P3 binding elements for tetrahydropyrido-pyrazole cathepsin S inhibitors

artículo científico publicado en 2010

Toreforant, A Histamine H4 Receptor Antagonist, in Patients with Active Rheumatoid Arthritis Despite Methotrexate Therapy: Results of 2 Phase II Studies

artículo científico publicado en 2016

Triamino pyrimidines and pyridines as histamine H4 receptor modulators

artículo científico publicado en 2011

Lista de obras de Robin L. Thurmond

A phase 2a study of toreforant, a histamine H4 receptor antagonist, in eosinophilic asthma

A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties

Agonist/antagonist modulation in a series of 2-aryl benzimidazole H4 receptor ligands

Alcaftadine, a new antihistamine with combined antagonist activity at histamine H1, H2, and H4 receptors

Antagonism of the histamine H4 receptor reduces LPS-induced TNF production in vivo ⬇️

Antigen Presenting Cells as Drug Targets

Antihistamines and itch

Behavioural phenotype of histamine H4 receptor knockout mice: Focus on central neuronal functions

Cathepsin S inhibitors as novel immunomodulators

Chapter 3 NMR Studies of Membrane Lipid Properties

Clinical Development of Histamine H4 Receptor Antagonists

Clinical and preclinical characterization of the histamine H(4) receptor antagonist JNJ-39758979.

Cloning and pharmacological characterization of the dog histamine H4 receptor

Cloning, expression, purification, and activity of dog (Canis familiaris) and monkey (Saimiri boliviensis) cathepsin S.

Conformational energetics of rhodopsin modulated by nonlamellar-forming lipids

Curvature, order, and dynamics of lipid hexagonal phases studied by deuterium NMR spectroscopy.

Deuterium NMR study of intermolecular interactions in lamellar phases containing palmitoyllysophosphatidylcholine

Diazinones as P2 replacements for pyrazole-based cathepsin S inhibitors

Discovery and SAR of 6-alkyl-2,4-diaminopyrimidines as histamine H₄ receptor antagonists

Discovery and SAR of novel pyrazole-based thioethers as cathepsin S inhibitors: part 1.

Discovery and SAR studies of a novel series of noncovalent cathepsin S inhibitors.

Elastic deformation of membrane bilayers probed by deuterium NMR relaxation

Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist

Functional Profiling of 2-Aminopyrimidine Histamine H4 Receptor Modulators

Gene-Expression - Based Responses to Drug Treatment

Histamine H 4 receptor antagonists

Histamine H4 receptor activation enhances LPS-induced IL-6 production in mast cells via ERK and PI3K activation

Histamine H4 receptor antagonism diminishes existing airway inflammation and dysfunction via modulation of Th2 cytokines

Histamine H4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus

Histamine H4 receptor expression is elevated in human nasal polyp tissue

Histamine H4 receptor mediates chemotaxis and calcium mobilization of mast cells

Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation

Histamine H4 receptor optimizes T regulatory cell frequency and facilitates anti-inflammatory responses within the central nervous system

Histamine H4-receptors inhibit mast cell renin release in ischemia/reperfusion via protein kinase C ε-dependent aldehyde dehydrogenase type-2 activation

Histamine H4receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation

Histamine Receptors and Signaling

Histamine down-regulates IL-27 production in antigen-presenting cells

Histamine inflammation. Preface

Identification of 2-arylbenzimidazoles as potent human histamine H4 receptor ligands

Identification of a Potent and Selective Noncovalent Cathepsin S Inhibitor ⬇️

Influences of membrane curvature in lipid hexagonal phases studied by deuterium NMR spectroscopy

Inhibitory effects of histamine H4 receptor antagonists on experimental colitis in the rat.

Kinetics of small molecule inhibitor binding to p38 kinase

Magnetic alignment and orientational order of dipalmitoylphosphatidylcholine bilayers containing palmitoyllsyophosphatidylcholine

Membrane Thickness and Molecular Ordering in Acholeplasma laidlawii Strain A Studied by 2H NMR Spectroscopy

Molecular determinants of ligand binding to H4R species variants

Nonpeptidic, noncovalent inhibitors of the cysteine protease cathepsin S.

Organic cation transporter 3 modulates murine basophil functions by controlling intracellular histamine levels

Peripheral Neuronal Mechanism of Itch

Pharmacological characterization of oxime agonists of the histamine H4 receptor

Phosphoinositide 3-kinase gamma (PI3Kgamma) inhibitors for the treatment of inflammation and autoimmune disease

Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists

Proteases as Drug Targets

Pyrazole-based arylalkyne cathepsin S inhibitors. Part II: optimization of cellular potency

Pyrazole-based cathepsin S inhibitors with arylalkynes as P1 binding elements

Pyrazole-based cathepsin S inhibitors with improved cellular potency

RHAMM, a receptor for hyaluronan-mediated motility, compensates for CD44 in inflamed CD44-knockout mice: a different interpretation of redundancy

Recent advances in the design of cathepsin S inhibitors

Results from a Phase IIA Parallel Group Study of JNJ-40346527, an Oral CSF-1R Inhibitor, in Patients with Active Rheumatoid Arthritis despite Disease-modifying Antirheumatic Drug Therapy

STAT1 phosphorylation and cleavage is regulated by the histamine (H4) receptor in human atopic and non-atopic lymphocytes

Structural requirements for inverse agonism and neutral antagonism of indole-, benzimidazole-, and thienopyrrole-derived histamine H4 receptor ligands

Structure and packing of phosphatidylcholines in lamellar and hexagonal liquid-crystalline mixtures with a nonionic detergent: a wide-line deuterium and phosphorus-31 NMR study

Subdomains in the F and G helices of bacteriorhodopsin regulate the conformational transitions of the reprotonation mechanism

TLR7/9 antagonists as therapeutics for immune-mediated inflammatory disorders

The Histamine H4 Receptor: Drug Discovery in the Post-genomic Era

The Role of Histamine H4 Receptor in Asthma and Atopic Dermatitis

The SAR of 4-substituted (6,6-bicyclic) piperidine cathepsin S inhibitors

The first potent and selective non-imidazole human histamine H4 receptor antagonists

The future antihistamines: histamine H3 and H4 receptor ligands

The histamine H(4) receptor: a novel modulator of inflammatory and immune disorders

The histamine H4 receptor and potential therapeutic uses for H4 ligands

The histamine H4 receptor as a new therapeutic target for inflammation

The histamine H4 receptor in autoimmune disease

The histamine H4 receptor is a potent inhibitor of adhesion-dependent degranulation in human neutrophils

The histamine H4 receptor mediates allergic airway inflammation by regulating the activation of CD4+ T cells

The histamine H4 receptor mediates inflammation and Th17 responses in preclinical models of arthritis

The histamine H4 receptor mediates inflammation and pruritus in Th2-dependent dermal inflammation

The histamine H4 receptor: from orphan to the clinic

The histamine H₄ receptor antagonist, JNJ 39758979, is effective in reducing histamine-induced pruritus in a randomized clinical study in healthy subjects