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Lista de obras de Shaomeng Wang

(alpha/beta+alpha)-peptide antagonists of BH3 domain/Bcl-x(L) recognition: toward general strategies for foldamer-based inhibition of protein-protein interactions

artículo científico publicado en 2007

-(-)Gossypol promotes the apoptosis of bladder cancer cells in vitro.

artículo científico publicado en 2008

3-(Hydroxymethyl)-bearing phosphatidylinositol ether lipid analogues and carbonate surrogates block PI3-K, Akt, and cancer cell growth

artículo científico publicado en 2000

A Message from the Editors-in-Chief

scientific article published on 22 February 2019

A Potent and Highly Efficacious Bcl-2/Bcl-xL Inhibitor ⬇️

artículo científico publicado el 22 de marzo de 2013

A Potent and Orally Active Antagonist (SM-406/AT-406) of Multiple Inhibitor of Apoptosis Proteins (IAPs) in Clinical Development for Cancer Treatment ⬇️

artículo científico publicado el 28 de marzo de 2011

A dual-readout F2 assay that combines fluorescence resonance energy transfer and fluorescence polarization for monitoring bimolecular interactions.

artículo científico publicado en 2011

A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53.

artículo científico publicado en 2013

A phase II trial of the BCL-2 homolog domain 3 mimetic AT-101 in combination with docetaxel for recurrent, locally advanced, or metastatic head and neck cancer.

artículo científico publicado en 2016

A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylation

artículo científico publicado en 2017

A potent small-molecule inhibitor of the MDM2-p53 interaction (MI-888) achieved complete and durable tumor regression in mice.

artículo científico publicado en 2013

A small molecule compound inhibits AKT pathway in ovarian cancer cell lines.

artículo científico publicado en 2005

A web-based 3D-database pharmacophore searching tool for drug discovery

artículo científico publicado en 2002

AM-8553: A Novel MDM2 Inhibitor with a Promising Outlook for Potential Clinical Development ⬇️

artículo científico publicado el 24 de mayo de 2012

Absolute quantitative (1)h NMR spectroscopy for compound purity determination.

artículo científico publicado en 2014

Activating STAT6 mutations in follicular lymphoma.

artículo científico publicado en 2014

Acylpyrogallols as inhibitors of antiapoptotic Bcl-2 proteins.

artículo científico publicado en 2008

Allosteric Inactivation of Polycomb Repressive Complex 2 (PRC2) by Inhibiting Its Adapter Protein: Embryonic Ectodomain Development (EED).

artículo científico publicado en 2017

Allosteric Modulators of Drug Targets Special Issue.

artículo científico publicado en 2018

Alzheimer's disease special thematic issue: call for papers.

artículo científico publicado en 2012

Analysis of Flexibility and Hotspots in Bcl-xL and Mcl-1 Proteins for the Design of Selective Small-Molecule Inhibitors

artículo científico publicado en 2012

Analysis of the interaction of BCL9 with beta-catenin and development of fluorescence polarization and surface plasmon resonance binding assays for this interaction.

artículo científico publicado en 2009

Anti-Mycobacterium avium activity of quinolones: in vitro activities

artículo científico publicado en 1993

Anti-oxidant treatment enhances anti-tumor cytotoxicity of (-)-gossypol.

artículo científico publicado en 2008

Artificial Intelligence in Drug Discovery: Into the Great Wide Open

artículo científico publicado en 2020

Ash2L enables P53-dependent apoptosis by favoring stable transcription pre-initiation complex formation on its pro-apoptotic target promoters

artículo científico publicado en 2014

BET Bromodomain Inhibitors Enhance Efficacy and Disrupt Resistance to AR Antagonists in the Treatment of Prostate Cancer

artículo científico publicado en 2016

BH3-mimetic small molecule inhibits the growth and recurrence of adenoid cystic carcinoma

artículo científico publicado en 2015

BM-1197: a novel and specific Bcl-2/Bcl-xL inhibitor inducing complete and long-lasting tumor regression in vivo

artículo científico publicado en 2014

Binding free energy contributions of interfacial waters in HIV-1 protease/inhibitor complexes

artículo científico publicado en 2006

Bioinformatics-based discovery and characterization of an AKT-selective inhibitor 9-chloro-2-methylellipticinium acetate (CMEP) in breast cancer cells.

artículo científico publicado en 2007

Bivalent Smac mimetics with a diazabicyclic core as highly potent antagonists of XIAP and cIAP1/2 and novel anticancer agents.

artículo científico publicado en 2011

Blockade of AKT activation in prostate cancer cells with a small molecule inhibitor, 9-chloro-2-methylellipticinium acetate (CMEP).

artículo científico publicado en 2006

Blockage of epidermal growth factor receptor-phosphatidylinositol 3-kinase-AKT signaling increases radiosensitivity of K-RAS mutated human tumor cells in vitro by affecting DNA repair.

artículo científico publicado en 2006

CHMIS-C: a comprehensive herbal medicine information system for cancer

scientific article published on 01 March 2005

CJ-1639: A Potent and Highly Selective Dopamine D3 Receptor Full Agonist

artículo científico publicado en 2011

CSAR benchmark exercise of 2010: combined evaluation across all submitted scoring functions.

artículo científico publicado en 2011

CSAR benchmark exercise of 2010: selection of the protein-ligand complexes.

artículo científico publicado en 2011

Case Study: discovery of inhibitors of the MDM2-p53 protein-protein interaction

artículo científico publicado en 2015

Chimeric (alpha/beta + alpha)-peptide ligands for the BH3-recognition cleft of Bcl-XL: critical role of the molecular scaffold in protein surface recognition

artículo científico publicado en 2005

Combined targeting of epidermal growth factor receptor, signal transducer and activator of transcription-3, and Bcl-X(L) enhances antitumor effects in squamous cell carcinoma of the head and neck.

artículo científico publicado en 2008

Comparison of the NCI open database with seven large chemical structural databases.

artículo científico publicado en 2001

Comprehensive biomarker and genomic analysis identifies p53 status as the major determinant of response to MDM2 inhibitors in chronic lymphocytic leukemia

scientific article published on 30 October 2007

Computational analysis of protein hotspots

artículo científico publicado en 2010

Conformationally constrained analogues of diacylglycerol (DAG). 14. Dissection of the roles of the sn-1 and sn-2 carbonyls in DAG mimetics by isopharmacophore replacement

artículo científico publicado en 1998

Conformationally constrained analogues of diacylglycerol (DAG). 15. The indispensable role of the sn-1 and sn-2 carbonyls in the binding of DAG-lactones to protein kinase C (PK-C)

artículo científico publicado en 1998

Confronting Racism in Chemistry Journals

scientific article published on 19 June 2020

Correction to "Discovery of SHP2-D26 as a First, Potent, and Effective PROTAC Degrader of SHP2 Protein"

artículo científico publicado en 2020

Correction to Design of Bcl-2 and Bcl-xL Inhibitors with Subnanomolar Binding Affinities Based upon a New Scaffold.

artículo científico publicado en 2012

Correction to Potent 5-Cyano-6-phenyl-pyrimidin-Based Derivatives Targeting DCN1-UBE2M Interaction

artículo científico publicado en 2020

Current Medicinal Chemistry Research in India: Progress and Opportunities

artículo científico publicado en 2017

Cyclic Peptidic Mimetics of Apollo Peptides Targeting Telomeric Repeat Binding Factor 2 (TRF2) and Apollo Interaction

scientific article published on 25 April 2018

Depsides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching.

artículo científico publicado en 1997

Design and characterization of bivalent Smac-based peptides as antagonists of XIAP and development and validation of a fluorescence polarization assay for XIAP containing both BIR2 and BIR3 domains

artículo científico publicado en 2007

Design and synthesis of a new, conformationally constrained, macrocyclic small-molecule inhibitor of STAT3 via 'click chemistry'

scientific article published on 03 May 2007

Design of High-Affinity Stapled Peptides To Target the Repressor Activator Protein 1 (RAP1)/Telomeric Repeat-Binding Factor 2 (TRF2) Protein-Protein Interaction in the Shelterin Complex.

artículo científico publicado en 2015

Design of Triazole-Stapled BCL9 α-Helical Peptides to Target the β-Catenin/B-Cell CLL/lymphoma 9 (BCL9) Protein–Protein Interaction ⬇️

artículo científico publicado el 24 de enero de 2012

Design of chemically stable, potent, and efficacious MDM2 inhibitors that exploit the retro-mannich ring-opening-cyclization reaction mechanism in spiro-oxindoles.

artículo científico publicado en 2014

Design of novel hexahydropyrazinoquinolines as potent and selective dopamine D3 receptor ligands with improved solubility.

artículo científico publicado en 2005

Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein-Protein Interaction

artículo científico publicado en 2017

Design, synthesis and structure-activity relationship studies of hexahydropyrazinoquinolines as a novel class of potent and selective dopamine receptor 3 (D3) ligands.

artículo científico publicado en 2005

Design, synthesis, and evaluation of a potent, cell-permeable, conformationally constrained second mitochondria derived activator of caspase (Smac) mimetic.

artículo científico publicado en 2006

Design, synthesis, and evaluation of peptidomimetics containing Freidinger lactams as STAT3 inhibitors.

artículo científico publicado en 2009

Digital chemistry in the Journal of Medicinal Chemistry.

artículo científico publicado en 2014

Direct observation of the folding and unfolding of a beta-hairpin in explicit water through computer simulation.

artículo científico publicado en 2002

Discovery of 4-((3'R,4'S,5'R)-6″-Chloro-4'-(3-chloro-2-fluorophenyl)-1'-ethyl-2″-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3″-indoline]-5'-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine [...]

artículo científico publicado en 2017

Discovery of ARD-69 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer

scientific article published on 10 January 2019

Discovery of CJ-2360 as a Potent and Orally Active Inhibitor of Anaplastic Lymphoma Kinase Capable of Achieving Complete Tumor Regression

artículo científico publicado en 2020

Discovery of ERD-308 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Estrogen Receptor (ER)

artículo científico publicado en 2019

Discovery of HIV-1 integrase inhibitors by pharmacophore searching.

artículo científico

Discovery of Highly Potent and Efficient PROTAC Degraders of Androgen Receptor (AR) by Employing Weak Binding Affinity VHL E3 Ligase Ligands

artículo científico publicado en 2019

Discovery of M-808 as a Highly Potent, Covalent, Small-Molecule Inhibitor of the Menin-MLL Interaction with Strong <i>In Vivo</i> Antitumor Activity

artículo científico publicado en 2020

Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression

artículo científico publicado en 2018

Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression

scientific article published on 18 July 2018

Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction.

artículo científico publicado en 2017

Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression.

artículo científico publicado en 2017

Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy.

artículo científico publicado en 2006

Discovery of a novel nonphosphorylated pentapeptide motif displaying high affinity for Grb2-SH2 domain by the utilization of 3'-substituted tyrosine derivatives.

artículo científico publicado en 2006

Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening

artículo científico publicado en 2001

Drug Annotations for a New Decade

artículo científico publicado en 2020

Drug Metabolism and Toxicology Special Issue Call for Papers

artículo científico publicado en 2019

E2F1-dependent oncogenic addiction of melanoma cells to MDM2.

artículo científico publicado en 2011

EEDi-5285: An Exceptionally Potent, Efficacious, and Orally Active Small-Molecule Inhibitor of Embryonic Ectoderm Development

artículo científico publicado en 2020

Effects of pramipexole on the reinforcing effectiveness of stimuli that were previously paired with cocaine reinforcement in rats ⬇️

artículo científico publicado el 24 de junio de 2011

Elucidation of Acquired Resistance to Bcl-2 and MDM2 Inhibitors in Acute Leukemia In Vitro and In Vivo.

artículo científico publicado en 2015

Elucidation of Resistance Mechanisms to Second-Generation ALK Inhibitors Alectinib and Ceritinib in Non-Small Cell Lung Cancer Cells.

artículo científico publicado en 2016

Epigenetics: Novel Therapeutics Targeting Epigenetics

scientific article published on 29 January 2016

Epigenetics: novel therapeutics targeting epigenetics

scientific article published on 22 December 2014

Estimation of aqueous solubility of organic molecules by the group contribution approach. Application to the study of biodegradation

artículo científico publicado el 1 de septiembre de 1992

Graph theory and group contributions in the estimation of boiling points

scientific article published on 01 November 1994

Hepatic TRAF2 regulates glucose metabolism through enhancing glucagon responses.

artículo científico publicado en 2012

Hepatitis C virus (HCV) therapies special thematic issue: call for papers.

artículo científico publicado en 2013

High-Affinity Peptidomimetic Inhibitors of the DCN1-UBC12 Protein-Protein Interaction.

artículo científico publicado en 2018

High-affinity and selective dopamine D₃ receptor full agonists

artículo científico publicado en 2012

High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction

artículo científico publicado en 2013

Hydrazide-containing inhibitors of HIV-1 integrase.

artículo científico publicado en 1997

Hydrophobic Binding Hot Spots of Bcl-xL Protein-Protein Interfaces by Cosolvent Molecular Dynamics Simulation

artículo científico publicado en 2011

Identification of a mutant α1 Na/K-ATPase that pumps but is defective in signal transduction.

artículo científico publicado en 2013

Identification of novel neuroprotective agents using pharmacophore modeling.

artículo científico publicado en 2005

Identification of the fibroblast growth factor (FGF)-interacting domain in a secreted FGF-binding protein by phage display

artículo científico publicado en 2006

Importance of ligand reorganization free energy in protein-ligand binding-affinity prediction.

scientific article published on September 2009

In vitro anti-Mycobacterium avium activities of quinolones: predicted active structures and mechanistic considerations

artículo científico publicado en 1994

In vitro effects of the BH3 mimetic, (-)-gossypol, on head and neck squamous cell carcinoma cells.

artículo científico publicado en 2004

In vitro metabolism of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin in human liver microsomes.

artículo científico publicado en 2010

Inducing Protein Degradation as a Therapeutic Strategy.

artículo científico publicado en 2016

Induction of p53 suppresses chronic myeloid leukemia.

artículo científico publicado en 2017

Interaction of a Cyclic, Bivalent Smac Mimetic with the X-Linked Inhibitor of Apoptosis Protein † ‡

artículo científico publicado en 2008

Introduction: Drug Metabolism and Toxicology Special Issue

scientific article published on 02 June 2020

Iridals Are a Novel Class of Ligands for Phorbol Ester Receptors with Modest Selectivity for the RasGRP Receptor Subfamily ⬇️

artículo científico publicado el 8 de noviembre de 2001

LDK378: A Promising Anaplastic Lymphoma Kinase (ALK) Inhibitor ⬇️

artículo científico publicado el 9 de julio de 2013

LRIG1 Modulates Cancer Cell Sensitivity to Smac Mimetics by Regulating TNFα Expression and Receptor Tyrosine Kinase Signaling ⬇️

artículo científico publicado el 12 de enero de 2012

MCDOCK: a Monte Carlo simulation approach to the molecular docking problem

scientific article published on 01 September 1999

MDM2 Inhibition Sensitizes Prostate Cancer Cells to Androgen Ablation and Radiotherapy in a p53-Dependent Manner.

artículo científico publicado en 2016

MI-63: a novel small-molecule inhibitor targets MDM2 and induces apoptosis in embryonal and alveolar rhabdomyosarcoma cells with wild-type p53.

artículo científico publicado en 2009

MLL1 Inhibition Reprograms Epiblast Stem Cells to Naive Pluripotency

artículo científico publicado en 2016

Metronomic dosing of BH3 mimetic small molecule yields robust antiangiogenic and antitumor effects

artículo científico publicado en 2011

Modeling, chemistry, and biology of the benzolactam analogues of indolactam V (ILV). 2. Identification of the binding site of the benzolactams in the CRD2 activator-binding domain of PKCdelta and discovery of an ILV analogue of improved isozyme sele

artículo científico publicado en 1997

Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells

artículo científico publicado en 2003

Molecular modeling of the three-dimensional structure of dopamine 3 (D3) subtype receptor: discovery of novel and potent D3 ligands through a hybrid pharmacophore- and structure-based database searching approach.

artículo científico publicado en 2003

Molecular modeling, structure--activity relationships and functional antagonism studies of 4-hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketones as a novel class of dopamine transporter inhibitors.

artículo científico publicado en 2001

National Cancer Institute Drug Information System 3D database.

artículo científico publicado en 1994

Nonphosphorylated peptide ligands for the Grb2 Src homology 2 domain

artículo científico publicado en 1997

Pharmacophore-based discovery of 3,4-disubstituted pyrrolidines as a novel class of monoamine transporter inhibitors.

artículo científico publicado en 2001

Pharmacophores in Drug Design and Discovery ⬇️

artículo científico publicado el 1 de enero de 1998

Physiologically based pharmacokinetic and pharmacodynamic modeling of an antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in a mouse xenograft model of human breast cancer.

artículo científico publicado en 2013

Potent 5-Cyano-6-phenyl-pyrimidin-Based Derivatives Targeting DCN1-UBE2M Interaction

scientific article published on 03 June 2019

Potent and selective small-molecule inhibitors of cIAP1/2 proteins reveal that the binding of Smac mimetics to XIAP BIR3 is not required for their effective induction of cell death in tumor cells.

artículo científico publicado en 2014

Potent bivalent Smac mimetics: effect of the linker on binding to inhibitor of apoptosis proteins (IAPs) and anticancer activity.

artículo científico publicado en 2011

Pramipexole derivatives as potent and selective dopamine D(3) receptor agonists with improved human microsomal stability.

artículo científico publicado en 2014

Preclinical studies of Apogossypolone: a new nonpeptidic pan small-molecule inhibitor of Bcl-2, Bcl-XL and Mcl-1 proteins in Follicular Small Cleaved Cell Lymphoma model

artículo científico publicado en 2008

Probing the binding of indolactam-V to protein kinase C through site-directed mutagenesis and computational docking simulations

artículo científico publicado en 1999

Proerectile effects of dopamine D2-like agonists are mediated by the D3 receptor in rats and mice.

artículo científico publicado en 2009

Protein kinase C. Modeling of the binding site and prediction of binding constants

scientific article published on 01 April 1994

Pyrimido[4,5‐d]pyrimidin‐4(1H)‐one Derivatives as Selective Inhibitors of EGFR Threonine790 to Methionine790 (T790M) Mutants ⬇️

artículo científico publicado el 26 de junio de 2013

RNF111-Dependent Neddylation Activates DNA Damage-Induced Ubiquitination ⬇️

artículo científico publicado el 7 de febrero de 2013

Radiosensitization of head and neck squamous cell carcinoma by a SMAC-mimetic compound, SM-164, requires activation of caspases.

artículo científico publicado en 2011

Reactivation of p53 by MDM2 Inhibitor MI-77301 for the Treatment of Endocrine-Resistant Breast Cancer

artículo científico publicado en 2016

Recognition and interaction of small rings with the ricin A-chain binding site

artículo científico publicado en 1998

Residues in the Second Cysteine-rich Region of Protein Kinase C δ Relevant to Phorbol Ester Binding as Revealed by Site-directed Mutagenesis ⬇️

artículo científico publicado el 15 de septiembre de 1995

Resiniferatoxin-amide and analogues as ligands for protein kinase C and vanilloid receptors and determination of their biological activities as vanilloids

scientific article published on 01 July 1995

Resistance to BET Inhibitor Leads to Alternative Therapeutic Vulnerabilities in Castration-Resistant Prostate Cancer.

artículo científico publicado en 2018

Reversal of cisplatin resistance with a BH3 mimetic, (-)-gossypol, in head and neck cancer cells: role of wild-type p53 and Bcl-xL.

artículo científico publicado en 2005

Role of BET proteins in castration-resistant prostate cancer.

artículo científico publicado en 2016

SAR405838: an optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression

artículo científico publicado en 2014

SMAC mimetic Debio 1143 synergizes with taxanes, topoisomerase inhibitors and bromodomain inhibitors to impede growth of lung adenocarcinoma cells.

artículo científico publicado en 2015

Selectively Targeting Tropomyosin Receptor Kinase A (TRKA) via PROTACs

artículo científico publicado en 2020

Significant Differences in the Development of Acquired Resistance to the MDM2 Inhibitor SAR405838 between In Vitro and In Vivo Drug Treatment

artículo científico publicado en 2015

Simple Structural Modifications Converting a Bona fide MDM2 PROTAC Degrader into a Molecular Glue Molecule: A Cautionary Tale in the Design of PROTAC Degraders

scientific article published on 21 October 2019

Smac mimetic compounds potentiate interleukin-1beta-mediated cell death

artículo científico publicado en 2010

Small molecule inhibitors of the MDM2-p53 interaction discovered by ensemble-based receptor models.

artículo científico publicado en 2007

Small-molecule PROTAC degraders of the Bromodomain and Extra Terminal (BET) proteins - A review

scientific article published on 01 April 2019

Small-molecule SMAC mimetics as new cancer therapeutics

artículo científico publicado en 2014

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction (MDM2 Inhibitors) in clinical trials for cancer treatment.

artículo científico publicado en 2014

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy

artículo científico publicado en 2009

Spiromastilactones: A new class of influenza virus inhibitors from deep-sea fungus

artículo científico publicado en 2015

Split Renilla luciferase protein fragment-assisted complementation (SRL-PFAC) to characterize Hsp90-Cdc37 complex and identify critical residues in protein/protein interactions.

artículo científico publicado en 2010

Structural basis of RasGRP binding to high-affinity PKC ligands.

artículo científico publicado en 2002

Structural basis of binding of high-affinity ligands to protein kinase C: prediction of the binding modes through a new molecular dynamics method and evaluation by site-directed mutagenesis.

artículo científico publicado en 2001

Structure-Based Design of Conformationally Constrained, Cell-Permeable STAT3 Inhibitors. ⬇️

artículo científico publicado en 2010

Structure-Based Design of High-Affinity Macrocyclic Peptidomimetics to Block the Menin-Mixed Lineage Leukemia 1 (MLL1) Protein–Protein Interaction ⬇️

artículo científico publicado el 17 de enero de 2013

Structure-Based Design of γ-Carboline Analogues as Potent and Specific BET Bromodomain Inhibitors

artículo científico publicado en 2015

Structure-Based Design, Synthesis, Evaluation, and Crystallographic Studies of Conformationally Constrained Smac Mimetics as Inhibitors of the X-linked Inhibitor of Apoptosis Protein (XIAP) †

artículo científico publicado en 2008

Structure-Based Discovery of 4-(6-Methoxy-2-methyl-4-(quinolin-4-yl)-9H-pyrimido[4,5-b]indol-7-yl)-3,5-dimethylisoxazole (CD161) as a Potent and Orally Bioavailable BET Bromodomain Inhibitor.

artículo científico publicado en 2017

Structure-Based Discovery of CF53 as a Potent and Orally Bioavailable Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitor

artículo científico publicado en 2018

Structure-Based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein-Protein Interaction

artículo científico publicado en 2019

Structure-Based Discovery of SD-36 as a Potent, Selective, and Efficacious PROTAC Degrader of STAT3 Protein

scientific article published on 10 December 2019

Structure-based design and synthesis of small molecule protein-tyrosine phosphatase 1B inhibitors

artículo científico publicado en 1998

Structure-based design of potent Bcl-2/Bcl-xL inhibitors with strong in vivo antitumor activity.

artículo científico publicado en 2012

Structure-based design, synthesis, and evaluation of conformationally constrained mimetics of the second mitochondria-derived activator of caspase that target the X-linked inhibitor of apoptosis protein/caspase-9 interaction site.

artículo científico publicado en 2004

Structure-based discovery of BM-957 as a potent small-molecule inhibitor of Bcl-2 and Bcl-xL capable of achieving complete tumor regression

artículo científico publicado en 2012

Synthesis and Biology of the Conformationally Restricted ACPD Analogue, 2-Aminobicyclo[2.1.1]hexane-2,5-dicarboxylic Acid-I, a Potent mGluR Agonist ⬇️

artículo científico publicado el 7 de mayo de 1998

Synthesis and anticholinesterase activity of huperzine A analogues containing phenol and catechol replacements for the pyridone ring

scientific article published on 01 June 1998

Synthesis and evaluation of the sunflower derived trypsin inhibitor as a potent inhibitor of the type II transmembrane serine protease, matriptase.

artículo científico publicado en 2001

Synthesis of 8-Oxa analogues of norcocaine endowed with interesting cocaine-like activity.

artículo científico publicado en 1999

Targeted Degradation of BET Proteins in Triple-Negative Breast Cancer.

artículo científico publicado en 2017

Targeting Bcl-2 and Bcl-X with nonpeptidic small-molecule antagonists ⬇️

artículo científico publicado el 1 de octubre de 2003

Targeting Inhibitor of Apoptosis Proteins Protects from Bleomycin-Induced Lung Fibrosis.

artículo científico publicado en 2015

Targeting Inhibitors of Apoptosis Proteins (IAPs) For New Breast Cancer Therapeutics ⬇️

artículo científico publicado el 29 de septiembre de 2012

Targeting apoptosis pathways for new cancer therapeutics.

artículo científico publicado en 2013

Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair.

artículo científico publicado en 2008

Targeting the MDM2-p53 Protein-Protein Interaction for New Cancer Therapy: Progress and Challenges.

artículo científico publicado en 2017

The Direct Molecular Target for Imipridone ONC201 Is Finally Established

artículo científico publicado en 2019

The Ecstasy and Agony of Assay Interference Compounds

artículo científico publicado en 2017

The Ecstasy and Agony of Assay Interference Compounds

artículo científico publicado en 2017

The Ecstasy and Agony of Assay Interference Compounds

The Ecstasy and Agony of Assay Interference Compounds

scientific article published in 2017

The Ecstasy and Agony of Assay Interference Compounds

artículo científico publicado en 2017

The Ecstasy and Agony of Assay Interference Compounds.

artículo científico publicado en 2017

The Future Is Now: Artificial Intelligence in Drug Discovery

artículo científico publicado en 2019

The discovery of novel, structurally diverse protein kinase C agonists through computer 3D-database pharmacophore search. Molecular modeling studies

scientific article published on 01 December 1994

The making of I-BET762, a BET bromodomain inhibitor now in clinical development

artículo científico publicado en 2013

The pre-clinical development of MDM2 inhibitors in chronic lymphocytic leukemia uncovers a central role for p53 status in sensitivity to MDM2 inhibitor-mediated apoptosis.

artículo científico publicado en 2008

The transition from a pharmacophore-guided approach to a receptor-guided approach in the design of potent protein kinase C ligands.

artículo científico publicado en 1999

Therapeutic Inhibition of the MDM2-p53 Interaction Prevents Recurrence of Adenoid Cystic Carcinomas.

artículo científico publicado en 2016

Therapeutic Potential and Molecular Mechanism of a Novel, Potent, Nonpeptide, Smac Mimetic SM-164 in Combination with TRAIL for Cancer Treatment ⬇️

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