Lista de obras - Gabriele Saretzki - Dominio Público Uruguay

A DNA damage checkpoint response in telomere-initiated senescence

artículo científico publicado en 2003

A human iPSC model of Ligase IV deficiency reveals an important role for NHEJ-mediated-DSB repair in the survival and genomic stability of induced pluripotent stem cells and emerging haematopoietic progenitors.

artículo científico publicado en 2013

A stochastic step model of replicative senescence explains ROS production rate in ageing cell populations

artículo científico publicado en 2012

Accelerated telomere shortening in fibroblasts after extended periods of confluency.

artículo científico publicado en 1998

Adult-onset, short-term dietary restriction reduces cell senescence in mice.

artículo científico publicado en 2010

Airway epithelial cell senescence in the lung allograft

artículo científico publicado en 2008

An Induced Pluripotent Stem Cell Patient Specific Model of Complement Factor H (Y402H) Polymorphism Displays Characteristic Features of Age-Related Macular Degeneration and Indicates a Beneficial Role for UV Light Exposure. ⬇️

artículo científico publicado en 2017

Atorvastatin induces T cell proliferation by a telomerase reverse transcriptase (TERT) mediated mechanism.

artículo científico publicado en 2014

BJ fibroblasts display high antioxidant capacity and slow telomere shortening independent of hTERT transfection.

artículo científico publicado en 2001

Brief report: human pluripotent stem cell models of fanconi anemia deficiency reveal an important role for fanconi anemia proteins in cellular reprogramming and survival of hematopoietic progenitors.

artículo científico publicado en 2013

Cellular senescence in the development and treatment of cancer.

artículo científico publicado en 2010

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice.

artículo científico publicado en 2014

DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?

artículo científico publicado en 2007

Decreased mTOR signalling reduces mitochondrial ROS in brain via accumulation of the telomerase protein TERT within mitochondria

artículo científico publicado en 2016

Derivation and functional analysis of patient-specific induced pluripotent stem cells as an in vitro model of chronic granulomatous disease

artículo científico publicado en 2012

Dietary restriction ameliorates haematopoietic ageing independent of telomerase, whilst lack of telomerase and short telomeres exacerbates the ageing phenotype.

artículo científico publicado en 2014

Dietary restriction mitigates age-related accumulation of DNA damage, but not all changes in mouse corneal epithelium.

artículo científico publicado en 2015

Downregulation of multiple stress defense mechanisms during differentiation of human embryonic stem cells

artículo científico publicado en 2007

Ectopically hTERT expressing adult human mesenchymal stem cells are less radiosensitive than their telomerase negative counterpart

scientific article published on 08 January 2007

Endogenous and ectopic expression of telomere regulating genes in chicken embryonic fibroblasts

artículo científico publicado en 2005

Endometriosis Is Associated with a Significant Increase in hTERC and Altered Telomere/Telomerase Associated Genes in the Eutopic Endometrium, an Ex-Vivo and In Silico Study

artículo científico publicado en 2020

Endometriosis is associated with aberrant endometrial expression of telomerase and increased telomere length.

artículo científico publicado en 2008

Extra-telomeric functions of human telomerase: cancer, mitochondria and oxidative stress.

artículo científico publicado en 2014

Extracellular superoxide dismutase is a major antioxidant in human fibroblasts and slows telomere shortening

artículo científico publicado en 2002

Feedback between p21 and reactive oxygen production is necessary for cell senescence

artículo científico publicado en 2010

Human cell senescence as a DNA damage response.

artículo científico publicado en 2005

Human endometrial epithelial telomerase is important for epithelial proliferation and glandular formation with potential implications in endometriosis.

artículo científico publicado en 2015

Human iPSC disease modelling reveals functional and structural defects in retinal pigment epithelial cells harbouring the m.3243A > G mitochondrial DNA mutation.

artículo científico publicado en 2017

Human induced pluripotent stem cell lines show stress defense mechanisms and mitochondrial regulation similar to those of human embryonic stem cells

artículo científico publicado en 2010

Identification of allelic losses in benign, borderline, and invasive epithelial ovarian tumors and correlation with clinical outcome

artículo científico publicado en 1997

Immediate and gradual gene expression changes in telomerase over-expressing fibroblasts

artículo científico publicado en 2010

Immortalisation of human ovarian surface epithelium with telomerase and temperature-senstitive SV40 large T antigen

artículo científico publicado en 2003

Implications of telomeres and telomerase in endometrial pathology

artículo científico publicado en 2016

Improvement of biological age by physical activity

artículo científico publicado en 2014

Inorganic Nitrate Supplementation in Young and Old Obese Adults Does Not Affect Acute Glucose and Insulin Responses but Lowers Oxidative Stress

artículo científico publicado en 2016

Low abundance of the matrix arm of complex I in mitochondria predicts longevity in mice

artículo científico publicado en 2014

Mild Hyperoxia Shortens Telomeres and Inhibits Proliferation of Fibroblasts: A Model for Senescence?

artículo científico publicado en 1995

MitoQ counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress

artículo científico publicado en 2003

Mitochondria are required for pro-ageing features of the senescent phenotype.

artículo científico publicado en 2016

Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence

artículo científico publicado en 2007

Mitochondrial dysfunction and cell senescence: cause or consequence?

artículo científico publicado en 2006

Mitochondrial telomerase protects cancer cells from nuclear DNA damage and apoptosis

artículo científico publicado en 2013

Overexpression of telomerase confers growth advantage, stress resistance, and enhanced differentiation of ESCs toward the hematopoietic lineage.

artículo científico publicado en 2005

Preferential Accumulation of Single-Stranded Regions in Telomeres of Human Fibroblasts ⬇️

artículo científico publicado el 25 de febrero de 1998

Premature senescence of mesothelial cells is associated with non-telomeric DNA damage

artículo científico publicado en 2007

Replicative aging, telomeres, and oxidative stress

artículo científico publicado en 2002

Replikative Seneszenz als Alternsmodell: Die Rolle von oxidativem Streß und Telomerenverkürzung - eine übersicht

scientific article published on 01 April 1999

SSEA-1 isolates human endometrial basal glandular epithelial cells: phenotypic and functional characterization and implications in the pathogenesis of endometriosis

artículo científico

Short telomeres in patients with vascular dementia: an indicator of low antioxidative capacity and a possible risk factor?

artículo científico publicado en 2000

Similar gene expression pattern in senescent and hyperoxic-treated fibroblasts.

artículo científico publicado en 1998

Stochastic variation in telomere shortening rate causes heterogeneity of human fibroblast replicative life span

artículo científico publicado en 2004

Stress defense in murine embryonic stem cells is superior to that of various differentiated murine cells

artículo científico publicado en 2004

TRF2 overexpression diminishes repair of telomeric single-strand breaks and accelerates telomere shortening in human fibroblasts

artículo científico publicado en 2007

Telomerase Activity is Downregulated Early During Human Brain Development.

artículo científico publicado en 2016

Telomerase activity in cervical smears.

artículo científico publicado en 2001

Telomerase and mTOR in the brain: the mitochondria connection.

artículo científico publicado en 2017

Telomerase as a promising target for human cancer gene therapy.

artículo científico publicado en 2003

Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress

artículo científico publicado en 2008

Telomerase inhibition as cancer therapy.

artículo científico publicado en 2003

Telomerase inhibition by induced expression of antisense RNA.

artículo científico publicado en 1998

Telomerase, mitochondria and oxidative stress.

artículo científico publicado en 2009

Telomere length as a marker of oxidative stress in primary human fibroblast cultures

artículo científico publicado en 2000

Telomere shortening in human fibroblasts is not dependent on the size of the telomeric-3'-overhang

artículo científico publicado en 2004

Telomere shortening triggers a p53-dependent cell cycle arrest via accumulation of G-rich single stranded DNA fragments.

artículo científico publicado en 1999

The 19S proteasome subunit Rpn7 stabilizes DNA damage foci upon genotoxic insult

artículo científico publicado en 2012

The cellular level of telomere dysfunction determines induction of senescence or apoptosis in vivo.

artículo científico publicado en 2005

The mitochondrial protein CHCHD2 primes the differentiation potential of human induced pluripotent stem cells to neuroectodermal lineages.

artículo científico publicado en 2016

The p.M292T NDUFS2 mutation causes complex I-deficient Leigh syndrome in multiple families ⬇️

artículo científico publicado el 6 de septiembre de 2010

The role of telomerase protein TERT in Alzheimer's disease and in tau-related pathology in vitro.

artículo científico publicado en 2015

The role of telomeres in Etoposide induced tumor cell death.

artículo científico publicado en 2004

Tumour-cell apoptosis after cisplatin treatment is not telomere dependent

artículo científico publicado en 2006

Well-known signaling proteins exert new functions in the nucleus and mitochondria.

scientific article published on August 2010

[Molecular mechanisms of senescence in cell culture].

artículo científico publicado en 1997

hTERT gene dosage correlates with telomerase activity in human lung cancer cell lines

article

Lista de obras de Gabriele Saretzki

A DNA damage checkpoint response in telomere-initiated senescence

A human iPSC model of Ligase IV deficiency reveals an important role for NHEJ-mediated-DSB repair in the survival and genomic stability of induced pluripotent stem cells and emerging haematopoietic progenitors.

A stochastic step model of replicative senescence explains ROS production rate in ageing cell populations

Accelerated telomere shortening in fibroblasts after extended periods of confluency.

Adult-onset, short-term dietary restriction reduces cell senescence in mice.

Airway epithelial cell senescence in the lung allograft

An Induced Pluripotent Stem Cell Patient Specific Model of Complement Factor H (Y402H) Polymorphism Displays Characteristic Features of Age-Related Macular Degeneration and Indicates a Beneficial Role for UV Light Exposure. ⬇️

Atorvastatin induces T cell proliferation by a telomerase reverse transcriptase (TERT) mediated mechanism.

BJ fibroblasts display high antioxidant capacity and slow telomere shortening independent of hTERT transfection.

Brief report: human pluripotent stem cell models of fanconi anemia deficiency reveal an important role for fanconi anemia proteins in cellular reprogramming and survival of hematopoietic progenitors.

Cellular senescence in the development and treatment of cancer.

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice.

DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?

Decreased mTOR signalling reduces mitochondrial ROS in brain via accumulation of the telomerase protein TERT within mitochondria

Derivation and functional analysis of patient-specific induced pluripotent stem cells as an in vitro model of chronic granulomatous disease

Dietary restriction ameliorates haematopoietic ageing independent of telomerase, whilst lack of telomerase and short telomeres exacerbates the ageing phenotype.

Dietary restriction mitigates age-related accumulation of DNA damage, but not all changes in mouse corneal epithelium.

Downregulation of multiple stress defense mechanisms during differentiation of human embryonic stem cells

Ectopically hTERT expressing adult human mesenchymal stem cells are less radiosensitive than their telomerase negative counterpart

Endogenous and ectopic expression of telomere regulating genes in chicken embryonic fibroblasts

Endometriosis Is Associated with a Significant Increase in hTERC and Altered Telomere/Telomerase Associated Genes in the Eutopic Endometrium, an Ex-Vivo and In Silico Study

Endometriosis is associated with aberrant endometrial expression of telomerase and increased telomere length.

Extra-telomeric functions of human telomerase: cancer, mitochondria and oxidative stress.

Extracellular superoxide dismutase is a major antioxidant in human fibroblasts and slows telomere shortening

Feedback between p21 and reactive oxygen production is necessary for cell senescence

Human cell senescence as a DNA damage response.

Human endometrial epithelial telomerase is important for epithelial proliferation and glandular formation with potential implications in endometriosis.

Human iPSC disease modelling reveals functional and structural defects in retinal pigment epithelial cells harbouring the m.3243A > G mitochondrial DNA mutation.

Human induced pluripotent stem cell lines show stress defense mechanisms and mitochondrial regulation similar to those of human embryonic stem cells

Identification of allelic losses in benign, borderline, and invasive epithelial ovarian tumors and correlation with clinical outcome

Immediate and gradual gene expression changes in telomerase over-expressing fibroblasts

Immortalisation of human ovarian surface epithelium with telomerase and temperature-senstitive SV40 large T antigen

Implications of telomeres and telomerase in endometrial pathology

Improvement of biological age by physical activity

Inorganic Nitrate Supplementation in Young and Old Obese Adults Does Not Affect Acute Glucose and Insulin Responses but Lowers Oxidative Stress

Low abundance of the matrix arm of complex I in mitochondria predicts longevity in mice

Mild Hyperoxia Shortens Telomeres and Inhibits Proliferation of Fibroblasts: A Model for Senescence?

MitoQ counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress

Mitochondria are required for pro-ageing features of the senescent phenotype.

Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence

Mitochondrial dysfunction and cell senescence: cause or consequence?

Mitochondrial telomerase protects cancer cells from nuclear DNA damage and apoptosis

Overexpression of telomerase confers growth advantage, stress resistance, and enhanced differentiation of ESCs toward the hematopoietic lineage.

Preferential Accumulation of Single-Stranded Regions in Telomeres of Human Fibroblasts ⬇️

Premature senescence of mesothelial cells is associated with non-telomeric DNA damage

Replicative aging, telomeres, and oxidative stress

Replikative Seneszenz als Alternsmodell: Die Rolle von oxidativem Streß und Telomerenverkürzung - eine übersicht

SSEA-1 isolates human endometrial basal glandular epithelial cells: phenotypic and functional characterization and implications in the pathogenesis of endometriosis

Short telomeres in patients with vascular dementia: an indicator of low antioxidative capacity and a possible risk factor?

Similar gene expression pattern in senescent and hyperoxic-treated fibroblasts.

Stochastic variation in telomere shortening rate causes heterogeneity of human fibroblast replicative life span

Stress defense in murine embryonic stem cells is superior to that of various differentiated murine cells

TRF2 overexpression diminishes repair of telomeric single-strand breaks and accelerates telomere shortening in human fibroblasts

Telomerase Activity is Downregulated Early During Human Brain Development.

Telomerase activity in cervical smears.

Telomerase and mTOR in the brain: the mitochondria connection.

Telomerase as a promising target for human cancer gene therapy.

Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress

Telomerase inhibition as cancer therapy.

Telomerase inhibition by induced expression of antisense RNA.

Telomerase, mitochondria and oxidative stress.

Telomere length as a marker of oxidative stress in primary human fibroblast cultures

Telomere shortening in human fibroblasts is not dependent on the size of the telomeric-3'-overhang

Telomere shortening triggers a p53-dependent cell cycle arrest via accumulation of G-rich single stranded DNA fragments.

The 19S proteasome subunit Rpn7 stabilizes DNA damage foci upon genotoxic insult

The cellular level of telomere dysfunction determines induction of senescence or apoptosis in vivo.

The mitochondrial protein CHCHD2 primes the differentiation potential of human induced pluripotent stem cells to neuroectodermal lineages.

The p.M292T NDUFS2 mutation causes complex I-deficient Leigh syndrome in multiple families ⬇️

The role of telomerase protein TERT in Alzheimer's disease and in tau-related pathology in vitro.

The role of telomeres in Etoposide induced tumor cell death.

Tumour-cell apoptosis after cisplatin treatment is not telomere dependent

Well-known signaling proteins exert new functions in the nucleus and mitochondria.

[Molecular mechanisms of senescence in cell culture].

hTERT gene dosage correlates with telomerase activity in human lung cancer cell lines