Lista de obras - Mercedes Martín-Martínez

2-Alkyl-2-carboxyazetidines as γ-turn inducers: incorporation into neurotrophin fragments

artículo científico publicado en 2010

5-(Tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine-Based Potent and Selective CCK1Receptor Antagonists: Structural Modifications at the Tryptophan Domain

scientific article published on 01 November 1999

5-(Tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine-based potent and selective CCK(1)receptor antagonists: structure-activity relationship studies on the substituent at N2-position.

artículo científico publicado en 2001

An iterative structure-assisted approach to sequence alignment and comparative modeling

Analogues of the neuroprotective tripeptide Gly-Pro-Glu (GPE): synthesis and structure-activity relationships.

artículo científico publicado en 2005

Azepane Quaternary Amino Acids As Effective Inducers of 310 Helix Conformations

artículo científico publicado en 2012

Azetidine-derived amino acids versus proline derivatives. alternative trends in reverse turn induction

artículo científico publicado en 2008

Combination of molecular modeling, site-directed mutagenesis, and SAR studies to delineate the binding site of pyridopyrimidine antagonists on the human CCK1 receptor.

artículo científico publicado en 2005

Conformationally constrained CCK4 analogues incorporating IBTM and BTD beta-turn mimetics.

artículo científico publicado en 2005

Cyclic amino acid linkers stabilizing key loops of brain derived neurotrophic factor.

artículo científico publicado en 2011

D242N, a KV7.1 LQTS mutation uncovers a key residue for IKs voltage dependence.

artículo científico publicado en 2017

De novo designed library of linear helical peptides: an exploratory tool in the discovery of protein-protein interaction modulators

artículo científico publicado en 2014

Disulfide and amide-bridged cyclic peptide analogues of the VEGF81–91 fragment: Synthesis, conformational analysis and biological evaluation

article

Divergent, stereoselective access to heterocyclic α,α-quaternary- and β2,3,3-amino acid derivatives from a N-Pmp-protected Orn-derived β-lactam

scientific article published on 01 May 2015

Effects of the incorporation of IBTM beta-turn mimetics into the dipeptoid CCK(1) receptor agonist PD 170292.

artículo científico publicado en 2002

Exceptional Stereoselectivity in the Synthesis of 1,3,4-Trisubstituted 4-Carboxy β-Lactam Derivatives from Amino Acids

artículo científico publicado en 2007

Experimental and Theoretical Studies on the Rearrangement of 2-Oxoazepane α,α-Amino Acids into 2′-Oxopiperidine β2,3,3-Amino Acids: An Example of Intramolecular Catalysis

artículo científico publicado en 2014

Gly-Pro-Glu protects beta-amyloid-induced somatostatin depletion in the rat cortex.

artículo científico publicado en 2004

Helical peptides from VEGF and Vammin hotspots for modulating the VEGF-VEGFR interaction.

artículo científico publicado en 2013

Highly constrained dipeptoid analogues containing a type II' beta-turn mimic as novel and selective CCK-A receptor ligands.

artículo científico publicado en 1999

Identification, functional gastrointestinal stability and molecular docking studies of lentil peptides with dual antioxidant and angiotensin I converting enzyme inhibitory activities.

artículo científico publicado en 2016

Modulating Mineralocorticoid Receptor with Non-steroidal Antagonists. New Opportunities for the Development of Potent and Selective Ligands without Off-Target Side Effects.

artículo científico publicado en 2017

Modulation of protein-protein interactions by stabilizing/mimicking protein secondary structure elements

artículo científico publicado en 2007

Parallel solid-phase synthesis of a small library of linear and hydrocarbon-bridged analogues of VEGF(81-91): potential biological tools for studying the VEGF/VEGFR-1 interaction.

artículo científico publicado en 2011

Quaternary α,α-2-Oxoazepane α-Amino Acids: Synthesis from Ornithine-Derived β-Lactams and Incorporation into Model Dipeptides

scientific article published on 18 July 2011

Strategies for design of non peptide CCK1R agonist/antagonist ligands.

artículo científico publicado en 2007

Synthesis and stereochemical structure-activity relationships of 1,3-dioxoperhydropyrido[1,2-c]pyrimidine derivatives: potent and selective cholecystokinin-A receptor antagonists.

artículo científico publicado en 1997

Synthesis, conformational analysis, and cytotoxicity of conformationally constrained aplidine and tamandarin A analogues incorporating a spirolactam beta-turn mimetic.

artículo científico publicado en 2004

The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity.

artículo científico publicado en 2006

beta-Turned dipeptoids as potent and selective CCK(1) receptor antagonists.

artículo científico publicado en 2000

Lista de obras de Mercedes Martín-Martínez

2-Alkyl-2-carboxyazetidines as γ-turn inducers: incorporation into neurotrophin fragments

5-(Tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine-Based Potent and Selective CCK1Receptor Antagonists: Structural Modifications at the Tryptophan Domain

5-(Tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine-based potent and selective CCK(1)receptor antagonists: structure-activity relationship studies on the substituent at N2-position.

An iterative structure-assisted approach to sequence alignment and comparative modeling

Analogues of the neuroprotective tripeptide Gly-Pro-Glu (GPE): synthesis and structure-activity relationships.

Azepane Quaternary Amino Acids As Effective Inducers of 310 Helix Conformations

Azetidine-derived amino acids versus proline derivatives. alternative trends in reverse turn induction

Combination of molecular modeling, site-directed mutagenesis, and SAR studies to delineate the binding site of pyridopyrimidine antagonists on the human CCK1 receptor.

Conformationally constrained CCK4 analogues incorporating IBTM and BTD beta-turn mimetics.

Cyclic amino acid linkers stabilizing key loops of brain derived neurotrophic factor.

D242N, a KV7.1 LQTS mutation uncovers a key residue for IKs voltage dependence.

De novo designed library of linear helical peptides: an exploratory tool in the discovery of protein-protein interaction modulators

Disulfide and amide-bridged cyclic peptide analogues of the VEGF81–91 fragment: Synthesis, conformational analysis and biological evaluation

Divergent, stereoselective access to heterocyclic α,α-quaternary- and β2,3,3-amino acid derivatives from a N-Pmp-protected Orn-derived β-lactam

Effects of the incorporation of IBTM beta-turn mimetics into the dipeptoid CCK(1) receptor agonist PD 170292.

Exceptional Stereoselectivity in the Synthesis of 1,3,4-Trisubstituted 4-Carboxy β-Lactam Derivatives from Amino Acids

Experimental and Theoretical Studies on the Rearrangement of 2-Oxoazepane α,α-Amino Acids into 2′-Oxopiperidine β2,3,3-Amino Acids: An Example of Intramolecular Catalysis

Gly-Pro-Glu protects beta-amyloid-induced somatostatin depletion in the rat cortex.

Helical peptides from VEGF and Vammin hotspots for modulating the VEGF-VEGFR interaction.

Highly constrained dipeptoid analogues containing a type II' beta-turn mimic as novel and selective CCK-A receptor ligands.

Identification, functional gastrointestinal stability and molecular docking studies of lentil peptides with dual antioxidant and angiotensin I converting enzyme inhibitory activities.

Modulating Mineralocorticoid Receptor with Non-steroidal Antagonists. New Opportunities for the Development of Potent and Selective Ligands without Off-Target Side Effects.

Modulation of protein-protein interactions by stabilizing/mimicking protein secondary structure elements

Parallel solid-phase synthesis of a small library of linear and hydrocarbon-bridged analogues of VEGF(81-91): potential biological tools for studying the VEGF/VEGFR-1 interaction.

Quaternary α,α-2-Oxoazepane α-Amino Acids: Synthesis from Ornithine-Derived β-Lactams and Incorporation into Model Dipeptides

Strategies for design of non peptide CCK1R agonist/antagonist ligands.

Synthesis and stereochemical structure-activity relationships of 1,3-dioxoperhydropyrido[1,2-c]pyrimidine derivatives: potent and selective cholecystokinin-A receptor antagonists.

Synthesis, conformational analysis, and cytotoxicity of conformationally constrained aplidine and tamandarin A analogues incorporating a spirolactam beta-turn mimetic.

The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity.

beta-Turned dipeptoids as potent and selective CCK(1) receptor antagonists.