Lista de obras - Enrico De Smaele - Dominio Público Uruguay

Alternative splicing of the ErbB-4 cytoplasmic domain and its regulation by hedgehog signaling identify distinct medulloblastoma subsets.

artículo científico publicado en 2006

An integrated approach identifies Nhlh1 and Insm1 as Sonic Hedgehog-regulated genes in developing cerebellum and medulloblastoma

artículo científico publicado en 2008

Cell survival and a Gadd45-factor deficiency

artículo científico publicado en 2003

Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells

artículo científico publicado en 2008

Curcumin blocks autophagy and activates apoptosis of malignant mesothelioma cell lines and increases the survival of mice intraperitoneally transplanted with a malignant mesothelioma cell line.

artículo científico publicado en 2017

Delta-cell-specific expression of hedgehog pathway Ptch1 receptor in murine and human endocrine pancreas.

artículo científico publicado en 2011

Druggable glycolytic requirement for Hedgehog-dependent neuronal and medulloblastoma growth

artículo científico publicado en 2014

ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP

artículo científico publicado en 2019

EZH2, JMJD3, and UTX epigenetically regulate hepatic plasticity inducing retro-differentiation and proliferation of liver cells

scientific article published on 08 July 2019

Ferritin Heavy Chain Upregulation by NF-κB Inhibits TNFα-Induced Apoptosis by Suppressing Reactive Oxygen Species

artículo científico publicado en 2004

Foxm1 controls a pro-stemness microRNA network in neural stem cells.

artículo científico publicado en 2018

Gadd45 beta mediates the NF-kappa B suppression of JNK signalling by targeting MKK7/JNKK2

artículo científico publicado en 2004

Gadd45 beta mediates the protective effects of CD40 costimulation against Fas-induced apoptosis

artículo científico publicado en 2003

Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors.

artículo científico publicado en 2014

Gli2 Acetylation at Lysine 757 Regulates Hedgehog-Dependent Transcriptional Output by Preventing Its Promoter Occupancy ⬇️

artículo científico publicado el 6 de junio de 2013

Glucocorticoids and neonatal brain injury: the hedgehog connection.

artículo científico publicado en 2009

Hedgehog antagonist REN(KCTD11) regulates proliferation and apoptosis of developing granule cell progenitors

scientific journal article

Hedgehog checkpoints in medulloblastoma: the chromosome 17p deletion paradigm.

artículo científico publicado en 2005

Hedgehog controls neural stem cells through p53-independent regulation of Nanog

artículo científico publicado en 2010

Hedgehog signaling pathway and its targets for treatment in basal cell carcinoma

artículo científico publicado en 2012

Hedgehog signaling pathway in neural development and disease.

artículo científico publicado en 2007

Hedgehog/Gli control by ubiquitination/acetylation interplay.

artículo científico publicado en 2012

Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation

artículo científico publicado en 2010

Identification and characterization of KCASH2 and KCASH3, 2 novel Cullin3 adaptors suppressing histone deacetylase and Hedgehog activity in medulloblastoma.

artículo científico publicado en 2011

Identification of nuclei from apoptotic, necrotic, and viable lymphoid cells by using multiparameter flow cytometry

scientific article published on 01 February 1999

In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors.

artículo científico publicado en 2016

Induction of gadd45beta by NF-kappaB downregulates pro-apoptotic JNK signalling.

artículo científico publicado en 2001

Insights into the Structural Basis of the GADD45β-mediated Inactivation of the JNK Kinase, MKK7/JNKK2

artículo científico publicado en 2007

Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis.

artículo científico publicado en 2018

KCTD15 inhibits the Hedgehog pathway in Medulloblastoma cells by increasing protein levels of the oncosuppressor KCASH2

scientific article published on 04 November 2019

MicroRNA profiling in human medulloblastoma.

artículo científico publicado en 2009

Mitogen-activated kinase kinase kinase 1 inhibits hedgehog signaling and medulloblastoma growth through GLI1 phosphorylation

artículo científico publicado en 2018

Molecular organization of the cullin E3 ligase adaptor KCTD11.

artículo científico publicado en 2011

NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration

artículo científico publicado en 2011

Non-canonical Hedgehog/AMPK-Mediated Control of Polyamine Metabolism Supports Neuronal and Medulloblastoma Cell Growth

artículo científico publicado en 2015

Noncanonical GLI1 signaling promotes stemness features and in vivo growth in lung adenocarcinoma

artículo científico publicado en 2017

Numb Isoforms Deregulation in Medulloblastoma and Role of p66 Isoform in Cancer and Neural Stem Cells

artículo científico publicado en 2018

Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal ⬇️

artículo científico publicado el 6 de septiembre de 2010

Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination

artículo científico publicado en 2006

PCAF ubiquitin ligase activity inhibits Hedgehog/Gli1 signaling in p53-dependent response to genotoxic stress

artículo científico publicado en 2013

Pharmacological activation of mGlu4 metabotropic glutamate receptors inhibits the growth of medulloblastomas.

artículo científico publicado en 2006

Protection by herpes simplex virus glycoprotein D against Fas-mediated apoptosis: role of nuclear factor kappaB.

artículo científico publicado en 2003

REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma

artículo científico publicado en 2004

Regulation of the gadd45beta promoter by NF-kappaB

artículo científico publicado en 2002

SMO-M2 mutation does not support cell-autonomous Hedgehog activity in cerebellar granule cell precursors

scientific article published on 23 December 2019

Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma.

artículo científico publicado en 2017

Sonic Hedgehog Medulloblastoma Cancer Stem Cells Mirnome and Transcriptome Highlight Novel Functional Networks

scientific article published on 08 August 2018

Suppressors of hedgehog signaling: Linking aberrant development of neural progenitors and tumorigenesis.

artículo científico publicado en 2006

The centrosomal deubiquitylase USP21 regulates Gli1 transcriptional activity and stability.

artículo científico publicado en 2016

The energy sensor AMPK regulates Hedgehog signaling in human cells through a unique Gli1 metabolic checkpoint

artículo científico publicado en 2016

c-FLIP efficiently rescues TRAF-2-/- cells from TNF-induced apoptosis

artículo científico publicado en 2002

microRNA-17-92 cluster is a direct Nanog target and controls neural stem cell through Trp53inp1.

artículo científico publicado en 2013

β-arrestin1-mediated acetylation of Gli1 regulates Hedgehog/Gli signaling and modulates self-renewal of SHH medulloblastoma cancer stem cells.

artículo científico publicado en 2017

Lista de obras de Enrico De Smaele

Alternative splicing of the ErbB-4 cytoplasmic domain and its regulation by hedgehog signaling identify distinct medulloblastoma subsets.

An integrated approach identifies Nhlh1 and Insm1 as Sonic Hedgehog-regulated genes in developing cerebellum and medulloblastoma

Cell survival and a Gadd45-factor deficiency

Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells

Curcumin blocks autophagy and activates apoptosis of malignant mesothelioma cell lines and increases the survival of mice intraperitoneally transplanted with a malignant mesothelioma cell line.

Delta-cell-specific expression of hedgehog pathway Ptch1 receptor in murine and human endocrine pancreas.

Druggable glycolytic requirement for Hedgehog-dependent neuronal and medulloblastoma growth

ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP

EZH2, JMJD3, and UTX epigenetically regulate hepatic plasticity inducing retro-differentiation and proliferation of liver cells

Ferritin Heavy Chain Upregulation by NF-κB Inhibits TNFα-Induced Apoptosis by Suppressing Reactive Oxygen Species

Foxm1 controls a pro-stemness microRNA network in neural stem cells.

Gadd45 beta mediates the NF-kappa B suppression of JNK signalling by targeting MKK7/JNKK2

Gadd45 beta mediates the protective effects of CD40 costimulation against Fas-induced apoptosis

Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors.

Gli2 Acetylation at Lysine 757 Regulates Hedgehog-Dependent Transcriptional Output by Preventing Its Promoter Occupancy ⬇️

Glucocorticoids and neonatal brain injury: the hedgehog connection.

Hedgehog antagonist REN(KCTD11) regulates proliferation and apoptosis of developing granule cell progenitors

Hedgehog checkpoints in medulloblastoma: the chromosome 17p deletion paradigm.

Hedgehog controls neural stem cells through p53-independent regulation of Nanog

Hedgehog signaling pathway and its targets for treatment in basal cell carcinoma

Hedgehog signaling pathway in neural development and disease.

Hedgehog/Gli control by ubiquitination/acetylation interplay.

Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation

Identification and characterization of KCASH2 and KCASH3, 2 novel Cullin3 adaptors suppressing histone deacetylase and Hedgehog activity in medulloblastoma.

Identification of nuclei from apoptotic, necrotic, and viable lymphoid cells by using multiparameter flow cytometry

In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors.

Induction of gadd45beta by NF-kappaB downregulates pro-apoptotic JNK signalling.

Insights into the Structural Basis of the GADD45β-mediated Inactivation of the JNK Kinase, MKK7/JNKK2

Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis.

KCTD15 inhibits the Hedgehog pathway in Medulloblastoma cells by increasing protein levels of the oncosuppressor KCASH2

MicroRNA profiling in human medulloblastoma.

Mitogen-activated kinase kinase kinase 1 inhibits hedgehog signaling and medulloblastoma growth through GLI1 phosphorylation

Molecular organization of the cullin E3 ligase adaptor KCTD11.

NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration

Non-canonical Hedgehog/AMPK-Mediated Control of Polyamine Metabolism Supports Neuronal and Medulloblastoma Cell Growth

Noncanonical GLI1 signaling promotes stemness features and in vivo growth in lung adenocarcinoma

Numb Isoforms Deregulation in Medulloblastoma and Role of p66 Isoform in Cancer and Neural Stem Cells

Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal ⬇️

Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination

PCAF ubiquitin ligase activity inhibits Hedgehog/Gli1 signaling in p53-dependent response to genotoxic stress

Pharmacological activation of mGlu4 metabotropic glutamate receptors inhibits the growth of medulloblastomas.

Protection by herpes simplex virus glycoprotein D against Fas-mediated apoptosis: role of nuclear factor kappaB.

REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma

Regulation of the gadd45beta promoter by NF-kappaB

SMO-M2 mutation does not support cell-autonomous Hedgehog activity in cerebellar granule cell precursors

Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma.

Sonic Hedgehog Medulloblastoma Cancer Stem Cells Mirnome and Transcriptome Highlight Novel Functional Networks

Suppressors of hedgehog signaling: Linking aberrant development of neural progenitors and tumorigenesis.

The centrosomal deubiquitylase USP21 regulates Gli1 transcriptional activity and stability.

The energy sensor AMPK regulates Hedgehog signaling in human cells through a unique Gli1 metabolic checkpoint

c-FLIP efficiently rescues TRAF-2-/- cells from TNF-induced apoptosis

microRNA-17-92 cluster is a direct Nanog target and controls neural stem cell through Trp53inp1.

β-arrestin1-mediated acetylation of Gli1 regulates Hedgehog/Gli signaling and modulates self-renewal of SHH medulloblastoma cancer stem cells.