Lista de obras - Tilman Brummer - Dominio Público Uruguay

A cell-based MAPK reporter assay reveals synergistic MAPK pathway activity suppression by MAPK inhibitor combination in BRAF-driven pediatric low-grade glioma cells

artículo científico publicado en 2020

A generic strategy for pharmacological caging of growth factors for tissue engineering.

artículo científico publicado en 2013

A novel MCF-10A line allowing conditional oncogene expression in 3D culture

artículo científico publicado en 2011

A revised and complete map of the chicken c-mil/raf-1 locus

artículo científico publicado en 2004

A self-enforcing CD44s/ZEB1 feedback loop maintains EMT and stemness properties in cancer cells.

artículo científico publicado en 2015

Aberrant B-Raf signaling in human cancer -- 10 years from bench to bedside

artículo científico

Activation loop phosphorylation regulates B-Raf in vivo and transformation by B-Raf mutants

artículo científico publicado en 2015

Adenosine and cAMP are potent inhibitors of the NF-kappa B pathway downstream of immunoreceptors

artículo científico publicado en 2005

Alterations of Gab2 signalling complexes in imatinib and dasatinib treated chronic myeloid leukaemia cells

artículo científico publicado en 2013

Axitinib and sorafenib are potent in tyrosine kinase inhibitor resistant chronic myeloid leukemia cells

artículo científico

B-Raf activation loop phosphorylation revisited

artículo científico publicado en 2016

B-Raf deficiency impairs tumor initiation and progression in a murine breast cancer model

artículo científico publicado en 2019

B-Raf inhibitors induce epithelial differentiation in BRAF-mutant colorectal cancer cells

artículo científico publicado en 2014

BRAF inhibition in hairy cell leukemia with low-dose vemurafenib

artículo científico publicado en 2016

BRAF inhibition upregulates a variety of receptor tyrosine kinases and their downstream effector Gab2 in colorectal cancer cell lines

artículo científico publicado en 2018

BRAF inhibitor-associated ERK activation drives development of chronic lymphocytic leukemia

artículo científico publicado en 2014

BRAF inhibitors in colorectal cancer: Toward a differentiation therapy?

artículo científico publicado en 2015

BRAFV600E drives dedifferentiation in small intestinal and colonic organoids and cooperates with mutant p53 and Apc loss in transformation

artículo científico publicado en 2020

Biglycan expression in the melanoma microenvironment promotes invasiveness via increased tissue stiffness inducing integrin-β1 expression

artículo científico publicado en 2017

CDK9-mediated phosphorylation controls the interaction of TIP60 with the transcriptional machinery.

artículo científico publicado en 2018

Cathepsin D deficiency in mammary epithelium transiently stalls breast cancer by interference with mTORC1 signaling

scientific article published on 12 October 2020

Combined targeted DNA and RNA sequencing of advanced NSCLC in routine molecular diagnostics: Analysis of the first 3,000 Heidelberg cases

scientific article published on 19 February 2019

DUSP26 negatively affects the proliferation of epithelial cells, an effect not mediated by dephosphorylation of MAPKs

artículo científico publicado en 2010

Depletion of STAT5 blocks TEL-SYK-induced APMF-type leukemia with myelofibrosis and myelodysplasia in mice.

artículo científico publicado en 2014

Differential tyrosine phosphorylation controls the function of CNK1 as a molecular switch in signal transduction.

artículo científico publicado en 2015

Discrete cytosolic macromolecular BRAF complexes exhibit distinct activities and composition

artículo científico publicado en 2017

Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling

artículo científico publicado en 2012

Dual-specificity phosphatases: critical regulators with diverse cellular targets

artículo científico publicado en 2009

EGFR-targeted TRAIL and a Smac mimetic synergize to overcome apoptosis resistance in KRAS mutant colorectal cancer cells

artículo científico publicado en 2014

ELF5 suppresses estrogen sensitivity and underpins the acquisition of antiestrogen resistance in luminal breast cancer.

artículo científico publicado en 2012

Effects of RAF inhibitors on PI3K/AKT signalling depend on mutational status of the RAS/RAF signalling axis

artículo científico publicado en 2016

Establishment and application of a novel patient-derived KIAA1549:BRAF-driven pediatric pilocytic astrocytoma model for preclinical drug testing

artículo científico publicado en 2016

Exometabolom analysis of breast cancer cell lines: Metabolic signature

artículo científico publicado en 2015

Expression pattern and first functional characterization of riok-1 in Caenorhabditis elegans

artículo científico publicado en 2014

FAM131B-BRAF Fusion Gene Resulting From 7q34 Deletion Leads to MAPK Pathway Activation in Pilocytic Astrocytoma

Feedback regulation of lymphocyte signalling

artículo científico publicado en 2004

Function, regulation and pathological roles of the Gab/DOS docking proteins

artículo científico publicado en 2009

Functional characterization of a BRAF insertion mutant associated with pilocytic astrocytoma

artículo científico publicado en 2011

Functional characterization of cancer-associated Gab1 mutations.

artículo científico publicado en 2012

Gab2 and Src co-operate in human mammary epithelial cells to promote growth factor independence and disruption of acinar morphogenesis.

artículo científico publicado en 2007

Gab2 is essential for Bcr-Abl-mediated leukemic transformation and hydronephrosis in a chronic myeloid leukemia mouse model.

artículo científico publicado en 2016

Gab2 regulates cytoskeletal organization and migration of mammary epithelial cells by modulating RhoA activation

artículo científico publicado en 2010

Gab2 signaling in chronic myeloid leukemia cells confers resistance to multiple Bcr-Abl inhibitors.

artículo científico publicado en 2012

Global gene expression profiling analysis reveals reduction of stemness after B-RAF inhibition in colorectal cancer cell lines

artículo científico publicado en 2015

Global kinome profiling reveals DYRK1A as critical activator of the human mitochondrial import machinery

artículo científico publicado en 2021

How to Grb2 a Gab.

artículo científico publicado en 2009

Identification and characterization of a BRAF fusion oncoprotein with retained autoinhibitory domains

scientific article published on 26 September 2019

Identification of novel ERK-mediated feedback phosphorylation sites at the C-terminus of B-Raf

artículo científico publicado en 2003

Increased proliferation and altered growth factor dependence of human mammary epithelial cells overexpressing the Gab2 docking protein

artículo científico publicado en 2006

Inducible gene deletion reveals different roles for B-Raf and Raf-1 in B-cell antigen receptor signalling

artículo científico publicado en 2002

Insulin-like growth factor-1 receptor (IGF1R) as a novel target in chronic lymphocytic leukemia

artículo científico publicado en 2013

Kidins220/ARMS associates with B-Raf and the TCR, promoting sustained Erk signaling in T cells

artículo científico publicado en 2013

Kidins220/ARMS binds to the B cell antigen receptor and regulates B cell development and activation

artículo científico publicado en 2015

MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib

artículo científico publicado en 2016

Metabolic reprogramming of donor T cells enhances graft-versus-leukemia effects in mice and humans

artículo científico publicado en 2020

Metadherin exon 11 skipping variant enhances metastatic spread of ovarian cancer.

artículo científico publicado en 2014

MicroRNA-146a reduces MHC-II expression via targeting JAK/STAT signaling in dendritic cells after stem cell transplantation

artículo científico publicado en 2017

Oncogenic FAM131B-BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma

artículo científico publicado en 2011

Oncogenic JAK2V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms.

artículo científico publicado en 2018

PKD controls mitotic Golgi complex fragmentation through a Raf-MEK1 pathway

artículo científico publicado en 2012

Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein

artículo científico publicado en 2008

Positive regulation of immune cell function and inflammatory responses by phosphatase PAC-1.

artículo científico publicado en 2006

ROCK1/2 signaling contributes to corticosteroid-refractory acute graft-versus-host disease

artículo científico publicado en 2024

Signalling by the EGF receptor in human cancers: accentuate the positive, eliminate the negative

Small-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface

artículo científico publicado en 2016

Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells.

artículo científico publicado en 2018

Spontaneous activity of the mitochondrial apoptosis pathway drives chromosomal defects, the appearance of micronuclei and cancer metastasis through the Caspase-Activated DNAse

artículo científico publicado en 2022

Strong negative feedback from Erk to Raf confers robustness to MAPK signalling.

artículo científico publicado en 2011

Targeting oncogenic Ras by the Clostridium perfringens toxin TpeL.

artículo científico publicado en 2018

Targeting rare and non-canonical driver variants in NSCLC – An uncharted clinical field

artículo científico publicado en 2021

The Atypical Kinase RIOK1 Promotes Tumor Growth and Invasive Behavior

artículo científico publicado en 2017

The EMT-activator ZEB1 induces bone metastasis associated genes including BMP-inhibitors

artículo científico publicado en 2015

The RhoGAP protein Deleted in Liver Cancer 3 (DLC3) is essential for adherens junctions integrity

artículo científico publicado en 2012

The Senescence-associated Secretory Phenotype Mediates Oncogene-induced Senescence in Pediatric Pilocytic Astrocytoma

artículo científico publicado en 2018

The Versatile Role of Gab1 in the Circulatory System

scientific article published on 11 July 2012

The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion.

artículo científico publicado en 2002

The immunohistochemical staining pattern of Gab2 correlates with distinct stages of chronic myeloid leukemia.

artículo científico publicado en 2011

UV-B-induced cutaneous inflammation and prospects for antioxidant treatment in Kindler syndrome.

artículo científico publicado en 2016

ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types

artículo científico

Lista de obras de Tilman Brummer

A cell-based MAPK reporter assay reveals synergistic MAPK pathway activity suppression by MAPK inhibitor combination in BRAF-driven pediatric low-grade glioma cells

A generic strategy for pharmacological caging of growth factors for tissue engineering.

A novel MCF-10A line allowing conditional oncogene expression in 3D culture

A revised and complete map of the chicken c-mil/raf-1 locus

A self-enforcing CD44s/ZEB1 feedback loop maintains EMT and stemness properties in cancer cells.

Aberrant B-Raf signaling in human cancer -- 10 years from bench to bedside

Activation loop phosphorylation regulates B-Raf in vivo and transformation by B-Raf mutants

Adenosine and cAMP are potent inhibitors of the NF-kappa B pathway downstream of immunoreceptors

Alterations of Gab2 signalling complexes in imatinib and dasatinib treated chronic myeloid leukaemia cells

Axitinib and sorafenib are potent in tyrosine kinase inhibitor resistant chronic myeloid leukemia cells

B-Raf activation loop phosphorylation revisited

B-Raf deficiency impairs tumor initiation and progression in a murine breast cancer model

B-Raf inhibitors induce epithelial differentiation in BRAF-mutant colorectal cancer cells

BRAF inhibition in hairy cell leukemia with low-dose vemurafenib

BRAF inhibition upregulates a variety of receptor tyrosine kinases and their downstream effector Gab2 in colorectal cancer cell lines

BRAF inhibitor-associated ERK activation drives development of chronic lymphocytic leukemia

BRAF inhibitors in colorectal cancer: Toward a differentiation therapy?

BRAFV600E drives dedifferentiation in small intestinal and colonic organoids and cooperates with mutant p53 and Apc loss in transformation

Biglycan expression in the melanoma microenvironment promotes invasiveness via increased tissue stiffness inducing integrin-β1 expression

CDK9-mediated phosphorylation controls the interaction of TIP60 with the transcriptional machinery.

Cathepsin D deficiency in mammary epithelium transiently stalls breast cancer by interference with mTORC1 signaling

Combined targeted DNA and RNA sequencing of advanced NSCLC in routine molecular diagnostics: Analysis of the first 3,000 Heidelberg cases

DUSP26 negatively affects the proliferation of epithelial cells, an effect not mediated by dephosphorylation of MAPKs

Depletion of STAT5 blocks TEL-SYK-induced APMF-type leukemia with myelofibrosis and myelodysplasia in mice.

Differential tyrosine phosphorylation controls the function of CNK1 as a molecular switch in signal transduction.

Discrete cytosolic macromolecular BRAF complexes exhibit distinct activities and composition

Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling

Dual-specificity phosphatases: critical regulators with diverse cellular targets

EGFR-targeted TRAIL and a Smac mimetic synergize to overcome apoptosis resistance in KRAS mutant colorectal cancer cells

ELF5 suppresses estrogen sensitivity and underpins the acquisition of antiestrogen resistance in luminal breast cancer.

Effects of RAF inhibitors on PI3K/AKT signalling depend on mutational status of the RAS/RAF signalling axis

Establishment and application of a novel patient-derived KIAA1549:BRAF-driven pediatric pilocytic astrocytoma model for preclinical drug testing

Exometabolom analysis of breast cancer cell lines: Metabolic signature

Expression pattern and first functional characterization of riok-1 in Caenorhabditis elegans

FAM131B-BRAF Fusion Gene Resulting From 7q34 Deletion Leads to MAPK Pathway Activation in Pilocytic Astrocytoma

FAM131B-BRAF Fusion Gene Resulting From 7q34 Deletion Leads to MAPK Pathway Activation in Pilocytic Astrocytoma

Feedback regulation of lymphocyte signalling

Function, regulation and pathological roles of the Gab/DOS docking proteins

Functional characterization of a BRAF insertion mutant associated with pilocytic astrocytoma

Functional characterization of cancer-associated Gab1 mutations.

Gab2 and Src co-operate in human mammary epithelial cells to promote growth factor independence and disruption of acinar morphogenesis.

Gab2 is essential for Bcr-Abl-mediated leukemic transformation and hydronephrosis in a chronic myeloid leukemia mouse model.

Gab2 regulates cytoskeletal organization and migration of mammary epithelial cells by modulating RhoA activation

Gab2 signaling in chronic myeloid leukemia cells confers resistance to multiple Bcr-Abl inhibitors.

Global gene expression profiling analysis reveals reduction of stemness after B-RAF inhibition in colorectal cancer cell lines

Global kinome profiling reveals DYRK1A as critical activator of the human mitochondrial import machinery

How to Grb2 a Gab.

Identification and characterization of a BRAF fusion oncoprotein with retained autoinhibitory domains

Identification of novel ERK-mediated feedback phosphorylation sites at the C-terminus of B-Raf

Increased proliferation and altered growth factor dependence of human mammary epithelial cells overexpressing the Gab2 docking protein

Inducible gene deletion reveals different roles for B-Raf and Raf-1 in B-cell antigen receptor signalling

Insulin-like growth factor-1 receptor (IGF1R) as a novel target in chronic lymphocytic leukemia

Kidins220/ARMS associates with B-Raf and the TCR, promoting sustained Erk signaling in T cells

Kidins220/ARMS binds to the B cell antigen receptor and regulates B cell development and activation

MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib

Metabolic reprogramming of donor T cells enhances graft-versus-leukemia effects in mice and humans

Metadherin exon 11 skipping variant enhances metastatic spread of ovarian cancer.

MicroRNA-146a reduces MHC-II expression via targeting JAK/STAT signaling in dendritic cells after stem cell transplantation

Oncogenic FAM131B-BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma

Oncogenic JAK2V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms.

PKD controls mitotic Golgi complex fragmentation through a Raf-MEK1 pathway

Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein

Positive regulation of immune cell function and inflammatory responses by phosphatase PAC-1.

ROCK1/2 signaling contributes to corticosteroid-refractory acute graft-versus-host disease

Signalling by the EGF receptor in human cancers: accentuate the positive, eliminate the negative

Small-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface

Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells.

Spontaneous activity of the mitochondrial apoptosis pathway drives chromosomal defects, the appearance of micronuclei and cancer metastasis through the Caspase-Activated DNAse

Strong negative feedback from Erk to Raf confers robustness to MAPK signalling.

Targeting oncogenic Ras by the Clostridium perfringens toxin TpeL.

Targeting rare and non-canonical driver variants in NSCLC – An uncharted clinical field

The Atypical Kinase RIOK1 Promotes Tumor Growth and Invasive Behavior

The EMT-activator ZEB1 induces bone metastasis associated genes including BMP-inhibitors

The RhoGAP protein Deleted in Liver Cancer 3 (DLC3) is essential for adherens junctions integrity

The Senescence-associated Secretory Phenotype Mediates Oncogene-induced Senescence in Pediatric Pilocytic Astrocytoma

The Versatile Role of Gab1 in the Circulatory System

The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion.

The immunohistochemical staining pattern of Gab2 correlates with distinct stages of chronic myeloid leukemia.

UV-B-induced cutaneous inflammation and prospects for antioxidant treatment in Kindler syndrome.