Lista de obras - Gerard Pujadas - Dominio Público Uruguay

A trimer plus a dimer-gallate reproduce the bioactivity described for an extract of grape seed procyanidins

article by Gemma Montagut et al published September 2009 in Food Chemistry

Activity and selectivity cliffs for DPP-IV inhibitors: Lessons we can learn from SAR studies and their application to virtual screening

scientific article published on 16 April 2018

BDT: an easy-to-use front-end application for automation of massive docking tasks and complex docking strategies with AutoDock

artículo científico publicado en 2006

Characterization of the activity and stability of amylase from saliva and detergent: laboratory practicals for studying the activity and stability of amylase from saliva and various commercial detergents

artículo científico publicado en 2012

Characterization of the protease activity of detergents: laboratory practicals for studying the protease profile and activity of various commercial detergents

artículo científico publicado en 2011

Combined Ligand- and Receptor-Based Virtual Screening Methodology to Identify Structurally Diverse Protein Tyrosine Phosphatase 1B Inhibitors

scientific article published on 23 August 2018

DecoyFinder: an easy-to-use python GUI application for building target-specific decoy sets.

artículo científico publicado en 2012

Development of docking-based 3D-QSAR models for PPARgamma full agonists

scientific article published on 14 March 2012

Dietary catechins and procyanidins modulate zinc homeostasis in human HepG2 cells

artículo científico publicado en 2010

Dietary procyanidins enhance transcriptional activity of bile acid-activated FXR in vitro and reduce triglyceridemia in vivo in a FXR-dependent manner.

artículo científico publicado en 2009

Dietary procyanidins lower triglyceride levels signaling through the nuclear receptor small heterodimer partner.

artículo científico publicado en 2008

Differential effects of grape-seed derived procyanidins on adipocyte differentiation markers in different in vivo situations

artículo científico publicado en 2007

Effects of a grapeseed procyanidin extract (GSPE) on insulin resistance.

artículo científico publicado en 2009

Erratum to “Moderate red-wine consumption partially prevents body weight gain in rats fed a hyperlipidic diet” [J Nutr Biochem 17 (2006) 139-142]

scholarly article published in Journal of Nutritional Biochemistry

Grape Seed-Derived Procyanidins Decrease Dipeptidyl-peptidase 4 Activity and Expression

scientific article published on 30 August 2012

Grape seed procyanidins inhibit the expression of metallothione in genes in human HepG2 cells

artículo científico publicado en 2007

Grape-seed procyanidins act as antiinflammatory agents in endotoxin-stimulated RAW 264.7 macrophages by inhibiting NFkB signaling pathway

artículo científico publicado en 2007

Grape-seed procyanidins prevent low-grade inflammation by modulating cytokine expression in rats fed a high-fat diet

artículo científico publicado en 2008

Identification of PPARgamma partial agonists of natural origin (I): development of a virtual screening procedure and in vitro validation

artículo científico publicado en 2012

Identification of PPARgamma partial agonists of natural origin (II): in silico prediction in natural extracts with known antidiabetic activity

artículo científico publicado en 2013

Identification of human IKK-2 inhibitors of natural origin (Part II): in Silico prediction of IKK-2 inhibitors in natural extracts with known anti-inflammatory activity

scientific article published on 22 September 2011

Identification of human IKK-2 inhibitors of natural origin (part I): modeling of the IKK-2 kinase domain, virtual screening and activity assays

artículo científico publicado en 2011

Identification of novel human dipeptidyl peptidase-IV inhibitors of natural origin (Part II): in silico prediction in antidiabetic extracts

artículo científico publicado en 2012

Identification of novel human dipeptidyl peptidase-IV inhibitors of natural origin (part I): virtual screening and activity assays

artículo científico publicado en 2012

In silico identification of red wine catechin binding sites on human and rat serotransferrins

artículo científico publicado en 2007

In vivo, in vitro, and in silico studies of Cu/Zn-superoxide dismutase regulation by molecules in grape seed procyanidin extract.

artículo científico publicado en 2009

Inhibition of angiotensin-converting enzyme activity by flavonoids: structure-activity relationship studies.

artículo científico publicado en 2012

Inhibitory effects of grape seed procyanidins on foam cell formation in vitro

artículo científico publicado en 2009

Locating the stabilizing residues in (alpha/beta)8 barrel proteins based on hydrophobicity, long-range interactions, and sequence conservation

artículo científico publicado en 2004

Mining large databases to find new leads with low similarity to known actives: application to find new DPP-IV inhibitors

artículo científico publicado en 2019

Modulatory effect of grape-seed procyanidins on local and systemic inflammation in diet-induced obesity rats

artículo científico publicado en 2010

Molecular fingerprint similarity search in virtual screening

artículo científico publicado en 2014

Molecular mimicry of substrate oxygen atoms by water molecules in the beta-amylase active site.

artículo científico

Oligomers of grape-seed procyanidin extract activate the insulin receptor and key targets of the insulin signaling pathway differently from insulin

artículo científico publicado en 2009

Procyanidin dimer B1 and trimer C1 impair inflammatory response signalling in human monocytes.

artículo científico publicado en 2011

Procyanidin effects on adipocyte-related pathologies.

artículo científico publicado en 2006

Procyanidins modify insulinemia by affecting insulin production and degradation

artículo científico publicado en 2012

Structural insights for the design of new PPARgamma partial agonists with high binding affinity and low transactivation activity

scientific article published on 21 June 2011

The Light and Dark Sides of Virtual Screening: What Is There to Know? ⬇️

scientific article published on 19 March 2019

The good, the bad and the dubious: VHELIBS, a validation helper for ligands and binding sites

artículo científico publicado en 2013

The lipid-lowering effect of dietary proanthocyanidins in rats involves both chylomicron-rich and VLDL-rich fractions

artículo científico publicado en 2011

Tools for in silico target fishing

artículo científico

Lista de obras de Gerard Pujadas

A trimer plus a dimer-gallate reproduce the bioactivity described for an extract of grape seed procyanidins

Activity and selectivity cliffs for DPP-IV inhibitors: Lessons we can learn from SAR studies and their application to virtual screening

BDT: an easy-to-use front-end application for automation of massive docking tasks and complex docking strategies with AutoDock

Characterization of the activity and stability of amylase from saliva and detergent: laboratory practicals for studying the activity and stability of amylase from saliva and various commercial detergents

Characterization of the protease activity of detergents: laboratory practicals for studying the protease profile and activity of various commercial detergents

Combined Ligand- and Receptor-Based Virtual Screening Methodology to Identify Structurally Diverse Protein Tyrosine Phosphatase 1B Inhibitors

DecoyFinder: an easy-to-use python GUI application for building target-specific decoy sets.

Development of docking-based 3D-QSAR models for PPARgamma full agonists

Dietary catechins and procyanidins modulate zinc homeostasis in human HepG2 cells

Dietary procyanidins enhance transcriptional activity of bile acid-activated FXR in vitro and reduce triglyceridemia in vivo in a FXR-dependent manner.

Dietary procyanidins lower triglyceride levels signaling through the nuclear receptor small heterodimer partner.

Differential effects of grape-seed derived procyanidins on adipocyte differentiation markers in different in vivo situations

Effects of a grapeseed procyanidin extract (GSPE) on insulin resistance.

Erratum to “Moderate red-wine consumption partially prevents body weight gain in rats fed a hyperlipidic diet” [J Nutr Biochem 17 (2006) 139-142]

Grape Seed-Derived Procyanidins Decrease Dipeptidyl-peptidase 4 Activity and Expression

Grape seed procyanidins inhibit the expression of metallothione in genes in human HepG2 cells

Grape-seed procyanidins act as antiinflammatory agents in endotoxin-stimulated RAW 264.7 macrophages by inhibiting NFkB signaling pathway

Grape-seed procyanidins prevent low-grade inflammation by modulating cytokine expression in rats fed a high-fat diet

Identification of PPARgamma partial agonists of natural origin (I): development of a virtual screening procedure and in vitro validation

Identification of PPARgamma partial agonists of natural origin (II): in silico prediction in natural extracts with known antidiabetic activity

Identification of human IKK-2 inhibitors of natural origin (Part II): in Silico prediction of IKK-2 inhibitors in natural extracts with known anti-inflammatory activity

Identification of human IKK-2 inhibitors of natural origin (part I): modeling of the IKK-2 kinase domain, virtual screening and activity assays

Identification of novel human dipeptidyl peptidase-IV inhibitors of natural origin (Part II): in silico prediction in antidiabetic extracts

Identification of novel human dipeptidyl peptidase-IV inhibitors of natural origin (part I): virtual screening and activity assays

In silico identification of red wine catechin binding sites on human and rat serotransferrins

In vivo, in vitro, and in silico studies of Cu/Zn-superoxide dismutase regulation by molecules in grape seed procyanidin extract.

Inhibition of angiotensin-converting enzyme activity by flavonoids: structure-activity relationship studies.

Inhibitory effects of grape seed procyanidins on foam cell formation in vitro

Locating the stabilizing residues in (alpha/beta)8 barrel proteins based on hydrophobicity, long-range interactions, and sequence conservation

Mining large databases to find new leads with low similarity to known actives: application to find new DPP-IV inhibitors

Modulatory effect of grape-seed procyanidins on local and systemic inflammation in diet-induced obesity rats

Molecular fingerprint similarity search in virtual screening

Molecular mimicry of substrate oxygen atoms by water molecules in the beta-amylase active site.

Oligomers of grape-seed procyanidin extract activate the insulin receptor and key targets of the insulin signaling pathway differently from insulin

Procyanidin dimer B1 and trimer C1 impair inflammatory response signalling in human monocytes.

Procyanidin effects on adipocyte-related pathologies.

Procyanidins modify insulinemia by affecting insulin production and degradation

Structural insights for the design of new PPARgamma partial agonists with high binding affinity and low transactivation activity

The Light and Dark Sides of Virtual Screening: What Is There to Know? ⬇️

The good, the bad and the dubious: VHELIBS, a validation helper for ligands and binding sites

The lipid-lowering effect of dietary proanthocyanidins in rats involves both chylomicron-rich and VLDL-rich fractions

Tools for in silico target fishing