Lista de obras - Paul Brear - Dominio Público Uruguay

A Random Forest Model for Predicting Allosteric and Functional Sites on Proteins.

artículo científico publicado en 2016

A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066.

artículo científico

Affinity maturation of the RLIP76 Ral binding domain to inform the design of stapled peptides targeting the Ral GTPases

artículo científico publicado en 2020

Aqueous methods for the preparation of 5'-substituted guanosine derivatives.

artículo científico publicado en 2009

Aqueous synthesis of N,S-dialkylthiophosphoramidates: design, optimisation and application to library construction and antileishmanial testing.

artículo científico publicado en 2013

Chain alignment of collagen I deciphered using computationally designed heterotrimers

scientific article published on 06 January 2020

Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein-protein interaction.

artículo científico publicado en 2019

Evolutionary plasticity in the allosteric regulator-binding site of pyruvate kinase isoform PykA from Pseudomonas aeruginosa

scientific article published on 04 September 2019

Gluconeogenic precursor availability regulates flux through the glyoxylate shunt in Pseudomonas aeruginosa

artículo científico publicado en 2018

Novel non-ATP competitive small molecules targeting the CK2 α/β interface

artículo científico publicado en 2018

Proposed Allosteric Inhibitors Bind to the ATP Site of CK2α

scientific article published on 29 October 2020

Second-generation CK2α inhibitors targeting the αD pocket.

artículo científico publicado en 2018

Specific inhibition of CK2α from an anchor outside the active site

artículo científico publicado en 2016

Structure, Function and Regulation of a Second Pyruvate Kinase Isozyme in <i>Pseudomonas aeruginosa</i>

artículo científico publicado en 2021

Synthesis and structural characterisation of selective non-carbohydrate-based inhibitors of bacterial sialidases

artículo científico publicado en 2012

Targeting of Fumarate Hydratase from Mycobacterium tuberculosis Using Allosteric Inhibitors with a Dimeric-Binding Mode

artículo científico publicado en 2019

Lista de obras de Paul Brear

A Random Forest Model for Predicting Allosteric and Functional Sites on Proteins.

A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066.

Affinity maturation of the RLIP76 Ral binding domain to inform the design of stapled peptides targeting the Ral GTPases

Aqueous methods for the preparation of 5'-substituted guanosine derivatives.

Aqueous synthesis of N,S-dialkylthiophosphoramidates: design, optimisation and application to library construction and antileishmanial testing.

Chain alignment of collagen I deciphered using computationally designed heterotrimers

Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein-protein interaction.

Evolutionary plasticity in the allosteric regulator-binding site of pyruvate kinase isoform PykA from Pseudomonas aeruginosa

Gluconeogenic precursor availability regulates flux through the glyoxylate shunt in Pseudomonas aeruginosa

Novel non-ATP competitive small molecules targeting the CK2 α/β interface

Proposed Allosteric Inhibitors Bind to the ATP Site of CK2α

Second-generation CK2α inhibitors targeting the αD pocket.

Specific inhibition of CK2α from an anchor outside the active site

Structure, Function and Regulation of a Second Pyruvate Kinase Isozyme in <i>Pseudomonas aeruginosa</i>

Synthesis and structural characterisation of selective non-carbohydrate-based inhibitors of bacterial sialidases

Targeting of Fumarate Hydratase from Mycobacterium tuberculosis Using Allosteric Inhibitors with a Dimeric-Binding Mode