Lista de obras - Xavier Lucas - Dominio Público Uruguay

3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation

artículo científico publicado en 2018

4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1)

artículo científico publicado en 2016

4-Acyl Pyrroles as Dual BET-BRD7/9 Bromodomain Inhibitors Address BETi Insensitive Human Cancer Cell Lines

artículo científico publicado en 2020

4-Acyl pyrroles: mimicking acetylated lysines in histone code reading

artículo científico publicado en 2013

A thorough anion–π interaction study in biomolecules: on the importance of cooperativity effects† †Electronic supplementary information (ESI) available: Fig. 1 and 2, Tables 1–24 and all interactions. See DOI: 10.1039/c5sc01386k.

artículo científico publicado en 2015

Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles.

artículo científico publicado en 2017

ChemicalToolBoX and its application on the study of the drug like and purchasable space.

artículo científico publicado en 2014

Counterintuitive substituent effect of the ethynyl group in ion-pi interactions

artículo científico publicado en 2009

Development and Benchmarking of Open Force Field v1.0.0—the Parsley Small-Molecule Force Field

artículo científico publicado en 2021

Discovery of the inhibitory effect of a phosphatidylinositol derivative on P-glycoprotein by virtual screening followed by in vitro cellular studies

artículo científico publicado en 2013

Hidden Specificities in Enzyme Catalysis: Structural Basis of Substrate Structure-Selectivity Relationship of a Ketoreductase

artículo científico publicado en 2019

Metabolic pathway monitoring of phenalinolactone biosynthesis from Streptomyces sp. Tü6071 by liquid chromatography/mass spectrometry coupling

artículo científico publicado en 2014

Preparation data of the bromodomains BRD3(1), BRD3(2), BRD4(1), and BRPF1B and crystallization of BRD4(1)-inhibitor complexes.

artículo científico publicado en 2016

Recognition of substrate degrons by E3 ubiquitin ligases and modulation by small-molecule mimicry strategies.

artículo científico publicado en 2017

StreptomeDB 2.0--an extended resource of natural products produced by streptomycetes

artículo científico publicado en 2015

StreptomeDB: a resource for natural compounds isolated from Streptomyces species

artículo científico publicado en 2013

Structural basis of PROTAC cooperative recognition for selective protein degradation

artículo científico publicado en 2017

Structural basis of molecular recognition of helical histone H3 tail by PHD finger domains.

artículo científico publicado en 2017

Structure-Based Design of a Macrocyclic PROTAC

scientific article published on 12 December 2019

Substituent effects in ion-pi interactions: fine-tuning via the ethynyl group

artículo científico publicado en 2010

Surface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase

scholarly article by Xavier Lucas et al published 23 August 2018 in Journal of Medicinal Chemistry

Target Fishing by Cross-Docking to Explain Polypharmacological Effects

Targeting Ligandable Pockets on Plant Homeodomain (PHD) Zinc Finger Domains by a Fragment-Based Approach.

artículo científico publicado en 2018

Targeting the BET family for the treatment of leukemia

artículo científico publicado en 2014

Targeting xanthine oxidase by natural products as a therapeutic approach for mental disorders

scientific article published on 21 June 2020

The ChemicalToolbox: reproducible, user-friendly cheminformatics analysis on the Galaxy platform

artículo científico publicado en 2020

The Role of the Ethynyl Substituent on the π–π Stacking Affinity of Benzene: A Theoretical Study ⬇️

artículo científico publicado el 22 de diciembre de 2010

The purchasable chemical space: a detailed picture.

artículo científico publicado en 2015

Thioamide substitution to probe the hydroxyproline recognition of VHL ligands.

artículo científico publicado en 2018

Using chiral molecules as an approach to address low-druggability recognition sites.

artículo científico publicado en 2014

Very Long-Range Effects: Cooperativity between Anion-π and Hydrogen-Bonding Interactions

scientific article published on 01 September 2009

Lista de obras de Xavier Lucas

3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation

4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1)

4-Acyl Pyrroles as Dual BET-BRD7/9 Bromodomain Inhibitors Address BETi Insensitive Human Cancer Cell Lines

4-Acyl pyrroles: mimicking acetylated lysines in histone code reading

A thorough anion–π interaction study in biomolecules: on the importance of cooperativity effects† †Electronic supplementary information (ESI) available: Fig. 1 and 2, Tables 1–24 and all interactions. See DOI: 10.1039/c5sc01386k.

Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles.

ChemicalToolBoX and its application on the study of the drug like and purchasable space.

Counterintuitive substituent effect of the ethynyl group in ion-pi interactions

Development and Benchmarking of Open Force Field v1.0.0—the Parsley Small-Molecule Force Field

Discovery of the inhibitory effect of a phosphatidylinositol derivative on P-glycoprotein by virtual screening followed by in vitro cellular studies

Hidden Specificities in Enzyme Catalysis: Structural Basis of Substrate Structure-Selectivity Relationship of a Ketoreductase

Metabolic pathway monitoring of phenalinolactone biosynthesis from Streptomyces sp. Tü6071 by liquid chromatography/mass spectrometry coupling

Preparation data of the bromodomains BRD3(1), BRD3(2), BRD4(1), and BRPF1B and crystallization of BRD4(1)-inhibitor complexes.

Recognition of substrate degrons by E3 ubiquitin ligases and modulation by small-molecule mimicry strategies.

StreptomeDB 2.0--an extended resource of natural products produced by streptomycetes

StreptomeDB: a resource for natural compounds isolated from Streptomyces species

Structural basis of PROTAC cooperative recognition for selective protein degradation

Structural basis of molecular recognition of helical histone H3 tail by PHD finger domains.

Structure-Based Design of a Macrocyclic PROTAC

Substituent effects in ion-pi interactions: fine-tuning via the ethynyl group

Surface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase

Target Fishing by Cross-Docking to Explain Polypharmacological Effects

Targeting Ligandable Pockets on Plant Homeodomain (PHD) Zinc Finger Domains by a Fragment-Based Approach.

Targeting the BET family for the treatment of leukemia

Targeting xanthine oxidase by natural products as a therapeutic approach for mental disorders

The ChemicalToolbox: reproducible, user-friendly cheminformatics analysis on the Galaxy platform

The Role of the Ethynyl Substituent on the π–π Stacking Affinity of Benzene: A Theoretical Study ⬇️

The purchasable chemical space: a detailed picture.

Thioamide substitution to probe the hydroxyproline recognition of VHL ligands.

Using chiral molecules as an approach to address low-druggability recognition sites.

Very Long-Range Effects: Cooperativity between Anion-π and Hydrogen-Bonding Interactions