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Lista de obras de Philippe Beaune

A Lack of Significant Effect of POR*28 Allelic Variant on Tacrolimus Exposure in Kidney Transplant Recipients

scientific article published on 01 April 2016

A Novel Extrinsic Pathway for the Unfolded Protein Response in the Kidney

artículo científico publicado en 2016

A double amino-acid change in the HLA-A peptide-binding groove is associated with response to psychotropic treatment in patients with schizophrenia

artículo científico publicado en 2015

A single d(GpG) cisplatin adduct on the estrogen response element decreases the binding of the estrogen receptor.

artículo científico

A slow acetylator genotype is a risk factor for sulphonamide-induced toxic epidermal necrolysis and Stevens-Johnson syndrome

scientific article published on 01 August 1995

A suicide gene therapy combining the improvement of cyclophosphamide tumor cytotoxicity and the development of an anti-tumor immune response

artículo científico publicado en 2014

A virus-directed enzyme prodrug therapy (VDEPT) strategy for lung cancer using a CYP2B6/NADPH-cytochrome P450 reductase fusion protein.

artículo científico publicado en 2005

Administration of high doses of human recombinant interleukin-2 decreases the expression of several cytochromes P-450 in the rat

scientific article published on 01 January 1994

An acenocoumarol dosing algorithm exploiting clinical and genetic factors in South Indian (Dravidian) population

artículo científico publicado en 2014

Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism

article

Angiogenin Mediates Cell-Autonomous Translational Control under Endoplasmic Reticulum Stress and Attenuates Kidney Injury

artículo científico publicado en 2015

Anti-cytochrome P450 autoantibodies in drug-induced disease.

artículo científico publicado en 1996

Anti-liver endoplasmic reticulum autoantibodies are directed against human cytochrome P-450IA2. A specific marker of dihydralazine-induced hepatitis.

artículo científico publicado en 1990

Anti-liver microsomes autoantibodies and dihydralazine-induced hepatitis: specificity of autoantibodies and inductive capacity of the drug

scientific article published on 01 August 1992

Antiapoptotic properties of recombinant human erythropoietin protects against tubular cyclosporine toxicity

artículo científico publicado en 2009

Association Analysis of Drug Metabolizing Enzyme Gene Polymorphisms in AIDS Patients with Cutaneous Reactions to Sulfonamides

article

Association between Parkinson's disease and the HLA-DRB1 locus

artículo científico publicado en 2012

Association of the multidrug resistance-1 gene single-nucleotide polymorphisms with the tacrolimus dose requirements in renal transplant recipients

artículo científico publicado en 2003

Autoantibodies against a kidney--liver protein associated with quinolone-induced acute interstitial nephritis or hepatitis

artículo científico publicado en 1997

Autoantibodies against cytochromes P-450 in drug-induced autoimmune hepatitis

scientific article published on 01 June 1993

Automated determination of serum alpha1-antitrypsin by antitryptic activity measurement

artículo científico publicado en 2009

Autophagy protects renal tubular cells against cyclosporine toxicity

artículo científico publicado en 2008

Biochemical and analytical development of the CIME cocktail for drug fate assessment in humans.

artículo científico publicado en 2010

Biotransformation of chloroform by rat and human liver microsomes; in vitro effect on some enzyme activities and mechanism of irreversible binding to macromolecules ⬇️

artículo científico publicado el 1 de febrero de 1979

Both cytochromes P450 2E1 and 1A1 are involved in the metabolism of chlorzoxazone

artículo científico publicado en 1993

CYP2D6 genotype and lung cancer risk according to histologic type and tobacco exposure.

artículo científico publicado en 1995

CYP3A5 and MDR1 genetic polymorphisms and cyclosporine pharmacokinetics after renal transplantation

artículo científico publicado en 2004

CYP3A5 is the major cytochrome P450 3A expressed in human colon and colonic cell lines.

artículo científico publicado en 1996

Cell localization and regulation of expression of cytochrome P450 1A1 and 2B1 in rat lung after induction with 3-methylcholanthrene using mRNA hybridization and immunohistochemistry

artículo científico publicado en 1994

Characterization of human lung microsomal cytochrome P-450 1A1 and its role in the oxidation of chemical carcinogens

artículo científico publicado en 1992

Characterization of mRNA species related to human liver cytochrome P-450 nifedipine oxidase and the regulation of catalytic activity.

artículo científico publicado en 1989

Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism

artículo científico publicado en 1986

Characterization of the microsomal cytochrome P-450 species inhibited in rat liver in the course of fascioliasis

artículo científico publicado en 1986

Childhood leukaemia, polymorphisms of metabolism enzyme genes, and interactions with maternal tobacco, coffee and alcohol consumption during pregnancy

artículo científico publicado en 2005

Clinical consequences of the polymorphism of azathioprine metabolism

artículo científico publicado en 2000

Clinical value of mitochondrial mutations in colorectal cancer.

artículo científico publicado en 2005

Collection of familial data in pharmacogenetics. Methodological problems

artículo científico publicado en 1993

Collection of human genomic DNA from buccal cells for genetics studies: comparison between cytobrush, mouthwash, and treated card

artículo científico publicado en 2005

Combined glutathione-S-transferase M1 and T1 genetic polymorphism and tacrine hepatotoxicity.

artículo científico publicado en 2000

Combined transcriptomic-(1)H NMR metabonomic study reveals that monoethylhexyl phthalate stimulates adipogenesis and glyceroneogenesis in human adipocytes.

artículo científico publicado en 2011

Comparison of different cellular models measuring in vitro the whole human serum cholesterol efflux capacity

article

Comparison of monooxygenase activities and cytochrome P-450 isozyme concentrations in human liver microsomes

artículo científico publicado en 1986

Comparison of mouse and human colon tumors with regard to phase I and phase II drug-metabolizing enzyme systems

scientific article published on 01 December 1992

Comparison of the effects of phenobarbital and its hydroxylated metabolites on drug-metabolizing enzymes during ontogenesis

scientific article published on 01 January 1981

Consequences of genetic polymorphisms for sirolimus requirements after renal transplant in patients on primary sirolimus therapy

artículo científico publicado en 2005

Contribution of human cytochrome P450 to benzo[a]pyrene and benzo[a]pyrene-7,8-dihydrodiol metabolism, as predicted from heterologous expression in yeast.

artículo científico publicado en 1996

Covalent binding of carbamazepine reactive metabolites to P450 isoforms present in the skin

artículo científico publicado en 1998

Cyclosporine triggers endoplasmic reticulum stress in endothelial cells: a role for endothelial phenotypic changes and death

artículo científico publicado en 2008

Cyclosporine-induced endoplasmic reticulum stress triggers tubular phenotypic changes and death

artículo científico publicado en 2008

Cytochrome P 450 isoenzymes, epoxide hydrolase and glutathione transferases in rat and human hepatic and extrahepatic tissues

scientific article published on 01 April 1990

Cytochrome P-450 3A4 and 2C8 are involved in zopiclone metabolism.

artículo científico publicado en 1999

Cytochrome P-450 enzymes involved in genetic polymorphism of drug oxidation in humans

scientific article published on 01 August 1987

Cytochrome P-450 isoenzyme content and monooxygenase activities in rat liver: effect of ontogenesis and pretreatment by phenobarbital and 3-methylcholanthrene.

artículo científico publicado en 1986

Cytochrome P-450 monooxygenase activities in human and rat liver microsomes

artículo científico publicado en 1981

Cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) genotypes as determinants of acenocoumarol sensitivity.

artículo científico publicado en 2005

Cytochrome P450 CYP2D6 gene polymorphism and lung cancer susceptibility in Caucasians.

artículo científico publicado en 1998

Cytochrome P450 induction and mutagenicity of 2-aminoanthracene (2AA) in rat liver and gut.

artículo científico publicado en 1992

Cytochrome P450 mediated bioactivation of methyleugenol to 1'-hydroxymethyleugenol in Fischer 344 rat and human liver microsomes

artículo científico publicado en 1997

Cytochrome P4502B follows a vesicular route to the plasma membrane in cultured rat hepatocytes

scientific article published on 01 April 1995

Cytochrome P4502C9 is the principal catalyst of racemic acenocoumarol hydroxylation reactions in human liver microsomes

artículo científico publicado en 2000

Cytochromes P-450 in human hepatocyte plasma membrane: recognition by several autoantibodies

artículo científico publicado en 1993

Cytochromes of the P450 2C subfamily are the major enzymes involved in the O-demethylation of verapamil in humans

artículo científico publicado en 1995

Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture

artículo científico publicado en 1993

Decrease in hepatic cytochrome P450 after interleukin-2 immunotherapy

artículo científico publicado en 1999

Delineation and candidate gene mutation screening of the 18q22 minimal region of deletion in head and neck squamous cell carcinoma.

artículo científico publicado en 2002

Detection of free-circulating tumor-associated DNA in plasma of colorectal cancer patients and its association with prognosis.

artículo científico publicado en 2002

Detection of plasma tumor DNA in head and neck squamous cell carcinoma by microsatellite typing and p53 mutation analysis

article

Determination of cytochrome P450 2D6 (CYP2D6) gene copy number by real-time quantitative PCR.

artículo científico publicado en 2005

Determination of microsatellite instability, p53 and K-RAS mutations in hepatic metastases from patients with colorectal cancer: relationship with response to 5-fluorouracil and survival

artículo científico publicado en 2001

Differential expression of drug metabolizing enzymes in primary and secondary liver neoplasm: immunohistochemical characterization of cytochrome P4503A and glutathione-S-transferase

artículo científico publicado en 1993

Differential sensitivity of rat hepatocyte CYP isoforms to self-generated nitric oxide.

artículo científico publicado en 2001

Drug interactions with macrolide antibiotics: specificity of pseudo-suicide inhibition and induction of cytochrome P-450

scientific article published on 01 January 1986

Drug-metabolizing enzyme expression in human normal, peritumoral and tumoral colorectal tissue samples.

artículo científico publicado en 1991

Drug-metabolizing enzymes in human foetal liver: partial resolution of multiple cytochromes P 450

scientific article published on 01 January 1982

Early acenocoumarol overanticoagulation among cytochrome P450 2C9 poor metabolizers

artículo científico publicado en 2001

Effect of CYP2C9, VKORC1, CYP4F2 and GGCX genetic variants on warfarin maintenance dose and explicating a new pharmacogenetic algorithm in South Indian population

artículo científico publicado en 2013

Effect of cytochrome P450 2C19 genotype on voriconazole exposure in cystic fibrosis lung transplant patients

scientific article published on 31 October 2010

Effect of retinol and retinoic acid supplemented diets on cytochrome P-450 content and UDP glucuronosyltransferase activities in vitamin A-deficient rat liver

scientific article published on 01 January 1990

Effects of ethanol and clofibrate on expression of cytochrome P-450 enzymes and epoxide hydrolase in cultures and cocultures of rat hepatocytes

artículo científico publicado en 1991

Effects of ethanol, dexamethasone and RU 486 on expression of cytochromes P450 2B, 2E, 3A and glutathione transferase pi in a rat hepatoma cell line (Fao)

artículo científico publicado el 1 de febrero de 1992

Effects of microsomal enzyme inducers on glutathione S-transferase isoenzymes in livers of rats and hamsters

artículo científico publicado en 1994

Effects of the bacterial status of rats on the changes in some liver cytochrome P450 (EC 1.14.14.1) apoproteins consequent to a glucosinolate-rich diet

artículo científico publicado en 1998

Effects of various inducers on the expression of cytochromes P-450 IIC8, 9, 10 and IIIA in cultured adult human hepatocytes

artículo científico publicado en 1990

Ellipticines and human liver microsomes: spectral interaction with cytochrome P-450 and hydroxylation. Inhibition of aryl hydrocarbon metabolism and mutagenicity

artículo científico publicado en 1981

Endoplasmic reticulum stress: an unrecognized actor in solid organ transplantation.

artículo científico publicado en 2009

Engineered mesenchymal stem cells as vectors in a suicide gene therapy against preclinical murine models for solid tumors

artículo científico publicado en 2016

Engineered yeast cells as model to study coupling between human xenobiotic metabolizing enzymes. Simulation of the two first steps of benzo[a]pyrene activation

artículo científico publicado en 1993

Enhanced removal of cholesterol from macrophage foam cells to serum from type IV hypertriglyceridemic subjects

artículo científico publicado en 2007

Epitope mapping of human CYP1A2 in dihydralazine-induced autoimmune hepatitis

scientific article published on 01 June 1997

Evaluation of caffeine as a test drug for CYP1A2, NAT2 and CYP2E1 phenotyping in man by in vivo versus in vitro correlations.

artículo científico publicado en 1996

Evaluation of isolated human hepatocytes

artículo científico publicado en 1983

Evidence for phosgene formation during liver microsomal oxidation of chloroform

artículo científico publicado en 1977

Evidence for the involvement of several cytochromes P-450 in the first steps of caffeine metabolism by human liver microsomes

artículo científico publicado en 1991

Expression and localization of CYP3A4 and CYP3A5 in human lung

artículo científico publicado en 1997

Expression in yeast, new substrates, and construction of a first 3D model of human orphan cytochrome P450 2U1: Interpretation of substrate hydroxylation regioselectivity from docking studies.

artículo científico publicado en 2015

Expression of CYP1A1, CYP1B1 and CYP3A, and polycyclic aromatic hydrocarbon-DNA adduct formation in bronchoalveolar macrophages of smokers and non-smokers

scientific article published on 01 June 2000

Expression of cytochrome P 450 3A enzymes in human lung: a combined RT-PCR and immunohistochemical analysis of normal tissue and lung tumours.

artículo científico publicado en 1996

Expression of cytochrome P-450 3A in HT29-MTX cells and Caco-2 clone TC7

artículo científico publicado en 1994

Expression of cytochrome P-450 enzymes in cultured human hepatocytes

artículo científico publicado en 1990

Expression of cytochrome P450 in rat pleural mesothelial cells in secondary cultures

scientific article published on 01 July 1994

Formation of Complexes between Microsomal Cytochrome P-450-Fe(II) and Nitrosoarenes Obtained by Oxidation of Arylhydroxylamines or Reduction of Nitroarenes in situ ⬇️

artículo científico publicado el 16 de mayo de 1978

Frequent allelic loss at chromosome 3p distinct from genetic alterations of the 8-oxoguanine DNA glycosylase 1 gene in head and neck cancer.

artículo científico publicado en 1999

GSTM1, smoking and lung cancer: a case-control study

scientific article published on 01 October 1999

Gene expression profiling of cytochromes P450, ABC transporters and their principal transcription factors in the amygdala and prefrontal cortex of alcoholics, smokers and drug-free controls by qRT-PCR.

artículo científico publicado en 2015

Genetic and environmental risk factors for oral anticoagulant overdose

artículo científico publicado en 2003

Genetic polymorphism of induction of CYP1A1 (EROD) activity ⬇️

artículo científico publicado el 1 de abril de 1995

Genetic polymorphisms of cytochrome P450 2A6 in a case-control study on lung cancer in a French population.

artículo científico publicado en 2001

Genetic polymorphisms of glutathione S-transferases as modulators of lung cancer susceptibility

artículo científico publicado en 2002

Genomic consequences of cytochrome P450 2C9 overexpression in human hepatoma cells.

artículo científico publicado en 2009

Glucocorticoid hormones prevent the induction of gamma-glutamyl transpeptidase by ethanol in a rat hepatoma cell line

scientific article published on 01 February 1989

Glutathione S-Transferase P1 Polymorphism (Ile105Val) Predicts Cumulative Neuropathy in Patients Receiving Oxaliplatin-Based Chemotherapy

artículo científico publicado en 2006

Glutathione S-transferase theta genetic polymorphism might influence tacrine hepatotoxicity in Alzheimer's patients.

artículo científico publicado en 1997

Glutathione S-transferases related to P. aeruginosa lung infection in cystic fibrosis children: preliminary study

artículo científico publicado en 2008

Glutathione-associated enzymes in head and neck squamous cell carcinoma and response to cisplatin-based neoadjuvant chemotherapy.

artículo científico publicado en 2001

High levels of DNA adducts in human colon are associated with colorectal cancer.

artículo científico publicado en 1995

High yield purification and characterization of engineered human P450 1A2 and generation of immuno-inhibitor antibodies

artículo científico publicado en 1999

Homozygote deficiency of thiopurine methyltransferase. A contraindication to the use of azathioprine in kidney transplantation

artículo científico publicado en 1995

Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug

artículo científico publicado en 1987

Human cytochrome P450 2E1 (CYP2E1): from genotype to phenotype.

artículo científico publicado en 1996

Human cytochromes P450 expressed in Escherichia coli: production of specific antibodies.

artículo científico publicado en 1996

Human cytochromes P450. Applications in pharmacology

artículo científico publicado en 1993

Human drug metabolism in vitro.

artículo científico publicado en 1988

Human epoxide hydrolase is the target of germander autoantibodies on the surface of human hepatocytes: enzymatic implications

scientific article published on 01 January 2001

Human hepatic cytochrome P-450 composition as probed by in vitro microsomal metabolism of warfarin

artículo científico publicado en 1984

Human microsomal epoxide hydrolase is the target of germander-induced autoantibodies on the surface of human hepatocytes

artículo científico publicado en 2000

Human-liver cytochromes P-450 expressed in yeast as tools for reactive-metabolite formation studies. Oxidative activation of tienilic acid by cytochromes P-450 2C9 and 2C10

artículo científico publicado en 1993

Hydrophobic chromatography: a one-step method for the purification of human liver microsomal epoxide hydrolase

artículo científico publicado en 1988

Hydroxylation and formation of electrophilic metabolites of tienilic acid and its isomer by human liver microsomes. Catalysis by a cytochrome P450 IIC different from that responsible for mephenytoin hydroxylation

artículo científico publicado en 1991

Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1

artículo científico publicado en 1990

Identification and characterization of the cytochrome P450 enzymes involved in N-dealkylation of propafenone: molecular base for interaction potential and variable disposition of active metabolites

artículo científico publicado en 1993

Identification of P450 enzymes involved in metabolism of verapamil in humans

scientific article published on 01 September 1993

Identification of a 16-nucleotide sequence that mediates post-transcriptional regulation of rat CYP2E1 by insulin.

artículo científico publicado en 2002

Identification of the cytochrome P450 IIIA family as the enzymes involved in the N-demethylation of tamoxifen in human liver microsomes

scientific article published on 01 June 1991

Identification of the highly polymorphic S-mephenytoin hydroxylase in humans

scientific article published on 01 January 1996

Idiosyncratiques et « omiques » peuvent-ils rimer ?

artículo científico publicado en 2010

Immunochemical characterization of some monooxygenase activities in liver microsomes from untreated and phenobarbital-treated rats

scientific article published on 01 July 1981

Immunocytochemical evidence for the maintenance of cytochrome P-450 isozymes, NADPH cytochrome C reductase, and epoxide hydrolase in pure and mixed primary cultures of adult human hepatocytes

artículo científico publicado en 1986

Immunohistochemical localization of cytochrome P450 2E1 in human pulmonary carcinoma and normal bronchial tissue

artículo científico publicado en 1995

Immunohistochemical localization of cytochrome P450 3A in human pulmonary carcinomas and normal bronchial tissue

artículo científico publicado en 1995

Immunoquantification of epoxide hydrolase and cytochrome P-450 isozymes in fetal and adult human liver microsomes

artículo científico publicado en 1985

Immunoquantitation of some cytochrome P-450 isozymes in liver microsomes from streptozotocin-diabetic rats

artículo científico publicado en 1986

Immunotoxicology and expression of human cytochrome P450 in microorganisms

artículo científico publicado en 1993

Impact of GSTT1, GSTM1, GSTP1 and NAT2 genotypes on KRAS2 and TP53 gene mutations in colorectal cancer

artículo científico publicado en 2004

Impact of android overweight or obesity and insulin resistance on basal and postprandial SR-BI and ABCA1-mediated serum cholesterol efflux capacities.

artículo científico publicado en 2009

Impact of cytochrome p450 3A5 genetic polymorphism on tacrolimus doses and concentration-to-dose ratio in renal transplant recipients.

artículo científico publicado en 2003

Important role of CYP2J2 in protein kinase inhibitor degradation: a possible role in intratumor drug disposition and resistance

artículo científico publicado en 2014

In vitro metabolism of chloroquine: identification of CYP2C8, CYP3A4, and CYP2D6 as the main isoforms catalyzing N-desethylchloroquine formation.

artículo científico publicado en 2003

In vitro metabolism of quinidine: the (3S)-3-hydroxylation of quinidine is a specific marker reaction for cytochrome P-4503A4 activity in human liver microsomes.

artículo científico publicado en 1999

Incidence of adverse reactions to cyclosporine after liver transplantation is predicted by the first blood level

artículo científico publicado en 1993

Indirect cytotoxicity of flucloxacillin toward human biliary epithelium via metabolite formation in hepatocytes.

artículo científico publicado en 2001

Induction of cytochrome P-450 in rat liver by the antibiotic troleandomycin: partial purificaton and properties of cytochrome P-450-troleandomycin metabolite complexes

artículo científico publicado en 1981

Induction of cytochrome P450 2B6 and 3A4 expression by phenobarbital and cyclophosphamide in cultured human liver slices.

artículo científico publicado en 2003

Induction of cytochrome P4501A by smoking or omeprazole in comparison with UDP-glucuronosyltransferase in biopsies of human duodenal mucosa

artículo científico publicado en 1995

Infantile phytanic acid storage disease, a possible variant of Refsum's disease: three cases, including ultrastructural studies of the liver

artículo científico publicado en 1982

Influence of ethanol and benzene on cytochrome P-450 fractions in rat liver microsomes

artículo científico publicado en 1983

Influence of fluvoxamine on tacrine metabolism in vitro: potential implication for the hepatotoxicity in vivo

scientific article published on 01 January 1996

Inhibition by omeprazole of proguanil metabolism: mechanism of the interaction in vitro and prediction of in vivo results from the in vitro experiments

artículo científico publicado en 1997

Inhibition of CYP1A2 and CYP3A4 by oltipraz results in reduction of aflatoxin B1 metabolism in human hepatocytes in primary culture.

artículo científico publicado en 1995

Interaction between ABCB1 and professional exposure to organochlorine insecticides in Parkinson disease

scholarly article by Fabien Dutheil et al published 1 June 2010 in Archives of Neurology

Interactions of dihydralazine with cytochromes P4501A: a possible explanation for the appearance of anti-cytochrome P4501A2 autoantibodies

artículo científico publicado en 1994

Interindividual variability in P450-dependent generation of neoantigens in halothane hepatitis.

artículo científico publicado en 1998

Interindividual variability in TPMT enzyme activity: 10 years of experience with thiopurine pharmacogenetics and therapeutic drug monitoring

artículo científico

Interindividual variability in catalytic activity and immunoreactivity of three major human liver cytochrome P450 isozymes

artículo científico publicado en 1996

Interindividual variability in dabigatran and rivaroxaban exposure: contribution ofABCB1genetic polymorphisms and interaction with clarithromycin

artículo científico publicado en 2017

Interspecies variations in caffeine metabolism related to cytochrome P4501A enzymes

artículo científico publicado en 1992

Intralobular distribution and quantitation of cytochrome P-450 enzymes in human liver as a function of age

scientific article published on 01 June 1991

Involvement of cytochrome P450 3A enzyme family in the major metabolic pathways of toremifene in human liver microsomes

scientific article published on 01 May 1994

Involvement of cytochrome P450 3A4 enzyme in the N-demethylation of methadone in human liver microsomes

artículo científico publicado en 1996

Involvement of endoplasmic reticulum stress in solid organ transplantation

artículo científico publicado en 2010

Is diclofenac a valuable CYP2C9 probe in humans?

artículo científico publicado en 2001

Isolation and sequence determination of a cDNA clone related to human cytochrome P-450 nifedipine oxidase

artículo científico publicado en 1986

Isolation of the human cytochrome P-450 IIC8 gene: multiple glucocorticoid responsive elements in the 5' region

artículo científico publicado en 1991

Kidney Transplant Recipients Carrying theCYP3A4*22Allelic Variant Have Reduced Tacrolimus Clearance and Often Reach Supratherapeutic Tacrolimus Concentrations

artículo científico publicado en 2015

La pharmacogénétique : le lien entre gènes et réponse aux médicaments

article

La vitamine K époxyde réductase: du sang neuf dans les traitements anticoagulants oraux

artículo científico publicado en 2006

Lidocaine metabolite formation in the liver donor as a predictive test for the safe and efficient introduction of cyclosporine in the recipient

artículo científico publicado en 1993

Long-Term Clinical Impact of Adaptation of Initial Tacrolimus Dosing to CYP3A5 Genotype

artículo científico publicado en 2016

Maintenance of cytochrome P-450 in cultured adult human hepatocytes

artículo científico publicado en 1985

Major pathway of imipramine metabolism is catalyzed by cytochromes P-450 1A2 and P-450 3A4 in human liver

artículo científico publicado en 1993

Matrix metalloproteinase 3 polymorphism: a predictive factor of response to neoadjuvant chemotherapy in head and neck squamous cell carcinoma.

artículo científico publicado en 2004

Membrane fluidity and drug metabolism in liver microsomes of lean, ob/ob and db/db mice.

artículo científico publicado en 1980

Mesenchymal stem cells as cellular vehicles for prodrug gene therapy against tumors

artículo científico

Metabolic activation of the nitroaromatic antiandrogen flutamide by rat and human cytochromes P-450, including forms belonging to the 3A and 1A subfamilies

artículo científico publicado en 1993

Metabolic stress promotes renal tubular inflammation by triggering the unfolded protein response.

artículo científico publicado en 2011

Metabolism of ketotifen by human liver microsomes. In vitro characterization of a tertiary amine glucuronidation

scientific article published on 01 November 1983

Microsatellite analysis and response to chemotherapy in head-and-neck squamous-cell carcinoma

scientific article published on 01 August 1999

Minocycline-induced DRESS: evidence for accumulation of the culprit drug.

artículo científico publicado en 2008

Modification of hepatic drug-metabolizing enzymes in rat fed naturally occurring allyl sulphides

scientific article published on 01 February 1994

Modulation of cytochrome P450 isozymes in human liver, by ethanol and drug intake

artículo científico publicado en 1989

Molecular insight into thiopurine resistance: transcriptomic signature in lymphoblastoid cell lines.

artículo científico publicado en 2015

Molecular pharmacogenetics in hospital laboratories in France: current data and future prospects

artículo científico publicado en 2007

Monitoring of azathioprine-induced immunosuppression with thiopurine methyltransferase activity in kidney transplant recipients

scientific article published on 01 October 1995

Monoclonal antibodies against human liver cytochrome P-450

artículo científico publicado en 1985

Multidrug resistance gene-1 polymorphisms and resistance to cyclosporine A in patients with steroid resistant ulcerative colitis.

artículo científico publicado en 2007

Myeloperoxidase genetic polymorphisms modulate human neutrophil enzyme activity: Genetic determinants for atherosclerosis?

artículo científico publicado en 2005

Myeloperoxidase: new polymorphisms and relation with lung cancer risk

artículo científico publicado en 2003

Nature of cytochromes P450 involved in the 2-/4-hydroxylations of estradiol in human liver microsomes

artículo científico publicado en 1992

Optimization and validation of a label-free MRM method for the quantification of cytochrome P450 isoforms in biological samples.

artículo científico publicado en 2014

Optimization of initial tacrolimus dose using pharmacogenetic testing

artículo científico publicado en 2010

Origin and fixation of pyrophosphates in the parietal bones of young rats ⬇️

artículo científico publicado el 1 de enero de 1977

Partial purification of human liver cytochrome P 450 ⬇️

artículo científico publicado el 13 de junio de 1979

Partial sequence and polymerase chain reaction-mediated analysis of expression of the human CYP2C18 gene ⬇️

artículo científico publicado el 1 de junio de 1992

Pharmacogenetic assessment of toxicity and outcome in patients with metastatic colorectal cancer treated with LV5FU2, FOLFOX, and FOLFIRI: FFCD 2000-05.

artículo científico publicado en 2010

Pharmacogenetics of acenocoumarol pharmacodynamics.

artículo científico publicado en 2004

Pharmacogenetics: from basic research to clinical applications

artículo científico publicado en 2007

Pharmacokinetic interaction between corticosteroids and tacrolimus after renal transplantation

artículo científico publicado en 2003

Phase I and phase II drug-metabolizing enzymes are expressed and heterogeneously distributed in the biliary epithelium

scientific article published on 01 December 1999

Phenobarbital increases DNA adduct and metabolites formed by ochratoxin A: role of CYP 2C9 and microsomal glutathione-S-transferase

scientific article published on 01 January 2000

Phenome-wide association studies on a quantitative trait: application to TPMT enzyme activity and thiopurine therapy in pharmacogenomics

artículo científico publicado en 2013

Polymorphisms of human aryl hydrocarbon receptor (AhR) gene in a French population: relationship with CYP1A1 inducibility and lung cancer

article

Poor response to thiopurine in inflammatory bowel disease: how to overcome therapeutic resistance?

artículo científico publicado en 2013

Possible involvement of multiple cytochrome P450S in fentanyl and sufentanil metabolism as opposed to alfentanil

artículo científico publicado en 1997

Possible involvement of multiple human cytochrome P450 isoforms in the liver metabolism of propofol

artículo científico publicado en 1998

Predictive Modeling of Tacrolimus Dose Requirement Based on High-Throughput Genetic Screening.

artículo científico publicado en 2016

Pregnenolone-7beta-hydroxylating activity of human cytochrome P450-1A1

artículo científico publicado en 1997

Preparation and characterization of monoclonal antibodies against phenobarbital-inducible cytochrome P-450

scientific article published on 01 March 1984

Presence of functional cytochrome P-450 on isolated rat hepatocyte plasma membrane

scientific article published on 01 May 1990

Presence of proteins recognized by mammalian cytochrome P-450 antibodies in Euglena gracilis

artículo científico publicado en 1993

Principal xenobiotic-metabolizing enzyme systems in human head and neck squamous cell carcinoma.

artículo científico publicado en 1993

Prolonged parenteral nutrition by cave catheter in child (author's transl)

artículo científico publicado el 1 de enero de 1978

Prospective evaluation of detoxification pathways as markers of cutaneous adverse reactions to sulphonamides in AIDS

article

Purification and characterization of six cytochrome P-450 isozymes from human liver microsomes

scientific article published on 01 November 1983

Purification of a new cytochrome P-450 from human liver microsomes

scientific article published in 1985

Quantification of two cytochrome P-450 isoenzymes by an enzyme-linked immunosorbent assay (ELISA)

artículo científico publicado en 1984

Rapamycin inhibits human renal epithelial cell proliferation: effect on cyclin D3 mRNA expression and stability

artículo científico publicado en 2005

Recombinant yeast in drug metabolism.

artículo científico publicado en 1993

Regulation of sucrase-isomaltase and hexose transporters in Caco-2 cells: a role for cytochrome P-4501A1?

scientific article published on 01 June 1996

Regulatory sequence responsible for insulin destabilization of cytochrome P450 2B1 (CYP2B1) mRNA.

artículo científico publicado en 2005

Relation between inducibility of CYP1A1, GSTM1 and lung cancer in a French population

artículo científico publicado en 2000

Relationship between cytochrome P-450 3A content of orthotopically transplanted liver and postoperative morbidity

artículo científico publicado en 1993

Relationship between graft cytochrome P-450 3A content and early morbidity after liver transplantation

scientific article published on 01 December 1993

Role of CYP2D6 in the N-hydroxylation of procainamide

scientific article published on 01 October 1997

Role of P-glycoprotein in cyclosporine cytotoxicity in the cyclosporine-sirolimus interaction

scientific article published on 12 July 2006

Role of pharmacogenetics of immunosuppressive drugs in organ transplantation.

artículo científico publicado en 2008

Safety and pharmacokinetics of the CIME combination of drugs and their metabolites after a single oral dosing in healthy volunteers.

artículo científico publicado en 2014

Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver.

artículo científico publicado en 2007

Separation of human liver microsomal tolbutamide hydroxylase and (S)-mephenytoin 4'-hydroxylase cytochrome P-450 enzymes

artículo científico publicado en 1991

Simulation of human benzo[a]pyrene metabolism deduced from the analysis of individual kinetic steps in recombinant yeast.

artículo científico publicado en 1996

Simultaneous measurement of 23 isoforms from the human cytochrome P450 families 1 to 3 by quantitative reverse transcriptase-polymerase chain reaction.

artículo científico publicado en 2005

Some erythromycin derivatives are strong inducers in rats of a cytochrome P-450 very similar to that induced by 16 alpha-pregnenolone carbonitrile

artículo científico publicado en 1985

Specificity of in vitro covalent binding of tienilic acid metabolites to human liver microsomes in relationship to the type of hepatotoxicity: comparison with two directly hepatotoxic drugs.

artículo científico publicado en 1994

Stable expression of human cytochrome P450 3A4 in conjunction with human NADPH-cytochrome P450 oxidoreductase in V79 Chinese hamster cells.

artículo científico publicado en 1996

TEGDMA modulates glutathione transferase P1 activity in gingival fibroblasts

artículo científico publicado en 2004

The Salmonella/mammalian microsome mutagenicity test: comparison of human and rat livers as activating systems

artículo científico publicado en 1985

The Use of Humanin VitroMetabolic Parameters to Explore the Risk Assessment of Hazardous Compounds: The Case of Ethylene Dibromide

artículo científico publicado en 1997

The biotransformation of clomipramine in vitro, identification of the cytochrome P450s responsible for the separate metabolic pathways

scientific article published on 01 June 1996

The dynamin chemical inhibitor dynasore impairs cholesterol trafficking and sterol-sensitive genes transcription in human HeLa cells and macrophages

artículo científico publicado en 2011

The effect of different hyperglucagonemic states on monooxygenase activities and isozymic pattern of cytochrome P-450 in mouse

artículo científico publicado en 1985

The interleukin-2 receptor down-regulates the expression of cytochrome P450 in cultured rat hepatocytes

scientific article published on 01 November 1995

The nature of the "455 nm absorbing complex" formed during the cytochrome P450 dependent oxidative metabolism of amphetamine

scientific article published on 01 March 1976

The unfolded protein response regulates an angiogenic response by the kidney epithelium during ischemic stress

artículo científico publicado en 2012

The urinary metabolome of chronic kidney disease

artículo científico publicado en 2014

The use of formic acid in carrier gas. Rapid method for identification and determination of phytanic acid by gas chromatography-mass spectrometry-chemical ionization

artículo científico publicado en 1980

Thiol compounds metabolism in mice, rats and humans: Comparative study and potential explanation of rodents protection against vascular diseases

scientific article published on 07 April 2006

Thiopurine methyltransferase activity: new conditions for reversed-phase high-performance liquid chromatographic assay without extraction and genotypic-phenotypic correlation

artículo científico publicado en 2002

Thiopurine-methyl-transferase activity to assess azathioprine myelotoxicity in renal transplant recipients

scientific article published on 01 June 1993

Third Santorini conference pharmacogenomics workshop report: “Pharmacogenomics at the crossroads: what else than good science will be needed for the field to become part of Personalized Medicine?”

artículo científico publicado en 2007

Thymidylate synthase gene polymorphism predicts toxicity in colorectal cancer patients receiving 5-fluorouracil-based chemotherapy

artículo científico publicado en 2004

Tienilic acid-induced autoimmune hepatitis: anti-liver and-kidney microsomal type 2 autoantibodies recognize a three-site conformational epitope on cytochrome P4502C9

artículo científico publicado en 1996

Tissue Accumulation of Lanthanum as Compared to Aluminum in Rats with Chronic Renal Failure – Possible Harmful Effects after Long-Term Exposure

artículo científico publicado en 2010

Tryptophan depletion and the kinase GCN2 mediate IFN-γ-induced autophagy.

artículo científico publicado en 2012

UDP-glucuronosyltransferase UGT1A7 genetic polymorphisms in hepatocellular carcinoma: a differential impact according to seropositivity of HBV or HCV markers?

artículo científico publicado en 2007

Urinary Metabolic Fingerprint of Acute Intermittent Porphyria Analyzed by 1H NMR Spectroscopy

artículo científico publicado en 2014

Urinary retinol binding protein is a marker of the extent of interstitial kidney fibrosis

artículo científico publicado en 2014

Use of heterologous expression systems to study autoimmune drug-induced hepatitis

artículo científico publicado en 1996

Use of heterologously expressed human cytochrome P4501A2 to predict tacrine-fluvoxamine drug interaction in man

scientific article published on 01 April 1998

VKORC1 haplotypes and long-term renal allograft survival

artículo científico publicado en 2009

Validation of an Ultra-High Performance Liquid Chromatography Tandem Mass Spectrometric Method for Quantifying Uracil and 5,6-Dihydrouracil in Human Plasma

scientific article published on 11 June 2012

Xenobiotic metabolizing enzymes in the central nervous system: Contribution of cytochrome P450 enzymes in normal and pathological human brain.

artículo científico publicado en 2007

Xenobiotic-metabolizing enzymes and transporters in the normal human brain: regional and cellular mapping as a basis for putative roles in cerebral function.

artículo científico publicado en 2009

Xenobiotic-metabolizing enzymes as autoantigens in human autoimmune disorders. An update.

artículo científico publicado en 2000

[A new, rapid and robust genotyping method for CYP2C9 and MDR1]

artículo científico publicado en 2003

[Development of a laboratory test on dried blood spots for facilitating early diagnosis of alpha-1-antitrypsin deficiency]

artículo científico publicado en 2014

[Diet, genetics and cancer]

scientific article published on 01 April 2001

[Effects of erythrocytes on electrometric pH measurements (author's transl)]

scientific article published on 01 January 1980

[Endoplasmic reticulum stress in kidney diseases: a question of life and death?]

artículo científico publicado en 2008

[In vitro study models of drug interactions]

artículo científico publicado en 1995

[Pharmacogenetics of oral anticoagulants: individualized drug treatment for more efficacy and safety]

artículo científico publicado en 2007

[Pharmacokinetic elements of sodium valproate. Use in febrile convulsions in children]

scientific article published on 01 January 1983

[Rapamycine and mTOR inhibitors: from bench to bedside]

scientific article published on 01 March 2006

[Relationship between hepatic cytochrome P-450 3A and acute cyclosporine toxicity in liver transplantation]

artículo científico publicado en 1994

[Screening of principal enzymes involved in the metabolism of anticancer drugs in human and murine colonic tumors]

scientific article published on 01 May 1993

[mTOR inhibitors: pleiotropic antiproliferative drugs].

artículo científico publicado en 2006

p53 alterations predict tumor response to neoadjuvant chemotherapy in head and neck squamous cell carcinoma: a prospective series.

artículo científico publicado en 2000

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