Lista de obras - Mark S. Searle - Dominio Público Uruguay

15 N and 1 H NMR evidence for multiple conformations of the complex of dihydrofolate reductase with its substrate, folate

article

31P NMR investigation of the backbone conformation and dynamics of the hexamer duplex d(5'-GCATGC)2 in its complex with the antibiotic nogalamycin

artículo científico publicado en 1992

7-Deazapurine biosynthesis: NMR study of toyocamycin biosynthesis in Streptomyces rimosus using 2-13C-7-15N-adenine

artículo científico publicado en 2011

A nonsynonymous TNFRSF11A variation increases NFκB activity and the severity of Paget's disease

artículo científico publicado en 2012

A sequence-based approach for prediction of CsrA/RsmA targets in bacteria with experimental validation in Pseudomonas aeruginosa

artículo científico publicado en 2014

A targeted oligonucleotide enhancer of SMN2 exon 7 splicing forms competing quadruplex and protein complexes in functional conditions

artículo científico

Aromatic residues engineered into the beta-turn nucleation site of ubiquitin lead to a complex folding landscape, non-native side-chain interactions, and kinetic traps.

artículo científico publicado en 2008

Bile Acid Interactions with Rabbit Ileal Lipid Binding Protein and an Engineered Helixless Variant Reveal Novel Ligand Binding Properties of a Versatile β-Clam Shell Protein Scaffold

artículo científico publicado en 2007

Characterization of a non-UBA domain missense mutation of sequestosome 1 (SQSTM1) in Paget's disease of bone

artículo científico publicado en 2009

Conformation and dynamics of the three-helix bundle UBA domain of p62 from experiment and simulation

artículo científico publicado en 2008

Consequences for molecular recognition and ligand-receptor complementary of entropy changes in phase transitions

scientific article published in 1992

Context-dependent effects of proline residues on the stability and folding pathway of ubiquitin

artículo científico publicado en 2004

Cooperative Assembly of a Nativelike Ubiquitin Structure through Peptide Fragment Complexation: Energetics of Peptide Association and Folding†

artículo científico publicado en 2000

Cooperativity in Drug−DNA Recognition: A Molecular Dynamics Study ⬇️

artículo científico publicado el 19 de diciembre de 2001

Coupling ligand recognition to protein folding in an engineered variant of rabbit ileal lipid binding protein

artículo científico publicado en 2006

DNA minor groove recognition by a tetrahydropyrimidinium analogue of hoechst 33258: NMR and molecular dynamics studies of the complex with d(GGTAATTACC)2 ⬇️

artículo científico publicado el 1 de abril de 1998

DNA recognition by the anthracycline antibiotic respinomycin D: NMR structure of the intercalation complex with d(AGACGTCT)2

artículo científico publicado en 2003

Defective recognition of LC3B by mutant SQSTM1/p62 implicates impairment of autophagy as a pathogenic mechanism in ALS-FTLD.

artículo científico publicado en 2016

Design of beta-sheet systems for understanding the thermodynamics and kinetics of protein folding

artículo científico publicado en 2004

Dihydrofolate reductase

scientific article published on 01 March 1986

Dimerisation of the UBA domain of p62 inhibits ubiquitin binding and regulates NF-kappaB signalling

artículo científico publicado en 2010

Disruption of ubiquitin-mediated processes in diseases of the brain and bone

artículo científico publicado en 2008

Drug recognition and stabilisation of the parallel-stranded DNA quadruplex d(TTAGGGT)4 containing the human telomeric repeat

artículo científico publicado en 2003

Effects of amino acid phi,psi propensities and secondary structure interactions in modulating H alpha chemical shifts in peptide and protein beta-sheet

artículo científico publicado en 2001

Engineering diverse changes in beta-turn propensities in the N-terminal beta-hairpin of ubiquitin reveals significant effects on stability and kinetics but a robust folding transition state

artículo científico publicado en 2006

Engineering enhanced protein stability through beta-turn optimization: insights for the design of stable peptide beta-hairpin systems

artículo científico publicado en 2005

Engineering stabilising beta-sheet interactions into a conformationally flexible region of the folding transition state of ubiquitin

artículo científico publicado en 2005

Enthalpy/entropy compensation effects from cavity desolvation underpin broad ligand binding selectivity for rat odorant binding protein 3

artículo científico publicado en 2014

Expression of electrostatic binding cooperativity in the recognition of cell-wall peptide analogues by vancomycin group antibiotics

article published in 1994

Extending the folding nucleus of ubiquitin with an independently folding beta-hairpin finger: hurdles to rapid folding arising from the stabilisation of local interactions

artículo científico publicado en 2005

Folding of a β-hairpin peptide derived from the N-terminus of ubiquitin

artículo científico publicado en 2000

Folding of single-stranded DNA quadruplexes containing an autonomously stable mini-hairpin loop

artículo científico publicado en 2009

Folding topology of a bimolecular DNA quadruplex containing a stable mini-hairpin motif within the diagonal loop

artículo científico publicado en 2009

Helix mutations stabilize a late productive intermediate on the folding pathway of ubiquitin

artículo científico publicado en 2008

Hoogsteen versus Watson-Crick A-T basepairing in DNA complexes of a new group of ‘quinomycin-like’ antibiotics

scientific article published on 01 October 1990

Identification of the 1 H resonances of valine and leucine residues in dihydrofolate reductase by using a combination of selective deuteration and two-dimensional correlation spectroscopy

artículo científico publicado en 1986

Impact of p62/SQSTM1 UBA domain mutations linked to Paget's disease of bone on ubiquitin recognition

artículo científico publicado en 2011

Incremental contribution to protein stability from a beta hairpin "finger": limits on the stability of designed beta hairpin peptides

artículo científico publicado en 2004

Independent interactions of ubiquitin-binding domains in a ubiquitin-mediated ternary complex

artículo científico publicado en 2011

Inhibition of Cullin RING Ligases by Cycle Inhibiting Factor: Evidence for Interference with Nedd8-Induced Conformational Control

article

Insights into stabilizing weak interactions in designed peptide beta-hairpins

artículo científico publicado en 2004

Insights into the Molecular Composition of Endogenous Unanchored Polyubiquitin Chains

article

Insights into the stability of native and partially folded states of ubiquitin: effects of cosolvents and denaturants on the thermodynamics of protein folding

artículo científico publicado en 2001

Interaction of Hoechst 33258 with the minor groove of the A + T‐rich DNA duplex d(GGTAATTACC)2 studied in solution by NMR spectroscopy ⬇️

artículo científico publicado el 1 de febrero de 1993

Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences

artículo científico publicado en 2014

Loss of Ubiquitin Binding Is a Unifying Mechanism by Which Mutations of SQSTM1 Cause Paget’s Disease of Bone

artículo científico publicado en 2006

Loss of Ubiquitin-Binding Associated With Paget's Disease of Bone p62 (SQSTM1) Mutations

article

Mechanism of Ligand-Induced Folding of a Natively Unfolded Helixless Variant of Rabbit I-BABP

artículo científico publicado en 2009

Modulation of intrinsic phi,psi propensities of amino acids by neighbouring residues in the coil regions of protein structures: NMR analysis and dissection of a beta-hairpin peptide.

artículo científico publicado en 1998

Mutant p62/SQSTM1 UBA domains linked to Paget's disease of bone differ in their abilities to function as stabilization signals

artículo científico publicado en 2010

NMR Studies of Drug—DNA interactions

article

Novel UBA domain mutations of SQSTM1 in Paget's disease of bone: genotype phenotype correlation, functional analysis, and structural consequences

artículo científico publicado en 2004

Occurrence of a Quadruplex Motif in a Unique Insert within Exon C of the Bovine Estrogen Receptor α Gene (ESR1)

article

On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts

scientific article published on 19 September 2013

Optimal antisense target reducing INS intron 1 retention is adjacent to a parallel G quadruplex

artículo científico publicado en 2014

Overview of Protein Folding Mechanisms: Experimental and Theoretical Approaches to Probing Energy Landscapes ⬇️

artículo científico publicado el 1 de abril de 2012

Paget disease of bone-associated UBA domain mutations of SQSTM1 exert distinct effects on protein structure and function

artículo científico publicado en 2014

Population of on-pathway intermediates in the folding of ubiquitin

artículo científico publicado en 2006

Prion protein fragments spanning helix 1 and both strands of beta sheet (residues 125-170) show evidence for predominantly helical propensity by CD and NMR.

artículo científico publicado en 1998

Probing affinity and ubiquitin linkage selectivity of ubiquitin-binding domains using mass spectrometry

artículo científico publicado en 2012

Probing the interaction of Hoechst 33258 with an A–T rich oligonucleotide duplex using1H NMR spectroscopy

Rational design and binding of modified cell-wall peptides to vancomycin-group antibiotics: Factorising free energy contributions to binding

Recognition and Stabilization of Quadruplex DNA by a Potent New Telomerase Inhibitor: NMR Studies of the 2:1 Complex of a Pentacyclic Methylacridinium Cation with d(TTAGGGT)4

scholarly article by Evripidis Gavathiotis et al published 17 December 2001 in Angewandte Chemie International Edition

Repression of translation of human estrogen receptor alpha by G-quadruplex formation

artículo científico publicado en 2009

SQSTM1 mutations--bridging Paget disease of bone and ALS/FTLD.

artículo científico publicado en 2014

Selectivity of small molecule ligands for parallel and anti-parallel DNA G-quadruplex structures.

artículo científico publicado en 2009

Sequence determinants for the tandem recognition of UGU and CUG rich RNA elements by the two N--terminal RRMs of CELF1

artículo científico publicado en 2011

Sequence specific conformation of a DNA decamer containing an adenine tract studied in solution by 1H-NMR spectroscopy

artículo científico publicado en 1990

Sequential barriers and an obligatory metastable intermediate define the apparent two-state folding pathway of the ubiquitin-like PB1 domain of NBR1.

artículo científico publicado en 2008

Solution structure and dynamics of the A-T tract DNA decamer duplex d(GGTAATTACC)2: implications for recognition by minor groove binding drugs.

artículo científico publicado en 1999

Stability and folding kinetics of a ubiquitin mutant with a strong propensity for nonnative beta-hairpin conformation in the unfolded state

artículo científico publicado en 2003

Stabilization of beta-hairpin peptides by salt bridges: role of preorganization in the energetic contribution of weak interactions

artículo científico publicado en 2003

Structural Rearrangement in an RsmA/CsrA Ortholog of Pseudomonas aeruginosa Creates a Dimeric RNA-Binding Protein, RsmN

artículo científico publicado en 2013

Structural and functional studies of mutations affecting the UBA domain of SQSTM1 (p62) which cause Paget's disease of bone

artículo científico publicado en 2004

Structural insights into specificity and diversity in mechanisms of ubiquitin recognition by ubiquitin-binding domains

artículo científico

Structural insights into the targeting of mRNA GU-rich elements by the three RRMs of CELF1.

artículo científico publicado en 2013

Structural insights into the two sequential folding transition states of the PB1 domain of NBR1 from Φ value analysis and biased molecular dynamics simulations

artículo científico publicado en 2010

Structure and K+ ion-dependent stability of a parallel-stranded DNA quadruplex containing a core A-tetrad

artículo científico publicado en 2004

Structure and folding dynamics of a DNA hairpin with a stabilising d(GNA) trinucleotide loop: influence of base pair mis-matches and point mutations on conformational equilibria

article

Structure of a drug-induced DNA T-bulge: implications for DNA frameshift mutations.

artículo científico publicado en 2002

Structure of the parallel-stranded DNA quadruplex d(TTAGGGT)4 containing the human telomeric repeat: evidence for A-tetrad formation from NMR and molecular dynamics simulations

artículo científico publicado en 2003

Structure of the ubiquitin-associated domain of p62 (SQSTM1) and implications for mutations that cause Paget's disease of bone

artículo científico publicado en 2003

Structure, dynamics and hydration of the nogalamycin-d(ATGCAT)2Complex determined by NMR and molecular dynamics simulations in solution

artículo científico publicado en 1999

Telomestatin: formal total synthesis and cation-mediated interaction of its seco-derivatives with G-quadruplexes.

artículo científico publicado en 2010

Templating peptide folding on the surface of a micelle

artículo científico publicado en 2000

The S349T mutation of SQSTM1 links Keap1/Nrf2 signalling to Paget's disease of bone.

artículo científico publicado en 2012

The combined use of selective deuteration and double resonance experiments in assigning the 1 H resonances of valine and tyrosine residues of dihydrofolate reductase

artículo científico publicado en 1984

The free energy change of restricting a bond rotation in the binding of peptide analogues to vancomycin group antibiotics

artículo científico publicado en 1993

The highly repetitive region of the Helicobacter pylori CagY protein comprises tandem arrays of an alpha-helical repeat module

artículo científico publicado en 2008

The role of short RNA loops in recognition of a single-hairpin exon derived from a mammalian-wide interspersed repeat

artículo científico publicado en 2015

The structure of an asymmetric dimer relevant to the mode of action of the glycopeptide antibiotics

artículo científico

The ‘n’ effect in molecular recognition

scientific article published on 01 March 1996

Tuneable DNA-based asymmetric catalysis using a G-quadruplex supramolecular assembly

artículo científico publicado en 2010

Ubiquitin recognition by the ubiquitin-associated domain of p62 involves a novel conformational switch

artículo científico publicado en 2008

Ubiquitin-binding domains: mechanisms of ubiquitin recognition and use as tools to investigate ubiquitin-modified proteomes

artículo científico publicado en 2014

p62 mutations, ubiquitin recognition and Paget's disease of bone

artículo científico publicado en 2006

Lista de obras de Mark S. Searle

15 N and 1 H NMR evidence for multiple conformations of the complex of dihydrofolate reductase with its substrate, folate

31P NMR investigation of the backbone conformation and dynamics of the hexamer duplex d(5'-GCATGC)2 in its complex with the antibiotic nogalamycin

7-Deazapurine biosynthesis: NMR study of toyocamycin biosynthesis in Streptomyces rimosus using 2-13C-7-15N-adenine

A nonsynonymous TNFRSF11A variation increases NFκB activity and the severity of Paget's disease

A sequence-based approach for prediction of CsrA/RsmA targets in bacteria with experimental validation in Pseudomonas aeruginosa

A targeted oligonucleotide enhancer of SMN2 exon 7 splicing forms competing quadruplex and protein complexes in functional conditions

Aromatic residues engineered into the beta-turn nucleation site of ubiquitin lead to a complex folding landscape, non-native side-chain interactions, and kinetic traps.

Bile Acid Interactions with Rabbit Ileal Lipid Binding Protein and an Engineered Helixless Variant Reveal Novel Ligand Binding Properties of a Versatile β-Clam Shell Protein Scaffold

Characterization of a non-UBA domain missense mutation of sequestosome 1 (SQSTM1) in Paget's disease of bone

Conformation and dynamics of the three-helix bundle UBA domain of p62 from experiment and simulation

Consequences for molecular recognition and ligand-receptor complementary of entropy changes in phase transitions

Context-dependent effects of proline residues on the stability and folding pathway of ubiquitin

Cooperative Assembly of a Nativelike Ubiquitin Structure through Peptide Fragment Complexation: Energetics of Peptide Association and Folding†

Cooperativity in Drug−DNA Recognition: A Molecular Dynamics Study ⬇️

Coupling ligand recognition to protein folding in an engineered variant of rabbit ileal lipid binding protein

DNA minor groove recognition by a tetrahydropyrimidinium analogue of hoechst 33258: NMR and molecular dynamics studies of the complex with d(GGTAATTACC)2 ⬇️

DNA recognition by the anthracycline antibiotic respinomycin D: NMR structure of the intercalation complex with d(AGACGTCT)2

Defective recognition of LC3B by mutant SQSTM1/p62 implicates impairment of autophagy as a pathogenic mechanism in ALS-FTLD.

Design of beta-sheet systems for understanding the thermodynamics and kinetics of protein folding

Dihydrofolate reductase

Dimerisation of the UBA domain of p62 inhibits ubiquitin binding and regulates NF-kappaB signalling

Disruption of ubiquitin-mediated processes in diseases of the brain and bone

Drug recognition and stabilisation of the parallel-stranded DNA quadruplex d(TTAGGGT)4 containing the human telomeric repeat

Effects of amino acid phi,psi propensities and secondary structure interactions in modulating H alpha chemical shifts in peptide and protein beta-sheet

Engineering diverse changes in beta-turn propensities in the N-terminal beta-hairpin of ubiquitin reveals significant effects on stability and kinetics but a robust folding transition state

Engineering enhanced protein stability through beta-turn optimization: insights for the design of stable peptide beta-hairpin systems

Engineering stabilising beta-sheet interactions into a conformationally flexible region of the folding transition state of ubiquitin

Enthalpy/entropy compensation effects from cavity desolvation underpin broad ligand binding selectivity for rat odorant binding protein 3

Expression of electrostatic binding cooperativity in the recognition of cell-wall peptide analogues by vancomycin group antibiotics

Extending the folding nucleus of ubiquitin with an independently folding beta-hairpin finger: hurdles to rapid folding arising from the stabilisation of local interactions

Folding of a β-hairpin peptide derived from the N-terminus of ubiquitin

Folding of single-stranded DNA quadruplexes containing an autonomously stable mini-hairpin loop

Folding topology of a bimolecular DNA quadruplex containing a stable mini-hairpin motif within the diagonal loop

Helix mutations stabilize a late productive intermediate on the folding pathway of ubiquitin

Hoogsteen versus Watson-Crick A-T basepairing in DNA complexes of a new group of ‘quinomycin-like’ antibiotics

Identification of the 1 H resonances of valine and leucine residues in dihydrofolate reductase by using a combination of selective deuteration and two-dimensional correlation spectroscopy

Impact of p62/SQSTM1 UBA domain mutations linked to Paget's disease of bone on ubiquitin recognition

Incremental contribution to protein stability from a beta hairpin "finger": limits on the stability of designed beta hairpin peptides

Independent interactions of ubiquitin-binding domains in a ubiquitin-mediated ternary complex

Inhibition of Cullin RING Ligases by Cycle Inhibiting Factor: Evidence for Interference with Nedd8-Induced Conformational Control

Insights into stabilizing weak interactions in designed peptide beta-hairpins

Insights into the Molecular Composition of Endogenous Unanchored Polyubiquitin Chains

Insights into the stability of native and partially folded states of ubiquitin: effects of cosolvents and denaturants on the thermodynamics of protein folding

Interaction of Hoechst 33258 with the minor groove of the A + T‐rich DNA duplex d(GGTAATTACC)2 studied in solution by NMR spectroscopy ⬇️

Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences

Loss of Ubiquitin Binding Is a Unifying Mechanism by Which Mutations of SQSTM1 Cause Paget’s Disease of Bone

Loss of Ubiquitin-Binding Associated With Paget's Disease of Bone p62 (SQSTM1) Mutations

Mechanism of Ligand-Induced Folding of a Natively Unfolded Helixless Variant of Rabbit I-BABP

Modulation of intrinsic phi,psi propensities of amino acids by neighbouring residues in the coil regions of protein structures: NMR analysis and dissection of a beta-hairpin peptide.

Mutant p62/SQSTM1 UBA domains linked to Paget's disease of bone differ in their abilities to function as stabilization signals

NMR Studies of Drug—DNA interactions

Novel UBA domain mutations of SQSTM1 in Paget's disease of bone: genotype phenotype correlation, functional analysis, and structural consequences

Occurrence of a Quadruplex Motif in a Unique Insert within Exon C of the Bovine Estrogen Receptor α Gene (ESR1)

On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts

Optimal antisense target reducing INS intron 1 retention is adjacent to a parallel G quadruplex

Overview of Protein Folding Mechanisms: Experimental and Theoretical Approaches to Probing Energy Landscapes ⬇️

Paget disease of bone-associated UBA domain mutations of SQSTM1 exert distinct effects on protein structure and function

Population of on-pathway intermediates in the folding of ubiquitin

Prion protein fragments spanning helix 1 and both strands of beta sheet (residues 125-170) show evidence for predominantly helical propensity by CD and NMR.

Probing affinity and ubiquitin linkage selectivity of ubiquitin-binding domains using mass spectrometry

Probing the interaction of Hoechst 33258 with an A–T rich oligonucleotide duplex using1H NMR spectroscopy

Rational design and binding of modified cell-wall peptides to vancomycin-group antibiotics: Factorising free energy contributions to binding

Recognition and Stabilization of Quadruplex DNA by a Potent New Telomerase Inhibitor: NMR Studies of the 2:1 Complex of a Pentacyclic Methylacridinium Cation with d(TTAGGGT)4

Repression of translation of human estrogen receptor alpha by G-quadruplex formation

SQSTM1 mutations--bridging Paget disease of bone and ALS/FTLD.

Selectivity of small molecule ligands for parallel and anti-parallel DNA G-quadruplex structures.

Sequence determinants for the tandem recognition of UGU and CUG rich RNA elements by the two N--terminal RRMs of CELF1

Sequence specific conformation of a DNA decamer containing an adenine tract studied in solution by 1H-NMR spectroscopy

Sequential barriers and an obligatory metastable intermediate define the apparent two-state folding pathway of the ubiquitin-like PB1 domain of NBR1.

Solution structure and dynamics of the A-T tract DNA decamer duplex d(GGTAATTACC)2: implications for recognition by minor groove binding drugs.

Stability and folding kinetics of a ubiquitin mutant with a strong propensity for nonnative beta-hairpin conformation in the unfolded state

Stabilization of beta-hairpin peptides by salt bridges: role of preorganization in the energetic contribution of weak interactions

Structural Rearrangement in an RsmA/CsrA Ortholog of Pseudomonas aeruginosa Creates a Dimeric RNA-Binding Protein, RsmN

Structural and functional studies of mutations affecting the UBA domain of SQSTM1 (p62) which cause Paget's disease of bone

Structural insights into specificity and diversity in mechanisms of ubiquitin recognition by ubiquitin-binding domains

Structural insights into the targeting of mRNA GU-rich elements by the three RRMs of CELF1.

Structural insights into the two sequential folding transition states of the PB1 domain of NBR1 from Φ value analysis and biased molecular dynamics simulations

Structure and K+ ion-dependent stability of a parallel-stranded DNA quadruplex containing a core A-tetrad

Structure and folding dynamics of a DNA hairpin with a stabilising d(GNA) trinucleotide loop: influence of base pair mis-matches and point mutations on conformational equilibria