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Lista de obras de Claudia Martini

1,2,3-Triazolo[1,5-a][1,4]- and 1,2,3-triazolo[1,5-a]-[1,5]benzodiazepine derivatives: synthesis and benzodiazepine receptor binding

artículo científico publicado en 1998

1,2,4-Triazolo[1,5-a]quinoxaline as a versatile tool for the design of selective human A3 adenosine receptor antagonists: synthesis, biological evaluation, and molecular modeling studies of 2-(hetero)aryl- and 2-carboxy-substituted derivatives.

artículo científico publicado en 2005

1,2,4-Triazolo[1,5-a]quinoxaline derivatives: synthesis and biological evaluation as adenosine receptor antagonists.

artículo científico publicado en 2004

1,2,4-Triazolo[4,3-a]quinoxalin-1-one: a versatile tool for the synthesis of potent and selective adenosine receptor antagonists

artículo científico publicado en 2000

1,2,4-triazolo[1,5-a]quinoxaline derivatives and their simplified analogues as adenosine A₃ receptor antagonists. Synthesis, structure-affinity relationships and molecular modeling studies.

artículo científico publicado en 2014

1,2,4-triazolo[4,3-a]quinoxalin-1-one moiety as an attractive scaffold to develop new potent and selective human A3 adenosine receptor antagonists: synthesis, pharmacological, and ligand-receptor modeling studies

artículo científico publicado en 2004

2,3-Butanedione inactivates the [3H]nitrendipine binding sites, whereas diethylpyrocarbonate does not.

artículo científico publicado en 1996

2-(Benzimidazol-2-yl)quinoxalines: a novel class of selective antagonists at human A(1) and A(3) adenosine receptors designed by 3D database searching

artículo científico publicado en 2005

2-Arylpyrazolo[1,5-a]pyrimidin-3-yl acetamides. New potent and selective peripheral benzodiazepine receptor ligands.

artículo científico publicado en 2001

2-aryl-8-chloro-1,2,4-triazolo[1,5-a]quinoxalin-4-amines as highly potent A1 and A3 adenosine receptor antagonists

artículo científico publicado en 2005

2‘-C-Methyl Analogues of Selective Adenosine Receptor Agonists: Synthesis and Binding Studies ⬇️

artículo científico publicado el 7 de mayo de 1998

3 alpha-hydroxy-5 alpha-pregnan-20-one modulation of solubilized GABA/benzodiazepine receptor complex.

artículo científico publicado en 1993

3-(Fur-2-yl)-10-(2-phenylethyl)-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one, a novel adenosine receptor antagonist with A(2A)-mediated neuroprotective effects

artículo científico publicado en 2011

3-(Methyleneaminoxy)methylpiperidine derivatives as uptake inhibitors of biogenic amines in the brain synaptosomal fraction

3-Aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-ones: tricyclic heteroaromatic derivatives as a new class of benzodiazepine receptor ligands

artículo científico publicado en 2000

3-Aryl[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-ones: a new class of selective A1 adenosine receptor antagonists.

artículo científico publicado en 2001

3-[(2-Ethoxyphenoxy)methyl]piperidine derivatives. Synthesis and antidepressant activity

artículo científico publicado en 1987

3-aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one: a novel template for the design of highly selective A₂B adenosine receptor antagonists

artículo científico publicado en 2012

3H-NECA Binding to Polymorphonuclear Membrane: Effect of Sera from Patients with Hodgkin's Disease

artículo científico publicado en 1994

4-[6-(Dansylamino)hexylamino]-7-methyl-2-phenyl-1,8-naphthyridine as a new potential fluorescent probe for studying A1-adenosine receptor

artículo científico publicado en 2002

4-amido-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-ones as new potent and selective human A3 adenosine receptor antagonists. synthesis, pharmacological evaluation, and ligand-receptor modeling studies

artículo científico publicado en 2006

4-amino-6-alkyloxy-2-alkylthiopyrimidine derivatives as novel non-nucleoside agonists for the adenosine A1 receptor

artículo científico publicado en 2016

5'-Carbamoyl derivatives of 2'-C-methyl-purine nucleosides as selective A1 adenosine receptor agonists: affinity, efficacy, and selectivity for A1 receptor from different species

artículo científico publicado en 2007

5-amino-2-phenyl[1,2,3]triazolo[1,2-a][1,2,4]benzotriazin-1-one: a versatile scaffold to obtain potent and selective A3 adenosine receptor antagonists.

artículo científico publicado en 2007

7-Nitrobenzofurazan (NBD) derivatives of 5'-N-ethylcarboxamidoadenosine (NECA) as new fluorescent probes for human A(3) adenosine receptors.

artículo científico publicado en 2001

8-Azaxanthine derivatives as antagonists of adenosine receptors

artículo científico publicado en 1994

A 3H-flunitrazepam binding inhibitor is present in psychiatric patients' sera

artículo científico publicado en 1987

A Public Dataset of 24-h Multi-Levels Psycho-Physiological Responses in Young Healthy Adults

artículo científico publicado en 2020

A Virtual Screening Study of the 18 kDa Translocator Protein using Pharmacophore Models Combined with 3D-QSAR Studies

artículo científico publicado en 2009

A ferritin-cyclohexyladenosine probe for electron microscope localization of A1 adenosine receptor.

artículo científico publicado en 1991

A mixed-valence diruthenium(II,III) complex endowed with high stability: from experimental evidence to theoretical interpretation

scientific article published on 13 October 2020

A new D₂ dopamine receptor agonist allosterically modulates A(2A) adenosine receptor signalling by interacting with the A(2A)/D₂ receptor heteromer

artículo científico publicado en 2011

A new class of pyrazolo[5,1-c][1,2,4]triazines as γ-aminobutyric type A (GABAA) receptor subtype ligand: synthesis and pharmacological evaluation

artículo científico publicado en 2018

A new tiazofurin pronucleotide: synthesis and biological evaluation of cyclosaligenyl-tiazofurin monophosphate.

artículo científico publicado en 2003

A novel selective GABA(A) alpha1 receptor agonist displaying sedative and anxiolytic-like properties in rodents.

artículo científico publicado en 2005

A promiscuous recognition mechanism between GPR17 and SDF-1: Molecular insights

artículo científico publicado en 2016

A rapid and efficient immunoenzymatic assay to detect receptor protein interactions: G protein-coupled receptors

artículo científico publicado en 2014

A(2A) adenosine receptor binding parameters in platelets from patients affected by pathological gambling

artículo científico publicado en 2011

A(2A) adenosine receptor ligands and proinflammatory cytokines induce PC 12 cell death through apoptosis

artículo científico publicado en 2003

A1 adenosine receptor antagonists, 3-aryl[1,2,4]triazino[4,3-a]benzimidazol-4-(10H)-ones (ATBIs) andN-alkyl andN-acyl-(7-substituted-2-phenylimidazo[1,2-a][1,3,5]triazin-4-yl)amines (ITAs): Different recognition of bovine and human binding sites

A1 and A2 adenosine receptors in synovial cells from patients with rheumatic diseases

artículo científico publicado en 1989

A2 Adenosine Receptors in Neutrophils from Health Volunteers and Patients with Rheumatic Disease ⬇️

artículo científico publicado el 1 de enero de 1991

A2a Adenosine receptors: guanine nucleotide derivative regulation in porcine striatal membranes and digitonin soluble fraction ⬇️

artículo científico publicado el 1 de agosto de 1998

A3 adenosine receptors in human astrocytoma cells: agonist-mediated desensitization, internalization, and down-regulation

artículo científico publicado en 2002

AM251 induces apoptosis and G2/M cell cycle arrest in A375 human melanoma cells

artículo científico publicado en 2015

Adenosine A2A receptor antagonists: new 8-substituted 9-ethyladenines as tools for in vivo rat models of Parkinson's disease

artículo científico publicado en 2009

Aerobic Exercise and Healthy Nutrition as Neuroprotective Agents for Brain Health in Patients with Parkinson's Disease: A Critical Review of the Literature

artículo científico publicado en 2020

Agonist-Induced Desensitization/Resensitization of Human G Protein-Coupled Receptor 17: A Functional Cross-Talk between Purinergic and Cysteinyl-Leukotriene Ligands

scientific article published on 29 April 2011

Agonist-Induced Internalization and Recycling of the Human A3 Adenosine Receptors

artículo científico publicado en 2000

Ala147Thr substitution in translocator protein is associated with adult separation anxiety in patients with depression

artículo científico publicado en 2009

Allosteric modulators of human A2B adenosine receptor

artículo científico publicado en 2013

An Effective Virtual Screening Protocol To Identify Promising p53-MDM2 Inhibitors

artículo científico publicado en 2016

An antibody-free strategy for screening putative HDM2 inhibitors using crude bacterial lysates expressing GST-HDM2 recombinant protein

artículo científico publicado en 2013

An efficient route to all stereoisomeric enantiopure 6-amino-3-alkyl-3- azabicyclo[3.2.1]octane-6-carboxylic acids.

artículo científico publicado en 2007

An in vitro comparative study of the antioxidant activity and SIRT1 modulation of natural compounds.

artículo científico publicado en 2018

An insight into hypothesized biological mechanisms contributing to the Flash effect

artículo científico publicado en 2023

Antioxidant Activity of Compounds Isolated from Elaeagnus umbellata Promotes Human Gingival Fibroblast Well-Being

artículo científico publicado en 2020

Antioxidant and Antisenescence Effects of Bergamot Juice

artículo científico publicado en 2018

Anxiolytic properties of a 2-phenylindolglyoxylamide TSPO ligand: Stimulation of in vitro neurosteroid production affecting GABAA receptor activity

article

Anxiolytic-like effects of N,N-dialkyl-2-phenylindol-3-ylglyoxylamides by modulation of translocator protein promoting neurosteroid biosynthesis

artículo científico publicado en 2008

Apoptosis therapy in cancer: the first single-molecule co-activating p53 and the translocator protein in glioblastoma.

artículo científico publicado en 2014

Autoradiographic distribution of peripheral benzodiazepine receptors in the retina of the albino rabbit, Lepus cunicula

artículo científico publicado en 2000

BDNF Val66Met homozygosity does not influence plasma BDNF levels in healthy human subjects

artículo científico publicado en 2012

Barbiturate enhancement of [3H]flunitrazepam binding to purified benzodiazepine/gaba receptor from rat brain

artículo científico publicado en 1987

Bax Activation Blocks Self-Renewal and Induces Apoptosis of Human Glioblastoma Stem Cells

artículo científico publicado en 2017

Benzodiazepine agonists reverse the effects of noise exposure on central benzodiazepine receptors and cardiac responsiveness.

artículo científico publicado en 1995

Benzodiazepine binding inhibitory activity: new supportive findings on its presence in psychiatric patients and further biochemical analyses

artículo científico publicado en 1996

Benzodiazepine receptor affinity and interaction of some N-(indol-3-ylglyoxylyl)amine derivatives.

artículo científico publicado en 1992

Benzodiazepine receptor ligands

scientific article published on 01 June 1999

Benzodiazepine receptor ligands — Part II. Synthesis and biological evaluation of pyrazolo[5,1-c][1,2,4]benzotriazine 4-oxide

Benzodiazepine receptor ligands. 4. Synthesis and pharmacological evaluation of 3-heteroaryl-8-chloropyrazolo[5,1-c][1,2,4] benzotriazine 5-oxides

artículo científico publicado en 1999

Benzodiazepine receptor ligands. 7. Synthesis and pharmacological evaluation of new 3-esters of the 8-chloropyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide. 3-(2-Thienylmethoxycarbonyl) derivative: an anxioselective agent in rodents.

artículo científico publicado en 2002

Benzodiazepine receptor ligands. 8: synthesis and pharmacological evaluation of new pyrazolo[5,1-c] [1,2,4]benzotriazine 5-oxide 3- and 8-disubstituted: high affinity ligands endowed with inverse-agonist pharmacological efficacy

artículo científico publicado en 2005

Benzodiazepine receptor ligands. Synthesis and pharmacological evaluation of 3-, 7- and 8-substituted [5,1-c][1,2,4]benzotriazines and 5-oxide derivatives. Part I

scholarly article by G Guerrini et al published January 1996 in European Journal of Medicinal Chemistry

Bifunctional Inhibitors as a New Tool To Reduce Cancer Cell Invasion by Impairing MMP-9 Homodimerization.

artículo científico publicado en 2017

Binding of [3H] muscimol to the retina of rabbit and turtle

artículo científico publicado en 1989

Binding of beta 1-adrenoceptor antagonist [3H]CGP 26505 in rat cerebral cortex and sinus atrial node

artículo científico publicado en 1996

Binding of the benzodiazepine ligand [3H]-RO 15-1788 to membrane preparations of the rabbit and turtle retina

artículo científico publicado en 1992

Biochemical and pharmacological characterization of periodate-oxidized adenosine analogues at adenosine A1 receptors

artículo científico publicado en 1995

Brain ageing and neurodegenerative disease: The role of cellular waste management

artículo científico publicado en 2018

C-nucleoside analogues of furanfurin as ligands to A1 adenosine receptors

artículo científico publicado en 2000

Carnosol controls the human glioblastoma stemness features through the epithelial-mesenchymal transition modulation and the induction of cancer stem cell apoptosis.

artículo científico publicado en 2017

Changes in Peripheral Benzodiazepine Receptors in Patients with Panic Disorder and Obsessive-Compulsive Disorder

Characterization of a voltage-dependent L-type calcium channel from rabbit and turtle brain

artículo científico publicado en 1996

Characterization of an urate binding alpha 2-globulin from human serum

scientific article published on 01 January 1984

Characterization of peripheral benzodiazepine receptors in purified large mammal pancreatic islets

artículo científico publicado en 1996

Characterization of peripheral-type benzodiazepine binding sites from rat and pig pancreas.

artículo científico publicado en 1994

Characterization of the enantiomeric 3-substituted-1,4-benzodiazepin-2-ones binding to the GABA—BDZ—chloride ionophore receptor complex

artículo científico publicado en 1992

Chemical modification of the dihydropyridines binding sites by lysine reagent, pyridoxal 5'-phosphate

artículo científico publicado en 1998

Chemical modifications of striatal A2A adenosine receptors: a possible role for tyrosine at the ligand binding sites.

artículo científico publicado en 1997

Cloning, pharmacological characterisation and distribution of the rat G-protein-coupled P2Y(13) receptor

scientific journal article

Clozapine, norclozapine plasma levels, their sum and ratio in 50 psychotic patients: influence of patient-related variables

artículo científico publicado en 2002

Co-localization and functional cross-talk between A1 and P2Y1 purine receptors in rat hippocampus.

artículo científico publicado en 2007

Combined inhibition of AKT/mTOR and MDM2 enhances Glioblastoma Multiforme cell apoptosis and differentiation of cancer stem cells

artículo científico publicado en 2015

Combining galantamine and memantine in multitargeted, new chemical entities potentially useful in Alzheimer's disease

artículo científico publicado en 2012

Computer-Aided Identification and Lead Optimization of Dual Murine Double Minute 2 and 4 Binders: Structure-Activity Relationship Studies and Pharmacological Activity

artículo científico publicado en 2017

Conformational effects on the activity of drugs. 13. A revision of previously proposed models for the activation of alpha- and beta-adrenergic receptors

artículo científico publicado en 1992

Conformationally restrained analogs of sympathomimetic catecholamines. Synthesis, conformational analysis, and adrenergic activity of isochroman derivatives.

artículo científico publicado en 1993

Conformationally restrained β-blocking oxime ethers: synthesis and β-adrenergic properties of diastereoisomeric anti and syn 2-(5′-isoxazolidinyl)-ethanolamines

Copper binding to naturally occurring, lactam form of angiogenin differs from that to recombinant protein, affecting their activity.

artículo científico publicado en 2015

Correction to "Discovery of the First-in-Class GSK-3β/HDAC Dual Inhibitor as Disease-Modifying Agent To Combat Alzheimer's Disease"

artículo científico publicado en 2019

Correlation between the sites labelled by [3H]-8 hydroxy-2-(di-N-propylamino)tetralin and [3H]-imipramine in human platelets

Cyclic adenosine monophosphate responsive element binding protein in post-traumatic stress disorder

artículo científico publicado en 2011

Cytokine secretion responsiveness of lymphomonocytes following cortisol cell exposure: Sex differences

artículo científico publicado en 2018

Deepening the Topology of the Translocator Protein Binding Site by Novel N,N-Dialkyl-2-arylindol-3-ylglyoxylamides

artículo científico publicado en 2015

Derivatives of 4-amino-6-hydroxy-2-mercaptopyrimidine as novel, potent, and selective A3 adenosine receptor antagonists

artículo científico publicado en 2008

Derivatives of Benzimidazol-2-ylquinoline and Benzimidazol-2-ylisoquinoline as Selective A1 Adenosine Receptor Antagonists with Stimulant Activity on Human Colon Motility

artículo científico publicado en 2011

Design and synthesis of 2-oxindole based multi-targeted inhibitors of PDK1/Akt signaling pathway for the treatment of glioblastoma multiforme

artículo científico publicado en 2015

Design, synthesis and biological evaluation of novel N-alkyl- and N-acyl-(7-substituted-2-phenylimidazo[1,2-a][1,3,5]triazin-4-yl)amines (ITAs) as novel A(1) adenosine receptor antagonists

artículo científico publicado en 2002

Development of ligands at γ-aminobutyrric acid type A (GABAA) receptor subtype as new agents for pain relief

artículo científico publicado en 2011

Differences in the neurotoxicity profile induced by ATP and ATPgammaS in cultured cerebellar granule neurons

artículo científico publicado en 2005

Differential effects of fondaparinux and bemiparin on angiogenic and vasculogenesis-like processes

artículo científico publicado en 2012

Discovery of the First-in-Class GSK-3β/HDAC Dual Inhibitor as Disease-Modifying Agent To Combat Alzheimer's Disease

scientific article published on 04 February 2019

Does GRK-β arrestin machinery work as a "switch on" for GPR17-mediated activation of intracellular signaling pathways?

artículo científico publicado en 2014

Dual Inhibition of PDK1 and Aurora Kinase A: An Effective Strategy to Induce Differentiation and Apoptosis of Human Glioblastoma Multiforme Stem Cells.

artículo científico publicado en 2016

Dual MET and SMO Negative Modulators Overcome Resistance to EGFR Inhibitors in Human Nonsmall Cell Lung Cancer

artículo científico publicado en 2017

Dysfunctions of peripheral CSN markers in anxiety disorders

Effect of noise exposure on rat cardiac peripheral benzodiazepine receptors.

artículo científico publicado en 2000

Effects of newly-developed benzodiazepine ligands on noise-induced mitochondrial damage in the rat

artículo científico publicado en 2000

Enantiomeric 4-Acylamino-6-alkyloxy-2 Alkylthiopyrimidines As Potential A3 Adenosine Receptor Antagonists: HPLC Chiral Resolution and Absolute Configuration Assignment by a Full Set of Chiroptical Spectroscopy.

artículo científico publicado en 2016

Epigenetic Modifications of the α-Synuclein Gene and Relative Protein Content Are Affected by Ageing and Physical Exercise in Blood from Healthy Subjects.

artículo científico publicado en 2018

Ether analogues of DPA-714 with subnanomolar affinity for the translocator protein (TSPO).

artículo científico publicado en 2015

Evaluation of novel N1-methyl-2-phenylindol-3-ylglyoxylamides as a new chemotype of 18 kDa translocator protein-selective ligand suitable for the development of positron emission tomography radioligands

artículo científico publicado en 2010

Evidence of soluble proteins binding adriamycin by affinity chromatography

article

Exploiting the 4-Phenylquinazoline Scaffold for the Development of High Affinity Fluorescent Probes for the Translocator Protein (TSPO).

artículo científico publicado en 2017

Exploiting the Indole Scaffold to Design Compounds Binding to Different Pharmacological Targets

scientific article published on 16 May 2020

Fluorescent probes for adenosine receptors: synthesis and biology of N6-dansylaminoalkyl-substituted NECA derivatives

artículo científico publicado en 1998

Frontal affinity chromatography-mass spectrometry useful for characterization of new ligands for GPR17 receptor.

artículo científico publicado en 2010

Functional characterization of two isoforms of the P2Y-like receptor GPR17: [35S]GTPgammaS binding and electrophysiological studies in 1321N1 cells

artículo científico publicado en 2009

Further studies on pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as potent and selective human A1 adenosine receptor antagonists

artículo científico publicado en 2014

Gender effect on the relationship between stress hormones and panic-agoraphobic spectrum dimensions in healthy subjects

Genetic analysis of dTSPO, an outer mitochondrial membrane protein, reveals its functions in apoptosis, longevity, and Ab42-induced neurodegeneration

artículo científico publicado en 2014

Geometrically constrained analogues of N-benzylindolylglyoxylylamides: [1, 2, 4]triazino[4, 3-a]benzimidazol-4(10H)-one derivatives as potential new ligands at the benzodiazepine receptor.

artículo científico publicado en 2003

High Levels of β-Amyloid, Tau, and Phospho-Tau in Red Blood Cells as Biomarkers of Neuropathology in Senescence-Accelerated Mouse

scientific article published on 09 June 2019

High affinity central benzodiazepine receptor ligands: synthesis and biological evaluation of a series of phenyltriazolobenzotriazindione derivatives.

artículo científico publicado en 2005

Human Neural Stem Cell Aging Is Counteracted by α-Glycerylphosphorylethanolamine.

artículo científico publicado en 2016

Human glioblastoma multiforme: p53 reactivation by a novel MDM2 inhibitor

artículo científico publicado en 2013

Identification of a New Pyrazolo[1,5-a]quinazoline Ligand Highly Affine to γ-Aminobutyric Type A (GABAA) Receptor Subtype with Anxiolytic-Like and Antihyperalgesic Activity

artículo científico publicado en 2017

Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the gamma-aminobutyric acid-A (GABAA) alpha2 benzodiazepine receptor.

artículo científico publicado en 2009

Impact of ApoE Polymorphism and Physical Activity on Plasma Antioxidant Capability and Erythrocyte Membranes

scientific article published on 09 November 2019

In silico identification of new ligands for GPR17: a promising therapeutic target for neurodegenerative diseases

artículo científico publicado en 2011

Inactivation of Benzodiazepine Binding Sites by N-Ethylmaleimide ⬇️

artículo científico publicado el 1 de junio de 1982

Inactivation of [35S]t-butylbicyclophosphorothionate binding sites by the arginine reagent, 2,3-butanedione

scientific article published on 01 January 1991

Influence of physical exercise on β-amyloid, α-synuclein and tau accumulation: an in vitro model of oxidative stress in human red blood cells

artículo científico

Inhibition of metalloproteinases derived from tumours: new insights in the treatment of human glioblastoma

artículo científico publicado en 2010

Insulin permeability across an in vitro dynamic model of endothelium

artículo científico publicado en 2002

Involvement of mitogen protein kinase cascade in agonist-mediated human A(3) adenosine receptor regulation

artículo científico publicado en 2002

Isolation of an urate-binding protein by affinity chromatography.

artículo científico publicado en 1982

Isosteric replacement of the indole nucleus by benzothiophene and benzofuran in a series of indolylglyoxylylamine derivatives with partial agonist activity at the benzodiazepine receptor

Lactate dehydrogenase-A inhibition induces human glioblastoma multiforme stem cell differentiation and death

artículo científico publicado en 2015

Lead Optimization of 2-Phenylindolylglyoxylyldipeptide Murine Double Minute (MDM)2/Translocator Protein (TSPO) Dual Inhibitors for the Treatment of Gliomas.

artículo científico publicado en 2016

Lifetime manic–hypomanic symptoms in post-traumatic stress disorder: Relationship with the 18 kDa mitochondrial translocator protein density

artículo científico publicado en 2010

Locking PDK1 in DFG-out conformation through 2-oxo-indole containing molecules: Another tools to fight glioblastoma

artículo científico publicado en 2016

Long Residence Time at the Neurosteroidogenic 18 kDa Translocator Protein Characterizes the Anxiolytic Ligand XBD173.

artículo científico publicado en 2016

Long lasting MDM2/Translocator protein modulator: a new strategy for irreversible apoptosis of human glioblastoma cells

artículo científico publicado en 2016

Long lasting inhibition of Mdm2-p53 interaction potentiates mesenchymal stem cell differentiation into osteoblasts

artículo científico publicado en 2019

Memantine prodrug as a new agent for Alzheimer's Disease

artículo científico publicado en 2019

Microglial Pro-Inflammatory and Anti-Inflammatory Phenotypes Are Modulated by Translocator Protein Activation

artículo científico publicado en 2019

Mitochondriotropic and Cardioprotective Effects of Triphenylphosphonium-Conjugated Derivatives of the Diterpenoid Isosteviol.

artículo científico publicado en 2017

Modulation of A1 and A2B adenosine receptor activity: a new strategy to sensitise glioblastoma stem cells to chemotherapy

artículo científico publicado en 2014

Modulation of A2B adenosine receptor by 1-Benzyl-3-ketoindole derivatives

artículo científico publicado en 2013

Modulation of PAR(1) signalling by benzimidazole compounds

artículo científico publicado en 2012

Multiscale morphology of organic semiconductor thin films controls the adhesion and viability of human neural cells.

artículo científico publicado en 2010

Mutation analysis of oxytocin gene in individuals with adult separation anxiety

article

N'-Phenylindol-3-ylglyoxylohydrazide derivatives: synthesis, structure-activity relationships, molecular modeling studies, and pharmacological action on brain benzodiazepine receptors.

artículo científico publicado en 1998

N,N-dialkyl-2-phenylindol-3-ylglyoxylamides. A new class of potent and selective ligands at the peripheral benzodiazepine receptor.

artículo científico publicado en 2004

Negative effects of a high tumour necrosis factor-α concentration on human gingival mesenchymal stem cell trophism: the use of natural compounds as modulatory agents.

artículo científico publicado en 2018

New 2-arylpyrazolo[3,4-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand-receptor modeling studies

artículo científico publicado en 2007

New 3-, 8-disubstituted pyrazolo[5,1-c][1,2,4]benzotriazines useful for studying the interaction with the HBp-3 area (hydrogen bond point area) in the benzodiazepine site on the γ-aminobutyric acid type A (GABAA) receptor.

artículo científico publicado en 2011

New 6- and 7-heterocyclyl-1H-indole derivatives as potent tubulin assembly and cancer cell growth inhibitors.

artículo científico publicado en 2018

New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer

artículo científico publicado en 2015

New fluorescent 2-phenylindolglyoxylamide derivatives as probes targeting the peripheral-type benzodiazepine receptor: design, synthesis, and biological evaluation.

artículo científico publicado en 2007

New fluoro derivatives of the pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide system: evaluation of fluorine binding properties in the benzodiazepine site on γ-aminobutyrric acid type A (GABA(A)) receptor. Design, synthesis, biological, and molecular mo

artículo científico publicado en 2010

New insight into the central benzodiazepine receptor-ligand interactions: design, synthesis, biological evaluation, and molecular modeling of 3-substituted 6-phenyl-4H-imidazo[1,5-a][1,4]benzodiazepines and related compounds

artículo científico publicado en 2011

New insights into the anticancer activity of carnosol: p53 reactivation in the U87MG human glioblastoma cell line

artículo científico publicado en 2016

New pyrazolo[3,4-b]pyridones as selective A(1) adenosine receptor antagonists: synthesis, biological evaluation and molecular modelling studies

artículo científico publicado en 2005

Norepinephrine-mediated regulation of 5HT1 receptor functioning in human platelets.

artículo científico publicado en 2008

Novel 3-aroylpyrazolo[5,1-c][1,2,4]benzotriazine 5-oxides 8-substituted, ligands at GABAA/benzodiazepine receptor complex: synthesis, pharmacological and molecular modeling studies

artículo científico publicado en 2008

Novel 3-iodo-8-ethoxypyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide as promising lead for design of alpha5-inverse agonist useful tools for therapy of mnemonic damage

artículo científico publicado en 2007

Novel N-(arylalkyl)indol-3-ylglyoxylylamides targeted as ligands of the benzodiazepine receptor: synthesis, biological evaluation, and molecular modeling analysis of the structure-activity relationships.

artículo científico publicado en 2001

Novel N-substituted indol-3-ylglyoxylamides probing the LDi and L1/L2 lipophilic regions of the benzodiazepine receptor site in search for subtype-selective ligands

artículo científico publicado en 2007

Novel N2-substituted pyrazolo[3,4-d]pyrimidine adenosine A3 receptor antagonists: inhibition of A3-mediated human glioblastoma cell proliferation.

artículo científico publicado en 2010

Novel fluorescent triazinobenzimidazole derivatives as probes for labelling human A1 and A2B adenosine receptor subtypes

artículo científico publicado en 2018

Novel imidazoline compounds as partial or full agonists of D2-like dopamine receptors inspired by I2-imidazoline binding sites ligand 2-BFI.

artículo científico publicado en 2010

Novel irreversible fluorescent probes targeting the 18 kDa translocator protein: synthesis and biological characterization.

artículo científico publicado en 2010

Novel positive allosteric modulators of A<sub>2B</sub> adenosine receptor acting as bone mineralisation promoters

artículo científico publicado en 2021

Novel, highly potent adenosine deaminase inhibitors containing the pyrazolo[3,4-d]pyrimidine ring system. Synthesis, structure-activity relationships, and molecular modeling studies.

artículo científico publicado en 2005

Osteoblast differentiation and survival: A role for A2B adenosine receptor allosteric modulators

artículo científico publicado en 2014

Osteogenesis Is Improved by Low Tumor Necrosis Factor Alpha Concentration through the Modulation of Gs-Coupled Receptor Signals

artículo científico publicado en 2017

Oxysterols act as promiscuous ligands of class-A GPCRs: in silico molecular modeling and in vitro validation

artículo científico publicado en 2014

Oxytocin receptor and G-protein polymorphisms in patients with depression and separation anxiety

artículo científico publicado en 2017

Oxytocin receptor gene variation, behavioural inhibition, and adult separation anxiety: Role in complicated grief

artículo científico publicado en 2018

Oxytocin receptor polymorphisms and adult attachment style in patients with depression

artículo científico publicado en 2009

PIGA (N,N-Di-n-butyl-5-chloro-2-(4-chlorophenyl)indol-3-ylglyoxylamide), a new mitochondrial benzodiazepine-receptor ligand, induces apoptosis in C6 glioma cells.

artículo científico publicado en 2005

PK 11195 differentially affects cell survival in human wild-type and 18 kDa translocator protein-silenced ADF astrocytoma cells

artículo científico publicado en 2008

Partial characterization of 3H-imipramine and 3H-paroxetine binding sites from calf striatum cerebral membranes

Peripheral benzodiazepine receptor ligands: mitochondrial transmembrane potential depolarization and apoptosis induction in rat C6 glioma cells

scientific journal article

Peripheral benzodiazepine receptor: characterization in human T-lymphoma Jurkat cells

artículo científico publicado en 2005

Peripheral-type benzodiazepine receptor binding sites in platelets of patients with panic disorder associated to separation anxiety symptoms

artículo científico publicado en 2005

Peripheral-type benzodiazepine receptor ligands: mitochondrial permeability transition induction in rat cardiac tissue.

artículo científico publicado en 2001

Phenotypic changes, signaling pathway, and functional correlates of GPR17-expressing neural precursor cells during oligodendrocyte differentiation

artículo científico publicado en 2011

Physical Exercise Improves Total Antioxidant Capacity and Gene Expression in Rat Hippocampal Tissue

artículo científico publicado en 2017

Plasma and serum brain-derived neurotrophic factor (BDNF) in depressed patients during 1 year of antidepressant treatments

artículo científico publicado en 2007

Platelet 18 kDa Translocator Protein density is reduced in depressed patients with adult separation anxiety

artículo científico publicado en 2007

Platelet peripheral benzodiazepine receptors are decreased in Parkinson's disease

artículo científico publicado en 1991

Platelet uptake of GABA and glutamate in patients with bipolar disorder

artículo científico publicado en 2012

Potential Diagnostic Value of Red Blood Cells α-Synuclein Heteroaggregates in Alzheimer's Disease

artículo científico publicado en 2019

Potential biomarkers and novel pharmacological targets in protein aggregation-related neurodegenerative diseases

artículo científico publicado en 2017

Preface

Preface to a supplement to Pharmacy World on the 5TH Symposium of the European Society for the Study of Purine & Pyrimidtne Metabolism in Man (ESSPPMM 1995)

Preparation and pharmacological characterization of trans-2-amino-5(6)-fluoro-6(5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes as D2-like dopamine receptor agonists

artículo científico publicado en 2005

Prevention of excessive endothelin-1 release in sclerotherapy: in vitro and in vivo studies

artículo científico publicado en 2014

Protective effect of high-dose montelukast on salbutamol-induced homologous desensitisation in airway smooth muscle

artículo científico publicado en 2013

Purification and characterization of the serotonin transporter from human brain

scholarly article by A. Rotondo et al published September 1994 in European Neuropsychopharmacology

Pyrazolo[1,5-a]pyrimidine acetamides: 4-Phenyl alkyl ether derivatives as potent ligands for the 18 kDa translocator protein (TSPO).

artículo científico publicado en 2010

Pyrazolo[1,5-a]quinazoline scaffold as 5-deaza analogue of pyrazolo[5,1-c][1,2,4]benzotriazine system: synthesis of new derivatives, biological activity on GABAA receptor subtype and molecular dynamic study.

artículo científico publicado en 2015

Pyrazolo[4,5-c]quinolines. 2. Synthesis and specific inhibition of benzodiazepine receptor binding.

artículo científico publicado en 1986

Pyrido[2,3-e]-1,2,4-triazolo[4,3-a]pyrazin-1-one as a new scaffold to develop potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand-receptor modeling studies

artículo científico publicado en 2009

Receptor crosstalk: haloperidol treatment enhances A2A adenosine receptor functioning in a transfected cell model ⬇️

artículo científico publicado el 12 de octubre de 2010

Reductions in Platelet 18-kDa Translocator Protein Density Are Associated with Adult Separation Anxiety in Patients with Bipolar Disorder

artículo científico publicado en 2010

Refinement of the benzodiazepine receptor site topology by structure-activity relationships of new N-(heteroarylmethyl)indol-3-ylglyoxylamides

artículo científico publicado en 2006

Regulation of A(2A) adenosine receptor expression and functioning following permanent focal ischemia in rat brain

artículo científico publicado en 2007

Regulation of A1 adenosine receptor functioning induced by P2Y1 purinergic receptor activation in human astroglial cells.

artículo científico publicado en 2008

Regulation of A2B adenosine receptor functioning by tumour necrosis factor a in human astroglial cells

artículo científico publicado en 2004

Regulation of Erythropoietin Receptor Activity in Endothelial Cells by Different Erythropoietin (EPO) Derivatives: An in Vitro Study

artículo científico publicado en 2013

Regulation of PC12 cell survival and differentiation by the new P2Y-like receptor GPR17.

artículo científico publicado en 2010

Regulation of agonist binding to A2A adenosine receptors: Effects of guanine nucleotides (GDP[S] and GTP[S]) and Mg2+ ion

artículo científico publicado en 1993

Remarkable Enhancement in Boron Uptake Within Glioblastoma Cells With Carboranyl-Indole Carboxamides

Residence Time, a New parameter to Predict Neurosteroidogenic Efficacy of Translocator Protein (TSPO) Ligands: the Case Study of N,N-Dialkyl-2-arylindol-3-ylglyoxylamides

artículo científico publicado en 2017

Ribose-modified nucleosides as ligands for adenosine receptors: synthesis, conformational analysis, and biological evaluation of 1'-C-methyl adenosine analogues

artículo científico publicado en 2002

Serotonin-mediated cyclic AMP inhibitory pathway in platelets of patients affected by panic disorder

artículo científico publicado en 2004

Serotonin-mediated phosphorylation of extracellular regulated kinases in platelets of patients with panic disorder versus controls

artículo científico publicado en 2004

Short-term TNF-Alpha treatment induced A2B adenosine receptor desensitization in human astroglial cells

artículo científico publicado en 2008

Short-term effects of 3,4-methylen-dioxy-metamphetamine (MDMA) on 5-HT(1A) receptors in the rat hippocampus

artículo científico publicado en 2007

Simultaneous Targeting of RGD-Integrins and Dual Murine Double Minute Proteins in Glioblastoma Multiforme.

artículo científico publicado en 2018

Solubilization and characterization of [3H]Imipramine and [3H]Paroxetine binding sites from calf striatum

artículo científico publicado en 1994

Solubilization of adenosine A(1) binding sites from sheep cortex

artículo científico publicado en 1985

Solubilization of rat kidney benzodiazepine binding sites ⬇️

artículo científico publicado el 9 de marzo de 1983

Specific Adsorbents for Affinity Chromatography of Benzodiazepine Binding Proteins

scientific article published on 01 January 1981

Specific inhibition of benzodiazepine receptor binding by some 6H-indolo[2,3-b] [1,8]naphthyridines and 11H-indolo [3,2-c] [1,8]naphthyridines

artículo científico publicado el 1 de noviembre de 1982

Specific inhibition of benzodiazepine receptor binding by some N-(2-methyl or 1,2-dimethylindol-3-ylglyoxylyl)amino acid derivatives.

artículo científico publicado en 1990

Specific inhibition of benzodiazepine receptor binding by some N-(indol-3-ylglyoxylyl) amino acid derivatives: stereoselective interactions

artículo científico publicado en 1989

Specific inhibition of binding to benzodiazepine receptors by 1,2,3-triazole derivatives

artículo científico publicado en 1992

Spirotetrahydronaphthalene analogues of sympathomimetic catecholamines. Synthesis and adrenergic activity of 5,6- and 6,7-dihydroxy-3,4-dihydrospiro[naphthalen-1 (2H)-3'-piperidines].

artículo científico publicado en 2002

Stress-related changes of benzodiazepine binding inhibitory activity (B.B.I.A.) in humans

artículo científico publicado en 1990

Structure-activity relationship refinement and further assessment of 4-phenylquinazoline-2-carboxamide translocator protein ligands as antiproliferative agents in human glioblastoma tumors

artículo científico publicado en 2014

Structure-activity relationship studies and in vitro and in vivo anticancer activity of novel 3-aroyl-1,4-diarylpyrroles against solid tumors and hematological malignancies

artículo científico publicado en 2019

Structure-activity relationships of 1,2,4-triazolo[1,5-a] quinoxalines and their 1-deaza analogues imidazo[1,2-a]quinoxalines at the benzodiazepine receptor

scientific article published on 01 September 1994

Structure-based lead optimization and biological evaluation of BAX direct activators as novel potential anticancer agents.

artículo científico publicado en 2015

Structure-based optimization of pyrazolo[3,4-d]pyrimidines as Abl inhibitors and antiproliferative agents toward human leukemia cell lines.

artículo científico publicado en 2008

Studies on Specific Inhibition of Benzodiazepine Receptor Binding by Some C-Benzoyl-1,2,3-triazole Derivatives

artículo científico publicado en 1993

Studies on annulated 1,4-benzothiazines and 1,5-benzothiazepines. IX. Imidazo [2,1-d][1,5] benzothiazepines: synthesis and in vitro benzodiazepine receptor affinity

Studies on enantioselectivity of chiral 4-acetylamino-6-alkyloxy-2-alkylthiopyrimidines acting as antagonists of the human A adenosine receptor

scientific article published on 09 November 2017

Substituted pyrazolo[3,4-b]pyridines as human A1 adenosine antagonists: developments in understanding the receptor stereoselectivity

artículo científico publicado en 2011

Substituted pyrazolo[3,4-b]pyridines as potent A1 adenosine antagonists: synthesis, biological evaluation, and development of an A1 bovine receptor model

artículo científico publicado en 2008

Synthesis and 3D QSAR of new pyrazolo[3,4-b]pyridines: potent and selective inhibitors of A1 adenosine receptors

artículo científico publicado en 2005

Synthesis and A1 and A2A adenosine binding activity of some pyrano[2,3-c]pyrazol-4-ones.

artículo científico publicado en 1998

Synthesis and Antihypertensive Action of New Imidazo[1,2-a]pyridine Derivatives , non Peptidic Angiotensin II Receptor Antagonists

artículo científico publicado en 2011

Synthesis and BZR affinity of pyrazolo[1,5-a]pyrimidine derivatives. Part 1: study of the structural features for BZR recognition

artículo científico publicado en 1999

Synthesis and Pharmacological Evaluation of Novel GABAA Subtype Receptor Ligands with Potential Anxiolytic-like and Anti-hyperalgesic Effect

scholarly article by Gabriella Guerrini et al published 11 May 2017 in Journal of Heterocyclic Chemistry

Synthesis and Structure−Activity Relationships of a New Set of 2-Arylpyrazolo[3,4-c]quinoline Derivatives as Adenosine Receptor Antagonists

artículo científico publicado en 2000

Synthesis and aldose reductase inhibitory activity of N-(arylsulfonyl)- and N-(aroyl)-N-(arylmethyloxy)glycines

Synthesis and benzodiazepine receptor affinity of derivatives of the new tricyclic heteroaromatic system pyrido[3',2':5,6]thiopyrano[4,3-c]pyridazin-3(2H,5H)-one

artículo científico publicado en 2005

Synthesis and benzodiazepine receptor affinity of pyrazolo[1,5-a]pyrimidine derivatives. 3. New 6-(3-thienyl) series as alpha 1 selective ligands.

artículo científico publicado en 2003

Synthesis and benzodiazepine receptor binding activity of 2, 9-disubstituted quinolino[2', 3'-5, 4](3-pyrazolino)[3, 2-b]purin-4-ones

artículo científico publicado en 2002

Synthesis and biological data of 4-amino-1-(2-chloro-2-phenylethyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl esters, a new series of A1-adenosine receptor (A1AR) ligands.

artículo científico publicado en 2001

Synthesis and biological evaluation in U87MG glioma cells of (ethynylthiophene)sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors

artículo científico publicado en 2011

Synthesis and biological evaluation of 4-phenylquinazoline-2-carboxamides designed as a novel class of potent ligands of the translocator protein

artículo científico publicado en 2012

Synthesis and evaluation of translocator 18 kDa protein (TSPO) positron emission tomography (PET) radioligands with low binding sensitivity to human single nucleotide polymorphism rs6971.

artículo científico publicado en 2014

Synthesis and pharmacological evaluation of pyrazolo[1,5-a]pyrimidin-7(4H)-one derivatives as potential GABAA-R ligands

artículo científico publicado en 2017

Synthesis and preliminary pharmacological evaluation of 5-hydroxy- and 5,6-dihydroxy-1,2,3,7,12,12a-hexahydrobenzo[5,6]cyclohepta[1,2,3-ij]isoquinoline derivatives as dopamine receptor ligands.

artículo científico publicado en 2001

Synthesis and preliminary pharmacological evaluation of trans-2-amino-5(6)-chloro-6(5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes as dopamine receptor ligands

artículo científico publicado en 2002

Synthesis and structure-activity relationships of 4-cycloalkylamino-1, 2, 4-triazolo[4, 3-a]quinoxalin-1- one derivatives as A1 and A3 adenosine receptor antagonists

artículo científico publicado en 2004

Synthesis and structure-activity relationships of a new set of 1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as adenosine receptor antagonists

artículo científico publicado en 2003

Synthesis and β-adrenergic properties of tetrahydronaphthalene analogs of dichloroisoproterenol

Synthesis of 1,5-diaryl-3-methyl-1H-pyrazolo[4,5-c]isoquinolines and studies of binding to specific peripheral benzodiazepine binding sites.

artículo científico publicado en 1989

Synthesis of 1-(2-chloro-2-phenylethyl)-6-methylthio-1H-pyrazolo[3,4-d]pyrimidines 4-amino substituted and their biological evaluation.

artículo científico publicado en 2004

Synthesis of 4-amino-6-(hetero)arylalkylamino-1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as potent A(2A) adenosine receptor antagonists

artículo científico publicado en 2003

Synthesis of 6-[¹⁸F]fluoro-PBR28, a novel radiotracer for imaging the TSPO 18 kDa with PET.

artículo científico publicado en 2011

Synthesis of New GABA Receptor Modulator with Pyrazolo[1,5-a]quinazoline (PQ) Scaffold ⬇️

scientific article published on 21 March 2019

Synthesis of novel 4-aryl-1,2,3,4-tetrahydroisoquinolines as probes for dopamine receptor ligands

artículo científico publicado en 2012

Synthesis of novel cognition enhancers with pyrazolo[5,1-c][1,2,4]benzotriazine core acting at γ-aminobutyric acid type A (GABA(A)) receptor

artículo científico publicado en 2013

Synthesis of some 2-aryl-1,2,4-triazolo[1,5-c][1,3]benzoxazin-5-ones as tools to define the essential pharmacophoric descriptors of a benzodiazepine receptor ligand

scientific article published on 01 June 1995

Synthesis of some tricyclic heteroaromatic systems and their A1 and A2a adenosine binding activity

Synthesis, benzodiazepine receptor affinity and in vivo testing of 3-aryl-4,7-dihydro-6-(N1′-alkylpyrazol-3′ - or 5′-yl)pyrazolo[1,5-a]pyrimidin-7-ones

Synthesis, benzodiazepine receptor binding and molecular modelling of isochromeno[4,3-c]pyrazol-5(1H)-one derivatives.

artículo científico publicado en 2012

Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists

artículo científico publicado en 2005

Synthesis, in vivo evaluation, and molecular modeling studies of new pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide derivatives. Identification of a bifunctional hydrogen bond area related to the inverse agonism

artículo científico publicado en 2009

Synthesis, ligand-receptor modeling studies and pharmacological evaluation of novel 4-modified-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as potent and selective human A3 adenosine receptor antagonists

artículo científico publicado en 2008

Synthesis, molecular modeling studies, and pharmacological activity of selective A(1) receptor antagonists

artículo científico publicado en 2002

Synthesis, structure-activity relationships, and molecular modeling studies of N-(indol-3-ylglyoxylyl)benzylamine derivatives acting at the benzodiazepine receptor.

artículo científico publicado en 1996

TSPO PIGA Ligands Promote Neurosteroidogenesis and Human Astrocyte Well-Being

artículo científico publicado en 2016

TSPO ligand residence time influences human glioblastoma multiforme cell death/life balance.

artículo científico publicado en 2015

TSPO ligand residence time: a new parameter to predict compound neurosteroidogenic efficacy

artículo científico publicado en 2016

TSPO over-expression increases motility, transmigration and proliferation properties of C6 rat glioma cells

scientific journal article

TSPO-ligands prevent oxidative damage and inflammatory response in C6 glioma cells by neurosteroid synthesis

artículo científico publicado en 2016

Targeting the 18-kDa translocator protein: recent perspectives for neuroprotection

artículo científico publicado en 2015

Tertiary amides with a five-membered heteroaromatic ring as new probes for the translocator protein.

artículo científico publicado en 2011

The 5-HT1A receptor subtype in various regions of the human brain

The A2B Adenosine Receptor Modulates the Epithelial- Mesenchymal Transition through the Balance of cAMP/PKA and MAPK/ERK Pathway Activation in Human Epithelial Lung Cells

artículo científico publicado en 2018

The Anxiolytic Etifoxine Binds to TSPO Ro5-4864 Binding Site with Long Residence Time Showing a High Neurosteroidogenic Activity

artículo científico publicado en 2017

The Citrus Flavanone Naringenin Produces Cardioprotective Effects in Hearts from 1 Year Old Rat, through Activation of mitoBK Channels.

artículo científico publicado en 2017

The Citrus Flavanone Naringenin Protects Myocardial Cells against Age-Associated Damage.

artículo científico publicado en 2017

The Citrus Flavonoid Naringenin Protects the Myocardium from Ageing-Dependent Dysfunction: Potential Role of SIRT1

scientific article published on 25 January 2020

The Ionophoric Activity of a Pro-Apoptotic VEGF165 Fragment on HUVEC Cells

scientific article published on 20 April 2020

The Peripheral-Type Benzodiazepine Receptor Ligands [3H]Ro 5-4864 and [3H]PK 11195 Bind to the Retina of Rabbit, but Not of Turtle

artículo científico publicado en 1993

The [(Methyloxy)imino]methyl Moiety as a Bioisoster of Aryl. A Novel Class of Completely Aliphatic .beta.-Adrenergic Receptor Antagonists

artículo científico publicado en 1994

The identification of the 2-phenylphthalazin-1(2H)-one scaffold as a new decorable core skeleton for the design of potent and selective human A3 adenosine receptor antagonists

artículo científico publicado en 2011

The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor

artículo científico publicado en 2006

The oxysterol-CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils

artículo científico publicado en 2013

The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair

artículo científico publicado en 2008

The role of newer antiglutamatergic agents as mood-stabilizers in bipolar disorder

artículo científico publicado en 2005

The role of peripheral benzodiazepine receptors on the function and survival of isolated human pancreatic islets

artículo científico publicado en 2004

The spontaneous Ala147Thr amino acid substitution within the translocator protein influences pregnenolone production in lymphomonocytes of healthy individuals

artículo científico publicado en 2009

The ubiquitin ligase Mdm2 controls oligodendrocyte maturation by intertwining mTOR with G protein-coupled receptor kinase 2 in the regulation of GPR17 receptor desensitization

artículo científico publicado en 2015

Theranostic properties of a survivin-directed molecular beacon in human melanoma cells

artículo científico publicado en 2014

Toward PET imaging of A2B adenosine receptors: a carbon-11 labeled triazinobenzimidazole tracer: Synthesis and imaging of a new A2B PET tracer.

artículo científico publicado en 2016

Toward highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitors

artículo científico publicado en 2012

Translocator Protein as a Promising Target for Novel Anxiolytics ⬇️

artículo científico publicado el 1 de enero de 2012

Translocator protein and steroidogenesis.

artículo científico publicado en 2018

Translocator protein ligands as promising therapeutic tools for anxiety disorders

artículo científico publicado en 2009

Trazodone regulates neurotrophic/growth factors, mitogen-activated protein kinases and lactate release in human primary astrocytes

artículo científico publicado en 2015

Trazodone treatment protects neuronal-like cells from inflammatory insult by inhibiting NF-κB, p38 and JNK.

artículo científico publicado en 2015

Tricyclic heteroaromatic systems. Synthesis and A1 and A2a adenosine binding activities of some 1-aryl-1,4-dihydro-3-methyl[1]benzopyrano[2,3-c] pyrazol-4-ones, 1-aryl-4,9-dihydro-3-methyl-1H-pyrazolo[3,4-b]quinolin-4- ones, and 1-aryl-1H-imidazo[4,

scientific article published on 01 April 1995

Tricyclic heteroaromatic systems. Synthesis and benzodiazepine binding activity of 1-substituted-3-methyl- and 3-phenylpyrazolo[4,5-c]quinolin-4-ones

artículo científico publicado el 1 de julio de 1992

Tricyclic heteroaromatic systems. Synthesis and benzodiazepine receptor affinity of 2-substituted-1-benzopyrano[3,4-d]oxazol-4-ones, -thiazol-4-ones, and -imidazol-4-ones

Tricyclic heteroaromatic systems. Synthesis of 1,3 and 1,2 disubstituted [1]benzopyrano[4,3-b]pyrrol-4-ones and structure-activity relationships as benzodiazepine receptor ligands

artículo científico publicado el 1 de octubre de 1991

Tricyclic heteroaromatic systems. [1]benzopyranopyrrol-4-ones and [1]benzopyrano-1,2,3-triazol-4-ones as benzodiazepine receptor ligands. Synthesis and structure-activity relationships

artículo científico publicado en 1990

Tricyclic heteroaromatic systems: [1]benzopyrano-pyrazol-4-ones as benzodiazepine receptor ligands.

artículo científico publicado en 1991

Tricyclic heteroaromatic systems: synthesis, [3H]flunitrazepam brain membrane binding inhibition, and structure-activity relationships of 2,3-dihydro-2-aryl-4-R-[1]benzopyrano[4,3-c]pyrazole-3-ones

artículo científico publicado en 1989

Unbinding of Translocator Protein 18 kDa (TSPO) Ligands: From in Vitro Residence Time to in Vivo Efficacy via in Silico Simulations

scientific article published on 03 July 2019

Up-regulation of A(2A) adenosine receptors by proinflammatory cytokines in rat PC12 cells

artículo científico publicado en 2002

Upregulation of A2A adenosine receptors in platelets from patients affected by bipolar disorders under treatment with typical antipsychotics

artículo científico publicado en 2006

Upregulation of mitochondrial peripheral benzodiazepine receptor expression by cytokine-induced damage of human pancreatic islets

artículo científico publicado en 2002

[(3)H]ouabain binding to ox brain membranes: Characterization of a high-affinity binding site.

artículo científico publicado en 1990

[35S]TBPS binding to purified benzodiazepine-GABA-ionophore receptor complex: the effect of GABA on the modulation exerted by benzodiazepine site ligands

artículo científico publicado en 1989

[3H]muscimol binding site on purified benzodiazepine receptor.

artículo científico publicado en 1983

p53 functional inhibitors behaving like pifithrin-β counteract the Alzheimer peptide non-β-amyloid component effects in human SH-SY5Y cells

artículo científico publicado en 2014

α-Synuclein Aggregated with Tau and β-Amyloid in Human Platelets from Healthy Subjects: Correlation with Physical Exercise.

artículo científico publicado en 2018

α-Synuclein Aggregates with β-Amyloid or Tau in Human Red Blood Cells: Correlation with Antioxidant Capability and Physical Exercise in Human Healthy Subjects

artículo científico publicado en 2017

α-Synuclein Heterocomplexes with β-Amyloid Are Increased in Red Blood Cells of Parkinson's Disease Patients and Correlate with Disease Severity.

artículo científico publicado en 2018

α-Synuclein Heteromers in Red Blood Cells of Alzheimer’s Disease and Lewy Body Dementia Patients

artículo científico publicado en 2021

♦Copper (II) ions modulate Angiogenin activity in human endothelial cells.

artículo científico publicado en 2015

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