Lista de obras - Sean M Kerwin - Dominio Público Uruguay

2-Alkynyl-N-propargyl pyridinium salts: pyridinium-based heterocyclic skipped aza-enediynes that cleave DNA by deoxyribosyl hydrogen-atom abstraction and guanine oxidation.

artículo científico publicado en 2006

A fluorescence-based assay for p38α recruitment site binders: identification of rooperol as a novel p38α kinase inhibitor.

artículo científico publicado en 2012

Alternative DNA structure formation in the mutagenic human c-MYC promoter

artículo científico publicado en 2017

An extremely facile aza-Bergman rearrangement of sterically unencumbered acyclic 3-aza-3-ene-1,5-diynes

artículo científico publicado en 2003

An improved synthesis of (+/-)-N'-nitrosonornicotine 5'-acetate

artículo científico publicado en 2009

ChemBioOffice Ultra 2010 suite

artículo científico publicado en 2010

Coupling reactions of bromoalkynes with imidazoles mediated by copper salts: synthesis of novel N-alkynylimidazoles

scientific article published on 23 July 2008

Cyclization kinetics and biological evaluation of an anticancer 1,2-dialkynylimidazole.

artículo científico publicado en 2010

Cytoprotection of human endothelial cells from menadione cytotoxicity by caffeic acid phenethyl ester: the role of heme oxygenase-1.

artículo científico publicado en 2008

Cytoprotective effect of caffeic acid phenethyl ester (CAPE) and catechol ring-fluorinated CAPE derivatives against menadione-induced oxidative stress in human endothelial cells.

artículo científico publicado en 2006

Cytotoxic 1,2-dialkynylimidazole-based aza-enediynes: aza-Bergman rearrangement rates do not predict cytotoxicity

artículo científico publicado en 2011

DNA modification by 4-aza-3-ene-1,6-diynes: DNA cleavage, pH-dependent cytosine-specific interactions, and cancer cell cytotoxicity

artículo científico publicado en 2002

Design of new topoisomerase II inhibitors based upon a quinobenzoxazine self-assembly model

scientific article published on 01 October 1998

Development and validation of an LCMS method to determine the pharmacokinetic profiles of caffeic acid phenethyl amide and caffeic acid phenethyl ester in male Sprague-Dawley rats.

artículo científico publicado en 2013

Duplex and quadruplex DNA binding and photocleavage by trioxatriangulenium ion.

artículo científico publicado en 2005

Efficient, Mg(2+)-dependent photochemical DNA cleavage by the antitumor quinobenzoxazine (S)-A-62176.

artículo científico

Efficient, regioselective access to bicyclic imidazo[1,2-x]- heterocycles via gold- and base-promoted cyclization of 1-alkynylimidazoles

artículo científico publicado en 2009

Enediynes from aza-enediynes: C,N-dialkynyl imines undergo both aza-Bergman rearrangement and conversion to enediynes and fumaronitriles

artículo científico publicado en 2006

Evaluation of binding of perylene diimide and benzannulated perylene diimide ligands to DNA by electrospray ionization mass spectrometry.

artículo científico

Evaluation of complexes of DNA duplexes and novel benzoxazoles or benzimidazoles by electrospray ionization mass spectrometry

artículo científico publicado en 2004

Evaluation of metal-mediated DNA binding of benzoxazole ligands by electrospray ionization mass spectrometry

artículo científico publicado en 2007

Flexible and modular 3D-printed peptide models

scientific article published on 26 April 2019

G-quadruplex DNA binding by a series of carbocyanine dyes

artículo científico publicado en 2001

G-quadruplex DNA cleavage preference and identification of a perylene diimide G-quadruplex photocleavage agent using a rapid fluorescent assay.

artículo científico publicado en 2012

Identification of the adduct between a 4-Aza-3-ene-1,6-diyne and DNA using electrospray ionization mass spectrometry

artículo científico publicado en 2006

Inhibition of human telomerase by 7-deaza-2'-deoxyguanosine nucleoside triphosphate analogs: potent inhibition by 6-thio-7-deaza-2'-deoxyguanosine 5'-triphosphate

artículo científico publicado en 2001

Inhibition of human telomerase by a G-quadruplex-interactive compound

artículo científico publicado en 1997

Investigation of quadruplex oligonucleotide-drug interactions by electrospray ionization mass spectrometry.

artículo científico publicado en 2002

N-Methylmesoporphyrin IX Exhibits G-Quadruplex-Specific Photocleavage Activity

scientific article published on 27 May 2019

N-propargyl-2-alkynylbenzothiazolium aza-enediynes: role of the 2-alkynylbenzothiazolium functionality in DNA cleavage

artículo científico publicado en 2001

NMR-Based model of a telomerase-inhibiting compound bound to G-quadruplex DNA.

artículo científico publicado en 1998

New transition metal ion complexes with benzimidazole-5-carboxylic acid hydrazides with antitumor activity

artículo científico publicado en 2008

Perylene diimide G-quadruplex DNA binding selectivity is mediated by ligand aggregation

artículo científico publicado en 2002

Pharmacokinetics of caffeic acid phenethyl ester and its catechol-ring fluorinated derivative following intravenous administration to rats.

artículo científico publicado en 2009

Preparation and Utility of -Alkynyl Azoles in Synthesis

Quantitative determination of fluorinated caffeic acid phenethyl ester derivative from rat blood plasma by liquid chromatography-electrospray ionization tandem mass spectrometry

artículo científico publicado en 2008

Real-time investigation of SV40 large T-antigen helicase activity using surface plasmon resonance

artículo científico publicado en 2008

Self-assembly of a quinobenzoxazine-Mg2+ complex on DNA: a new paradigm for the structure of a drug-DNA complex and implications for the structure of the quinolone bacterial gyrase-DNA complex

scientific article published on 01 February 1995

Simian virus 40 large T-antigen G-quadruplex DNA helicase inhibition by G-quadruplex DNA-interactive agents

artículo científico

Solution structure of a conserved DNA sequence from the HIV-1 genome: restrained molecular dynamics simulation with distance and torsion angle restraints derived from two-dimensional NMR spectra

artículo científico publicado en 1993

Stability of caffeic acid phenethyl amide (CAPA) in rat plasma

artículo científico publicado en 2011

Stability of caffeic acid phenethyl ester and its fluorinated derivative in rat plasma

artículo científico publicado en 2007

Structure-activity relationships in the cytoprotective effect of caffeic acid phenethyl ester (CAPE) and fluorinated derivatives: effects on heme oxygenase-1 induction and antioxidant activities

artículo científico publicado en 2010

Structure-based design and characterization of novel platforms for ricin and shiga toxin inhibition

artículo científico publicado en 2002

Synthesis and Evaluation of a Rationally Designed Click-Based Library for G-Quadruplex Selective DNA Photocleavage.

artículo científico publicado en 2015

Synthesis and biological evaluation of p38alpha kinase-targeting dialkynylimidazoles.

artículo científico publicado en 2009

Synthesis and docking studies of novel antitumor benzimidazoles.

artículo científico publicado en 2012

Synthesis and evaluation of anticancer benzoxazoles and benzimidazoles related to UK-1.

artículo científico publicado en 2002

Synthesis and thermolysis of heterocyclic 3-aza-3-ene-1,5-diynes(1).

artículo científico publicado en 2002

Synthesis of 2-substituted 9-oxa-guanines {5-aminooxazolo[5,4-d]pyrimidin-7(6H)-ones} and 9-oxa-2-thio-xanthines {5-mercaptooxazolo[5,4-d]pyrimidin-7(6H)-ones}.

artículo científico publicado en 2008

Synthesis of a series of caffeic acid phenethyl amide (CAPA) fluorinated derivatives: comparison of cytoprotective effects to caffeic acid phenethyl ester (CAPE).

artículo científico publicado en 2010

Synthesis, DNA cleavage, and cytotoxicity of a series of bis(propargylic) sulfone crown ethers

scientific article published on 01 November 2001

Synthesis, metal ion binding, and biological evaluation of new anticancer 2-(2'-hydroxyphenyl)benzoxazole analogs of UK-1

artículo científico publicado en 2007

The aggregation and G-quadruplex DNA selectivity of charged 3,4,9,10-perylenetetracarboxylic acid diimides

artículo científico publicado en 2002

The relationship between ligand aggregation and G-quadruplex DNA selectivity in a series of 3,4,9,10-perylenetetracarboxylic acid diimides

artículo científico publicado en 2002

Thermally induced DNA.RNA hybrid to G-quadruplex transitions: possible implications for telomere synthesis by telomerase

scientific article published on 01 December 1996

Toward bioengineering anticancer drugs.

artículo científico publicado en 2002

alpha,5-didehydro-3-picoline diradicals from skipped azaenediynes: computational and trapping studies of an aza-Myers-Saito cyclization

scientific article published on 01 June 2004

Lista de obras de Sean M Kerwin

2-Alkynyl-N-propargyl pyridinium salts: pyridinium-based heterocyclic skipped aza-enediynes that cleave DNA by deoxyribosyl hydrogen-atom abstraction and guanine oxidation.

A fluorescence-based assay for p38α recruitment site binders: identification of rooperol as a novel p38α kinase inhibitor.

Alternative DNA structure formation in the mutagenic human c-MYC promoter

An extremely facile aza-Bergman rearrangement of sterically unencumbered acyclic 3-aza-3-ene-1,5-diynes

An improved synthesis of (+/-)-N'-nitrosonornicotine 5'-acetate

ChemBioOffice Ultra 2010 suite

Coupling reactions of bromoalkynes with imidazoles mediated by copper salts: synthesis of novel N-alkynylimidazoles

Cyclization kinetics and biological evaluation of an anticancer 1,2-dialkynylimidazole.

Cytoprotection of human endothelial cells from menadione cytotoxicity by caffeic acid phenethyl ester: the role of heme oxygenase-1.

Cytoprotective effect of caffeic acid phenethyl ester (CAPE) and catechol ring-fluorinated CAPE derivatives against menadione-induced oxidative stress in human endothelial cells.

Cytotoxic 1,2-dialkynylimidazole-based aza-enediynes: aza-Bergman rearrangement rates do not predict cytotoxicity

DNA modification by 4-aza-3-ene-1,6-diynes: DNA cleavage, pH-dependent cytosine-specific interactions, and cancer cell cytotoxicity

Design of new topoisomerase II inhibitors based upon a quinobenzoxazine self-assembly model

Development and validation of an LCMS method to determine the pharmacokinetic profiles of caffeic acid phenethyl amide and caffeic acid phenethyl ester in male Sprague-Dawley rats.

Duplex and quadruplex DNA binding and photocleavage by trioxatriangulenium ion.

Efficient, Mg(2+)-dependent photochemical DNA cleavage by the antitumor quinobenzoxazine (S)-A-62176.

Efficient, regioselective access to bicyclic imidazo[1,2-x]- heterocycles via gold- and base-promoted cyclization of 1-alkynylimidazoles

Enediynes from aza-enediynes: C,N-dialkynyl imines undergo both aza-Bergman rearrangement and conversion to enediynes and fumaronitriles

Evaluation of binding of perylene diimide and benzannulated perylene diimide ligands to DNA by electrospray ionization mass spectrometry.

Evaluation of complexes of DNA duplexes and novel benzoxazoles or benzimidazoles by electrospray ionization mass spectrometry

Evaluation of metal-mediated DNA binding of benzoxazole ligands by electrospray ionization mass spectrometry

Flexible and modular 3D-printed peptide models

G-quadruplex DNA binding by a series of carbocyanine dyes

G-quadruplex DNA cleavage preference and identification of a perylene diimide G-quadruplex photocleavage agent using a rapid fluorescent assay.

Identification of the adduct between a 4-Aza-3-ene-1,6-diyne and DNA using electrospray ionization mass spectrometry

Inhibition of human telomerase by 7-deaza-2'-deoxyguanosine nucleoside triphosphate analogs: potent inhibition by 6-thio-7-deaza-2'-deoxyguanosine 5'-triphosphate

Inhibition of human telomerase by a G-quadruplex-interactive compound

Investigation of quadruplex oligonucleotide-drug interactions by electrospray ionization mass spectrometry.

N-Methylmesoporphyrin IX Exhibits G-Quadruplex-Specific Photocleavage Activity

N-propargyl-2-alkynylbenzothiazolium aza-enediynes: role of the 2-alkynylbenzothiazolium functionality in DNA cleavage

NMR-Based model of a telomerase-inhibiting compound bound to G-quadruplex DNA.

New transition metal ion complexes with benzimidazole-5-carboxylic acid hydrazides with antitumor activity

Perylene diimide G-quadruplex DNA binding selectivity is mediated by ligand aggregation

Pharmacokinetics of caffeic acid phenethyl ester and its catechol-ring fluorinated derivative following intravenous administration to rats.

Preparation and Utility of -Alkynyl Azoles in Synthesis

Quantitative determination of fluorinated caffeic acid phenethyl ester derivative from rat blood plasma by liquid chromatography-electrospray ionization tandem mass spectrometry

Real-time investigation of SV40 large T-antigen helicase activity using surface plasmon resonance

Self-assembly of a quinobenzoxazine-Mg2+ complex on DNA: a new paradigm for the structure of a drug-DNA complex and implications for the structure of the quinolone bacterial gyrase-DNA complex

Simian virus 40 large T-antigen G-quadruplex DNA helicase inhibition by G-quadruplex DNA-interactive agents

Solution structure of a conserved DNA sequence from the HIV-1 genome: restrained molecular dynamics simulation with distance and torsion angle restraints derived from two-dimensional NMR spectra

Stability of caffeic acid phenethyl amide (CAPA) in rat plasma

Stability of caffeic acid phenethyl ester and its fluorinated derivative in rat plasma

Structure-activity relationships in the cytoprotective effect of caffeic acid phenethyl ester (CAPE) and fluorinated derivatives: effects on heme oxygenase-1 induction and antioxidant activities

Structure-based design and characterization of novel platforms for ricin and shiga toxin inhibition

Synthesis and Evaluation of a Rationally Designed Click-Based Library for G-Quadruplex Selective DNA Photocleavage.

Synthesis and biological evaluation of p38alpha kinase-targeting dialkynylimidazoles.

Synthesis and docking studies of novel antitumor benzimidazoles.

Synthesis and evaluation of anticancer benzoxazoles and benzimidazoles related to UK-1.

Synthesis and thermolysis of heterocyclic 3-aza-3-ene-1,5-diynes(1).

Synthesis of 2-substituted 9-oxa-guanines {5-aminooxazolo[5,4-d]pyrimidin-7(6H)-ones} and 9-oxa-2-thio-xanthines {5-mercaptooxazolo[5,4-d]pyrimidin-7(6H)-ones}.

Synthesis of a series of caffeic acid phenethyl amide (CAPA) fluorinated derivatives: comparison of cytoprotective effects to caffeic acid phenethyl ester (CAPE).

Synthesis, DNA cleavage, and cytotoxicity of a series of bis(propargylic) sulfone crown ethers

Synthesis, metal ion binding, and biological evaluation of new anticancer 2-(2'-hydroxyphenyl)benzoxazole analogs of UK-1

The aggregation and G-quadruplex DNA selectivity of charged 3,4,9,10-perylenetetracarboxylic acid diimides

The relationship between ligand aggregation and G-quadruplex DNA selectivity in a series of 3,4,9,10-perylenetetracarboxylic acid diimides

Thermally induced DNA.RNA hybrid to G-quadruplex transitions: possible implications for telomere synthesis by telomerase

Toward bioengineering anticancer drugs.

alpha,5-didehydro-3-picoline diradicals from skipped azaenediynes: computational and trapping studies of an aza-Myers-Saito cyclization