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Lista de obras de Thomas Mandrup-Poulsen

(19)F-heptuloses as tools for the non-invasive imaging of GLUT2-expressing cells

artículo científico publicado en 2011

35th Annual Meeting of the European Association for the Study of Diabetes

artículo científico

35th Annual Meeting of the European Association for the Study of Diabetes : Brussels, Belgium, 28 September-2 October 1999

article

A Placebo-Controlled Study on the Effects of the Glucagon-Like Peptide-1 Mimetic, Exenatide, on Insulin Secretion, Body Composition and Adipokines in Obese, Client-Owned Cats

artículo científico publicado en 2016

A Systematic Comparison of Purification and Normalization Protocols for Quantitative MicroRNA Expressional Profiling in Insulin-Producing Cells

artículo científico publicado en 2016

A genetic marker for atherosclerosis?

scientific article published on 01 May 1984

A guiding map for inflammation

artículo científico publicado en 2017

Affinity-purified human interleukin I is cytotoxic to isolated islets of Langerhans

artículo científico publicado en 1986

Age-dependent decline of β-cell function in type 1 diabetes after diagnosis: a multi-centre longitudinal study

artículo científico publicado en 2013

Altering β-cell number through stable alteration of miR-21 and miR-34a expression

artículo científico publicado en 2014

An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection

artículo científico publicado en 2015

An immune origin of type 2 diabetes?

artículo científico publicado en 2005

Anti-cytokine therapies in T1D: Concepts and strategies

artículo científico

Anti-inflammatory properties of a novel peptide interleukin 1 receptor antagonist

artículo científico publicado en 2014

Antitumorigenic effect of proteasome inhibitors on insulinoma cells.

artículo científico publicado en 2004

Apolipoprotein CIII reduces proinflammatory cytokine-induced apoptosis in rat pancreatic islets via the Akt prosurvival pathway

artículo científico publicado en 2011

Apoptosis and the pathogenesis of IDDM: a question of life and death ⬇️

artículo científico publicado el 1 de octubre de 1998

Apoptotic signal transduction pathways in diabetes ⬇️

artículo científico publicado el 15 de octubre de 2003

Association of a functional 17beta-estradiol sensitive IL6-174G/C promoter polymorphism with early-onset type 1 diabetes in females

artículo científico publicado en 2003

Association of a microsatellite in FASL to type II diabetes and of the FAS-670G>A genotype to insulin resistance

article

BMI is an important driver of β-cell loss in type 1 diabetes upon diagnosis in 10 to 18-year-old children

artículo científico publicado en 2014

Beta cell death and protection

artículo científico publicado en 2003

Blockade of interleukin 1 in type 1 diabetes mellitus

artículo científico publicado en 2010

Calcium has a permissive role in interleukin-1beta-induced c-jun N-terminal kinase activation in insulin-secreting cells

artículo científico publicado en 2005

Calcium- and proteasome-dependent degradation of the JNK scaffold protein islet-brain 1.

artículo científico publicado en 2003

Cardiovascular and All-Cause Mortality Risk Associated With Urinary Excretion of 8-oxoGuo, a Biomarker for RNA Oxidation, in Patients With Type 2 Diabetes: A Prospective Cohort Study

artículo científico publicado en 2017

Ciliary neurotrophic factor potentiates the beta-cell inhibitory effect of IL-1beta in rat pancreatic islets associated with increased nitric oxide synthesis and increased expression of inducible nitric oxide synthase ⬇️

artículo científico publicado el 1 de octubre de 1998

Circulating interleukin-1 receptor antagonist concentrations are increased in adult patients with thermal injury

artículo científico publicado en 1995

Combination of ferric ammonium citrate with cytokines involved in apoptosis and insulin secretion of human pancreatic beta cells related to diabetes in thalassemia

artículo científico publicado en 2020

Complete mutation scan of the human Fas ligand gene: Linkage studies in Type I diabetes mellitus families

article

Complete mutation scan of the human Fas ligand gene: linkage studies in Type I diabetes mellitus families

artículo científico publicado en 2002

Cytokine-induced proapoptotic gene expression in insulin-producing cells is related to rapid, sustained, and nonoscillatory nuclear factor-kappaB activation

scientific article published on 23 March 2006

Cytokines and Pancreatic β-Cell Apoptosis

artículo científico publicado en 2016

Cytokines and beta-cell biology: from concept to clinical translation

artículo científico publicado en 2007

Cytokines and type 1 diabetes: a numbers game

artículo científico publicado en 2011

Cytokines cause functional and structural damage to isolated islets of Langerhans

artículo científico publicado en 1985

Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells

artículo científico publicado en 2005

DNA sequences flanking the insulin gene on chromosome 11 confer risk of atherosclerosis

artículo científico publicado en 1984

Deficiency of erythropoietin is not responsible for the anaemia associated with cyclosporin treatment of insulin-dependent diabetes mellitus. Canadian-European Randomized Control Trial Group

scientific article published on 01 June 1993

Dexamethasone prevents interleukin-1beta-mediated inhibition of rat islet insulin secretion without decreasing nitric oxide production

scientific article published on 01 August 1997

Diabetes

artículo científico publicado en 1998

Diabetes and suppressors of cytokine signaling proteins

artículo científico publicado en 2007

Diabetes mellitus, atherosclerosis, and the 5' flanking polymorphism of the human insulin gene

artículo científico publicado en 1986

Dietary Supplementation with co-3-Polyunsaturated Fatty Acids Decreases Mononuclear Cell Proliferation and Interleukin-1beta Content but not Monokine Secretion in Healthy and Insulin-Dependent Diabetic Individuals

artículo científico publicado en 1991

Differential interleukin-1 receptor antagonism on pancreatic beta and alpha cells. Studies in rodent and human islets and in normal rats

scientific article published on 01 August 1993

Direct demonstration of NCAM cis-dimerization and inhibitory effect of palmitoylation using the BRET2 technique

artículo científico publicado en 2011

Disappearance and reappearance of islet cell cytoplasmic antibodies in cyclosporin-treated insulin-dependent diabetics

artículo científico publicado en 1985

Divalent Metal Transporter 1 Regulates Iron-Mediated ROS and Pancreatic β Cell Fate in Response to Cytokines

article

Effects of gevokizumab on glycemia and inflammatory markers in type 2 diabetes

artículo científico publicado en 2012

Elevated transferrin saturation and risk of diabetes: three population-based studies

artículo científico publicado en 2011

Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 Is Essential for Proinsulin Handling

artículo científico publicado en 2019

Endothelial Progenitor Cells in Long-Standing Asymptomatic Type 1 Diabetic Patients with or without Diabetic Nephropathy

artículo científico publicado en 2011

Enhancer of Zeste Homolog 2 (EZH2) Mediates Glucolipotoxicity-Induced Apoptosis in β-Cells

artículo científico publicado en 2020

Erratum: IL-1 family nomenclature

scholarly article by Charles A. Dinarello et al published March 2011 in Nature Immunology

Extracellular signal-regulated kinase is essential for interleukin-1-induced and nuclear factor kappaB-mediated gene expression in insulin-producing INS-1E cells

artículo científico publicado en 2005

Fasting and meal-stimulated residual beta cell function is positively associated with serum concentrations of proinflammatory cytokines and negatively associated with anti-inflammatory and regulatory cytokines in patients with longer term type 1 dia

artículo científico publicado en 2013

Functional SOCS1 polymorphisms are associated with variation in obesity in whites.

artículo científico publicado en 2009

Functional and morphological effects of interleukin-1 beta on the perfused rat pancreas

scientific article published on 01 January 1990

Functional promoter haplotypes of the human FAS gene are associated with the phenotype of SLE characterized by thrombocytopenia.

artículo científico publicado en 2005

G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction

scientific journal article

Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective po

artículo científico publicado en 2004

Glutathione depletion inhibits IL-1 beta-stimulated nitric oxide production by reducing inducible nitric oxide synthase gene expression

artículo científico publicado en 2000

Granzyme A in the Pathogenesis of Type 1 Diabetes: The Yes and the No.

artículo científico publicado en 2017

Growth arrest- and DNA-damage-inducible 45beta gene inhibits c-Jun N-terminal kinase and extracellular signal-regulated kinase and decreases IL-1beta-induced apoptosis in insulin-producing INS-1E cells

artículo científico publicado en 2006

HDAC inhibitor-mediated beta-cell protection against cytokine-induced toxicity is STAT1 Tyr701 phosphorylation independent

artículo científico publicado en 2014

Helsinki alert of biodiversity and health

artículo científico publicado en 2015

High glucose suppresses human islet insulin biosynthesis by inducing miR-133a leading to decreased polypyrimidine tract binding protein-expression

artículo científico publicado en 2010

Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus

artículo científico publicado en 2011

Histone deacetylase 3 inhibition improves glycaemia and insulin secretion in obese diabetic rats

scientific article published on 26 May 2015

Histone deacetylases 1 and 3 but not 2 mediate cytokine-induced beta cell apoptosis in INS-1 cells and dispersed primary islets from rats and are differentially regulated in the islets of type 1 diabetic children

scientific journal article

IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin

artículo científico publicado en 2002

IAPP boosts islet macrophage IL-1 in type 2 diabetes

scientific article published on 01 October 2010

IL-1 family nomenclature

artículo científico publicado en 2010

IL-1 receptor antagonism and muscle gene expression in patients with type 2 diabetes

artículo científico publicado en 2009

IL-1beta-induced chemokine and Fas expression are inhibited by suppressor of cytokine signalling-3 in insulin-producing cells

artículo científico publicado en 2008

IL-1beta-induced pro-apoptotic signalling is facilitated by NCAM/FGF receptor signalling and inhibited by the C3d ligand in the INS-1E rat beta cell line

artículo científico publicado en 2006

IL-1β induced protein changes in diabetes prone BB rat islets of Langerhans identified by proteome analysis

article

Identification of a type 1 diabetes-associated CD4 promoter haplotype with high constitutive activity

artículo científico publicado en 2004

Increased reduction in fasting C-peptide is associated with islet cell antibodies in type 1 (insulin-dependent) diabetic patients

artículo científico publicado en 1985

Indomethacin treatment prevents high fat diet-induced obesity and insulin resistance but not glucose intolerance in C57BL/6J mice

artículo científico publicado en 2014

Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes

artículo científico publicado en 2003

Inhibition of beta cell growth and function by bone morphogenetic proteins

artículo científico publicado en 2014

Inhibition of histone deacetylases prevents cytokine-induced toxicity in beta cells

artículo científico publicado en 2007

Inhibition of nuclear factor-kappaB or Bax prevents endoplasmic reticulum stress- but not nitric oxide-mediated apoptosis in INS-1E cells

artículo científico publicado en 2009

Insulin autoantibodies are associated with islet cell antibodies; their relation to insulin antibodies and B-cell function in diabetic children

artículo científico publicado en 1988

Insulin-gene flanking sequences, diabetes mellitus and atherosclerosis: a review

artículo científico publicado en 1985

Interferon-gamma induces interleukin-1 converting enzyme expression in pancreatic islets by an interferon regulatory factor-1-dependent mechanism

artículo científico publicado en 2000

Interleukin 1 beta induces diabetes and fever in normal rats by nitric oxide via induction of different nitric oxide synthases.

artículo científico publicado en 1994

Interleukin 1 dose-dependently affects the biosynthesis of (pro)insulin in isolated rat islets of Langerhans

artículo científico publicado en 1987

Interleukin-1 Antagonists and Other Cytokine Blockade Strategies for Type 1 Diabetes ⬇️

artículo científico publicado el 28 de diciembre de 2012

Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials ⬇️

artículo científico publicado el 5 de abril de 2013

Interleukin-1 antagonism moderates the inflammatory state associated with Type 1 diabetes during clinical trials conducted at disease onset

artículo científico publicado en 2015

Interleukin-1 antagonism: a sturdy companion for immune tolerance induction in type 1 diabetes?

artículo científico publicado en 2014

Interleukin-1 antagonists for diabetes

artículo científico

Interleukin-1-receptor antagonist in type 2 diabetes mellitus

artículo científico publicado en 2007

Interleukin-1beta-induced rat pancreatic islet nitric oxide synthesis requires both the p38 and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases

artículo científico publicado en 1998

Interleukin-6 and diabetes: the good, the bad, or the indifferent?

artículo científico publicado en 2005

Intra-Peritoneal Administration of Interleukin-1β Induces Impaired Insulin Release from the Perfused Rat Pancreas

artículo científico publicado en 1990

Iron Regulation of Pancreatic Beta-Cell Functions and Oxidative Stress

artículo científico publicado en 2016

Iron Status and Gestational Diabetes-A Meta-Analysis.

artículo científico publicado en 2018

Iron: the hard player in diabetes pathophysiology.

artículo científico

Islet cell cytoplasmic antibodies (ICA) in diabetes and disorders of glucose tolerance

artículo científico publicado en 1991

JNK1 Deficient Insulin-Producing Cells Are Protected against Interleukin-1β-Induced Apoptosis Associated with Abrogated Myc Expression

artículo científico publicado en 2016

JNK1 protects against glucolipotoxicity-mediated beta-cell apoptosis

scientific journal article

Linkage disequilibrium testing of four interleukin-1 gene-cluster polymorphisms in Danish multiplex families with insulin-dependent diabetes mellitus

artículo científico publicado en 2000

Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and β-cell protection

article published in the Proceedings of the National Academy of Sciences of the United States of America

Lysine deacetylases are produced in pancreatic beta cells and are differentially regulated by proinflammatory cytokines

artículo científico publicado en 2010

Lysine demethylase inhibition protects pancreatic β cells from apoptosis and improves β-cell function

artículo científico publicado en 2017

Mechanisms of pancreatic islet cell destruction. Dose-dependent cytotoxic effect of soluble blood mononuclear cell mediators on isolated islets of Langerhans

artículo científico publicado en 1986

MicroRNAs as regulators of beta-cell function and dysfunction

artículo científico

Monocyte Function in IDDM Patients and Healthy Individuals

artículo científico publicado en 1990

Multifactorial treatment increases endothelial progenitor cells in patients with type 2 diabetes.

artículo científico publicado en 2010

Mutation scan of a type 1 diabetes candidate gene: the human interleukin-18 binding protein gene

artículo científico publicado en 2003

Need for reclassification of diabetes secondary to iron overload in the ADA and WHO classifications

artículo científico publicado en 2014

Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt.

artículo científico publicado en 2005

Over-expression of Follistatin-like 3 attenuates fat accumulation and improves insulin sensitivity in mice

artículo científico publicado en 2014

Perspective: Testing failures

journal article; published in Nature on 2012-05-16

Plasma cytokine levels in young and elderly twins: genes versus environment and relation to in vivo insulin action

artículo científico publicado en 2005

Poor pregnancy outcome in women with type 2 diabetes

artículo científico publicado en 2005

Prevalence of hereditary haemochromatosis in late-onset type 1 diabetes mellitus: a retrospective study

artículo científico publicado en 2001

Process measures and outcome research as tools for future improvement of diabetes treatment quality

artículo científico publicado en 2002

Proinflammatory Cytokines Perturb Mouse and Human Pancreatic Islet Circadian Rhythmicity and Induce Uncoordinated β-Cell Clock Gene Expression via Nitric Oxide, Lysine Deacetylases, and Immunoproteasomal Activity

artículo científico publicado en 2020

Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells

scientific article published on 26 May 2009

Proliferation of sorted human and rat beta cells

artículo científico publicado en 2007

RELATION BETWEEN BREAST-FEEDING AND INCIDENCE RATES OF INSULIN-DEPENDENT DIABETES MELLITUS

artículo científico publicado en 1984

RNA modifications by oxidation: a novel disease mechanism?

artículo científico

RX871024 reduces NO production but does not protect against pancreatic beta-cell death induced by proinflammatory cytokines

artículo científico

Repetitive exposure of pancreatic islets to interleukin-1 beta. An in vitro model of pre-diabetes?

artículo científico publicado en 1991

Repetitive in vivo treatment with human recombinant interleukin-1 beta modifies beta-cell function in normal rats

artículo científico publicado en 1992

Response to Comment on: Ellervik et al. Elevated Transferrin Saturation and Risk of Diabetes: Three Population-Based Studies. Diabetes Care 2011;34:2256–2258.

artículo científico publicado en 2012

Role of IL-1beta in type 2 diabetes

artículo científico publicado en 2010

Serum Proteome Pool Changes in Type 2 Diabetic Patients Treated with Anakinra

Serum adipokines as biomarkers of beta-cell function in patients with type 1 diabetes: positive association with leptin and resistin and negative association with adiponectin

artículo científico publicado en 2013

Skeletal Muscle to Pancreatic β-Cell Cross-talk: The Effect of Humoral Mediators Liberated by Muscle Contraction and Acute Exercise on β-Cell Apoptosis

artículo científico publicado en 2015

Skeletal muscle apolipoprotein B expression reduces muscular triglyceride accumulation

artículo científico publicado en 2014

Small-molecule inhibition of inflammatory β-cell death

artículo científico publicado en 2013

Suppressor of cytokine Signaling-3 inhibits interleukin-1 signaling by targeting the TRAF-6/TAK1 complex

artículo científico publicado en 2006

Suppressor of cytokine signaling 3 (SOCS-3) protects beta -cells against interleukin-1beta - and interferon-gamma -mediated toxicity

artículo científico publicado en 2001

Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways

artículo científico publicado en 2004

Suppressor of cytokine signalling-3 expression inhibits cytokine-mediated destruction of primary mouse and rat pancreatic islets and delays allograft rejection

artículo científico publicado en 2008

Suppressor of cytokine signalling-3 inhibits Tumor necrosis factor-alpha induced apoptosis and signalling in beta cells

artículo científico publicado en 2009

Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes.

scientific article published on 19 June 2009

Synergistic reversal of type 1 diabetes in NOD mice with anti-CD3 and interleukin-1 blockade: evidence of improved immune regulation

artículo científico publicado en 2011

TNFalpha and IFNgamma potentiate IL-1beta induced mitogen activated protein kinase activity in rat pancreatic islets of Langerhans

artículo científico publicado en 2000

TRAF2 mediates JNK and STAT3 activation in response to IL-1β and IFNγ and facilitates apoptotic death of insulin-producing β-cells

artículo científico publicado en 2015

The Connexin 43 Regulator Rotigaptide Reduces Cytokine-Induced Cell Death in Human Islets

artículo científico publicado en 2020

The Fas pathway is involved in pancreatic beta cell secretory function

artículo científico publicado en 2007

The JNK binding domain of islet-brain 1 inhibits IL-1 induced JNK activity and apoptosis but not the transcription of key proapoptotic or protective genes in insulin-secreting cell lines

artículo científico publicado en 2003

The Lysine Demethylase KDM5B Regulates Islet Function and Glucose Homeostasis

scientific article published on 28 July 2019

The No-Go and Nonsense-Mediated RNA Decay Pathways Are Regulated by Inflammatory Cytokines in Insulin-Producing Cells and Human Islets and Determine β-Cell Insulin Biosynthesis and Survival

scientific article published on 31 July 2018

The anti-interleukin-1 in type 1 diabetes action trial--background and rationale

artículo científico publicado en 2009

The global diabetes epidemic as a consequence of lifestyle-induced low-grade inflammation

artículo científico publicado en 2009

The imidazoline RX871024 induces death of proliferating insulin-secreting cells by activation of c-jun N-terminal kinase

artículo científico publicado en 2008

The immunoproteasome is induced by cytokines and regulates apoptosis in human islets

artículo científico publicado en 2017

The intercellular adhesion molecule-1 K469E polymorphism in type 1 diabetes

artículo científico publicado en 2000

The intermediate proteasome is constitutively expressed in pancreatic beta cells and upregulated by stimulatory, low concentrations of interleukin 1 β

artículo científico publicado en 2020

The lysine deacetylase inhibitor Givinostat inhibits β-cell IL-1β induced IL-1β transcription and processing

artículo científico publicado en 2012

The oral histone deacetylase inhibitor ITF2357 reduces cytokines and protects islet β cells in vivo and in vitro

artículo científico publicado en 2010

The role of growth hormone and glucocorticoid in glucose handling in vivo

artículo científico publicado en 1999

The role of interleukin-1 in the pathogenesis of IDDM.

artículo científico publicado en 1996

The use of interleukin-1-receptor antagonists in the treatment of diabetes mellitus

artículo científico publicado en 2008

TiSH--a robust and sensitive global phosphoproteomics strategy employing a combination of TiO2, SIMAC, and HILIC.

artículo científico publicado en 2012

Total and cause-specific mortality by elevated transferrin saturation and hemochromatosis genotype in individuals with diabetes: two general population studies

artículo científico publicado en 2013

Total mortality by elevated transferrin saturation in patients with diabetes

artículo científico publicado en 2013

Transcriptional and translational regulation of cytokine signaling in inflammatory β-cell dysfunction and apoptosis

artículo científico

Treatment of type 2 diabetes by targeting interleukin-1: a meta-analysis of 2921 patients

artículo científico publicado en 2019

Type 2 diabetes mellitus: a metabolic autoinflammatory disease

artículo científico publicado en 2013

Variations of the interleukin-6 promoter are associated with features of the metabolic syndrome in Caucasian Danes.

artículo científico publicado en 2005

What are the types and cellular sources of free radicals in the pathogenesis of type 1 (insulin-dependent) diabetes mellitus?

artículo científico publicado en 1993

Tissue Inhibitor Of Matrix Metalloproteinase-1 Is Required for High-Fat Diet-Induced Glucose Intolerance and Hepatic Steatosis in Mice.

artículo científico publicado en 2015

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