Lista de obras - François Noe͏̈l - Dominio Público Uruguay

2-Methoxy-3,8,9-trihydroxy coumestan: a new synthetic inhibitor of Na+,K+-ATPase with an original mechanism of action

artículo científico publicado en 2003

21-Benzylidene digoxin: a proapoptotic cardenolide of cancer cells that up-regulates Na,K-ATPase and epithelial tight junctions

artículo científico publicado en 2014

A (Ca(2+)-Mg2+)ATPase from Schistosoma mansoni is coupled to an active transport of calcium

scientific article published on 01 June 1992

A Ca2+-stimulated, Mg2+-dependent ATPase activity in subcellular fractions from Schistosoma mansoni

scientific article published on 01 December 1988

A comparison of the affinities of rat (Na+ + K+)-ATPase isozymes for cardioactive steroids, role of lactone ring, sugar moiety and KCl concentration

artículo científico publicado en 1990

A new piperazine derivative: 1-(4-(3,5-di-tert-butyl-4-hydroxybenzyl) piperazin-1-yl)-2-methoxyethan-1-one with antioxidant and central activity

artículo científico publicado en 2017

ADME studies and preliminary safety pharmacology of LDT5, a lead compound for the treatment of benign prostatic hyperplasia.

artículo científico publicado en 2016

Adaptive expression pattern of different proteins involved in cellular calcium homeostasis in denervated rat vas deferens.

artículo científico publicado en 2005

Assessment of mechanisms involved in antinociception produced by the alkaloid caulerpine.

artículo científico publicado en 2014

Binding of [3H]MK-801 in subcellular fractions of Schistosoma mansoni: evidence for interaction with nicotinic receptors

artículo científico publicado en 2005

Biosynthesis of human diazepam and clonazepam metabolites

artículo científico publicado en 2015

Biotransformation of LASSBio-579 and pharmacological evaluation of p -hydroxylated metabolite a N -phenylpiperazine antipsychotic lead compound

artículo científico publicado en 2012

Bufadienolides from parotoid gland secretions of Cuban toad Peltophryne fustiger (Bufonidae): Inhibition of human kidney Na(+)/K(+)-ATPase activity.

artículo científico publicado en 2015

Cellular mechanisms involved in the increased contraction of portal veins from Schistosoma mansoni-infected mice.

artículo científico publicado en 2002

Characterization of a GABAergic neurotransmission in adult Schistosoma mansoni

artículo científico publicado en 2004

Characterization of a new synthetic isoflavonoid with inverse agonist activity at the central benzodiazepine receptor

artículo científico publicado en 2004

Characterization of an isoform of Na+/K(+)-ATPase with high affinity for [3H]ouabain in the rat vas deferens

artículo científico publicado en 1997

Characterization of subcellular fractions and distribution profiles of transport components involved in Ca(2+) homeostasis in rat vas deferens

artículo científico publicado en 2002

Characterization of two classes of benzodiazepine binding sites in Schistosoma mansoni

artículo científico publicado en 2007

Cyclic GMP-dependent vasodilatory properties of LASSBio 294 in rat aorta

artículo científico publicado en 2002

Design of new dopamine D2 receptor ligands: biosynthesis and pharmacological evaluation of the hydroxylated metabolite of LASSBio-581.

artículo científico publicado en 2010

Determination of pharmacological interactions of uliginosin B, a natural phloroglucinol derivative, with amitriptyline, clonidine and morphine by isobolographic analysis

artículo científico publicado en 2014

Discovery of LASSBio-772, a 1,3-benzodioxole N-phenylpiperazine derivative with potent alpha 1A/D-Adrenergic receptor blocking properties

artículo científico publicado en 2011

Distribution of alpha 1 and alpha 2 (Na+,K+)-ATPase isoforms between the junctional (t-tubular) and non-junctional sarcolemmal domains of rat ventricle

scientific article published on 01 January 1991

Down-regulation of Na(+)/K(+)-ATPase alpha(2) isoform in denervated rat vas deferens

artículo científico publicado en 2000

Effect of heparin treatment on the expression and activity of different ion-motive P-type ATPase isoforms from mouse extensor digitorum longus muscle during degeneration and regeneration after Bothrops jararacussu venom injection

scientific article published on 03 July 2009

Effects of cardiotonic steroids on isolated perfused kidney and NHE3 activity in renal proximal tubules

artículo científico publicado en 2017

Effects of diene valepotriates from Valeriana glechomifolia on Na+/K+-ATPase activity in the cortex and hippocampus of mice.

artículo científico publicado en 2015

Evidence for functional ryanodine receptors in Schistosoma mansoni and their putative role in the control of calcium homeostasis

article

Evidence for ryanodine receptors in Schistosoma mansoni

article

Evidence for the presence of glutamatergic receptors in adult Schistosoma mansoni

artículo científico publicado en 2002

Evidence for the presence of two (Ca(2+)-Mg2+) ATPases with different sensitivities to thapsigargin and cyclopiazonic acid in the human flatworm Schistosoma mansoni

scientific article published on 01 June 1996

Flavones and phenylpropanoids from a sedative extract of Lantana trifolia L.

artículo científico publicado en 2009

Formation of a highly stable complex between BN 50730 [tetrahydro-4,7,8,10 methyl-1(chloro-2 phenyl)-6 (methoxy-4 phenyl-carbamoyl)-9 pyrido [4′,3′-4,5] thieno [3,2-f] triazolo-1,2,4 [4,3-α] diazepine-1,4] and the platelet-activating factor rece

artículo científico publicado en 1996

Functional binding assays for estimation of the intrinsic efficacy of ligands at the 5-HT1A receptor: application for screening drug candidates

artículo científico publicado en 2014

Heterogeneity of ouabain binding sites in Schistosoma mansoni. First evidence for the presence of two (Na+ + K+)-ATPase isoforms in platyhelminths

artículo científico publicado en 1994

Heterogeneity of ouabain specific binding sites and (Na+ + K+)-ATPase inhibition in microsomes from rat heart

artículo científico publicado en 1984

Identification and characterization of coumestans as novel HCV NS5B polymerase inhibitors.

artículo científico publicado en 2008

In vitro effect of valepotriates isolated from Valeriana glechomifolia on rat P-type ATPases

artículo científico publicado en 2011

Increased endothelial cell-leukocyte interaction in murine schistosomiasis: possible priming of endothelial cells by the disease.

artículo científico publicado en 2011

Increased reactivity to 5-hydroxytryptamine of portal veins from mice infected with Schistosoma mansoni

artículo científico publicado en 1998

Influence of development on Na(+)/K(+)-ATPase expression: isoform- and tissue-dependency.

artículo científico publicado en 2002

Inhibition of the alpha1beta1 isoform of the Na, K-ATPase by 8-methoxycoumestrol without positive inotropic effect in human myocardium--novel aspects of cardiac glycoside pharmacology.

artículo científico publicado en 2009

Inhibitory effect of combinations of digoxin and endogenous cardiotonic steroids on Na+/K+-ATPase activity in human kidney membrane preparation

artículo científico publicado en 2010

Insights into the mechanism of Na+,K+-ATPase inhibition by 2-methoxy-3,8,9-trihydroxy coumestan

artículo científico publicado en 2008

Insights into the mechanism of erythrocyte Na+/K+-ATPase inhibition by nitric oxide and peroxynitrite anion

artículo científico publicado en 2003

Ivermectin is a nonselective inhibitor of mammalian P-type ATPases

artículo científico publicado en 2009

LASSBio-1422: a new molecular scaffold with efficacy in animal models of schizophrenia and disorders of attention and cognition

artículo científico publicado en 2016

LASSBio-897 Reduces Lung Injury Induced by Silica Particles in Mice: Potential Interaction with the A2A Receptor

artículo científico publicado en 2017

Lack of evidence for regulation of cardiac P-type ATPases and MAP kinases in transgenic mice with cardiac-specific overexpression of constitutively active α1B-adrenoceptors

scientific article published on 16 April 2010

Mechanisms associated to impaired activity of cardiac P-type ATPases in endothelial nitric oxide synthase knockout mice

artículo científico publicado en 2012

Multiple level C in vitro/in vivo correlation of dissolution profiles of two L-thyroxine tablets with pharmacokinetics data obtained from patients treated for hypothyroidism.

artículo científico publicado en 2004

Na+/K(+)-ATPase density is sexually dimorphic in the adult rat kidney

artículo científico publicado en 1997

Na+/K+-ATPase alpha isoforms expression in stroke-prone spontaneously hypertensive rat heart ventricles: effect of salt loading and lacidipine treatment

scientific article published on 24 March 2007

Natriuretic effect of bufalin in isolated rat kidneys involves activation of the Na+-K+-ATPase-Src kinase pathway

artículo científico publicado en 2012

New Multi-target Antagonists of α1A-, α1D-Adrenoceptors and 5-HT1A Receptors Reduce Human Hyperplastic Prostate Cell Growth and the Increase of Intraurethral Pressure.

artículo científico publicado en 2015

New insights into pharmacological profile of LASSBio-579, a multi-target N-phenylpiperazine derivative active on animal models of schizophrenia

artículo científico publicado en 2012

Noradrenaline-induced contraction of mice aorta is enhanced in schistosomiasis

artículo científico publicado en 2006

Novel orally active analgesic and anti-inflammatory cyclohexyl-N-acylhydrazone derivatives.

artículo científico publicado en 2015

On-line solid-phase extraction coupled with high-performance liquid chromatography and tandem mass spectrometry (SPE-HPLC-MS-MS) for quantification of bromazepam in human plasma: an automated method for bioequivalence studies.

artículo científico publicado en 2005

Partial agonism and fast dissociation of LASSBio-579 at dopamine D2 receptor

artículo científico publicado en 2015

Pharmacokinetic/pharmacodynamic modeling of psychomotor impairment induced by oral clonazepam in healthy volunteers.

artículo científico publicado en 2009

Pharmacological characterization of N1-(2-methoxyphenyl)-N4-hexylpiperazine as a multi-target antagonist of α1A/α1D-adrenoceptors and 5-HT1A receptors that blocks prostate contraction and cell growth.

artículo científico publicado en 2013

Quantitative analysis of the high-affinity binding sites for [3H]ouabain in the rat vas deferens and their immunological identification as the alpha 2 isoform of Na+/K(+)-ATPase

artículo científico publicado en 1998

Rat vas deferens SERCA2 is modulated by Ca2+/calmodulin protein kinase II-mediated phosphorylation.

scientific article published on 19 March 2013

Revisiting the Pharmacodynamic Uroselectivity of α 1-Adrenergic Receptor Antagonists

scientific article published on 08 July 2019

Revisiting the binding kinetics and inhibitory potency of cardiac glycosides on Na+,K+-ATPase (α1β1): Methodological considerations

artículo científico publicado en 2018

Role of calcium influx through voltage-operated calcium channels and of calcium mobilization in the physiology of Schistosoma mansoni muscle contractions

artículo científico publicado en 2006

Role of noradrenaline on the expression of the Na+/K+-ATPase alpha2 isoform and the contractility of cultured rat vas deferens

artículo científico publicado en 2002

Schistosoma mansoni infection enhances host portal vein contraction: role of potassium channels and p38 MAP kinase.

artículo científico publicado en 2007

Schistosoma mansoni: preparation, characterization of (Na+ + K+)ATPase from tegument and carcass

artículo científico publicado en 1986

Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors.

artículo científico publicado en 2010

Selective destruction of nigrostriatal dopaminergic neurons does not alter [3H]-ryanodine binding in rat striatum

artículo científico publicado en 2000

Stereoselective synthesis and preliminary evaluation of new D-3-heteroarylcarbonylalanines as ligands of the NMDA receptor

artículo científico publicado en 2004

Structure-activity relationship of wedelolactone analogues: structural requirements for inhibition of Na+, K+ -ATPase and binding to the central benzodiazepine receptor

artículo científico publicado en 2006

Synergistic interaction between ouabain and 8-methoxy-3,9-dihydroxy coumestan, a non-steroidal synthetic inhibitor of Na+,K+-ATPase.

artículo científico publicado en 2007

Synthesis and pharmacological evaluation of new N-phenylpiperazine derivatives designed as homologues of the antipsychotic lead compound LASSBio-579.

artículo científico publicado en 2013

Synthesis and preliminary pharmacological evaluation of new (+/-) 1,4-naphthoquinones structurally related to lapachol.

artículo científico publicado en 2002

Synthesis, biological evaluation, and structure-activity relationship of clonazepam, meclonazepam, and 1,4-benzodiazepine compounds with schistosomicidal activity

artículo científico publicado en 2012

Taurine prevents the neurotoxicity of beta-amyloid and glutamate receptor agonists: activation of GABA receptors and possible implications for Alzheimer's disease and other neurological disorders

artículo científico publicado en 2004

Telocinobufagin and Marinobufagin Produce Different Effects in LLC-PK1 Cells: A Case of Functional Selectivity of Bufadienolides

scientific article published on 14 September 2018

The effects of 3-methylclonazepam on Schistosoma mansoni musculature are not mediated by benzodiazepine receptors

artículo científico publicado en 2009

The inotropic effect of ouabain and its antagonism by dihydroouabain in rat isolated atria and ventricles in relation to specific binding sites.

artículo científico publicado en 1983

The novel piperazine-containing compound LQFM018: Necroptosis cell death mechanisms, dopamine D4 receptor binding and toxicological assessment.

artículo científico publicado en 2018

Time course of the effect of praziquantel on Schistosoma mansoni attachment in vitro: comparison with its effects on worm length and motility

scientific article published on 01 January 1995

Validation of a Na+-shift binding assay for estimation of the intrinsic efficacy of ligands at the A2A adenosine receptor

artículo científico publicado en 2016

Vanadate sensitivity of Na+, K+-ATPase from Schistosoma mansoni and its modulation by Na+, K+ and Mg2+.

artículo científico publicado en 1989

Yangambin: A New Naturally-Occurring Platelet-Activating Factor Receptor Antagonist: Binding andIn VitroFunctional Studies

Δ²,³-ivermectin ethyl secoester, a conjugated ivermectin derivative with leishmanicidal activity but without inhibitory effect on mammalian P-type ATPases

artículo científico publicado en 2010

γ-Benzylidene digoxin derivatives synthesis and molecular modeling: Evaluation of anticancer and the Na,K-ATPase activity effect.

artículo científico publicado en 2015

Lista de obras de François Noe͏̈l

2-Methoxy-3,8,9-trihydroxy coumestan: a new synthetic inhibitor of Na+,K+-ATPase with an original mechanism of action

21-Benzylidene digoxin: a proapoptotic cardenolide of cancer cells that up-regulates Na,K-ATPase and epithelial tight junctions

A (Ca(2+)-Mg2+)ATPase from Schistosoma mansoni is coupled to an active transport of calcium

A Ca2+-stimulated, Mg2+-dependent ATPase activity in subcellular fractions from Schistosoma mansoni

A comparison of the affinities of rat (Na+ + K+)-ATPase isozymes for cardioactive steroids, role of lactone ring, sugar moiety and KCl concentration

A new piperazine derivative: 1-(4-(3,5-di-tert-butyl-4-hydroxybenzyl) piperazin-1-yl)-2-methoxyethan-1-one with antioxidant and central activity

ADME studies and preliminary safety pharmacology of LDT5, a lead compound for the treatment of benign prostatic hyperplasia.

Adaptive expression pattern of different proteins involved in cellular calcium homeostasis in denervated rat vas deferens.

Assessment of mechanisms involved in antinociception produced by the alkaloid caulerpine.

Binding of [3H]MK-801 in subcellular fractions of Schistosoma mansoni: evidence for interaction with nicotinic receptors

Biosynthesis of human diazepam and clonazepam metabolites

Biotransformation of LASSBio-579 and pharmacological evaluation of p -hydroxylated metabolite a N -phenylpiperazine antipsychotic lead compound

Bufadienolides from parotoid gland secretions of Cuban toad Peltophryne fustiger (Bufonidae): Inhibition of human kidney Na(+)/K(+)-ATPase activity.

Cellular mechanisms involved in the increased contraction of portal veins from Schistosoma mansoni-infected mice.

Characterization of a GABAergic neurotransmission in adult Schistosoma mansoni

Characterization of a new synthetic isoflavonoid with inverse agonist activity at the central benzodiazepine receptor

Characterization of an isoform of Na+/K(+)-ATPase with high affinity for [3H]ouabain in the rat vas deferens

Characterization of subcellular fractions and distribution profiles of transport components involved in Ca(2+) homeostasis in rat vas deferens

Characterization of two classes of benzodiazepine binding sites in Schistosoma mansoni

Cyclic GMP-dependent vasodilatory properties of LASSBio 294 in rat aorta

Design of new dopamine D2 receptor ligands: biosynthesis and pharmacological evaluation of the hydroxylated metabolite of LASSBio-581.

Determination of pharmacological interactions of uliginosin B, a natural phloroglucinol derivative, with amitriptyline, clonidine and morphine by isobolographic analysis

Discovery of LASSBio-772, a 1,3-benzodioxole N-phenylpiperazine derivative with potent alpha 1A/D-Adrenergic receptor blocking properties

Distribution of alpha 1 and alpha 2 (Na+,K+)-ATPase isoforms between the junctional (t-tubular) and non-junctional sarcolemmal domains of rat ventricle

Down-regulation of Na(+)/K(+)-ATPase alpha(2) isoform in denervated rat vas deferens

Effect of heparin treatment on the expression and activity of different ion-motive P-type ATPase isoforms from mouse extensor digitorum longus muscle during degeneration and regeneration after Bothrops jararacussu venom injection

Effects of cardiotonic steroids on isolated perfused kidney and NHE3 activity in renal proximal tubules

Effects of diene valepotriates from Valeriana glechomifolia on Na+/K+-ATPase activity in the cortex and hippocampus of mice.

Evidence for functional ryanodine receptors in Schistosoma mansoni and their putative role in the control of calcium homeostasis

Evidence for ryanodine receptors in Schistosoma mansoni

Evidence for the presence of glutamatergic receptors in adult Schistosoma mansoni

Evidence for the presence of two (Ca(2+)-Mg2+) ATPases with different sensitivities to thapsigargin and cyclopiazonic acid in the human flatworm Schistosoma mansoni

Flavones and phenylpropanoids from a sedative extract of Lantana trifolia L.

Formation of a highly stable complex between BN 50730 [tetrahydro-4,7,8,10 methyl-1(chloro-2 phenyl)-6 (methoxy-4 phenyl-carbamoyl)-9 pyrido [4′,3′-4,5] thieno [3,2-f] triazolo-1,2,4 [4,3-α] diazepine-1,4] and the platelet-activating factor rece

Functional binding assays for estimation of the intrinsic efficacy of ligands at the 5-HT1A receptor: application for screening drug candidates

Heterogeneity of ouabain binding sites in Schistosoma mansoni. First evidence for the presence of two (Na+ + K+)-ATPase isoforms in platyhelminths

Heterogeneity of ouabain specific binding sites and (Na+ + K+)-ATPase inhibition in microsomes from rat heart

Identification and characterization of coumestans as novel HCV NS5B polymerase inhibitors.

In vitro effect of valepotriates isolated from Valeriana glechomifolia on rat P-type ATPases

Increased endothelial cell-leukocyte interaction in murine schistosomiasis: possible priming of endothelial cells by the disease.

Increased reactivity to 5-hydroxytryptamine of portal veins from mice infected with Schistosoma mansoni

Influence of development on Na(+)/K(+)-ATPase expression: isoform- and tissue-dependency.

Inhibition of the alpha1beta1 isoform of the Na, K-ATPase by 8-methoxycoumestrol without positive inotropic effect in human myocardium--novel aspects of cardiac glycoside pharmacology.

Inhibitory effect of combinations of digoxin and endogenous cardiotonic steroids on Na+/K+-ATPase activity in human kidney membrane preparation

Insights into the mechanism of Na+,K+-ATPase inhibition by 2-methoxy-3,8,9-trihydroxy coumestan

Insights into the mechanism of erythrocyte Na+/K+-ATPase inhibition by nitric oxide and peroxynitrite anion

Ivermectin is a nonselective inhibitor of mammalian P-type ATPases

LASSBio-1422: a new molecular scaffold with efficacy in animal models of schizophrenia and disorders of attention and cognition

LASSBio-897 Reduces Lung Injury Induced by Silica Particles in Mice: Potential Interaction with the A2A Receptor

Lack of evidence for regulation of cardiac P-type ATPases and MAP kinases in transgenic mice with cardiac-specific overexpression of constitutively active α1B-adrenoceptors

Mechanisms associated to impaired activity of cardiac P-type ATPases in endothelial nitric oxide synthase knockout mice

Multiple level C in vitro/in vivo correlation of dissolution profiles of two L-thyroxine tablets with pharmacokinetics data obtained from patients treated for hypothyroidism.

Na+/K(+)-ATPase density is sexually dimorphic in the adult rat kidney

Na+/K+-ATPase alpha isoforms expression in stroke-prone spontaneously hypertensive rat heart ventricles: effect of salt loading and lacidipine treatment

Natriuretic effect of bufalin in isolated rat kidneys involves activation of the Na+-K+-ATPase-Src kinase pathway

New Multi-target Antagonists of α1A-, α1D-Adrenoceptors and 5-HT1A Receptors Reduce Human Hyperplastic Prostate Cell Growth and the Increase of Intraurethral Pressure.

New insights into pharmacological profile of LASSBio-579, a multi-target N-phenylpiperazine derivative active on animal models of schizophrenia

Noradrenaline-induced contraction of mice aorta is enhanced in schistosomiasis

Novel orally active analgesic and anti-inflammatory cyclohexyl-N-acylhydrazone derivatives.

On-line solid-phase extraction coupled with high-performance liquid chromatography and tandem mass spectrometry (SPE-HPLC-MS-MS) for quantification of bromazepam in human plasma: an automated method for bioequivalence studies.

Partial agonism and fast dissociation of LASSBio-579 at dopamine D2 receptor

Pharmacokinetic/pharmacodynamic modeling of psychomotor impairment induced by oral clonazepam in healthy volunteers.

Pharmacological characterization of N1-(2-methoxyphenyl)-N4-hexylpiperazine as a multi-target antagonist of α1A/α1D-adrenoceptors and 5-HT1A receptors that blocks prostate contraction and cell growth.

Quantitative analysis of the high-affinity binding sites for [3H]ouabain in the rat vas deferens and their immunological identification as the alpha 2 isoform of Na+/K(+)-ATPase

Rat vas deferens SERCA2 is modulated by Ca2+/calmodulin protein kinase II-mediated phosphorylation.

Revisiting the Pharmacodynamic Uroselectivity of α 1-Adrenergic Receptor Antagonists

Revisiting the binding kinetics and inhibitory potency of cardiac glycosides on Na+,K+-ATPase (α1β1): Methodological considerations

Role of calcium influx through voltage-operated calcium channels and of calcium mobilization in the physiology of Schistosoma mansoni muscle contractions

Role of noradrenaline on the expression of the Na+/K+-ATPase alpha2 isoform and the contractility of cultured rat vas deferens

Schistosoma mansoni infection enhances host portal vein contraction: role of potassium channels and p38 MAP kinase.

Schistosoma mansoni: preparation, characterization of (Na+ + K+)ATPase from tegument and carcass

Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors.

Selective destruction of nigrostriatal dopaminergic neurons does not alter [3H]-ryanodine binding in rat striatum

Stereoselective synthesis and preliminary evaluation of new D-3-heteroarylcarbonylalanines as ligands of the NMDA receptor

Structure-activity relationship of wedelolactone analogues: structural requirements for inhibition of Na+, K+ -ATPase and binding to the central benzodiazepine receptor

Synergistic interaction between ouabain and 8-methoxy-3,9-dihydroxy coumestan, a non-steroidal synthetic inhibitor of Na+,K+-ATPase.

Synthesis and pharmacological evaluation of new N-phenylpiperazine derivatives designed as homologues of the antipsychotic lead compound LASSBio-579.

Synthesis and preliminary pharmacological evaluation of new (+/-) 1,4-naphthoquinones structurally related to lapachol.

Synthesis, biological evaluation, and structure-activity relationship of clonazepam, meclonazepam, and 1,4-benzodiazepine compounds with schistosomicidal activity