Lista de obras - Darren Tomlinson - Dominio Público Uruguay

A Decade of FGF Receptor Research in Bladder Cancer: Past, Present, and Future Challenges ⬇️

artículo científico publicado el 31 de julio de 2012

A high-throughput assay to identify modifiers of premature chromosome condensation ⬇️

artículo científico publicado en 2013

A place for precision medicine in bladder cancer: targeting the FGFRs ⬇️

artículo científico publicado en 2016

Adhiron: a stable and versatile peptide display scaffold for molecular recognition applications ⬇️

artículo científico publicado en 2014

Affimer Tagged Cubosomes: Targeting of Carcinoembryonic Antigen Expressing Colorectal Cancer Cells Using <i>In Vitro</i> and <i>In Vivo</i> Models

scientific article published on 23 February 2022

Affimer proteins are versatile and renewable affinity reagents ⬇️

artículo científico publicado en 2017

Affimer proteins for F-actin: novel affinity reagents that label F-actin in live and fixed cells ⬇️

artículo científico publicado en 2018

Affimer proteins inhibit immune complex binding to FcγRIIIa with high specificity through competitive and allosteric modes of action ⬇️

artículo científico publicado en 2017

Affimer reagents as tools in diagnosing plant virus diseases

article

Altered Splicing of FGFR1 Is Associated with High Tumor Grade and Stage and Leads to Increased Sensitivity to FGF1 in Bladder Cancer ⬇️

artículo científico publicado el 1 de octubre de 2010

Alternative reagents to antibodies in imaging applications ⬇️

artículo científico publicado en 2017

Alternative splicing of fibroblast growth factor receptor 3 produces a secreted isoform that inhibits fibroblast growth factor-induced proliferation and is repressed in urothelial carcinoma cell lines

artículo científico publicado en 2005

An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes ⬇️

scientific journal article

Antibody Mimetics for the Detection of Small Organic Compounds Using a Quartz Crystal Microbalance

artículo científico publicado en 2017

Antibody mimetic receptor proteins for label-free biosensors. ⬇️

artículo científico publicado en 2015

Chapter Eight - Ubiquitin-Mediated Regulation of Cellular Responses to Vascular Endothelial Growth Factors.

artículo científico publicado en 2016

Characterization and applications of a Crimean-Congo hemorrhagic fever virus nucleoprotein-specific Affimer: Inhibitory effects in viral replication and development of colorimetric diagnostic tests

scientific article published on 03 June 2020

Development and characterisation of a 3D multi-cellular in vitro model of normal human breast: a tool for cancer initiation studies ⬇️

artículo científico publicado en 2015

Development of an Affimer-antibody combined immunological diagnosis kit for glypican-3. ⬇️

artículo científico publicado en 2017

Differential effects of transforming growth factor-beta1 on cellular proliferation in the developing prostate

scientific journal article

Exploration of the HIF-1α/p300 interface using peptide and Adhiron phage display technologies ⬇️

artículo científico publicado en 2015

FGFR1-induced epithelial to mesenchymal transition through MAPK/PLCγ/COX-2-mediated mechanisms

artículo científico publicado en 2012

FGFR3 and Ras gene mutations are mutually exclusive genetic events in urothelial cell carcinoma

artículo científico publicado en 2005

FGFR3 mutation affects cell growth, apoptosis and attachment in keratinocytes

artículo científico publicado en 2010

FGFR3 mutation increases bladder tumourigenesis by suppressing acute inflammation

artículo científico publicado en 2018

FGFR3 protein expression and its relationship to mutation status and prognostic variables in bladder cancer

artículo científico publicado en 2007

Fibroblast growth factor receptor 1 promotes proliferation and survival via activation of the mitogen-activated protein kinase pathway in bladder cancer

artículo científico publicado en 2009

Generation of specific inhibitors of SUMO-1- and SUMO-2/3-mediated protein-protein interactions using Affimer (Adhiron) technology ⬇️

artículo científico publicado en 2017

High-content, high-throughput screening for the identification of cytotoxic compounds based on cell morphology and cell proliferation markers ⬇️

artículo científico publicado en 2014

Hypofibrinolysis in diabetes: a therapeutic target for the reduction of cardiovascular risk ⬇️

artículo científico publicado en 2017

Inactivation of the Rb pathway and overexpression of both isoforms of E2F3 are obligate events in bladder tumours with 6p22 amplification.

artículo científico publicado en 2007

Interfacing native and non-native peptides: using Affimers to recognise α-helix mimicking foldamers ⬇️

artículo científico publicado en 2017

Isolation of isoform-specific binding proteins (Affimers) by phage display using negative selection ⬇️

artículo científico publicado en 2017

Knockdown by shRNA identifies S249C mutant FGFR3 as a potential therapeutic target in bladder cancer.

artículo científico publicado en 2007

Label-free electrochemical impedance biosensor to detect human interleukin-8 in serum with sub-pg/ml sensitivity. ⬇️

artículo científico publicado en 2016

Mechanisms of FGFR3 actions in endocrine resistant breast cancer ⬇️

artículo científico publicado el 29 de agosto de 2011

Multidrug-resistant breast cancer: current perspectives ⬇️

artículo científico publicado en 2014

Non-immunoglobulin scaffold proteins: Precision tools for studying protein-protein interactions in cancer ⬇️

artículo científico publicado en 2018

Phage display selected magnetite interacting Adhirons for shape controlled nanoparticle synthesis. ⬇️

artículo científico publicado en 2015

RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site

artículo científico publicado en 2021

Regulation of Fgf10 gene expression in the prostate: identification of transforming growth factor-beta1 and promoter elements

artículo científico publicado en 2004

Selective and Potent Proteomimetic Inhibitors of Intracellular Protein-Protein Interactions ⬇️

artículo científico publicado en 2015

Selective and potent proteomimetic inhibitors of intracellular protein-protein interactions ⬇️

artículo científico publicado en 2015

Sensitive and selective Affimer-functionalised interdigitated electrode-based capacitive biosensor for Her4 protein tumour biomarker detection. ⬇️

artículo científico publicado en 2018

Site-Specific Labeling of Affimers for DNA-PAINT Microscopy ⬇️

artículo científico publicado en 2018

Small molecule FGF receptor inhibitors block FGFR-dependent urothelial carcinoma growth in vitro and in vivo. ⬇️

artículo científico publicado en 2011

Sonic hedgehog regulates prostatic growth and epithelial differentiation

scientific journal article

Structure-function studies of an engineered scaffold protein derived from Stefin A. II: Development and applications of the SQT variant

artículo científico publicado en 2011

The cellular response to vascular endothelial growth factors requires co-ordinated signal transduction, trafficking and proteolysis ⬇️

artículo científico publicado en 2015

The use of a neutral peptide aptamer scaffold to anchor BH3 peptides constitutes a viable approach to studying their function ⬇️

artículo científico publicado en 2014

Trivalent Gd-DOTA reagents for modification of proteins ⬇️

artículo científico publicado en 2015

Tumor heterogeneity of fibroblast growth factor receptor 3 (FGFR3) mutations in invasive bladder cancer: implications for perioperative anti-FGFR3 treatment. ⬇️

artículo científico publicado en 2016

Ubiquitination of basal VEGFR2 regulates signal transduction and endothelial function ⬇️

artículo científico publicado en 2017

Ultraefficient Cap-Exchange Protocol To Compact Biofunctional Quantum Dots for Sensitive Ratiometric Biosensing and Cell Imaging ⬇️

artículo científico publicado en 2017

Upregulated WEE1 protects endothelial cells of colorectal cancer liver metastases ⬇️

artículo científico publicado en 2017

VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis ⬇️

artículo científico publicado en 2016

VEGFR2 Trafficking, Signaling and Proteolysis is Regulated by the Ubiquitin Isopeptidase USP8. ⬇️

artículo científico publicado en 2015

Vascular endothelial growth factor A-stimulated signaling from endosomes in primary endothelial cells ⬇️

artículo científico publicado en 2014

Vascular endothelial growth factors: multitasking functionality in metabolism, health and disease

artículo científico

Lista de obras de Darren Tomlinson

A Decade of FGF Receptor Research in Bladder Cancer: Past, Present, and Future Challenges ⬇️

A high-throughput assay to identify modifiers of premature chromosome condensation ⬇️

A place for precision medicine in bladder cancer: targeting the FGFRs ⬇️

Adhiron: a stable and versatile peptide display scaffold for molecular recognition applications ⬇️

Affimer Tagged Cubosomes: Targeting of Carcinoembryonic Antigen Expressing Colorectal Cancer Cells Using <i>In Vitro</i> and <i>In Vivo</i> Models

Affimer proteins are versatile and renewable affinity reagents ⬇️

Affimer proteins for F-actin: novel affinity reagents that label F-actin in live and fixed cells ⬇️

Affimer proteins inhibit immune complex binding to FcγRIIIa with high specificity through competitive and allosteric modes of action ⬇️

Affimer reagents as tools in diagnosing plant virus diseases

Altered Splicing of FGFR1 Is Associated with High Tumor Grade and Stage and Leads to Increased Sensitivity to FGF1 in Bladder Cancer ⬇️

Alternative reagents to antibodies in imaging applications ⬇️

Alternative splicing of fibroblast growth factor receptor 3 produces a secreted isoform that inhibits fibroblast growth factor-induced proliferation and is repressed in urothelial carcinoma cell lines

An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes ⬇️

Antibody Mimetics for the Detection of Small Organic Compounds Using a Quartz Crystal Microbalance

Antibody mimetic receptor proteins for label-free biosensors. ⬇️

Chapter Eight - Ubiquitin-Mediated Regulation of Cellular Responses to Vascular Endothelial Growth Factors.

Characterization and applications of a Crimean-Congo hemorrhagic fever virus nucleoprotein-specific Affimer: Inhibitory effects in viral replication and development of colorimetric diagnostic tests

Development and characterisation of a 3D multi-cellular in vitro model of normal human breast: a tool for cancer initiation studies ⬇️

Development of an Affimer-antibody combined immunological diagnosis kit for glypican-3. ⬇️

Differential effects of transforming growth factor-beta1 on cellular proliferation in the developing prostate

Exploration of the HIF-1α/p300 interface using peptide and Adhiron phage display technologies ⬇️

FGFR1-induced epithelial to mesenchymal transition through MAPK/PLCγ/COX-2-mediated mechanisms

FGFR3 and Ras gene mutations are mutually exclusive genetic events in urothelial cell carcinoma

FGFR3 mutation affects cell growth, apoptosis and attachment in keratinocytes

FGFR3 mutation increases bladder tumourigenesis by suppressing acute inflammation

FGFR3 protein expression and its relationship to mutation status and prognostic variables in bladder cancer

Fibroblast growth factor receptor 1 promotes proliferation and survival via activation of the mitogen-activated protein kinase pathway in bladder cancer

Generation of specific inhibitors of SUMO-1- and SUMO-2/3-mediated protein-protein interactions using Affimer (Adhiron) technology ⬇️

High-content, high-throughput screening for the identification of cytotoxic compounds based on cell morphology and cell proliferation markers ⬇️

Hypofibrinolysis in diabetes: a therapeutic target for the reduction of cardiovascular risk ⬇️

Inactivation of the Rb pathway and overexpression of both isoforms of E2F3 are obligate events in bladder tumours with 6p22 amplification.

Interfacing native and non-native peptides: using Affimers to recognise α-helix mimicking foldamers ⬇️

Isolation of isoform-specific binding proteins (Affimers) by phage display using negative selection ⬇️

Knockdown by shRNA identifies S249C mutant FGFR3 as a potential therapeutic target in bladder cancer.

Label-free electrochemical impedance biosensor to detect human interleukin-8 in serum with sub-pg/ml sensitivity. ⬇️

Mechanisms of FGFR3 actions in endocrine resistant breast cancer ⬇️

Multidrug-resistant breast cancer: current perspectives ⬇️

Non-immunoglobulin scaffold proteins: Precision tools for studying protein-protein interactions in cancer ⬇️

Phage display selected magnetite interacting Adhirons for shape controlled nanoparticle synthesis. ⬇️

RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site

Regulation of Fgf10 gene expression in the prostate: identification of transforming growth factor-beta1 and promoter elements

Selective and Potent Proteomimetic Inhibitors of Intracellular Protein-Protein Interactions ⬇️

Selective and potent proteomimetic inhibitors of intracellular protein-protein interactions ⬇️

Sensitive and selective Affimer-functionalised interdigitated electrode-based capacitive biosensor for Her4 protein tumour biomarker detection. ⬇️

Site-Specific Labeling of Affimers for DNA-PAINT Microscopy ⬇️

Small molecule FGF receptor inhibitors block FGFR-dependent urothelial carcinoma growth in vitro and in vivo. ⬇️

Sonic hedgehog regulates prostatic growth and epithelial differentiation

Structure-function studies of an engineered scaffold protein derived from Stefin A. II: Development and applications of the SQT variant

The cellular response to vascular endothelial growth factors requires co-ordinated signal transduction, trafficking and proteolysis ⬇️

The use of a neutral peptide aptamer scaffold to anchor BH3 peptides constitutes a viable approach to studying their function ⬇️

Trivalent Gd-DOTA reagents for modification of proteins ⬇️

Tumor heterogeneity of fibroblast growth factor receptor 3 (FGFR3) mutations in invasive bladder cancer: implications for perioperative anti-FGFR3 treatment. ⬇️

Ubiquitination of basal VEGFR2 regulates signal transduction and endothelial function ⬇️

Ultraefficient Cap-Exchange Protocol To Compact Biofunctional Quantum Dots for Sensitive Ratiometric Biosensing and Cell Imaging ⬇️

Upregulated WEE1 protects endothelial cells of colorectal cancer liver metastases ⬇️

VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis ⬇️

VEGFR2 Trafficking, Signaling and Proteolysis is Regulated by the Ubiquitin Isopeptidase USP8. ⬇️

Vascular endothelial growth factor A-stimulated signaling from endosomes in primary endothelial cells ⬇️

Vascular endothelial growth factors: multitasking functionality in metabolism, health and disease