Lista de obras - Karolina Pytka - Dominio Público Uruguay

A Comparison of the Anorectic Effect and Safety of the Alpha2-Adrenoceptor Ligands Guanfacine and Yohimbine in Rats with Diet-Induced Obesity

artículo científico publicado en 2015

Antiarrhythmic activity of new 2-methoxyphenylpiperazine xanthone derivatives after ischemia/reperfusion in rats

artículo científico publicado en 2015

Antiarrhythmic, hypotensive and α1-adrenolytic properties of new 2-methoxyphenylpiperazine derivatives of xanthone

scientific article published on 18 April 2014

Antidepressant- and Anxiolytic-Like Effects of New Dual 5-HT₁A and 5-HT₇ Antagonists in Animal Models

artículo científico publicado en 2015

Antidepressant-like activity of a new piperazine derivative of xanthone in the forced swim test in mice: The involvement of serotonergic system.

artículo científico publicado en 2014

Antidepressant-like activity of aroxyalkyl derivatives of 2-methoxyphenylpiperazine and evidence for the involvement of serotonin receptor subtypes in their mechanism of action

artículo científico publicado en 2015

Antihistaminic activity of carane derivatives in isolated guinea pig ileum

artículo científico publicado en 2009

Biofunctional studies of new 2-methoxyphenylpiperazine xanthone derivatives with α₁-adrenolytic properties

artículo científico publicado en 2014

Cardiovascular activity of the chiral xanthone derivatives.

artículo científico publicado en 2015

Chemically Homogenous Compounds with Antagonistic Properties at All α1-Adrenoceptor Subtypes but not β1-Adrenoceptor Attenuate Adrenaline-Induced Arrhythmia in Rats

artículo científico publicado en 2016

Design, synthesis and anticonvulsant-analgesic activity of new -[(phenoxy)alkyl]- and -[(phenoxy)ethoxyethyl]aminoalkanols

scientific article published on 11 November 2016

Design, synthesis and evaluation of activity and pharmacokinetic profile of new derivatives of xanthone and piperazine in the central nervous system

artículo científico publicado en 2019

Discovery of novel pERK1/2- or β-Arrestin-Preferring 5-HT1A Receptor Biased Agonists: Diversified Therapeutic-Like vs. Side Effects Profile

artículo científico publicado en 2020

Essential elements in depression and anxiety. Part I.

artículo científico publicado en 2014

Essential elements in depression and anxiety. Part II.

artículo científico publicado en 2014

Evaluation of antidepressant-like and anxiolytic-like activity of purinedione-derivatives with affinity for adenosine A2A receptors in mice

artículo científico publicado en 2016

H3 histamine receptor antagonist pitolisant reverses some subchronic disturbances induced by olanzapine in mice.

artículo científico publicado en 2016

HBK-14 and HBK-15 Do Not Influence Blood Pressure, Lipid Profile, Glucose Level, or Liver Enzymes Activity after Chronic Treatment in Rats

artículo científico publicado en 2016

HBK-14 and HBK-15 with antidepressant-like and/or memory-enhancing properties increase serotonin levels in the hippocampus after chronic treatment in mice.

artículo científico publicado en 2016

HBK-14 and HBK-15, triple 5-HT 1A , 5-HT 7 and 5-HT 3 antagonists with potent antidepressant- and anxiolytic-like properties, increase seizure threshold in various seizure tests in mice

artículo científico publicado en 2017

HBK-15 protects mice from stress-induced behavioral disturbances and changes in corticosterone, BDNF, and NGF levels

artículo científico publicado en 2017

HBK-17, a 5-HT Receptor Ligand With Anxiolytic-Like Activity, Preferentially Activates ß-Arrestin Signaling

scientific article published on 16 October 2018

HBK-7 - A new xanthone derivative and a 5-HT1A receptor antagonist with antidepressant-like properties.

artículo científico publicado en 2016

Metabolic and Cardiovascular Benefits and Risks of EMD386088-A 5-HT6 Receptor Partial Agonist and Dopamine Transporter Inhibitor

artículo científico publicado en 2017

Mitogen-activated protein kinase phosphatase-2 deletion modifies ventral tegmental area function and connectivity and alters reward processing

scientific article published on 27 January 2020

Multifunctional 6-fluoro-3-[3-(pyrrolidin-1-yl)propyl]-1,2-benzoxazoles targeting behavioral and psychological symptoms of dementia (BPSD)

scientific article published on 18 February 2020

Novel 3-(1,2,3,6-Tetrahydropyridin-4-yl)-1H-indole-Based Multifunctional Ligands with Antipsychotic-Like, Mood-Modulating, and Procognitive Activity

artículo científico publicado en 2017

Novel Aryloxyethyl Derivatives of 1-(1-Benzoylpiperidin-4-yl)methanamine as the Extracellular Regulated Kinases 1/2 (ERK1/2) Phosphorylation-Preferring Serotonin 5-HT1A Receptor-Biased Agonists with Robust Antidepressant-like Activity

scientific article published on 02 March 2019

PRELIMINARY EVALUATION OF CENTRAL NERVOUS SYSTEM ACTIVITY OF (E)-N-2-METHYL-3-PHENYLPROP-2-ENYL ((E)-N- α-METHYLCINNAMYL) DERIVATIVES OF SELECTED AMINOALKANOLS.

artículo científico publicado en 2016

Pharmacotherapy of Parkinson's disease: progress or regress?

artículo científico publicado en 2013

Pitolisant protects mice chronically treated with corticosterone from some behavioral but not metabolic changes in corticosterone-induced depression model

artículo científico publicado en 2020

Serotonin receptors in depression and anxiety: Insights from animal studies

scientific article published on 23 August 2018

Single Administration of HBK-15-a Triple 5-HT1A, 5-HT7, and 5-HT3 Receptor Antagonist-Reverses Depressive-Like Behaviors in Mouse Model of Depression Induced by Corticosterone.

artículo científico publicado en 2017

Synthesis and Evaluation of Antidepressant-like Activity of Some 4-Substituted 1-(2-methoxyphenyl)Piperazine Derivatives

scientific article published on 14 August 2014

Synthesis and Evaluation of the Antidepressant-like Properties of HBK-10, a Novel 2-Methoxyphenylpiperazine Derivative Targeting the 5-HT1A and D2 Receptors

artículo científico publicado en 2021

Synthesis and activity of di- or trisubstituted N -(phenoxyalkyl)- or N -{2-[2-(phenoxy)ethoxy]ethyl}piperazine derivatives on the central nervous system

artículo científico publicado en 2018

Synthesis and evaluation of pharmacological properties of some new xanthone derivatives with piperazine moiety.

artículo científico publicado en 2013

Synthesis and preliminary evaluation of pharmacological properties of some piperazine derivatives of xanthone

scientific article published on 24 November 2012

Synthesis of N ‐(phenoxyalkyl)‐, N ‐{2‐[2‐(phenoxy)ethoxy]ethyl}‐ or N ‐(phenoxyacetyl)piperazine Derivatives and Their Activity Within the Central Nervous System

artículo científico publicado en 2019

The Antiarrhythmic Activity of Novel Pyrrolidin-2-one Derivative S-75 in Adrenaline-Induced Arrhythmia

artículo científico publicado en 2021

The antidepressant- and anxiolytic-like activities of new xanthone derivative with piperazine moiety in behavioral tests in mice.

artículo científico publicado en 2016

The antidepressant-like activity of 6-methoxy-2-[4-(2-methoxyphenyl)piperazin-1-yl]-9H-xanthen-9-one involves serotonergic 5-HT(1A) and 5-HT(2A/C) receptors activation

artículo científico publicado en 2015

The antidepressant-like activity of chiral xanthone derivatives may be mediated by 5-HT1A receptor and β-arrestin signalling

artículo científico publicado en 2020

The role of glutamatergic, GABA-ergic, and cholinergic receptors in depression and antidepressant-like effect.

artículo científico publicado en 2015

The role of melatonin, neurokinin, neurotrophic tyrosine kinase and glucocorticoid receptors in antidepressant-like effect

artículo científico publicado en 2017

The role of serotonergic, adrenergic and dopaminergic receptors in antidepressant-like effect

artículo científico publicado en 2015

The selective 5-HT receptor biased agonists, F15599 and F13714, show antidepressant-like properties after a single administration in the mouse model of unpredictable chronic mild stress

artículo científico publicado en 2021

Lista de obras de Karolina Pytka

A Comparison of the Anorectic Effect and Safety of the Alpha2-Adrenoceptor Ligands Guanfacine and Yohimbine in Rats with Diet-Induced Obesity

Antiarrhythmic activity of new 2-methoxyphenylpiperazine xanthone derivatives after ischemia/reperfusion in rats

Antiarrhythmic, hypotensive and α1-adrenolytic properties of new 2-methoxyphenylpiperazine derivatives of xanthone

Antidepressant- and Anxiolytic-Like Effects of New Dual 5-HT₁A and 5-HT₇ Antagonists in Animal Models

Antidepressant-like activity of a new piperazine derivative of xanthone in the forced swim test in mice: The involvement of serotonergic system.

Antidepressant-like activity of aroxyalkyl derivatives of 2-methoxyphenylpiperazine and evidence for the involvement of serotonin receptor subtypes in their mechanism of action

Antihistaminic activity of carane derivatives in isolated guinea pig ileum

Biofunctional studies of new 2-methoxyphenylpiperazine xanthone derivatives with α₁-adrenolytic properties

Cardiovascular activity of the chiral xanthone derivatives.

Chemically Homogenous Compounds with Antagonistic Properties at All α1-Adrenoceptor Subtypes but not β1-Adrenoceptor Attenuate Adrenaline-Induced Arrhythmia in Rats

Design, synthesis and anticonvulsant-analgesic activity of new -[(phenoxy)alkyl]- and -[(phenoxy)ethoxyethyl]aminoalkanols

Design, synthesis and evaluation of activity and pharmacokinetic profile of new derivatives of xanthone and piperazine in the central nervous system

Discovery of novel pERK1/2- or β-Arrestin-Preferring 5-HT1A Receptor Biased Agonists: Diversified Therapeutic-Like vs. Side Effects Profile

Essential elements in depression and anxiety. Part I.

Essential elements in depression and anxiety. Part II.

Evaluation of antidepressant-like and anxiolytic-like activity of purinedione-derivatives with affinity for adenosine A2A receptors in mice

H3 histamine receptor antagonist pitolisant reverses some subchronic disturbances induced by olanzapine in mice.

HBK-14 and HBK-15 Do Not Influence Blood Pressure, Lipid Profile, Glucose Level, or Liver Enzymes Activity after Chronic Treatment in Rats

HBK-14 and HBK-15 with antidepressant-like and/or memory-enhancing properties increase serotonin levels in the hippocampus after chronic treatment in mice.

HBK-14 and HBK-15, triple 5-HT 1A , 5-HT 7 and 5-HT 3 antagonists with potent antidepressant- and anxiolytic-like properties, increase seizure threshold in various seizure tests in mice

HBK-15 protects mice from stress-induced behavioral disturbances and changes in corticosterone, BDNF, and NGF levels

HBK-17, a 5-HT Receptor Ligand With Anxiolytic-Like Activity, Preferentially Activates ß-Arrestin Signaling

HBK-7 - A new xanthone derivative and a 5-HT1A receptor antagonist with antidepressant-like properties.

Metabolic and Cardiovascular Benefits and Risks of EMD386088-A 5-HT6 Receptor Partial Agonist and Dopamine Transporter Inhibitor

Mitogen-activated protein kinase phosphatase-2 deletion modifies ventral tegmental area function and connectivity and alters reward processing

Multifunctional 6-fluoro-3-[3-(pyrrolidin-1-yl)propyl]-1,2-benzoxazoles targeting behavioral and psychological symptoms of dementia (BPSD)

Novel 3-(1,2,3,6-Tetrahydropyridin-4-yl)-1H-indole-Based Multifunctional Ligands with Antipsychotic-Like, Mood-Modulating, and Procognitive Activity

Novel Aryloxyethyl Derivatives of 1-(1-Benzoylpiperidin-4-yl)methanamine as the Extracellular Regulated Kinases 1/2 (ERK1/2) Phosphorylation-Preferring Serotonin 5-HT1A Receptor-Biased Agonists with Robust Antidepressant-like Activity

PRELIMINARY EVALUATION OF CENTRAL NERVOUS SYSTEM ACTIVITY OF (E)-N-2-METHYL-3-PHENYLPROP-2-ENYL ((E)-N- α-METHYLCINNAMYL) DERIVATIVES OF SELECTED AMINOALKANOLS.

Pharmacotherapy of Parkinson's disease: progress or regress?

Pitolisant protects mice chronically treated with corticosterone from some behavioral but not metabolic changes in corticosterone-induced depression model

Serotonin receptors in depression and anxiety: Insights from animal studies

Single Administration of HBK-15-a Triple 5-HT1A, 5-HT7, and 5-HT3 Receptor Antagonist-Reverses Depressive-Like Behaviors in Mouse Model of Depression Induced by Corticosterone.

Synthesis and Evaluation of Antidepressant-like Activity of Some 4-Substituted 1-(2-methoxyphenyl)Piperazine Derivatives

Synthesis and Evaluation of the Antidepressant-like Properties of HBK-10, a Novel 2-Methoxyphenylpiperazine Derivative Targeting the 5-HT1A and D2 Receptors

Synthesis and activity of di- or trisubstituted N -(phenoxyalkyl)- or N -{2-[2-(phenoxy)ethoxy]ethyl}piperazine derivatives on the central nervous system

Synthesis and evaluation of pharmacological properties of some new xanthone derivatives with piperazine moiety.

Synthesis and preliminary evaluation of pharmacological properties of some piperazine derivatives of xanthone

Synthesis of N ‐(phenoxyalkyl)‐, N ‐{2‐[2‐(phenoxy)ethoxy]ethyl}‐ or N ‐(phenoxyacetyl)piperazine Derivatives and Their Activity Within the Central Nervous System

The Antiarrhythmic Activity of Novel Pyrrolidin-2-one Derivative S-75 in Adrenaline-Induced Arrhythmia

The antidepressant- and anxiolytic-like activities of new xanthone derivative with piperazine moiety in behavioral tests in mice.

The antidepressant-like activity of 6-methoxy-2-[4-(2-methoxyphenyl)piperazin-1-yl]-9H-xanthen-9-one involves serotonergic 5-HT(1A) and 5-HT(2A/C) receptors activation

The antidepressant-like activity of chiral xanthone derivatives may be mediated by 5-HT1A receptor and β-arrestin signalling

The role of glutamatergic, GABA-ergic, and cholinergic receptors in depression and antidepressant-like effect.

The role of melatonin, neurokinin, neurotrophic tyrosine kinase and glucocorticoid receptors in antidepressant-like effect

The role of serotonergic, adrenergic and dopaminergic receptors in antidepressant-like effect

The selective 5-HT receptor biased agonists, F15599 and F13714, show antidepressant-like properties after a single administration in the mouse model of unpredictable chronic mild stress