Lista de obras - Kim De Keersmaecker - Dominio Público Uruguay

A novel mouse model provides insights into the neutropenia associated with the ribosomopathy Shwachman-Diamond syndrome

artículo científico publicado en 2015

An activating intragenic deletion in NOTCH1 in human T-ALL ⬇️

artículo científico publicado el 17 de abril de 2012

Bypass of the pre-60S ribosomal quality control as a pathway to oncogenesis

artículo científico publicado en 2014

Cancer Biogenesis in Ribosomopathies

scientific article published on 11 March 2019

Carfilzomib-induced reticulocytosis in patients with multiple myeloma is caused by impaired terminal erythroid maturation

scientific article published on 29 August 2019

Chronic myeloproliferative disorders: a tyrosine kinase tale.

artículo científico publicado en 2006

Codon bias analyses on thyroid carcinoma genes

artículo científico publicado en 2020

Comprehensive analysis of transcriptome variation uncovers known and novel driver events in T-cell acute lymphoblastic leukemia

artículo científico publicado en 2013

Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia

artículo científico publicado en 2010

Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia

artículo científico publicado en 2010

Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia

artículo científico publicado en 2007

Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia

artículo científico publicado en 2012

Fusion of EML1 to ABL1 in T-cell acute lymphoblastic leukemia with cryptic t(9;14)(q34;q32).

artículo científico publicado en 2005

Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia

artículo científico publicado en 2012

Genetic insights in the pathogenesis of T-cell acute lymphoblastic leukemia.

artículo científico publicado en 2005

Genome-wide RNA-mediated interference screen identifies miR-19 targets in Notch-induced T-cell acute lymphoblastic leukaemia

artículo científico publicado en 2010

Heterogeneous patterns of amplification of the NUP214-ABL1 fusion gene in T-cell acute lymphoblastic leukemia.

artículo científico publicado en 2008

High accuracy mutation detection in leukemia on a selected panel of cancer genes

artículo científico publicado en 2012

How Ribosomes Translate Cancer.

artículo científico publicado en 2017

In vitro validation of gamma-secretase inhibitors alone or in combination with other anti-cancer drugs for the treatment of T-cell acute lymphoblastic leukemia.

artículo científico publicado en 2008

Intrinsic differences between the catalytic properties of the oncogenic NUP214-ABL1 and BCR-ABL1 fusion protein kinases

artículo científico publicado en 2008

JAK1 mutation analysis in T-cell acute lymphoblastic leukemia cell lines.

artículo científico publicado en 2009

Loss or inhibition of stromal-derived PlGF prolongs survival of mice with imatinib-resistant Bcr-Abl1(+) leukemia

artículo científico publicado en 2011

Low frequency mutations in ribosomal proteins RPL10 and RPL5 in multiple myeloma.

artículo científico publicado en 2017

Monitoring of Leukemia Clones in B-cell Acute Lymphoblastic Leukemia at Diagnosis and During Treatment by Single-cell DNA Amplicon Sequencing

artículo científico publicado en 2022

Mutation of the receptor tyrosine phosphatase PTPRC (CD45) in T-cell acute lymphoblastic leukemia

artículo científico publicado en 2012

NUP214-ABL1-mediated cell proliferation in T-cell acute lymphoblastic leukemia is dependent on the LCK kinase and various interacting proteins

artículo científico publicado en 2013

Novel insights on TLX1 function in T-ALL pave the way towards differentiation therapy ⬇️

artículo científico publicado el 1 de junio de 2012

PSEN1-selective gamma-secretase inhibition in combination with kinase or XPO-1 inhibitors effectively targets T cell acute lymphoblastic leukemia

scientific article published on 24 June 2021

RPL5 on 1p22.1 is recurrently deleted in multiple myeloma and its expression is linked to bortezomib response

artículo científico publicado en 2016

Rearrangement of NOTCH1 or BCL3 can independently trigger progression of CLL

artículo científico publicado en 2012

Repurposing the antidepressant sertraline as SHMT inhibitor to suppress serine/glycine synthesis addicted breast tumor growth

artículo científico publicado en 2020

Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL.

artículo científico publicado en 2012

Ribosomal Lesions Promote Oncogenic Mutagenesis

scientific article published on 27 November 2018

Ribosomal RNA analysis in the diagnosis of Diamond-Blackfan Anaemia.

artículo científico publicado en 2016

Ribosomal proteins: a novel class of oncogenic drivers.

artículo científico publicado en 2017

Ribosomopathies and the paradox of cellular hypo- to hyperproliferation.

artículo científico publicado en 2015

Single-cell sequencing reveals the origin and the order of mutation acquisition in T-cell acute lymphoblastic leukemia.

artículo científico publicado en 2018

T-ALL: ALL a matter of Translation?

artículo científico publicado en 2015

T-Cell acute lymphoblastic leukemia with a "pinch" of BCR-ABL1.

artículo científico publicado en 2009

TLX1-induced T-cell acute lymphoblastic leukemia

artículo científico publicado en 2011

Targeting nonclassical oncogenes for therapy in T-ALL.

artículo científico publicado en 2012

The T-cell leukemia-associated ribosomal RPL10 R98S mutation enhances JAK-STAT signaling.

artículo científico publicado en 2017

The TLX1 oncogene drives aneuploidy in T cell transformation

artículo científico publicado en 2010

The XPO1 inhibitor KPT-8602 synergizes with dexamethasone in acute lymphoblastic leukemia

scientific article published on 21 August 2020

The genetics and molecular biology of T-ALL.

artículo científico publicado en 2017

The other Achilles' heel of BCR-ABL1.

artículo científico publicado en 2012

The ribosomal RPL10 R98S mutation drives IRES-dependent BCL-2 translation in T-ALL.

artículo científico publicado en 2018

The ribosomal protein gene RPL5 is a haploinsufficient tumor suppressor in multiple cancer types.

artículo científico publicado en 2017

Transition from EML1-ABL1 to NUP214-ABL1 positivity in a patient with acute T-lymphoblastic leukemia

artículo científico publicado en 2006

Translatome analysis reveals altered serine and glycine metabolism in T-cell acute lymphoblastic leukemia cells

scientific article published on 11 June 2019

VEGFC Antibody Therapy Drives Differentiation of AML

artículo científico publicado en 2018

Lista de obras de Kim De Keersmaecker

A novel mouse model provides insights into the neutropenia associated with the ribosomopathy Shwachman-Diamond syndrome

An activating intragenic deletion in NOTCH1 in human T-ALL ⬇️

Bypass of the pre-60S ribosomal quality control as a pathway to oncogenesis

Cancer Biogenesis in Ribosomopathies

Carfilzomib-induced reticulocytosis in patients with multiple myeloma is caused by impaired terminal erythroid maturation

Chronic myeloproliferative disorders: a tyrosine kinase tale.

Codon bias analyses on thyroid carcinoma genes

Comprehensive analysis of transcriptome variation uncovers known and novel driver events in T-cell acute lymphoblastic leukemia

Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia

Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia

Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia

Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia

Fusion of EML1 to ABL1 in T-cell acute lymphoblastic leukemia with cryptic t(9;14)(q34;q32).

Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia

Genetic insights in the pathogenesis of T-cell acute lymphoblastic leukemia.

Genome-wide RNA-mediated interference screen identifies miR-19 targets in Notch-induced T-cell acute lymphoblastic leukaemia

Heterogeneous patterns of amplification of the NUP214-ABL1 fusion gene in T-cell acute lymphoblastic leukemia.

High accuracy mutation detection in leukemia on a selected panel of cancer genes

How Ribosomes Translate Cancer.

In vitro validation of gamma-secretase inhibitors alone or in combination with other anti-cancer drugs for the treatment of T-cell acute lymphoblastic leukemia.

Intrinsic differences between the catalytic properties of the oncogenic NUP214-ABL1 and BCR-ABL1 fusion protein kinases

JAK1 mutation analysis in T-cell acute lymphoblastic leukemia cell lines.

Loss or inhibition of stromal-derived PlGF prolongs survival of mice with imatinib-resistant Bcr-Abl1(+) leukemia

Low frequency mutations in ribosomal proteins RPL10 and RPL5 in multiple myeloma.

Monitoring of Leukemia Clones in B-cell Acute Lymphoblastic Leukemia at Diagnosis and During Treatment by Single-cell DNA Amplicon Sequencing

Mutation of the receptor tyrosine phosphatase PTPRC (CD45) in T-cell acute lymphoblastic leukemia

NUP214-ABL1-mediated cell proliferation in T-cell acute lymphoblastic leukemia is dependent on the LCK kinase and various interacting proteins

Novel insights on TLX1 function in T-ALL pave the way towards differentiation therapy ⬇️

PSEN1-selective gamma-secretase inhibition in combination with kinase or XPO-1 inhibitors effectively targets T cell acute lymphoblastic leukemia

RPL5 on 1p22.1 is recurrently deleted in multiple myeloma and its expression is linked to bortezomib response

Rearrangement of NOTCH1 or BCL3 can independently trigger progression of CLL

Repurposing the antidepressant sertraline as SHMT inhibitor to suppress serine/glycine synthesis addicted breast tumor growth

Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL.

Ribosomal Lesions Promote Oncogenic Mutagenesis

Ribosomal RNA analysis in the diagnosis of Diamond-Blackfan Anaemia.

Ribosomal proteins: a novel class of oncogenic drivers.

Ribosomopathies and the paradox of cellular hypo- to hyperproliferation.

Single-cell sequencing reveals the origin and the order of mutation acquisition in T-cell acute lymphoblastic leukemia.

T-ALL: ALL a matter of Translation?

T-Cell acute lymphoblastic leukemia with a "pinch" of BCR-ABL1.

TLX1-induced T-cell acute lymphoblastic leukemia

Targeting nonclassical oncogenes for therapy in T-ALL.

The T-cell leukemia-associated ribosomal RPL10 R98S mutation enhances JAK-STAT signaling.

The TLX1 oncogene drives aneuploidy in T cell transformation

The XPO1 inhibitor KPT-8602 synergizes with dexamethasone in acute lymphoblastic leukemia

The genetics and molecular biology of T-ALL.

The other Achilles' heel of BCR-ABL1.

The ribosomal RPL10 R98S mutation drives IRES-dependent BCL-2 translation in T-ALL.

The ribosomal protein gene RPL5 is a haploinsufficient tumor suppressor in multiple cancer types.

Transition from EML1-ABL1 to NUP214-ABL1 positivity in a patient with acute T-lymphoblastic leukemia

Translatome analysis reveals altered serine and glycine metabolism in T-cell acute lymphoblastic leukemia cells

VEGFC Antibody Therapy Drives Differentiation of AML