Lista de obras - Kirill Alexandrov - Dominio Público Uruguay

"Inject-mix-react-separate-and-quantitate" (IMReSQ) method for screening enzyme inhibitors

artículo científico publicado en 2008

A cell-free approach to accelerate the study of protein-protein interactions in vitro.

artículo científico publicado en 2013

A generic building block for C- and N-terminal protein-labeling and protein-immobilization

artículo científico publicado en 2006

A genetically encodable microtag for chemo-enzymatic derivatization and purification of recombinant proteins

scientific article published on 01 January 2005

Allosteric regulation of substrate binding and product release in geranylgeranyltransferase type II

artículo científico publicado en 2001

An inverted CAV1 (caveolin 1) topology defines novel autophagy-dependent exosome secretion from prostate cancer cells

artículo científico publicado en 2020

Analysis of the eukaryotic prenylome by isoprenoid affinity tagging

artículo científico publicado en 2009

Application of protein semisynthesis for the construction of functionalized posttranslationally modified rab GTPases

artículo científico publicado en 2005

Artificial linear episome-based protein expression system for protozoon Leishmania tarentolae.

artículo científico publicado en 2010

Biophysical Analysis of the Interaction of Rab6a GTPase with Its Effector Domains

artículo científico publicado en 2008

Boolean Logic Networks Mimicked with Chimeric Enzymes Activated/Inhibited by Several Input Signals

scientific article published on 01 April 2020

C-Terminal Fluorescence Labeling of Proteins for Interaction Studies on the Single-Molecule Level

scientific article published on 01 June 2006

Cellular FRET-Biosensors to Detect Membrane Targeting Inhibitors of N-Myristoylated Proteins

artículo científico publicado en 2013

Chaperone-assisted production of active human Rab8A GTPase in Escherichia coli

scientific journal article

Characterization of the ternary complex between Rab7, REP-1 and Rab geranylgeranyl transferase

scientific article published on 01 October 1999

Chemical biology of protein lipidation: semi-synthesis and structure elucidation of prenylated RabGTPases

artículo científico publicado en 2005

Construction and analysis of Leishmania tarentolae transgenic strains free of selection markers.

artículo científico publicado en 2007

Control of Allosteric Protein Electrochemical Switches with Biomolecular and Electronic Signals

artículo científico publicado en 2020

Cortactin scaffolds Arp2/3 and WAVE2 at the epithelial zonula adherens

artículo científico publicado en 2014

Crystal structure of the GAP domain of Gyp1p: first insights into interaction with Ypt/Rab proteins

artículo científico publicado en 2000

Crystallization and preliminary X-ray diffraction analysis of monoprenylated Rab7 GTPase in complex with Rab escort protein 1

artículo científico publicado en 2003

Crystallization and preliminary X-ray diffraction analysis of the Rab escort protein-1 in complex with Rab geranylgeranyltransferase

artículo científico publicado en 2001

Design of a methotrexate-controlled chemical dimerization system and its use in bio-electronic devices

artículo científico publicado en 2021

Design, synthesis, and characterization of peptide-based rab geranylgeranyl transferase inhibitors

artículo científico publicado en 2009

Development of an inducible protein expression system based on the protozoan host Leishmania tarentolae

artículo científico publicado en 2005

Development of selective RabGGTase inhibitors and crystal structure of a RabGGTase-inhibitor complex

artículo científico publicado en 2008

Diels-Alder ligation and surface immobilization of proteins.

artículo científico publicado en 2005

Diels–Alder Ligation of Peptides and Proteins

Diversity and phylogeny of insect trypanosomatids based on small subunit rRNA genes: polyphyly of Leptomonas and Blastocrithidia.

artículo científico publicado en 2001

Double prenylation by RabGGTase can proceed without dissociation of the mono-prenylated intermediate

artículo científico publicado en 2001

Engineering and exploiting synthetic allostery of NanoLuc luciferase

artículo científico publicado en 2022

Exploiting the Substrate Tolerance of Farnesyltransferase for Site-Selective Protein Derivatization

scholarly article by Uyen T. T. Nguyen published in March 2007

Expression of mammalian Rab Escort protein-1 and -2 in yeast Saccharomyces cerevisiae

artículo científico publicado en 2002

Farnesylation of pex19p is required for its structural integrity and function in peroxisome biogenesis

artículo científico publicado en 2009

Flexible and general synthesis of functionalized phosphoisoprenoids for the study of prenylation in vivo and in vitro

artículo científico publicado en 2012

GTPase activity of Rab5 acts as a timer for endocytic membrane fusion

artículo científico publicado en 1996

Generalizable Protein Biosensors Based on Synthetic Switch Modules

artículo científico publicado en 2019

High-resolution crystal structure of S. cerevisiae Ypt51(DeltaC15)-GppNHp, a small GTP-binding protein involved in regulation of endocytosis

artículo científico publicado en 2000

Identification and specificity profiling of protein prenyltransferase inhibitors using new fluorescent phosphoisoprenoids

artículo científico publicado en 2006

In vitro assembly, purification, and crystallization of the rab geranylgeranyl transferase:substrate complex

artículo científico publicado en 2002

Intein-mediated construction of a library of fluorescent Rab GTPase probes

artículo científico publicado en 2011

Intein-mediated synthesis of geranylgeranylated Rab7 protein in vitro

artículo científico publicado en 2002

Interaction analysis of prenylated Rab GTPase with Rab escort protein and GDP dissociation inhibitor explains the need for both regulators

artículo científico publicado en 2007

Interaction of yeast Rab geranylgeranyl transferase with its protein and lipid substrates

artículo científico publicado en 2002

Isotopic labeling of recombinant proteins expressed in the protozoan host Leishmania tarentolae

artículo científico publicado en 2006

Leishmania cell-free protein expression system.

artículo científico publicado en 2011

Lipidated ras and rab peptides and proteins--synthesis, structure, and function

artículo científico publicado en 2006

Mapping Interactions among Cell-Free Expressed Zika Virus Proteins

scientific article published on 09 March 2020

Mapping of Ras-related GTP-binding proteins by GTP overlay following two-dimensional gel electrophoresis.

artículo científico publicado en 1994

Mechanism of activation of protein kinase JAK2 by the growth hormone receptor

artículo científico publicado en 2014

Moderate discrimination of REP-1 between Rab7⋅GDP and Rab7⋅GTP arises from a difference of an order of magnitude in dissociation rates1

scholarly article by Kirill Alexandrov published in April 1998

Nocardiopsins: new FKBP12-binding macrolide polyketides from an Australian marine-derived actinomycete, Nocardiopsis sp.

artículo científico publicado en 2010

Non-pathogenic trypanosomatid protozoa as a platform for protein research and production

artículo científico publicado en 2002

Nucleotide exchange via local protein unfolding--structure of Rab8 in complex with MSS4.

artículo científico publicado en 2006

Organization and Function of the Rab Prenylation and Recycling Machinery

Oriented Immobilization of Farnesylated Proteins by the Thiol-Ene Reaction

artículo científico publicado en 2010

Phosphoisoprenoid Binding Specificity of Geranylgeranyltransferase Type II

artículo científico publicado en 2000

Phosphoisoprenoids modulate association of Rab geranylgeranyltransferase with REP-1.

artículo científico publicado en 2001

Polyketides from the marine-derived fungus Ascochyta salicorniae and their potential to inhibit protein phosphatases.

artículo científico publicado en 2006

Production of eukaryotic cell-free lysate from Leishmania tarentolae

artículo científico publicado en 2014

Psoromic acid is a selective and covalent Rab-prenylation inhibitor targeting autoinhibited RabGGTase

artículo científico publicado en 2012

Quantitative Analysis of Prenylated RhoA Interaction with Its Chaperone, RhoGDI

artículo científico publicado en 2012

Rab GTPase prenylation hierarchy and its potential role in choroideremia disease

artículo científico publicado en 2013

Rab-subfamily-specific regions of Ypt7p are structurally different from other RabGTPases

artículo científico publicado en 2002

Rapid production of functionalized recombinant proteins: marrying ligation independent cloning and in vitro protein ligation

artículo científico publicado en 2006

Semi-synthetic Rab proteins as tools for studying intermolecular interactions

artículo científico publicado en 2000

Site-Selective Protein Immobilization by Staudinger Ligation

artículo científico publicado en 2006

Site-specific attachment of polyethylene glycol-like oligomers to proteins and peptides.

artículo científico publicado en 2006

Structural and thermodynamic analysis of the GFP:GFP-nanobody complex

artículo científico publicado en 2010

Structure of Rab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase

artículo científico publicado en 2003

Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase

artículo científico publicado en 2003

Structure of doubly prenylated Ypt1:GDI complex and the mechanism of GDI-mediated Rab recycling

artículo científico publicado en 2006

Structure of the disordered C terminus of Rab7 GTPase induced by binding to the Rab geranylgeranyl transferase catalytic complex reveals the mechanism of Rab prenylation

artículo científico publicado en 2009

Structure-guided development of selective RabGGTase inhibitors

artículo científico publicado en 2011

Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation

artículo científico publicado en 2008

Subunit organisation of in vitro reconstituted HOPS and CORVET multisubunit membrane tethering complexes

artículo científico publicado en 2013

Synthesis of Functionalized Rab GTPases by a Combination of Solution- or Solid-Phase Lipopeptide Synthesis with Expressed Protein Ligation

scientific article published on 01 April 2005

Synthesis of a fluorescent analogue of geranylgeranyl pyrophosphate and its use in a high-throughput fluorometric assay for Rab geranylgeranyltransferase

artículo científico publicado en 2007

Synthesis of fluorescently labeled mono- and diprenylated Rab7 GTPase

artículo científico publicado en 2004

Towards the construction of expressed proteomes using a Leishmania tarentolae based cell-free expression system

artículo científico publicado en 2010

Vps9, Rabex-5 and DSS4: proteins with weak but distinct nucleotide-exchange activities for Rab proteins

artículo científico publicado en 2001

Lista de obras de Kirill Alexandrov

"Inject-mix-react-separate-and-quantitate" (IMReSQ) method for screening enzyme inhibitors

A cell-free approach to accelerate the study of protein-protein interactions in vitro.

A generic building block for C- and N-terminal protein-labeling and protein-immobilization

A genetically encodable microtag for chemo-enzymatic derivatization and purification of recombinant proteins

Allosteric regulation of substrate binding and product release in geranylgeranyltransferase type II

An inverted CAV1 (caveolin 1) topology defines novel autophagy-dependent exosome secretion from prostate cancer cells

Analysis of the eukaryotic prenylome by isoprenoid affinity tagging

Application of protein semisynthesis for the construction of functionalized posttranslationally modified rab GTPases

Artificial linear episome-based protein expression system for protozoon Leishmania tarentolae.

Biophysical Analysis of the Interaction of Rab6a GTPase with Its Effector Domains

Boolean Logic Networks Mimicked with Chimeric Enzymes Activated/Inhibited by Several Input Signals

C-Terminal Fluorescence Labeling of Proteins for Interaction Studies on the Single-Molecule Level

Cellular FRET-Biosensors to Detect Membrane Targeting Inhibitors of N-Myristoylated Proteins

Chaperone-assisted production of active human Rab8A GTPase in Escherichia coli

Characterization of the ternary complex between Rab7, REP-1 and Rab geranylgeranyl transferase

Chemical biology of protein lipidation: semi-synthesis and structure elucidation of prenylated RabGTPases

Construction and analysis of Leishmania tarentolae transgenic strains free of selection markers.

Control of Allosteric Protein Electrochemical Switches with Biomolecular and Electronic Signals

Cortactin scaffolds Arp2/3 and WAVE2 at the epithelial zonula adherens

Crystal structure of the GAP domain of Gyp1p: first insights into interaction with Ypt/Rab proteins

Crystallization and preliminary X-ray diffraction analysis of monoprenylated Rab7 GTPase in complex with Rab escort protein 1

Crystallization and preliminary X-ray diffraction analysis of the Rab escort protein-1 in complex with Rab geranylgeranyltransferase

Design of a methotrexate-controlled chemical dimerization system and its use in bio-electronic devices

Design, synthesis, and characterization of peptide-based rab geranylgeranyl transferase inhibitors

Development of an inducible protein expression system based on the protozoan host Leishmania tarentolae

Development of selective RabGGTase inhibitors and crystal structure of a RabGGTase-inhibitor complex

Diels-Alder ligation and surface immobilization of proteins.

Diels–Alder Ligation of Peptides and Proteins

Diversity and phylogeny of insect trypanosomatids based on small subunit rRNA genes: polyphyly of Leptomonas and Blastocrithidia.

Double prenylation by RabGGTase can proceed without dissociation of the mono-prenylated intermediate

Engineering and exploiting synthetic allostery of NanoLuc luciferase

Exploiting the Substrate Tolerance of Farnesyltransferase for Site-Selective Protein Derivatization

Expression of mammalian Rab Escort protein-1 and -2 in yeast Saccharomyces cerevisiae

Farnesylation of pex19p is required for its structural integrity and function in peroxisome biogenesis

Flexible and general synthesis of functionalized phosphoisoprenoids for the study of prenylation in vivo and in vitro

GTPase activity of Rab5 acts as a timer for endocytic membrane fusion

Generalizable Protein Biosensors Based on Synthetic Switch Modules

High-resolution crystal structure of S. cerevisiae Ypt51(DeltaC15)-GppNHp, a small GTP-binding protein involved in regulation of endocytosis

Identification and specificity profiling of protein prenyltransferase inhibitors using new fluorescent phosphoisoprenoids

In vitro assembly, purification, and crystallization of the rab geranylgeranyl transferase:substrate complex

Intein-mediated construction of a library of fluorescent Rab GTPase probes

Intein-mediated synthesis of geranylgeranylated Rab7 protein in vitro

Interaction analysis of prenylated Rab GTPase with Rab escort protein and GDP dissociation inhibitor explains the need for both regulators

Interaction of yeast Rab geranylgeranyl transferase with its protein and lipid substrates

Isotopic labeling of recombinant proteins expressed in the protozoan host Leishmania tarentolae

Leishmania cell-free protein expression system.

Lipidated ras and rab peptides and proteins--synthesis, structure, and function

Mapping Interactions among Cell-Free Expressed Zika Virus Proteins

Mapping of Ras-related GTP-binding proteins by GTP overlay following two-dimensional gel electrophoresis.

Mechanism of activation of protein kinase JAK2 by the growth hormone receptor

Moderate discrimination of REP-1 between Rab7⋅GDP and Rab7⋅GTP arises from a difference of an order of magnitude in dissociation rates1

Nocardiopsins: new FKBP12-binding macrolide polyketides from an Australian marine-derived actinomycete, Nocardiopsis sp.

Non-pathogenic trypanosomatid protozoa as a platform for protein research and production

Nucleotide exchange via local protein unfolding--structure of Rab8 in complex with MSS4.

Organization and Function of the Rab Prenylation and Recycling Machinery

Oriented Immobilization of Farnesylated Proteins by the Thiol-Ene Reaction

Phosphoisoprenoid Binding Specificity of Geranylgeranyltransferase Type II

Phosphoisoprenoids modulate association of Rab geranylgeranyltransferase with REP-1.

Polyketides from the marine-derived fungus Ascochyta salicorniae and their potential to inhibit protein phosphatases.

Production of eukaryotic cell-free lysate from Leishmania tarentolae

Psoromic acid is a selective and covalent Rab-prenylation inhibitor targeting autoinhibited RabGGTase

Quantitative Analysis of Prenylated RhoA Interaction with Its Chaperone, RhoGDI

Rab GTPase prenylation hierarchy and its potential role in choroideremia disease

Rab-subfamily-specific regions of Ypt7p are structurally different from other RabGTPases

Rapid production of functionalized recombinant proteins: marrying ligation independent cloning and in vitro protein ligation

Semi-synthetic Rab proteins as tools for studying intermolecular interactions

Site-Selective Protein Immobilization by Staudinger Ligation

Site-specific attachment of polyethylene glycol-like oligomers to proteins and peptides.

Structural and thermodynamic analysis of the GFP:GFP-nanobody complex

Structure of Rab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase

Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase

Structure of doubly prenylated Ypt1:GDI complex and the mechanism of GDI-mediated Rab recycling

Structure of the disordered C terminus of Rab7 GTPase induced by binding to the Rab geranylgeranyl transferase catalytic complex reveals the mechanism of Rab prenylation

Structure-guided development of selective RabGGTase inhibitors

Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation

Subunit organisation of in vitro reconstituted HOPS and CORVET multisubunit membrane tethering complexes

Synthesis of Functionalized Rab GTPases by a Combination of Solution- or Solid-Phase Lipopeptide Synthesis with Expressed Protein Ligation

Synthesis of a fluorescent analogue of geranylgeranyl pyrophosphate and its use in a high-throughput fluorometric assay for Rab geranylgeranyltransferase

Synthesis of fluorescently labeled mono- and diprenylated Rab7 GTPase