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Lista de obras de Dominique Heymann

12b80 - Hydroxybisphosphonate Linked Doxorubicin: Bone Targeted Strategy for Treatment of Osteosarcoma

scientific article published on 10 May 2019

3D curved multiplanar cone beam CT reconstruction for intracochlear position assessment of straight electrodes array. A temporal bone and clinical study

artículo científico publicado en 2016

99mTc-NTP 15-5 assessment of the early therapeutic response of chondrosarcoma to zoledronic acid in the Swarm rat orthotopic model

artículo científico publicado en 2013

A Disintegrin And Metalloproteinase 12 produced by tumour cells accelerates osteosarcoma tumour progression and associated osteolysis

artículo científico publicado en 2013

A One-Pot Synthesis of 1-Hydroxy-1,1-bis(phosphonic acid)s Starting from the Corresponding Carboxylic Acids

artículo científico publicado en 2011

A Simple 3D Cell Culture Method for Studying the Interactions between Human Mesenchymal Stromal/Stem Cells and Patients Derived Glioblastoma

artículo científico publicado en 2023

A combination of methotrexate and zoledronic acid prevents bone erosions and systemic bone mass loss in collagen induced arthritis

artículo científico publicado en 2009

A functional, new short isoform of death receptor 4 in Ewing's sarcoma cell lines may be involved in TRAIL sensitivity/resistance mechanisms

artículo científico publicado en 2012

A new experimental rat model of osteosarcoma established by intrafemoral tumor cell inoculation, useful for biology and therapy investigations

artículo científico publicado en 2005

Adapting palliative radiation therapy for bone metastases during the Covid-19 pandemic: GEMO position paper

artículo científico publicado en 2020

Advantages of bioluminescence imaging to follow siRNA or chemotherapeutic treatments in osteosarcoma preclinical models

artículo científico publicado en 2010

Allele-specific Col1a1 silencing reduces mutant collagen in fibroblasts from Brtl mouse, a model for classical osteogenesis imperfecta

artículo científico publicado en 2013

Analysis of gap junctional intercellular communications using a dielectrophoresis-based microchip

artículo científico publicado en 2017

Anti-Metastatic Properties of a Marine Bacterial Exopolysaccharide-Based Derivative Designed to Mimic Glycosaminoglycans

artículo científico publicado en 2016

Anti-PD1 therapy induces lymphocyte-derived exosomal miRNA-4315 release inhibiting Bim-mediated apoptosis of tumor cells

artículo científico publicado en 2020

Anticancer activity of halofuginone in a preclinical model of osteosarcoma: inhibition of tumor growth and lung metastases

artículo científico publicado en 2015

Are Fluorescent Organic Nanoparticles Relevant Tools for Tracking Cancer Cells or Macrophages?

artículo científico publicado en 2015

Association of human growth hormone and calcium phosphate by dynamic compaction:In vitro biocompatibility and bioactivity ⬇️

artículo científico publicado el 1 de agosto de 1997

Autophagy in osteoblasts is involved in mineralization and bone homeostasis

artículo científico publicado en 2014

BYL719, a new α-specific PI3K inhibitor: single administration and in combination with conventional chemotherapy for the treatment of osteosarcoma

artículo científico publicado en 2014

Bidirectional regulation of bone formation by exogenous and osteosarcoma-derived Sema3A.

artículo científico publicado en 2018

Biological activities of sustained polymyxin B release from calcium phosphate biomaterial prepared by dynamic compaction: an in vitro study

artículo científico publicado en 1999

Biology of Bone Sarcomas and New Therapeutic Developments

artículo científico publicado en 2017

Bisphosphonates: new therapeutic agents for the treatment of bone tumors

artículo científico publicado en 2004

Blocking HSP90 Addiction Inhibits Tumor Cell Proliferation, Metastasis Development, and Synergistically Acts with Zoledronic Acid to Delay Osteosarcoma Progression

artículo científico publicado en 2015

Bone Morphogenetic Protein 2 and Transforming Growth Factor β1 Inhibit the Expression of the Proinflammatory Cytokine IL-34 in Rheumatoid Arthritis Synovial Fibroblasts

artículo científico publicado en 2016

Bone Tumor Environment as a Potential Therapeutic Target in Ewing Sarcoma

artículo científico publicado en 2015

Bone microenvironment has an influence on the histological response of osteosarcoma to chemotherapy: retrospective analysis and preclinical modeling

artículo científico publicado en 2017

Bone remodelling and tumour grade modifications induced by interactions between bone and swarm rat chondrosarcoma

artículo científico publicado en 2002

Cancer stem cells in osteosarcoma

artículo científico publicado en 2016

Caractérisation de la dormance d’une lignée cellulaire d’ostéosarcome en culture trois-dimensions

artículo científico publicado en 2022

Carotid and femoral atherosclerotic plaques show different morphology ⬇️

artículo científico publicado el 1 de marzo de 2011

Cell-free circulating epimarks in cancer monitoring

scientific article published on 09 January 2020

Cellular activity and signaling induced by osteoprotegerin in osteoclasts: involvement of receptor activator of nuclear factor kappaB ligand and MAPK.

artículo científico publicado en 2004

Characterization of osteoprotegerin binding to glycosaminoglycans by surface plasmon resonance: role in the interactions with receptor activator of nuclear factor kappaB ligand (RANKL) and RANK.

artículo científico

Circulating Tumor Cell-Derived Pre-Clinical Models for Personalized Medicine

Circulating Tumor Cells: A Review of Non-EpCAM-Based Approaches for Cell Enrichment and Isolation

artículo científico publicado en 2016

Circulating Tumor Cells: The Importance of Single Cell Analysis

artículo científico publicado en 2018

Clusterin inhibition using OGX-011 synergistically enhances zoledronic acid activity in osteosarcoma

artículo científico publicado en 2014

Concise review: embryonic stem cells: a new tool to study osteoblast and osteoclast differentiation

artículo científico publicado en 2006

Conditioned media from mouse osteosarcoma cells promote MC3T3-E1 cell proliferation using JAKs and PI3-K/Akt signal crosstalk

artículo científico publicado en 2008

Connexin43 intercellular communication drives the early differentiation of human bone marrow stromal cells into osteoblasts

artículo científico publicado en 2017

Constitutive expression of TNF-related activation-induced cytokine (TRANCE)/receptor activating NF-κB ligand (RANK)-L by rat plasmacytoid dendritic cells

artículo científico publicado en 2012

Culturing of cells from giant cell tumour of bone on natural and synthetic calcified substrata: the effect of leukaemia inhibitory factor and vitamin D3 on the resorbing activity of osteoclast-like cells

artículo científico publicado en 1995

Current therapeutic strategies and novel approaches in osteosarcoma

artículo científico

Cysteine protease production by human osteosarcoma cells (MG63, SAOS2) and its modulation by soluble factors

artículo científico publicado en 2000

Cytokine production by human thymic epithelial cells: control by the immune recognition of the neurohypophysial self-antigen.

artículo científico publicado en 1996

Cytokines, growth factors and osteoclasts

artículo científico publicado en 1998

Cytosine methylation of mature microRNAs inhibits their functions and is associated with poor prognosis in glioblastoma multiforme

artículo científico publicado en 2020

DU145 human prostate cancer cells express functional receptor activator of NFkappaB: new insights in the prostate cancer bone metastasis process

artículo científico publicado en 2006

Damage to inner ear structure during cochlear implantation: Correlation between insertion force and radio-histological findings in temporal bone specimens

artículo científico publicado en 2016

Design and validation of a tunable inertial microfluidic system for the efficient enrichment of circulating tumor cells in blood

artículo científico publicado en 2022

Development of enzymo-immunoassays (EIA) for macrophage colony-stimulating factor (M-CSF) and leukaemia inhibitory factor (LIF) by using the same capture and signal generating polyclonal antibody

artículo científico publicado en 1996

Development of prohibitin ligands against osteoporosis ⬇️

artículo científico publicado en 2020

Differentiation of osteoblasts from mouse embryonic stem cells without generation of embryoid body

artículo científico publicado en 2007

Direct anti-cancer effect of oncostatin M on chondrosarcoma

artículo científico publicado en 2011

Distinct roles of Bcl-2 and Bcl-Xl in the apoptosis of human bone marrow mesenchymal stem cells during differentiation

artículo científico publicado en 2011

Dormant, quiescent, tolerant and persister cells: four synonyms for the same target in cancer

artículo científico publicado en 2018

Downregulation of osteoblast markers and induction of the glial fibrillary acidic protein by oncostatin M in osteosarcoma cells require PKCdelta and STAT3.

artículo científico publicado en 2004

Drugs in early clinical development for the treatment of osteosarcoma

artículo científico publicado en 2016

Drugs targeting the bone microenvironment: new therapeutic tools in Ewing's sarcoma? ⬇️

artículo científico publicado el 20 de agosto de 2013

Dysregulation of macrophage polarization is associated with the metastatic process in osteosarcoma

artículo científico publicado en 2016

Effect of adding bone marrow to ceramic graft materials with different interconnectivities in lumbar arthrodesis : quantification of bone formation.

artículo científico publicado en 2012

Effects of leukemia inhibitory factor and oncostatin M on bone mineral formed in in vitro rat bone-marrow stromal cell culture: physicochemical aspects

artículo científico publicado en 1998

Enhanced tumor regression and tissue repair when zoledronic acid is combined with ifosfamide in rat osteosarcoma

artículo científico publicado en 2005

Excimer laser-assisted lamellar endothelial keratoplasty (ExALEK): Technique and results

artículo científico publicado en 2016

Expression of leukemia inhibitory factor by cartilage-forming tumors of bone: an immunohistochemical study

artículo científico publicado en 1999

Extraosseous bone formation obtained by association of mesenchymal stem cells with a periosteal flap in the rat.

artículo científico publicado en 2007

Factor VIII-von Willebrand factor complex inhibits osteoclastogenesis and controls cell survival

artículo científico publicado en 2009

Farnesyl diphosphate synthase is involved in the resistance to zoledronic acid of osteosarcoma cells

artículo científico publicado en 2008

First preclinical imaging of primary cartilage neoplasm and its local recurrence using 99mTc-NTP 15-5 radiotracer

artículo científico publicado en 2009

Formulated siRNAs targeting Rankl prevent osteolysis and enhance chemotherapeutic response in osteosarcoma models

artículo científico publicado en 2011

Genetically-achieved disturbances to the expression levels of TNFSF11 receptors modulate the effects of zoledronic acid on growing mouse skeletons

scientific article published on 28 June 2019

Glycosaminoglycans as potential regulators of osteoprotegerin therapeutic activity in osteosarcoma

artículo científico publicado en 2009

Glycosaminoglycans inhibit the adherence and the spreading of osteoclasts and their precursors: role in osteoclastogenesis and bone resorption

artículo científico publicado en 2010

Growth hormone stimulates multinucleated cell formation in long-term bone marrow cultures

artículo científico publicado en 1998

Growth hormone stimulates the degradation of calcium phosphate biomaterial by human monocytes macrophagesin vitro

artículo científico publicado en 1998

Growth hormone-loaded macroporous calcium phosphate ceramic: in vitro biopharmaceutical characterization and preliminary in vivo study

artículo científico publicado en 1998

Hamstring insertion site healing after anterior cruciate ligament reconstruction in patients with symptomatic hardware or repeat rupture: a histologic study in 12 patients

artículo científico publicado en 2003

Heterotopic implantation of mouse bone-marrow cells: an in vivo model allowing analysis of mineral phases during mineralization processes.

artículo científico publicado en 1998

Human breast cancer cells educate macrophages toward the M2 activation status

artículo científico publicado en 2015

Human growth hormone locally released in bone sites by calcium-phosphate biomaterial stimulates ceramic bone substitution without systemic effects: a rabbit study

artículo científico publicado en 1998

IL-1β and TNFα promote monocyte viability through the induction of GM-CSF expression by rheumatoid arthritis synovial fibroblasts

artículo científico publicado en 2014

IL-33 is expressed in human osteoblasts, but has no direct effect on bone remodeling

artículo científico publicado en 2010

IL-34 and M-CSF form a novel heteromeric cytokine and regulate the M-CSF receptor activation and localization.

artículo científico publicado en 2015

IL-6, RANKL, TNF-alpha/IL-1: interrelations in bone resorption pathophysiology

artículo científico publicado en 2004

Identification of genomic differences among peripheral arterial beds in atherosclerotic and healthy arteries

artículo científico publicado en 2018

Imatinib mesylate exerts anti-proliferative effects on osteosarcoma cells and inhibits the tumour growth in immunocompetent murine models

artículo científico publicado en 2014

Impact of oncopediatric dosing regimen of zoledronic acid on bone growth: Preclinical studies and case report of an osteosarcoma pediatric patient ⬇️

artículo científico publicado el 1 de octubre de 2011

Implication of molecular vascular smooth muscle cell heterogeneity among arterial beds in arterial calcification.

artículo científico publicado en 2018

In vitro and in vivo discrepancy in inducing apoptosis by mesenchymal stromal cells delivering membrane-bound tumor necrosis factor–related apoptosis inducing ligand in osteosarcoma pre-clinical models

artículo científico publicado en 2018

In vitro assessment of combining osteogenic cells with macroporous calcium-phosphate ceramics

artículo científico publicado en 2001

Increased levels of leukaemia inhibitory factor (LIF) in urine and tissue culture supernatant from human primary bone tumours

artículo científico publicado en 1998

Induction of osteogenesis in mesenchymal stem cells by activated monocytes/macrophages depends on oncostatin M signaling

artículo científico publicado en 2012

Influence of biphasic calcium phosphate granulometry on bone ingrowth, ceramic resorption, and inflammatory reactions: preliminary in vitro and in vivo study

artículo científico publicado en 1999

Influence of bone environment on ceramic osteointegration in spinal fusion: comparison of bone-poor and bone-rich sites ⬇️

artículo científico publicado el 1 de octubre de 2001

Influence of metal ion solutions on rabbit osteoclast activities in vitro

artículo científico publicado en 2002

Inhibition of BET proteins and epigenetic signaling as a potential treatment for osteoporosis

artículo científico publicado en 2016

Inhibition of apatite formation by vitronectin

artículo científico publicado en 2000

Inhibition of osteolysis and increase of bone formation after local administration of siRNA-targeting RANK in a polyethylene particle-induced osteolysis model

artículo científico publicado en 2015

Interaction of Cutibacterium ( formerly Propionibacterium) acnes with bone cells: a step toward understanding bone and joint infection development

artículo científico publicado en 2017

Interleukin 34 expression is associated with synovitis severity in rheumatoid arthritis patients

artículo científico publicado en 2011

Interleukin-34 is expressed by giant cell tumours of bone and plays a key role in RANKL-induced osteoclastogenesis

artículo científico publicado en 2010

Interleukin-34 promotes tumor progression and metastatic process in osteosarcoma through induction of angiogenesis and macrophage recruitment

artículo científico publicado en 2014

Interleukin-6 inhibits receptor activator of nuclear factor kappaB ligand-induced osteoclastogenesis by diverting cells into the macrophage lineage: key role of Serine727 phosphorylation of signal transducer and activator of transcription 3.

artículo científico publicado en 2008

Jaw osteosarcoma models in mice: first description

Joint bleeding in factor VIII deficient mice causes an acute loss of trabecular bone and calcification of joint soft tissues which is prevented with aggressive factor replacement

artículo científico publicado en 2014

Key roles of the OPG-RANK-RANKL system in bone oncology

artículo científico publicado en 2007

Killer dendritic cells link innate and adaptive immunity against established osteosarcoma in rats

artículo científico publicado en 2008

L-MTP-PE and zoledronic acid combination in osteosarcoma: preclinical evidence of positive therapeutic combination for clinical transfer

artículo científico publicado en 2016

LPS increases biomaterial degradation by human monocytes in vitro

artículo científico publicado en 1997

Leukaemia inhibitory factor (LIF) production in pleural effusions: comparison with production of IL-4, IL-8, IL-10 and macrophage-colony stimulating factor (M-CSF)

artículo científico publicado en 1996

Leukemia inhibitory factor and oncostatin M influence the mineral phases formed in a murine heterotopic calcification model: a Fourier transform-infrared microspectroscopic study

artículo científico publicado en 1998

Liposomal muramyl tripeptide phosphatidyl ethanolamine: a safe and effective agent against osteosarcoma pulmonary metastases

artículo científico publicado en 2008

Long term oncostatin M treatment induces an osteocyte-like differentiation on osteosarcoma and calvaria cells

artículo científico publicado en 2009

Loss of connexin43 expression in Ewing's sarcoma cells favors the development of the primary tumor and the associated bone osteolysis.

artículo científico publicado en 2013

Loss of miR-198 and -206 during primary tumor progression enables metastatic dissemination in human osteosarcoma

Low-Dose Pesticide Mixture Induces Accelerated Mesenchymal Stem Cell Aging In Vitro

scientific article published on 17 April 2019

Low-Dose Pesticide Mixture Induces Senescence in Normal Mesenchymal Stem Cells (MSC) and Promotes Tumorigenic Phenotype in Premalignant MSC.

artículo científico publicado en 2016

Maternal RANKL Reduces the Osteopetrotic Phenotype of Null Mutant Mouse Pups

artículo científico publicado en 2018

Mechanisms of bone repair and regeneration

artículo científico publicado en 2009

Mechanistic study of the proangiogenic effect of osteoprotegerin

artículo científico publicado en 2013

Mesenchymal stem cells increase proliferation but do not change quiescent state of osteosarcoma cells: Potential implications according to the tumor resection status

artículo científico publicado en 2015

Mesenchymal stem cells induce a weak immune response in the rat striatum after allo or xenotransplantation

artículo científico publicado en 2009

Metastatic osteosarcoma challenged by regorafenib

artículo científico publicado en 2018

Metatarsal giant cell tumors and giant cell reparative granuloma are similar entities

artículo científico publicado en 2003

Mifamurtide for the treatment of nonmetastatic osteosarcoma

artículo científico publicado en 2011

Modulation by soluble factors of gelatinase activities released by osteoblastic cells

artículo científico publicado en 2000

Modulation of LIF expression in human melanoma cells by oncostatin M

artículo científico publicado en 1995

Modulation of integrin alpha-v-beta-1 expression on human tumor cells by leukemia inhibitory factor (LIF) and oncostatin M (OSM)

artículo científico publicado en 1996

Modulatory effects of proteoglycans on proteinase activities

artículo científico publicado en 2012

Molecular alterations associated with osteosarcoma development

artículo científico publicado en 2012

Murine Models of Bone Sarcomas

scientific article published on 01 January 2019

NVP-BEZ235, a dual PI3K/mTOR inhibitor, inhibits osteosarcoma cell proliferation and tumor development in vivo with an improved survival rate

artículo científico publicado en 2013

Novel RANK antagonists for the treatment of bone-resorptive disease: theoretical predictions and experimental validation

artículo científico publicado en 2014

Novel anti-cancer strategy in bone tumors by targeting molecular and cellular modulators of bone resorption

artículo científico publicado en 2008

OPG, RANK and RANK ligand expression in thyroid lesions

artículo científico publicado en 2008

OPG/membranous--RANKL complex is internalized via the clathrin pathway before a lysosomal and a proteasomal degradation

artículo científico publicado en 2006

Oncostatin M induces bone loss and sensitizes rat osteosarcoma to the antitumor effect of Midostaurin in vivo

artículo científico publicado en 2008

Oncostatin M is a growth factor for Ewing sarcoma

artículo científico publicado en 2012

Oncostatin m, an inflammatory cytokine produced by macrophages, supports intramembranous bone healing in a mouse model of tibia injury

artículo científico publicado en 2015

Opposite Effects of Soluble Factors Secreted by Adipose Tissue on Proliferating and Quiescent Osteosarcoma Cells

artículo científico publicado en 2016

Oral administration of edelfosine encapsulated lipid nanoparticles causes regression of lung metastases in pre-clinical models of osteosarcoma

artículo científico publicado en 2018

Origins of Alterations to Rankl Null Mutant Mouse Dental Root Development

artículo científico publicado en 2020

Orthopaedic implant failure: aseptic implant loosening--the contribution and future challenges of mouse models in translational research

artículo científico publicado en 2014

Osteoblastic and osteoclastic differentiation of human mesenchymal stem cells and monocytes in a miniaturized three-dimensional culture with mineral granules.

artículo científico publicado en 2014

Osteoclastic resorption of biphasic calcium phosphate ceramic in vitro

artículo científico publicado en 1997

Osteoclastic resorption of calcium phosphate ceramics with different hydroxyapatite/beta-tricalcium phosphate ratios

artículo científico publicado en 1997

Osteoclasts in RA: diverse origins and functions

artículo científico

Osteogenic potential in vitro of human bone marrow cells cultured on macroporous biphasic calcium phosphate ceramic

artículo científico publicado en 1999

Osteoimmunology of Oral and Maxillofacial Diseases: Translational Applications Based on Biological Mechanisms

artículo científico publicado en 2019

Osteolytic bone diseases: physiological analogues of bone resorption effectors as alternative therapeutic tools

artículo científico publicado en 2005

Osteoprotegerin Induces CD34+ Differentiation in Endothelial Progenitor Cells

Osteoprotegerin inhibits bone resorption and prevents tumor development in a xenogenic model of Ewing's sarcoma by inhibiting RANKL

artículo científico publicado en 2013

Osteoprotegerin regulates cancer cell migration through SDF-1/CXCR4 axis and promotes tumour development by increasing neovascularization

artículo científico publicado en 2017

Osteoprotegerin, a new actor in vasculogenesis, stimulates endothelial colony-forming cells properties.

artículo científico publicado en 2011

Osteoprotegerin, pericytes and bone-like vascular calcification are associated with carotid plaque stability

artículo científico publicado en 2014

Osteoprotegerin: a new therapeutic agent for the treatment of bone disease

artículo científico publicado en 2001

Osteoprotegerin: multiple partners for multiple functions

artículo científico

Osteosarcoma: current status of immunotherapy and future trends (Review).

artículo científico publicado en 2006

Overexpression of smad7 blocks primary tumor growth and lung metastasis development in osteosarcoma

artículo científico publicado en 2014

Oxytocin reverses osteoporosis in a sex-dependent manner

artículo científico publicado en 2015

Oxytocin reverses ovariectomy-induced osteopenia and body fat gain

artículo científico publicado en 2014

Paradoxical effects of JZL184, an inhibitor of monoacylglycerol lipase, on bone remodelling in healthy and cancer-bearing mice

scientific article published on 29 May 2019

Paradoxical side effects of bisphosphonates on the skeleton: what do we know and what can we do?

artículo científico publicado en 2018

Pathogenic potential of Escherichia coli clinical strains from orthopedic implant infections towards human osteoblastic cells

artículo científico publicado en 2015

Pericyte-like progenitors show high immaturity and engraftment potential as compared with mesenchymal stem cells.

artículo científico publicado en 2012

Pharmacodynamics of bisphosphonates in arthritis

artículo científico

Pharmacological blocking of the osteoclastic biocorrosion of surgical stainless steel in vitro

artículo científico publicado en 2012

Phenotypic and functional analysis of lymphocytes infiltrating osteolytic tumors: use as a possible therapeutic approach of osteosarcoma

artículo científico publicado en 2005

Polymyxin B inhibits biphasic calcium phosphate degradation induced by lipopolysaccharide-activated human monocytes/macrophages

artículo científico publicado en 1998

Potential synergies between matrix proteins and soluble factors on resorption and proteinase activities of rabbit bone cells.

artículo científico publicado en 2001

Pre-clinical studies of bone regeneration with human bone marrow stromal cells and biphasic calcium phosphate

artículo científico publicado en 2014

Preclinical evidence of potential craniofacial adverse effect of zoledronic acid in pediatric patients with bone malignancies

artículo científico publicado en 2014

Preclinical evidence that use of TRAIL in Ewing's sarcoma and osteosarcoma therapy inhibits tumor growth, prevents osteolysis, and increases animal survival

artículo científico publicado en 2010

Presence of leukaemia inhibitory factor (LIF) and LIF-receptor chain (gp190) in osteoclast-like cells cultured from human giant cell tumour of bone. Ultrastructural distribution

artículo científico publicado en 1999

Primary Retention of Molars and RANKL Signaling Alteration during Craniofacial Growth

artículo científico publicado en 2020

Pro-osteoclastic in vitro effect of Polyethylene-like nanoparticles: Involvement in the pathogenesis of implant aseptic loosening

artículo científico publicado en 2016

Proteases and bone remodelling

artículo científico publicado en 2008

Proteoglycans and osteolysis

artículo científico publicado en 2012

Proteoglycans on bone tumor development

scientific article published on 27 May 2010

Proteoglycans: key partners in bone cell biology

artículo científico publicado en 2007

RANK-RANKL signalling in cancer

artículo científico publicado en 2016

RANKL directly induces bone morphogenetic protein-2 expression in RANK-expressing POS-1 osteosarcoma cells.

artículo científico publicado en 2006

RANKL, RANK, osteoprotegerin: key partners of osteoimmunology and vascular diseases

artículo científico publicado en 2007

RANKL/RANK/OPG: key therapeutic target in bone oncology

artículo científico publicado en 2008

RANKL/RANK/OPG: new therapeutic targets in bone tumours and associated osteolysis

artículo científico publicado en 2004

Radiotherapy-induced overexpression of exosomal miRNA-378a-3p in cancer cells limits natural killer cells cytotoxicity

scientific article published on 08 April 2020

Recent advances in TGF-beta effects on chondrocyte metabolism. Potential therapeutic roles of TGF-beta in cartilage disorders.

artículo científico publicado en 2002

Receptor activator of nuclear factor kappaB ligand (RANKL)/osteoprotegerin (OPG) ratio is increased in severe osteolysis

artículo científico publicado en 2003

Receptor activator of nuclear factor-kappa B ligand (RANKL) stimulates bone-associated tumors through functional RANK expressed on bone-associated cancer cells?

artículo científico publicado en 2009

Receptor activator of nuclear factor-kappaB ligand (RANKL) directly modulates the gene expression profile of RANK-positive Saos-2 human osteosarcoma cells.

artículo científico publicado en 2007

Receptor tyrosine kinases: Characterisation, mechanism of action and therapeutic interests for bone cancers

artículo científico publicado en 2015

Regulation and function of immunosuppressive molecule human leukocyte antigen G5 in human bone tissue

artículo científico publicado en 2013

Regulation of osteoclast protease expression by RANKL.

artículo científico publicado en 2003

Relevance of a new rat model of osteoblastic metastases from prostate carcinoma for preclinical studies using zoledronic acid

artículo científico publicado en 2008

Relevance of an in vitro osteoclastogenesis system to study receptor activator of NF-kB ligand and osteoprotegerin biological activities

artículo científico publicado en 2004

Relevance of the POS-1 orthotopic model as an "imaging model" for in vivo and simultaneous monitoring of tumor proliferation and bone remodeling in osteosarcoma

artículo científico publicado en 2012

Report from the 4th European Bone Sarcoma Networking meeting: focus on osteosarcoma

Role for interleukin-6 in structural joint damage and systemic bone loss in rheumatoid arthritis

artículo científico publicado en 2010

Role of the OPG/RANK/RANKL triad in calcifications of the atheromatous plaques: Comparison between carotid and femoral beds ⬇️

artículo científico publicado el 7 de marzo de 2012

Safety concern between autologous fat graft, mesenchymal stem cell and osteosarcoma recurrence

artículo científico publicado en 2010

Sarcoma treatment in the era of molecular medicine

artículo científico publicado en 2020

Scanning electron microscopic description of cellular activity and mineral changes in feline odontoclastic resorptive lesions.

artículo científico publicado en 2001

Selective inhibition of BET bromodomain epigenetic signalling interferes with the bone-associated tumour vicious cycle

artículo científico publicado en 2014

Severe compromise of preosteoblasts in a surgical mouse model of bisphosphonate-associated osteonecrosis of the jaw

artículo científico publicado en 2016

Sex-specific autophagy modulation in osteoblastic lineage: a critical function to counteract bone loss in female

scientific article published on 13 September 2016

Skeletal consequences of RANKL-blocking antibody (IK22-5) injections during growth: Mouse strain disparities and synergic effect with zoledronic acid

artículo científico publicado en 2015

Small animal models for the study of bone sarcoma pathogenesis:characteristics, therapeutic interests and limitations

artículo científico publicado en 2018

Syndecan-1 regulates the biological activities of interleukin-34.

artículo científico publicado en 2015

Syndromic surveillance: two decades experience of sustainable systems - its people not just data!

article

Synergistic inhibitory effect of apomine and lovastatin on osteosarcoma cell growth

artículo científico publicado en 2011

TH1579, MTH1 inhibitor, delays tumour growth and inhibits metastases development in osteosarcoma model

artículo científico publicado en 2020

TRAIL delivered by mesenchymal stromal/stem cells counteracts tumor development in orthotopic Ewing sarcoma models

artículo científico publicado en 2016

TRAIL receptor signaling and therapeutic option in bone tumors: the trap of the bone microenvironment.

artículo científico publicado en 2011

TRAIL-based therapy in pediatric bone tumors: how to overcome resistance

artículo científico publicado en 2015

Targeting the epigenetic readers in Ewing sarcoma inhibits the oncogenic transcription factor EWS/Fli1.

artículo científico publicado en 2016

The Challenges of Detecting Circulating Tumor Cells in Sarcoma

artículo científico publicado en 2016

The Intrinsic and Extrinsic Implications of RANKL/RANK Signaling in Osteosarcoma: From Tumor Initiation to Lung Metastases

artículo científico publicado en 2018

The Release of Inflammatory Mediators from Acid-Stimulated Mesenchymal Stromal Cells Favours Tumour Invasiveness and Metastasis in Osteosarcoma

artículo científico publicado en 2021

The contribution of immune infiltrates and the local microenvironment in the pathogenesis of osteosarcoma

artículo científico publicado en 2017

The molecular triad OPG/RANK/RANKL: involvement in the orchestration of pathophysiological bone remodeling

artículo científico publicado en 2004

The twin cytokines interleukin-34 and CSF-1: masterful conductors of macrophage homeostasis

artículo científico publicado en 2021

The vertebral interbody grafting site's low concentration in osteogenic progenitors can greatly benefit from addition of iliac crest bone marrow

artículo científico publicado en 2005

Therapeutic efficacy of soluble receptor activator of nuclear factor-kappa B-Fc delivered by nonviral gene transfer in a mouse model of osteolytic osteosarcoma

artículo científico publicado en 2008

Therapeutic relevance of osteoprotegerin gene therapy in osteosarcoma: blockade of the vicious cycle between tumor cell proliferation and bone resorption

artículo científico publicado en 2007

Tumor ENPP1 (CD203a)/Haptoglobin Axis Exploits Myeloid-Derived Suppressor Cells to Promote Post-Radiotherapy Local Recurrence in Breast Cancer

artículo científico publicado en 2022

Tumour Heterogeneity: The Key Advantages of Single-Cell Analysis

artículo científico publicado en 2016

Ultrastructural evidence in vitro of osteoclast-induced degradation of calcium phosphate ceramic by simultaneous resorption and phagocytosis mechanisms

artículo científico publicado en 2001

Upmodulation of alpha v beta 1 integrin expression on human tumor cells by human interleukin for DA cells/leukemia inhibitory factor and oncostatin M: correlation with increased cell adhesion on fibronectin.

artículo científico publicado en 1995

Upmodulation of multinucleated cell formation in long-term human bone marrow cultures by leukaemia inhibitory factor (LIF)

artículo científico publicado en 1997

Zebrafish xenograft models of cancer and metastasis for drug discovery.

artículo científico publicado en 2017

Zoledronic acid activates the DNA S-phase checkpoint and induces osteosarcoma cell death characterized by apoptosis-inducing factor and endonuclease-G translocation independently of p53 and retinoblastoma status

artículo científico publicado en 2006

Zoledronic acid as a new adjuvant therapeutic strategy for Ewing's sarcoma patients

artículo científico publicado en 2010

Zoledronic acid inhibits pulmonary metastasis dissemination in a preclinical model of Ewing's sarcoma via inhibition of cell migration

artículo científico publicado en 2014

Zoledronic acid slows down rat primary chondrosarcoma development, recurrent tumor progression after intralesional curretage and increases overall survival

artículo científico publicado en 2006

Zoledronic acid suppresses lung metastases and prolongs overall survival of osteosarcoma-bearing mice

artículo científico publicado en 2005

mAbs targeting RANKL in bone metastasis treatment

artículo científico publicado en 2013

mTOR inhibitors (rapamycin and its derivatives) and nitrogen containing bisphosphonates: bi-functional compounds for the treatment of bone tumours

artículo científico publicado en 2007

miRNA-193a-5p repression of p73 controls Cisplatin chemoresistance in primary bone tumors

artículo científico publicado en 2016

ΔNp63α Silences a miRNA Program to Aberrantly Initiate a Wound-Healing Program That Promotes TGFβ-Induced Metastasis

artículo científico publicado en 2016

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