Lista de obras - Jan Brábek - Dominio Público Uruguay

6-Substituted purines as ROCK inhibitors with anti-metastatic activity

scientific article published on 06 June 2019

A Screen for PKN3 Substrates Reveals an Activating Phosphorylation of ARHGAP18

scientific article published on 20 October 2020

A homozygous stop-gain variant in ARHGAP42 is associated with childhood interstitial lung disease, systemic hypertension, and immunological findings

artículo científico publicado en 2021

ARHGAP42 is activated by Src-mediated tyrosine phosphorylation to promote cell motility

artículo científico publicado en 2017

Affordable cancer care

artículo científico publicado en 2012

Assaying protein kinase activity

artículo científico publicado en 2004

CAS directly interacts with vinculin to control mechanosensing and focal adhesion dynamics.

scientific article published on 25 August 2013

CAS promotes invasiveness of Src-transformed cells

artículo científico publicado en 2004

Cancer, checkpoint inhibitors, and confusion

artículo científico publicado en 2017

Cell polarity signaling in the plasticity of cancer cell invasiveness

artículo científico publicado en 2016

Confocal microscopy reveals Myzitiras and Vthela morphotypes as new signatures of malignancy progression.

artículo científico publicado en 2009

Contractile forces in tumor cell migration

artículo científico publicado en 2008

Crk-associated substrate tyrosine phosphorylation sites are critical for invasion and metastasis of SRC-transformed cells

artículo científico publicado en 2005

Drugs for solid cancer: the productivity crisis prompts a rethink

artículo científico publicado en 2013

Exosomes produced by melanoma cells significantly influence the biological properties of normal and cancer-associated fibroblasts

artículo científico publicado en 2021

Fibroblasts potentiate melanoma cells in vitro invasiveness induced by UV-irradiated keratinocytes.

artículo científico publicado en 2018

Focal adhesion kinase signaling activities and their implications in the control of cell survival and motility

artículo científico publicado en 2003

Global impact of oncogenic Src on a phosphotyrosine proteome

artículo científico publicado en 2008

High-throughput transcriptomic and proteomic profiling of mesenchymal-amoeboid transition in 3D collagen

artículo científico publicado en 2020

Interleukin-6: Molecule in the Intersection of Cancer, Ageing and COVID-19

artículo científico publicado en 2020

Interleukin-6: a molecule with complex biological impact in cancer

artículo científico publicado en 2018

Invadopodia Structure in 3D Environment Resolved by Near-Infrared Branding Protocol Combining Correlative Confocal and FIB-SEM Microscopy ⬇️

artículo científico

Invasive cells in animals and plants: searching for LECA machineries in later eukaryotic life ⬇️

artículo científico publicado en 2013

Limits to Precision Cancer Medicine.

artículo científico publicado en 2017

Mechanosensors in integrin signaling: the emerging role of p130Cas

artículo científico publicado en 2014

Metastasis of aggressive amoeboid sarcoma cells is dependent on Rho/ROCK/MLC signaling.

artículo científico publicado en 2013

Microtubule-targeting agents and their impact on cancer treatment

artículo científico publicado en 2020

Migrastatics-Anti-metastatic and Anti-invasion Drugs: Promises and Challenges. ⬇️

artículo científico publicado en 2017

Migrastatics: Redirecting R&D in Solid Cancer Towards Metastasis?

artículo científico publicado en 2019

NG2-mediated Rho activation promotes amoeboid invasiveness of cancer cells.

artículo científico publicado en 2012

Neoplastic progression of the human breast cancer cell line G3S1 is associated with elevation of cytoskeletal dynamics and upregulation of MT1-MMP.

artículo científico publicado en 2010

Novel FRET-Based Src Biosensor Reveals Mechanisms of Src Activation and Its Dynamics in Focal Adhesions

artículo científico publicado en 2018

PKCα promotes the mesenchymal to amoeboid transition and increases cancer cell invasiveness

artículo científico publicado en 2015

Pentamethinium salts suppress key metastatic processes by regulating mitochondrial function and inhibiting dihydroorotate dehydrogenase respiration

artículo científico publicado en 2022

Pragmatic medicine in solid cancer: a translational alternative to precision medicine

artículo científico publicado en 2016

Quantitative phase imaging unravels new insight into dynamics of mesenchymal and amoeboid cancer cell invasion

artículo científico publicado en 2018

RNA-seq of macrophages of amoeboid or mesenchymal migratory phenotype due to specific structure of environment

artículo científico publicado en 2018

ROCK inhibitors as emerging therapeutic candidates for sarcomas

artículo científico publicado en 2010

Regulation and localization of CAS substrate domain tyrosine phosphorylation

artículo científico publicado en 2004

Role of Interleukin-6 in Lung Complications in Patients With COVID-19: Therapeutic Implications

artículo científico publicado en 2020

SH3 domain tyrosine phosphorylation--sites, role and evolution.

artículo científico publicado en 2012

Simultaneous blocking of IL-6 and IL-8 is sufficient to fully inhibit CAF-induced human melanoma cell invasiveness

artículo científico publicado en 2016

Solid cancer: the new tumour spread endpoint opens novel opportunities

scientific article published on 20 August 2019

Src kinase: key effector in mechanosignalling

artículo científico publicado en 2020

Src transformation of colonic epithelial cells: enhanced anchorage-independent growth in an Apc(+/min) background

artículo científico publicado en 2009

Structural characterization of CAS SH3 domain selectivity and regulation reveals new CAS interaction partners.

artículo científico publicado en 2017

Sustained Inflammatory Signalling through Stat1/Stat2/IRF9 Is Associated with Amoeboid Phenotype of Melanoma Cells

scientific article published on 28 August 2020

The SH3 domain of Src can downregulate its kinase activity in the absence of the SH2 domain-pY527 interaction.

artículo científico publicado en 2002

The fission yeast ortholog of the coregulator SKIP interacts with the small subunit of U2AF.

artículo científico publicado en 2001

The interaction of p130Cas with PKN3 promotes malignant growth

scientific article published on 03 December 2018

The molecular mechanisms of transition between mesenchymal and amoeboid invasiveness in tumor cells.

scientific article published on 26 August 2009

The role of focal adhesion anchoring domains of CAS in mechanotransduction

artículo científico publicado en 2017

The role of the tissue microenvironment in the regulation of cancer cell motility and invasion.

scientific article published on 07 September 2010

The structure of invadopodia in a complex 3D environment.

artículo científico publicado en 2010

Translation in solid cancer: are size-based response criteria an anachronism?

artículo científico publicado en 2014

Tyrosine phosphorylation within the SH3 domain regulates CAS subcellular localization, cell migration, and invasiveness

artículo científico publicado en 2011

Up-Regulation of Rho/ROCK Signaling in Sarcoma Cells Drives Invasion and Increased Generation of Protrusive Forces

artículo científico publicado en 2008

Vimentin Intermediate Filaments as Potential Target for Cancer Treatment

scientific article published on 11 January 2020

Wnt Signaling Cascades and the Roles of Syndecan Proteoglycans

artículo científico

Lista de obras de Jan Brábek

6-Substituted purines as ROCK inhibitors with anti-metastatic activity

A Screen for PKN3 Substrates Reveals an Activating Phosphorylation of ARHGAP18

A homozygous stop-gain variant in ARHGAP42 is associated with childhood interstitial lung disease, systemic hypertension, and immunological findings

ARHGAP42 is activated by Src-mediated tyrosine phosphorylation to promote cell motility

Affordable cancer care

Assaying protein kinase activity

CAS directly interacts with vinculin to control mechanosensing and focal adhesion dynamics.

CAS promotes invasiveness of Src-transformed cells

Cancer, checkpoint inhibitors, and confusion

Cell polarity signaling in the plasticity of cancer cell invasiveness

Confocal microscopy reveals Myzitiras and Vthela morphotypes as new signatures of malignancy progression.

Contractile forces in tumor cell migration

Crk-associated substrate tyrosine phosphorylation sites are critical for invasion and metastasis of SRC-transformed cells

Drugs for solid cancer: the productivity crisis prompts a rethink

Exosomes produced by melanoma cells significantly influence the biological properties of normal and cancer-associated fibroblasts

Fibroblasts potentiate melanoma cells in vitro invasiveness induced by UV-irradiated keratinocytes.

Focal adhesion kinase signaling activities and their implications in the control of cell survival and motility

Global impact of oncogenic Src on a phosphotyrosine proteome

High-throughput transcriptomic and proteomic profiling of mesenchymal-amoeboid transition in 3D collagen

Interleukin-6: Molecule in the Intersection of Cancer, Ageing and COVID-19

Interleukin-6: a molecule with complex biological impact in cancer

Invadopodia Structure in 3D Environment Resolved by Near-Infrared Branding Protocol Combining Correlative Confocal and FIB-SEM Microscopy ⬇️

Invasive cells in animals and plants: searching for LECA machineries in later eukaryotic life ⬇️

Limits to Precision Cancer Medicine.

Mechanosensors in integrin signaling: the emerging role of p130Cas

Metastasis of aggressive amoeboid sarcoma cells is dependent on Rho/ROCK/MLC signaling.

Microtubule-targeting agents and their impact on cancer treatment

Migrastatics-Anti-metastatic and Anti-invasion Drugs: Promises and Challenges. ⬇️

Migrastatics: Redirecting R&D in Solid Cancer Towards Metastasis?

NG2-mediated Rho activation promotes amoeboid invasiveness of cancer cells.

Neoplastic progression of the human breast cancer cell line G3S1 is associated with elevation of cytoskeletal dynamics and upregulation of MT1-MMP.

Novel FRET-Based Src Biosensor Reveals Mechanisms of Src Activation and Its Dynamics in Focal Adhesions

PKCα promotes the mesenchymal to amoeboid transition and increases cancer cell invasiveness

Pentamethinium salts suppress key metastatic processes by regulating mitochondrial function and inhibiting dihydroorotate dehydrogenase respiration

Pragmatic medicine in solid cancer: a translational alternative to precision medicine

Quantitative phase imaging unravels new insight into dynamics of mesenchymal and amoeboid cancer cell invasion

RNA-seq of macrophages of amoeboid or mesenchymal migratory phenotype due to specific structure of environment

ROCK inhibitors as emerging therapeutic candidates for sarcomas

Regulation and localization of CAS substrate domain tyrosine phosphorylation

Role of Interleukin-6 in Lung Complications in Patients With COVID-19: Therapeutic Implications

SH3 domain tyrosine phosphorylation--sites, role and evolution.

Simultaneous blocking of IL-6 and IL-8 is sufficient to fully inhibit CAF-induced human melanoma cell invasiveness

Solid cancer: the new tumour spread endpoint opens novel opportunities

Src kinase: key effector in mechanosignalling

Src transformation of colonic epithelial cells: enhanced anchorage-independent growth in an Apc(+/min) background

Structural characterization of CAS SH3 domain selectivity and regulation reveals new CAS interaction partners.

Sustained Inflammatory Signalling through Stat1/Stat2/IRF9 Is Associated with Amoeboid Phenotype of Melanoma Cells

The SH3 domain of Src can downregulate its kinase activity in the absence of the SH2 domain-pY527 interaction.

The fission yeast ortholog of the coregulator SKIP interacts with the small subunit of U2AF.

The interaction of p130Cas with PKN3 promotes malignant growth

The interaction of p130Cas with PKN3 promotes malignant growth

The molecular mechanisms of transition between mesenchymal and amoeboid invasiveness in tumor cells.

The role of focal adhesion anchoring domains of CAS in mechanotransduction

The role of the tissue microenvironment in the regulation of cancer cell motility and invasion.

The structure of invadopodia in a complex 3D environment.

Translation in solid cancer: are size-based response criteria an anachronism?

Tyrosine phosphorylation within the SH3 domain regulates CAS subcellular localization, cell migration, and invasiveness

Up-Regulation of Rho/ROCK Signaling in Sarcoma Cells Drives Invasion and Increased Generation of Protrusive Forces

Vimentin Intermediate Filaments as Potential Target for Cancer Treatment

Wnt Signaling Cascades and the Roles of Syndecan Proteoglycans