Lista de obras - Douglas V Laurents - Dominio Público Uruguay

"Structural characterization of the minimal segment of TDP-43 competent for aggregation".

artículo científico

(1)H, (13)C and (15)N resonance assignments of the Onconase FL-G zymogen.

artículo científico publicado en 2012

3D Domain Swapping Provides a Minor Alternative Refolding Pathway for Ribonuclease A

artículo científico publicado en 2011

A new method for determining the heat capacity change for protein folding

artículo científico publicado en 1989

A pulse-chase-competition experiment to determine if a folding intermediate is on or off-pathway: application to ribonuclease A

article

Alzheimer's Abeta40 studied by NMR at low pH reveals that sodium 4,4-dimethyl-4-silapentane-1-sulfonate (DSS) binds and promotes beta-ball oligomerization.

artículo científico publicado en 2004

An Arg-rich putative prebiotic protein is as stable as its Lys-rich variant

scientific article published on 26 September 2012

Carbodiimide EDC induces cross-links that stabilize RNase A C-dimer against dissociation: EDC adducts can affect protein net charge, conformation, and activity.

artículo científico publicado en 2009

Characterization of the structure and self-recognition of the human centrosomal protein NA14: implications for stability and function.

artículo científico publicado en 2011

Characterization of the unfolding pathway of hen egg white lysozyme

artículo científico publicado en 1997

Charge substitution shows that repulsive electrostatic interactions impede the oligomerization of Alzheimer amyloid peptides.

artículo científico publicado en 2005

Charge-charge interactions are key determinants of the pK values of ionizable groups in ribonuclease Sa (pI=3.5) and a basic variant (pI=10.2).

artículo científico publicado en 2003

Combining Classical MD and QM calculations to elucidate complex system nucleation: a twisted, three-stranded, parallel β-sheet seeds amyloid fibril conception.

artículo científico publicado en 2014

Common features at the start of the neurodegeneration cascade

artículo científico publicado en 2012

Conformation specificity and arene binding in a peptide composed only of Lys, Ile, Ala and Gly

artículo científico publicado en 2011

Crowding agents and osmolytes provide insight into the formation and dissociation of RNase A oligomers

artículo científico publicado en 2010

Cytotoxicity of polyspermine-ribonuclease A and polyspermine-dimeric ribonuclease A.

artículo científico publicado en 2007

Destabilizing mutations alter the hydrogen exchange mechanism in ribonuclease A.

artículo científico publicado en 2008

Different protein sequences can give rise to highly similar folds through different stabilizing interactions.

artículo científico publicado en 1994

Dimerization and Folding Processes ofTreponemadenticolaCystalysin: The Role of Pyridoxal 5‘-Phosphate†

scientific article published on 01 November 2006

Double domain swapping in bovine seminal RNase: formation of distinct N- and C-swapped tetramers and multimers with increasing biological activities

artículo científico publicado en 2012

Folding Kinetics of Phage 434 Cro Protein†

artículo científico publicado en 2000

Folding pathway of the pyridoxal 5'-phosphate C-S lyase MalY from Escherichia coli.

artículo científico publicado en 2005

Formation, Structure, and Dissociation of the Ribonuclease S Three-dimensional Domain-swapped Dimer

scientific article published in Journal of Biological Chemistry

Gemini surfactants affect the structure, stability, and activity of ribonuclease Sa.

artículo científico publicado en 2014

Getting specificity from simplicity in putative proteins from the prebiotic Earth

artículo científico publicado en 2007

Glycosylation and specific deamidation of ribonuclease B affect the formation of three-dimensional domain-swapped oligomers.

artículo científico publicado en 2003

Helix-Stabilizing Nonpolar Interactions between Tyrosine and Leucine in Aqueous and TFE Solutions: 2D-1H NMR and CD Studies in Alanine-Lysine Peptides†

artículo científico publicado en 1998

Holo- and apo-cystalysin from Treponema denticola: two different conformations

artículo científico publicado en 2006

Increase of RNase AN-terminus Polarity orC-terminus Apolarity Changes the Two Domains' Propensity To Swap and Form the Two Dimeric Conformers of the Protein†

artículo científico publicado en 2006

Interaction of PiB-derivative metal complexes with beta-amyloid peptides: selective recognition of the aggregated forms

artículo científico publicado en 2015

Interactions crucial for three-dimensional domain swapping in the HP-RNase variant PM8.

artículo científico publicado en 2011

Interactions of gemini surfactants with two model proteins: NMR, CD, and fluorescence spectroscopies

article

Kinetic analysis provides insight into the mechanism of ribonuclease A oligomer formation

artículo científico publicado en 2009

Molecular Basis of Orb2 Amyloidogenesis and Blockade of Memory Consolidation.

artículo científico publicado en 2016

NMR spectroscopy reveals a preferred conformation with a defined hydrophobic cluster for polyglutamine binding peptide 1.

artículo científico publicado en 2014

NMR spectroscopy reveals that RNase A is chiefly denatured in 40% acetic acid: implications for oligomer formation by 3D domain swapping.

artículo científico publicado en 2010

NMR structural determinants of eosinophil cationic protein binding to membrane and heparin mimetics

artículo científico publicado en 2010

Nucleotide-induced folding of cell division protein FtsZ from Staphylococcus aureus

artículo científico publicado en 2020

Point mutations in the N-terminal domain of transactive response DNA-binding protein 43 kDa (TDP-43) compromise its stability, dimerization, and functions.

artículo científico publicado en 2017

Preparation of Ribonuclease S Domain-Swapped Dimers Conjugated with DNA and PNA: Modulating the Activity of Ribonucleases

artículo científico publicado en 2007

Pressure-jump-induced kinetics reveals a hydration dependent folding/unfolding mechanism of ribonuclease A

artículo científico publicado en 2006

Purification of recombinant ribonuclease T1 expressed in Escherichia coli.

artículo científico publicado en 1990

Putative one-pot prebiotic polypeptides with ribonucleolytic activity

artículo científico publicado en 2010

Salt anions promote the conversion of HypF-N into amyloid-like oligomers and modulate the structure of the oligomers and the monomeric precursor state.

artículo científico publicado en 2012

Sequential assignment and solution secondary structure of doubly labelled ribonuclease Sa

artículo científico publicado en 1999

Some biological actions of PEG-conjugated RNase A oligomers.

artículo científico publicado en 2006

Structural and functional relationships of natural and artificial dimeric bovine ribonucleases: new scaffolds for potential antitumor drugs

artículo científico

Structural similarity of DNA-binding domains of bacteriophage repressors and the globin core.

artículo científico publicado en 1993

Structural transitions in Orb2 prion-like domain relevant for functional aggregation in memory consolidation

artículo científico publicado en 2020

Structure of a simplified β-hairpin and its ATP complex.

artículo científico publicado en 2013

Structure of the C-terminal domain of transcription factor IIB from Trypanosoma brucei

artículo científico publicado en 2009

Tautomeric state of alpha-sarcin histidines. Ndelta tautomers are a common feature in the active site of extracellular microbial ribonucleases.

artículo científico publicado en 2003

Temperature dependence of ligand–protein complex formation as reflected by saturation transfer difference NMR experiments

article

The Singular NMR Fingerprint of a Polyproline II Helical Bundle

scientific article published on 29 November 2018

The TDP-43 N-terminal domain structure at high resolution

artículo científico publicado en 2016

The structural determinants that lead to the formation of particular oligomeric structures in the pancreatic-type ribonuclease family.

artículo científico publicado en 2008

Thermal stability and enzymatic activity of RNase A in the presence of cationic gemini surfactants

artículo científico publicado en 2012

Thermodynamic Analysis of the Structural Stability of Phage 434 Cro Protein†

article

Three-dimensional domain-swapped oligomers of ribonuclease A: identification of a fifth tetramer, pentamers and hexamers, and detection of trace heptameric, octameric and nonameric species

artículo científico publicado en 2005

Towards tricking a pathogen's protease into fighting infection: the 3D structure of a stable circularly permuted onconase variant cleavedby HIV-1 protease

artículo científico publicado en 2013

Urea denaturation of barnase: pH dependence and characterization of the unfolded state

artículo científico publicado en 1992

pH dependence of the urea and guanidine hydrochloride denaturation of ribonuclease A and ribonuclease T1.

artículo científico publicado en 1990

pH-Dependent Conformational Stability of the Ribotoxin α-Sarcin and Four Active Site Charge Substitution Variants†

artículo científico publicado en 2006

Lista de obras de Douglas V Laurents

"Structural characterization of the minimal segment of TDP-43 competent for aggregation".

(1)H, (13)C and (15)N resonance assignments of the Onconase FL-G zymogen.

3D Domain Swapping Provides a Minor Alternative Refolding Pathway for Ribonuclease A

A new method for determining the heat capacity change for protein folding

A pulse-chase-competition experiment to determine if a folding intermediate is on or off-pathway: application to ribonuclease A

Alzheimer's Abeta40 studied by NMR at low pH reveals that sodium 4,4-dimethyl-4-silapentane-1-sulfonate (DSS) binds and promotes beta-ball oligomerization.

An Arg-rich putative prebiotic protein is as stable as its Lys-rich variant

Carbodiimide EDC induces cross-links that stabilize RNase A C-dimer against dissociation: EDC adducts can affect protein net charge, conformation, and activity.

Characterization of the structure and self-recognition of the human centrosomal protein NA14: implications for stability and function.

Characterization of the unfolding pathway of hen egg white lysozyme

Charge substitution shows that repulsive electrostatic interactions impede the oligomerization of Alzheimer amyloid peptides.

Charge-charge interactions are key determinants of the pK values of ionizable groups in ribonuclease Sa (pI=3.5) and a basic variant (pI=10.2).

Combining Classical MD and QM calculations to elucidate complex system nucleation: a twisted, three-stranded, parallel β-sheet seeds amyloid fibril conception.

Common features at the start of the neurodegeneration cascade

Conformation specificity and arene binding in a peptide composed only of Lys, Ile, Ala and Gly

Crowding agents and osmolytes provide insight into the formation and dissociation of RNase A oligomers

Cytotoxicity of polyspermine-ribonuclease A and polyspermine-dimeric ribonuclease A.

Destabilizing mutations alter the hydrogen exchange mechanism in ribonuclease A.

Different protein sequences can give rise to highly similar folds through different stabilizing interactions.

Dimerization and Folding Processes ofTreponemadenticolaCystalysin: The Role of Pyridoxal 5‘-Phosphate†

Double domain swapping in bovine seminal RNase: formation of distinct N- and C-swapped tetramers and multimers with increasing biological activities

Folding Kinetics of Phage 434 Cro Protein†

Folding pathway of the pyridoxal 5'-phosphate C-S lyase MalY from Escherichia coli.

Formation, Structure, and Dissociation of the Ribonuclease S Three-dimensional Domain-swapped Dimer

Gemini surfactants affect the structure, stability, and activity of ribonuclease Sa.

Getting specificity from simplicity in putative proteins from the prebiotic Earth

Glycosylation and specific deamidation of ribonuclease B affect the formation of three-dimensional domain-swapped oligomers.

Helix-Stabilizing Nonpolar Interactions between Tyrosine and Leucine in Aqueous and TFE Solutions: 2D-1H NMR and CD Studies in Alanine-Lysine Peptides†

Holo- and apo-cystalysin from Treponema denticola: two different conformations

Increase of RNase AN-terminus Polarity orC-terminus Apolarity Changes the Two Domains' Propensity To Swap and Form the Two Dimeric Conformers of the Protein†

Interaction of PiB-derivative metal complexes with beta-amyloid peptides: selective recognition of the aggregated forms

Interactions crucial for three-dimensional domain swapping in the HP-RNase variant PM8.

Interactions of gemini surfactants with two model proteins: NMR, CD, and fluorescence spectroscopies

Kinetic analysis provides insight into the mechanism of ribonuclease A oligomer formation

Molecular Basis of Orb2 Amyloidogenesis and Blockade of Memory Consolidation.

NMR spectroscopy reveals a preferred conformation with a defined hydrophobic cluster for polyglutamine binding peptide 1.

NMR spectroscopy reveals that RNase A is chiefly denatured in 40% acetic acid: implications for oligomer formation by 3D domain swapping.

NMR structural determinants of eosinophil cationic protein binding to membrane and heparin mimetics

Nucleotide-induced folding of cell division protein FtsZ from Staphylococcus aureus

Point mutations in the N-terminal domain of transactive response DNA-binding protein 43 kDa (TDP-43) compromise its stability, dimerization, and functions.

Preparation of Ribonuclease S Domain-Swapped Dimers Conjugated with DNA and PNA: Modulating the Activity of Ribonucleases

Pressure-jump-induced kinetics reveals a hydration dependent folding/unfolding mechanism of ribonuclease A

Purification of recombinant ribonuclease T1 expressed in Escherichia coli.

Putative one-pot prebiotic polypeptides with ribonucleolytic activity

Salt anions promote the conversion of HypF-N into amyloid-like oligomers and modulate the structure of the oligomers and the monomeric precursor state.

Sequential assignment and solution secondary structure of doubly labelled ribonuclease Sa

Some biological actions of PEG-conjugated RNase A oligomers.

Structural and functional relationships of natural and artificial dimeric bovine ribonucleases: new scaffolds for potential antitumor drugs

Structural similarity of DNA-binding domains of bacteriophage repressors and the globin core.

Structural transitions in Orb2 prion-like domain relevant for functional aggregation in memory consolidation

Structure of a simplified β-hairpin and its ATP complex.

Structure of the C-terminal domain of transcription factor IIB from Trypanosoma brucei

Tautomeric state of alpha-sarcin histidines. Ndelta tautomers are a common feature in the active site of extracellular microbial ribonucleases.

Temperature dependence of ligand–protein complex formation as reflected by saturation transfer difference NMR experiments

The Singular NMR Fingerprint of a Polyproline II Helical Bundle

The TDP-43 N-terminal domain structure at high resolution

The structural determinants that lead to the formation of particular oligomeric structures in the pancreatic-type ribonuclease family.

Thermal stability and enzymatic activity of RNase A in the presence of cationic gemini surfactants

Thermodynamic Analysis of the Structural Stability of Phage 434 Cro Protein†

Three-dimensional domain-swapped oligomers of ribonuclease A: identification of a fifth tetramer, pentamers and hexamers, and detection of trace heptameric, octameric and nonameric species

Towards tricking a pathogen's protease into fighting infection: the 3D structure of a stable circularly permuted onconase variant cleavedby HIV-1 protease

Urea denaturation of barnase: pH dependence and characterization of the unfolded state

pH dependence of the urea and guanidine hydrochloride denaturation of ribonuclease A and ribonuclease T1.

pH-Dependent Conformational Stability of the Ribotoxin α-Sarcin and Four Active Site Charge Substitution Variants†