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Lista de obras de Pamela Lein

2,2',3,5',6-Pentachlorobiphenyl (PCB 95) and its hydroxylated metabolites are enantiomerically enriched in female mice

artículo científico publicado en 2012

3,3'-Dichlorobiphenyl (PCB 11) promotes dendritic arborization in primary rat cortical neurons via a CREB-dependent mechanism

scholarly article by Sunjay Sethi et al published November 2018 in Archives of Toxicology

A Microfluidic Platform to Study Astrocyte Adhesion on Nanoporous Gold Thin Films

A magnetic resonance imaging study of early brain injury in a rat model of acute DFP intoxication.

artículo científico publicado en 2017

A multi-tiered, in vivo, quantitative assay suite for environmental disruptors of thyroid hormone signaling

artículo científico publicado en 2017

A novel carboline derivative inhibits nitric oxide formation in macrophages independent of effects on tumor necrosis factor α and interleukin-1β expression

artículo científico publicado en 2014

A review of experimental evidence linking neurotoxic organophosphorus compounds and inflammation

artículo científico publicado en 2012

Acute hippocampal slice preparation and hippocampal slice cultures

artículo científico publicado en 2011

Allele and genotype frequencies of CYP2B6 and CYP2C19 polymorphisms in Egyptian agricultural workers

artículo científico publicado en 2012

Allopregnanolone and perampanel as adjuncts to midazolam for treating diisopropylfluorophosphate-induced status epilepticus in rats

artículo científico publicado en 2020

Animal models of autism spectrum disorders: information for neurotoxicologists

artículo científico publicado en 2009

Antigen sensitization influences organophosphorus pesticide-induced airway hyperreactivity

artículo científico publicado en 2008

BDE-99 impairs differentiation of human and mouse NPCs into the oligodendroglial lineage by species-specific modes of action

scientific article published on 20 March 2017

BMP7-induced dendritic growth in sympathetic neurons requires p75(NTR) signaling.

artículo científico publicado en 2015

Behavioral assessment of NIH Swiss mice acutely intoxicated with tetramethylenedisulfotetramine

artículo científico publicado en 2015

Bifenthrin causes transcriptomic alterations in mTOR and ryanodine receptor-dependent signaling and delayed hyperactivity in developing zebrafish (Danio rerio)

article published in 2018

Biomarkers of chlorpyrifos exposure and effect in Egyptian cotton field workers

artículo científico publicado en 2011

Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons

artículo científico publicado en 2001

Bone morphogenetic proteins regulate ionotropic glutamate receptors in human retina

artículo científico publicado en 2004

Cerebrospinal fluid contains biologically active bone morphogenetic protein-7.

artículo científico publicado en 2001

Changes in thyroid hormone activity disrupt photomotor behavior of larval zebrafish

artículo científico publicado en 2019

Characterization of seizures induced by acute and repeated exposure to tetramethylenedisulfotetramine

artículo científico publicado en 2012

Characterization of α-cypermethrin exposure in Egyptian agricultural workers

artículo científico publicado en 2014

Chasing the Elusive Benzofuran Impurity of the THR Antagonist NH-3: Synthesis, Isotope Labeling, and Biological Activity

artículo científico publicado en 2016

Chlorpyrifos and chlorpyrifos-oxon inhibit axonal growth by interfering with the morphogenic activity of acetylcholinesterase

artículo científico publicado en 2008

Chlorpyrifos exerts opposing effects on axonal and dendritic growth in primary neuronal cultures

artículo científico publicado en 2005

Chlorpyrifos-oxon disrupts zebrafish axonal growth and motor behavior

artículo científico publicado en 2011

Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures

artículo científico publicado en 2015

Comparative Analyses of the 12 Most Abundant PCB Congeners Detected in Human Maternal Serum for Activity at the Thyroid Hormone Receptor and Ryanodine Receptor

artículo científico publicado en 2019

Correlating neurobehavioral performance with biomarkers of organophosphorous pesticide exposure

artículo científico publicado en 2011

Cross-talk between fibroblast growth factor and bone morphogenetic proteins regulates gap junction-mediated intercellular communication in lens cells

artículo científico publicado en 2008

Cytochrome p450 mRNA expression in the rodent brain: species-, sex-, and region-dependent differences

artículo científico publicado en 2013

Dendritic growth induced by BMP-7 requires Smad1 and proteasome activity

Dental Pulp Stem Cells Model Early Life and Imprinted DNA Methylation Patterns

artículo científico publicado en 2016

Detection of 3,3'-Dichlorobiphenyl in Human Maternal Plasma and Its Effects on Axonal and Dendritic Growth in Primary Rat Neurons

artículo científico publicado en 2017

Developing and applying the adverse outcome pathway concept for understanding and predicting neurotoxicity

artículo científico publicado en 2016

Developmental exposure to near roadway pollution produces behavioral phenotypes relevant to neurodevelopmental disorders in juvenile rats

artículo científico publicado en 2020

Developmental exposure to polychlorinated biphenyls influences stroke outcome in adult rats

artículo científico publicado en 2008

Developmental exposure to polychlorinated biphenyls interferes with experience-dependent dendritic plasticity and ryanodine receptor expression in weanling rats

artículo científico publicado en 2008

Dichlorvos exposure results in large scale disruption of energy metabolism in the liver of the zebrafish, Danio rerio

artículo científico publicado en 2015

Distinct spatial localization of specific mRNAs in cultured sympathetic neurons

scientific article published on 01 December 1990

Editor's Highlight: Congener-Specific Disposition of Chiral Polychlorinated Biphenyls in Lactating Mice and Their Offspring: Implications for PCB Developmental Neurotoxicity

artículo científico publicado en 2017

Editor's Highlight: Spatiotemporal Progression and Remission of Lesions in the Rat Brain Following Acute Intoxication With Diisopropylfluorophosphate.

artículo científico publicado en 2017

Effect of leukemia inhibitory factor (LIF) on the morphology and survival of cultured hippocampal neurons and glial cells ⬇️

artículo científico publicado el 6 de julio de 1998

Effect of pregnancy on the disposition of 2,2',3,5',6-pentachlorobiphenyl (PCB 95) atropisomers and their hydroxylated metabolites in female mice

artículo científico publicado en 2015

Effect of short-term exposure to hexachlorophene on rat brain cell specific marker enzymes

artículo científico publicado en 1988

Effects of cytokines on nuclear factor-kappa B, cell viability, and synaptic connectivity in a human neuronal cell line

scientific article published on 21 January 2020

Effects of early life exposure to traffic-related air pollution on brain development in juvenile Sprague-Dawley rats

artículo científico publicado en 2020

Effects of thyroid hormone disruption on the ontogenetic expression of thyroid hormone signaling genes in developing zebrafish (Danio rerio)

scientific article published on 15 November 2018

Emerging concepts in neurotoxicology: Models, mechanisms and modifying factors

artículo científico publicado en 2012

Epoxyeicosatrienoic acids enhance axonal growth in primary sensory and cortical neuronal cell cultures

artículo científico publicado en 2011

Evidence Implicating Non-Dioxin-Like Congeners as the Key Mediators of Polychlorinated Biphenyl (PCB) Developmental Neurotoxicity

artículo científico publicado en 2020

Experimental strategy for translational studies of organophosphorus pesticide neurotoxicity based on real-world occupational exposures to chlorpyrifos

artículo científico publicado en 2012

Expression of bone morphogenetic proteins in the brain during normal aging and in 6-hydroxydopamine-lesioned animals

artículo científico publicado en 2003

Extracellular signal-regulated kinases regulate dendritic growth in rat sympathetic neurons

scientific journal article

From the Cover: BDE-47 and BDE-49 Inhibit Axonal Growth in Primary Rat Hippocampal Neuron-Glia Co-Cultures via Ryanodine Receptor-Dependent Mechanisms

artículo científico publicado en 2016

From the Cover: MagneticResonance Imaging Reveals Progressive Brain Injury in Rats Acutely Intoxicated With Diisopropylfluorophosphate.

artículo científico publicado en 2017

Hepatic metabolism affects the atropselective disposition of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) in mice

artículo científico publicado en 2014

High abundant protein removal from rodent blood for biomarker discovery

artículo científico publicado en 2014

Identification of Psychoplastogenic N,N-Dimethylaminoisotryptamine (isoDMT) Analogues through Structure-Activity Relationship Studies

scientific article published on 24 January 2020

Immunologic and neurodevelopmental susceptibilities of autism

artículo científico publicado en 2008

In vitro and other alternative approaches to developmental neurotoxicity testing (DNT).

artículo científico publicado en 2005

In vivo and in vitro sex differences in the dendritic morphology of developing murine hippocampal and cortical neurons

artículo científico publicado en 2017

Increased Severity of Fragile X Spectrum Disorders in the Agricultural Community of Ricaurte, Colombia

scientific article published on 29 October 2018

Inducing Dendritic Growth in Cultured Sympathetic Neurons ⬇️

artículo científico publicado el 21 de marzo de 2012

Intravenous administration of bone morphogenetic protein-7 after ischemia improves motor function in stroke rats

artículo científico publicado en 2003

Laminin and a basement membrane extract have different effects on axonal and dendritic outgrowth from embryonic rat sympathetic neurons in vitro

scientific article published on 01 December 1989

Laminin selectively enhances axonal growth and accelerates the development of polarity by hippocampal neurons in culture

artículo científico publicado en 1992

Leukemia inhibitory factor and ciliary neurotrophic factor regulate dendritic growth in cultures of rat sympathetic neurons

artículo científico publicado en 1997

Longitudinal assessment of occupational exposures to the organophosphorous insecticides chlorpyrifos and profenofos in Egyptian cotton field workers

artículo científico publicado en 2015

Macrophage TNF-α mediates parathion-induced airway hyperreactivity in guinea pigs

artículo científico publicado en 2013

Manganese induces neurite outgrowth in PC12 cells via upregulation of alpha(v) integrins.

artículo científico publicado en 2000

Mechanisms of Reduced Astrocyte Surface Coverage in Cortical Neuron-Glia Co-cultures on Nanoporous Gold Surfaces.

artículo científico publicado en 2016

Mechanisms of manganese-induced rat pheochromocytoma (PC12) cell death and cell differentiation

artículo científico publicado en 2002

Mechanisms of neuronal polarity

artículo científico publicado en 1997

Mechanisms of organophosphate insecticide-induced airway hyperreactivity

artículo científico publicado en 2004

Mechanisms of organophosphorus pesticide toxicity in the context of airway hyperreactivity and asthma

article

Meeting report: alternatives for developmental neurotoxicity testing

artículo científico publicado en 2007

Metabolism of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) atropisomers in tissue slices from phenobarbital or dexamethasone-induced rats is sex-dependent

artículo científico publicado en 2013

Metabolism of profenofos to 4-bromo-2-chlorophenol, a specific and sensitive exposure biomarker

artículo científico publicado en 2013

Microcystins alter chemotactic behavior in Caenorhabditis elegans by selectively targeting the AWA sensory neuron

artículo científico publicado en 2014

Minding the calcium store: Ryanodine receptor activation as a convergent mechanism of PCB toxicity

artículo científico publicado en 2010

Models to identify treatments for the acute and persistent effects of seizure-inducing chemical threat agents

artículo científico publicado en 2016

Mutagenic activity of surface waters adjacent to a nuclear fuel processing facility

scientific article published on 01 September 1987

Mutant IDH1 and seizures in patients with glioma.

artículo científico publicado en 2017

Nanoporous Gold Biointerfaces: Modifying Nanostructure to Control Neural Cell Coverage and Enhance Electrophysiological Recording Performance.

artículo científico publicado en 2016

Nanoporous gold as a neural interface coating: effects of topography, surface chemistry, and feature size.

artículo científico publicado en 2015

Nanostructure Introduces Artifacts in Quantitative Immunofluorescence by Influencing Fluorophore Intensity.

artículo científico publicado en 2017

Neural mechanisms of functional impairment across the lifespan: The 15th Biennial Meeting of the International Neurotoxicology Association and 39th Annual Meeting of the Neurobehavioral Teratology Society.

artículo científico publicado en 2017

Neuregulin-1 inhibits neuroinflammatory responses in a rat model of organophosphate-nerve agent-induced delayed neuronal injury

artículo científico publicado en 2015

Neuregulin-1 is neuroprotective in a rat model of organophosphate-induced delayed neuronal injury

artículo científico publicado en 2012

Neuronal connectivity as a convergent target of gene × environment interactions that confer risk for Autism Spectrum Disorders

artículo científico publicado en 2013

Neurotoxicity in preclinical models of occupational exposure to organophosphorus compounds

artículo científico publicado en 2017

Neurotoxicity of polychlorinated biphenyls and related organohalogens

artículo científico publicado en 2019

Noncholinesterase mechanisms of chlorpyrifos neurotoxicity: altered phosphorylation of Ca2+/cAMP response element binding protein in cultured neurons

artículo científico publicado en 2002

Nucleic acid binding agents exert local toxic effects on neurites via a non-nuclear mechanism

artículo científico publicado en 2006

Ontogenetic alterations in molecular and structural correlates of dendritic growth after developmental exposure to polychlorinated biphenyls

artículo científico publicado en 2007

Ontogeny of biochemical, morphological and functional parameters of synaptogenesis in primary cultures of rat hippocampal and cortical neurons

artículo científico publicado en 2015

Organophosphorus Pesticides Induce Cytokine Release from Differentiated Human THP1 Cells

scientific article published on 01 November 2019

Organophosphorus pesticides decrease M2 muscarinic receptor function in guinea pig airway nerves via indirect mechanisms

artículo científico publicado en 2010

Osteogenic protein-1 induces dendritic growth in rat sympathetic neurons

artículo científico publicado en 1995

Oxygen tension modulates differentiation and primary macrophage functions in the human monocytic THP-1 cell line

artículo científico publicado en 2013

PCB 136 atropselectively alters morphometric and functional parameters of neuronal connectivity in cultured rat hippocampal neurons via ryanodine receptor-dependent mechanisms

artículo científico publicado en 2014

PCB 95 promotes dendritic growth in primary rat hippocampal neurons via mTOR-dependent mechanisms

scholarly article by Kimberly P Keil et al published October 2018 in Archives of Toxicology

PCB-95 modulates the calcium-dependent signaling pathway responsible for activity-dependent dendritic growth

artículo científico publicado en 2012

PCB-95 promotes dendritic growth via ryanodine receptor-dependent mechanisms

artículo científico publicado en 2012

PON1 status does not influence cholinesterase activity in Egyptian agricultural workers exposed to chlorpyrifos

artículo científico publicado en 2012

Para- and ortho-substitutions are key determinants of polybrominated diphenyl ether activity toward ryanodine receptors and neurotoxicity

artículo científico publicado en 2011

Persistent neuroinflammation and cognitive impairment in a rat model of acute diisopropylfluorophosphate intoxication

scientific article published on 12 October 2016

Pharmacokinetics and pharmacodynamics of chlorpyrifos in adult male Long-Evans rats following repeated subcutaneous exposure to chlorpyrifos

artículo científico publicado en 2011

Phenobarbital use and neurological problems in FMR1 premutation carriers

artículo científico publicado en 2016

Placenta and fetal brain share a neurodevelopmental disorder DNA methylation profile in a mouse model of prenatal PCB exposure

artículo científico publicado en 2022

Polychlorinated Biphenyls (PCBs): Risk Factors for Autism Spectrum Disorder?

scientific article published on 17 September 2020

Polychlorinated biphenyls induce caspase-dependent cell death in cultured embryonic rat hippocampal but not cortical neurons via activation of the ryanodine receptor

artículo científico publicado en 2003

Post-exposure administration of diazepam combined with soluble epoxide hydrolase inhibition stops seizures and modulates neuroinflammation in a murine model of acute TETS intoxication

artículo científico publicado en 2014

Pretreatment with pyridostigmine bromide has no effect on seizure behavior or 24 hour survival in the rat model of acute diisopropylfluorophosphate intoxication

artículo científico publicado en 2019

Protein synthesis is required for the initiation of dendritic growth in embryonic rat sympathetic neurons in vitro

artículo científico publicado en 1991

Putative adverse outcome pathways relevant to neurotoxicity

artículo científico publicado en 2015

Rapid throughput analysis demonstrates that chemicals with distinct seizurogenic mechanisms differentially alter Ca2+ dynamics in networks formed by hippocampal neurons in culture

artículo científico publicado en 2015

Reactive oxygen species are involved in BMP-induced dendritic growth in cultured rat sympathetic neurons

artículo científico publicado en 2015

Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their selection and use.

artículo científico publicado en 2016

Repeated exposure to neurotoxic levels of chlorpyrifos alters hippocampal expression of neurotrophins and neuropeptides

artículo científico publicado en 2016

Rit signaling contributes to interferon-gamma-induced dendritic retraction via p38 mitogen-activated protein kinase activation

artículo científico publicado en 2008

Sex-dependent effects of 2,2',3,5',6-pentachlorobiphenyl (PCB 95) on dendritic arborization of primary mouse neurons

scientific article published on 01 March 2019

Spatiotemporal pattern of neuronal injury induced by DFP in rats: a model for delayed neuronal cell death following acute OP intoxication

artículo científico publicado en 2011

Species and Sex Differences in the Morphogenic Response of Primary Rodent Neurons to 3,3'-Dichlorobiphenyl (PCB 11).

artículo científico publicado en 2017

Statins decrease dendritic arborization in rat sympathetic neurons by blocking RhoA activation

artículo científico publicado en 2009

Statins decrease expression of the proinflammatory neuropeptides calcitonin gene-related peptide and substance P in sensory neurons

artículo científico publicado en 2008

Subacute nicotine co-exposure has no effect on 2,2',3,5',6- pentachlorobiphenyl disposition but alters hepatic cytochrome P450 expression in the male rat.

artículo científico publicado en 2015

Susceptibility of larval zebrafish to the seizurogenic activity of GABA type A receptor antagonists

artículo científico publicado en 2019

Teratological and behavioral screening of the National Toxicology Program 91-compound library in zebrafish (Danio rerio)

artículo científico publicado en 2019

Tetramethylenedisulfotetramine alters Ca²⁺ dynamics in cultured hippocampal neurons: mitigation by NMDA receptor blockade and GABA(A) receptor-positive modulation

artículo científico publicado en 2012

The Organophosphorus Pesticide Chlorpyrifos Induces Sex-Specific Airway Hyperreactivity in Adult Rats

scholarly article by Frances C Shaffo et al published 1 September 2018 in Toxicological Sciences

The chemical convulsant diisopropylfluorophosphate (DFP) causes persistent neuropathology in adult male rats independent of seizure activity

artículo científico publicado en 2020

The developmental neurotoxicity of legacy vs. contemporary polychlorinated biphenyls (PCBs): similarities and differences

scientific article published on 12 November 2019

The effects of extracellular matrix and osteogenic protein-1 on the morphological differentiation of rat sympathetic neurons

artículo científico publicado en 1996

The environmental neurotoxicant PCB 95 promotes synaptogenesis via ryanodine receptor-dependent miR132 upregulation.

artículo científico publicado en 2014

The influence of sensitization on mechanisms of organophosphorus pesticide-induced airway hyperreactivity

artículo científico publicado en 2015

The novel GTPase Rit differentially regulates axonal and dendritic growth

artículo científico publicado en 2007

Transcriptional responses of cultured rat sympathetic neurons during BMP-7-induced dendritic growth

artículo científico publicado en 2011

Transcriptomic profiling of mTOR and ryanodine receptor signaling molecules in developing zebrafish in the absence and presence of PCB 95.

artículo científico publicado en 2017

Translating neurobehavioural endpoints of developmental neurotoxicity tests into in vitro assays and readouts

artículo científico publicado en 2012

Translational Toxicology in Zebrafish

artículo científico publicado en 2020

Using the Morris water maze to assess spatial learning and memory in weanling mice

artículo científico publicado en 2015

Valid statistical approaches for analyzing sholl data: Mixed effects versus simple linear models

artículo científico publicado en 2017

Workgroup report: incorporating in vitro alternative methods for developmental neurotoxicity into international hazard and risk assessment strategies

artículo científico publicado en 2007

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