Lista de obras - David J. Klinke - Dominio Público Uruguay

A multi-scale model of dendritic cell education and trafficking in the lung: implications for T cell polarization

artículo científico publicado en 2007

A multiscale systems perspective on cancer, immunotherapy, and Interleukin-12

artículo científico publicado en 2010

A quantitative systems approach to identify paracrine mechanisms that locally suppress immune response to Interleukin-12 in the B16 melanoma model

artículo científico publicado en 2012

Age-corrected beta cell mass following onset of type 1 diabetes mellitus correlates with plasma C-peptide in humans

artículo científico publicado en 2011

An age-structured model of dendritic cell trafficking in the lung.

artículo científico publicado en 2006

An elastic-net logistic regression approach to generate classifiers and gene signatures for types of immune cells and T helper cell subsets

artículo científico publicado en 2019

An empirical Bayesian approach for model-based inference of cellular signaling networks

artículo científico publicado en 2009

An evolutionary perspective on anti-tumor immunity

artículo científico publicado en 2012

An in silico exploration of combining Interleukin-12 with Oxaliplatin to treat liver-metastatic colorectal cancer

scientific article published on 08 January 2020

CD8(+) T cell response to adenovirus vaccination and subsequent suppression of tumor growth: modeling, simulation and analysis

artículo científico publicado en 2015

Cell Communication Network Factor 4 (CCN4/WISP1) Shifts Melanoma Cells from a Fragile Proliferative State to a Resilient Metastatic State

artículo científico publicado en 2019

Differential proteomic analysis of caveolin-1 KO cells reveals Sh2b3 and Clec12b as novel interaction partners of caveolin-1 and Capns1 as a potential mediator of caveolin-1-induced apoptosis

artículo científico publicado en 2013

Eavesdropping on altered cell-to-cell signaling in cancer by secretome profiling

artículo científico publicado en 2015

Enhancing the discovery and development of immunotherapies for cancer using quantitative and systems pharmacology: Interleukin-12 as a case study

artículo científico publicado en 2015

Exosomes derived from B16F0 melanoma cells alter the transcriptome of cytotoxic T cells that impacts mitochondrial respiration

artículo científico publicado en 2018

Exosomes: improved methods to characterize their morphology, RNA content, and surface protein biomarkers.

artículo científico publicado en 2015

Extent of beta cell destruction is important but insufficient to predict the onset of type 1 diabetes mellitus

artículo científico publicado en 2008

Identification and classification of bcl genes and proteins of Bacillus cereus group organisms and their application in Bacillus anthracis detection and fingerprinting

artículo científico publicado en 2009

Identifying causal networks linking cancer processes and anti-tumor immunity using Bayesian network inference and metagene constructs.

artículo científico publicado en 2016

Identifying local mechanisms for tumor-derived immunosuppression: an integrated phenotypic screening approach

artículo científico publicado en 2014

In silico model-based inference: a contemporary approach for hypothesis testing in network biology

artículo científico publicado en 2014

In silico model-based inference: an emerging approach for inverse problems in engineering better medicines

artículo científico publicado en 2015

Induction of Wnt-inducible signaling protein-1 correlates with invasive breast cancer oncogenesis and reduced type 1 cell-mediated cytotoxic immunity: a retrospective study

artículo científico publicado en 2014

Inferring alterations in cell-to-cell communication in HER2+ breast cancer using secretome profiling of three cell models

artículo científico publicado en 2014

Inferring predominant pathways in cellular models of breast cancer using limited sample proteomic profiling

artículo científico publicado en 2010

Inferring relevant control mechanisms for interleukin-12 signaling in naïve CD4+ T cells

artículo científico publicado en 2010

Inferring the Impact of Regulatory Mechanisms that Underpin CD8+ T Cell Control of B16 Tumor Growth In vivo Using Mechanistic Models and Simulation

artículo científico publicado en 2016

Integrating epidemiological data into a mechanistic model of type 2 diabetes: validating the prevalence of virtual patients

artículo científico publicado en 2007

Interlocked positive and negative feedback network motifs regulate β-catenin activity in the adherens junction pathway.

artículo científico publicado en 2015

Is immune checkpoint modulation a potential therapeutic option in triple negative breast cancer?

artículo científico publicado en 2014

Melanoma exosomes deliver a complex biological payload that upregulates PTPN11 to suppress T lymphocyte function.

artículo científico publicado en 2016

Protein-based identification of quantitative trait loci associated with malignant transformation in two HER2+ cellular models of breast cancer

artículo científico publicado en 2012

Quantifying crosstalk among interferon-γ, interleukin-12, and tumor necrosis factor signaling pathways within a TH1 cell model

artículo científico publicado en 2012

Scalable analysis of flow cytometry data using R/Bioconductor

artículo científico publicado en 2009

Signal transduction networks in cancer: quantitative parameters influence network topology

artículo científico publicado en 2010

Simulation Study on Effects of Order and Step Size of Runge-Kutta Methods that Solve Contagious Disease and Tumor Models

artículo científico publicado en 2016

The ratio of P40 monomer to dimer is an important determinant of IL-12 bioactivity

artículo científico publicado en 2006

Timescale analysis of rule‐based biochemical reaction networks ⬇️

artículo científico publicado el 26 de septiembre de 2011

Understanding immunology via engineering design: the role of mathematical prototyping.

artículo científico publicado en 2012

WNT1-inducible signaling pathway protein 1 (WISP1/CCN4) stimulates melanoma invasion and metastasis by promoting the epithelial-mesenchymal transition

scientific article published on 05 February 2019

Lista de obras de David J. Klinke

A multi-scale model of dendritic cell education and trafficking in the lung: implications for T cell polarization

A multiscale systems perspective on cancer, immunotherapy, and Interleukin-12

A quantitative systems approach to identify paracrine mechanisms that locally suppress immune response to Interleukin-12 in the B16 melanoma model

Age-corrected beta cell mass following onset of type 1 diabetes mellitus correlates with plasma C-peptide in humans

An age-structured model of dendritic cell trafficking in the lung.

An elastic-net logistic regression approach to generate classifiers and gene signatures for types of immune cells and T helper cell subsets

An empirical Bayesian approach for model-based inference of cellular signaling networks

An evolutionary perspective on anti-tumor immunity

An in silico exploration of combining Interleukin-12 with Oxaliplatin to treat liver-metastatic colorectal cancer

CD8(+) T cell response to adenovirus vaccination and subsequent suppression of tumor growth: modeling, simulation and analysis

Cell Communication Network Factor 4 (CCN4/WISP1) Shifts Melanoma Cells from a Fragile Proliferative State to a Resilient Metastatic State

Differential proteomic analysis of caveolin-1 KO cells reveals Sh2b3 and Clec12b as novel interaction partners of caveolin-1 and Capns1 as a potential mediator of caveolin-1-induced apoptosis

Eavesdropping on altered cell-to-cell signaling in cancer by secretome profiling

Enhancing the discovery and development of immunotherapies for cancer using quantitative and systems pharmacology: Interleukin-12 as a case study

Exosomes derived from B16F0 melanoma cells alter the transcriptome of cytotoxic T cells that impacts mitochondrial respiration

Exosomes: improved methods to characterize their morphology, RNA content, and surface protein biomarkers.

Extent of beta cell destruction is important but insufficient to predict the onset of type 1 diabetes mellitus

Identification and classification of bcl genes and proteins of Bacillus cereus group organisms and their application in Bacillus anthracis detection and fingerprinting

Identifying causal networks linking cancer processes and anti-tumor immunity using Bayesian network inference and metagene constructs.

Identifying local mechanisms for tumor-derived immunosuppression: an integrated phenotypic screening approach

In silico model-based inference: a contemporary approach for hypothesis testing in network biology

In silico model-based inference: an emerging approach for inverse problems in engineering better medicines

Induction of Wnt-inducible signaling protein-1 correlates with invasive breast cancer oncogenesis and reduced type 1 cell-mediated cytotoxic immunity: a retrospective study

Inferring alterations in cell-to-cell communication in HER2+ breast cancer using secretome profiling of three cell models

Inferring predominant pathways in cellular models of breast cancer using limited sample proteomic profiling

Inferring relevant control mechanisms for interleukin-12 signaling in naïve CD4+ T cells

Inferring the Impact of Regulatory Mechanisms that Underpin CD8+ T Cell Control of B16 Tumor Growth In vivo Using Mechanistic Models and Simulation

Integrating epidemiological data into a mechanistic model of type 2 diabetes: validating the prevalence of virtual patients

Interlocked positive and negative feedback network motifs regulate β-catenin activity in the adherens junction pathway.

Is immune checkpoint modulation a potential therapeutic option in triple negative breast cancer?

Melanoma exosomes deliver a complex biological payload that upregulates PTPN11 to suppress T lymphocyte function.

Protein-based identification of quantitative trait loci associated with malignant transformation in two HER2+ cellular models of breast cancer

Quantifying crosstalk among interferon-γ, interleukin-12, and tumor necrosis factor signaling pathways within a TH1 cell model

Scalable analysis of flow cytometry data using R/Bioconductor

Signal transduction networks in cancer: quantitative parameters influence network topology

Simulation Study on Effects of Order and Step Size of Runge-Kutta Methods that Solve Contagious Disease and Tumor Models

The ratio of P40 monomer to dimer is an important determinant of IL-12 bioactivity

Timescale analysis of rule‐based biochemical reaction networks ⬇️

Understanding immunology via engineering design: the role of mathematical prototyping.

WNT1-inducible signaling pathway protein 1 (WISP1/CCN4) stimulates melanoma invasion and metastasis by promoting the epithelial-mesenchymal transition