Lista de obras - Daniel Krappmann - Dominio Público Uruguay

A Linear Diubiquitin-Based Probe for Efficient and Selective Detection of the Deubiquitinating Enzyme OTULIN.

artículo científico publicado en 2017

A pervasive role of ubiquitin conjugation in activation and termination of IkappaB kinase pathways

artículo científico publicado en 2005

A20 and CYLD do not share significant overlapping functions during B cell development and activation

artículo científico publicado en 2012

A20 negatively regulates T cell receptor signaling to NF-kappaB by cleaving Malt1 ubiquitin chains.

artículo científico publicado en 2009

AIP augments CARMA1-BCL10-MALT1 complex formation to facilitate NF-κB signaling upon T cell activation.

artículo científico publicado en 2014

Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B.

artículo científico publicado en 2002

Activity-based probes for detection of active MALT1 paracaspase in immune cells and lymphomas

artículo científico publicado en 2015

Alternative splicing of MALT1 controls signalling and activation of CD4(+) T cells

artículo científico publicado en 2016

Attacking MALT1 for ABC-DLBCL therapy ⬇️

artículo científico publicado el 1 de diciembre de 2012

B-cell receptor-driven MALT1 activity regulates MYC signaling in mantle cell lymphoma.

artículo científico publicado en 2016

BCL10 - Bridging CARDs to Immune Activation

scientific article published on 04 July 2018

BCL10-CARD11 Fusion Mimics an Active CARD11 Seed That Triggers Constitutive BCL10 Oligomerization and Lymphocyte Activation

artículo científico publicado en 2018

Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells

artículo científico publicado en 2019

CARD-Bcl10-Malt1 signalosomes: missing link to NF-kappaB.

artículo científico publicado en 2007

COP9 signalosome controls the Carma1-Bcl10-Malt1 complex upon T-cell stimulation

artículo científico publicado en 2009

Canonical NF-κB signaling in hepatocytes acts as a tumor-suppressor in hepatitis B virus surface antigen-driven hepatocellular carcinoma by controlling the unfolded protein response.

artículo científico publicado en 2016

Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation

artículo científico publicado en 2014

Combinatorial BTK and MALT1 inhibition augments killing of CD79 mutant diffuse large B cell lymphoma.

artículo científico publicado en 2015

Constitutive NF-kappaB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells

artículo científico publicado en 2001

Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells ⬇️

artículo científico publicado el 15 de diciembre de 1997

Controlling NF-kappaB activation in T cells by costimulatory receptors

artículo científico publicado en 2006

Correction: S1PR1 drives a feedforward signalling loop to regulate BATF3 and the transcriptional programme of Hodgkin lymphoma cells

scientific article published on 01 August 2019

Critical role of PI3K signaling for NF-kappaB-dependent survival in a subset of activated B-cell-like diffuse large B-cell lymphoma cells.

artículo científico publicado en 2010

Degradation of Bcl10 induced by T-cell activation negatively regulates NF-kappa B signaling

artículo científico publicado en 2004

Dephosphorylation of Carma1 by PP2A negatively regulates T-cell activation

artículo científico publicado en 2011

Detection of recombinant and cellular MALT1 paracaspase activity

artículo científico publicado en 2015

Development of new Malt1 inhibitors and probes.

artículo científico publicado en 2016

Distinct isocomplexes of the TRAPP trafficking factor coexist inside human cells

artículo científico publicado en 2008

Dlg3 trafficking and apical tight junction formation is regulated by nedd4 and nedd4-2 e3 ubiquitin ligases

scientific journal article

Essential role for IkappaB kinase beta in remodeling Carma1-Bcl10-Malt1 complexes upon T cell activation

artículo científico publicado en 2006

GSK3β modulates NF-κB activation and RelB degradation through site-specific phosphorylation of BCL10.

artículo científico publicado en 2018

Hectd3 promotes pathogenic Th17 lineage through Stat3 activation and Malt1 signaling in neuroinflammation

scientific article published in Nature Communications

Immunoproteasome subunit deficiency has no influence on the canonical pathway of NF-κB activation.

artículo científico publicado en 2017

In vitro detection of NEMO-ubiquitin binding using DELFIA and microscale thermophoresis assays

artículo científico publicado en 2015

In vitro susceptibility to TRAIL-induced apoptosis of acute leukemia cells in the context of TRAIL receptor gene expression and constitutive NF-kappa B activity

artículo científico publicado en 2001

Inactivation of the putative ubiquitin-E3 ligase PDLIM2 in classical Hodgkin and anaplastic large cell lymphoma

scientific article published on 19 August 2016

Inhibition of Canonical NF-κB Signaling by a Small Molecule Targeting NEMO-Ubiquitin Interaction

artículo científico publicado en 2016

Inhibition of MALT1 protease activity is selectively toxic for activated B cell–like diffuse large B cell lymphoma cells

artículo científico publicado en 2009

Lymphocyte signaling and activation by the CARMA1-BCL10-MALT1 signalosome.

artículo científico publicado en 2016

Lymphotoxin and lipopolysaccharide induce NF-kappaB-p52 generation by a co-translational mechanism

artículo científico publicado en 2003

MALT1 activation by TRAF6 needs neither BCL10 nor CARD11

artículo científico publicado en 2018

MALT1 directs B cell receptor–induced canonical nuclear factor-κB signaling selectively to the c-Rel subunit

artículo científico publicado en 2007

MALT1 protease: equilibrating immunity versus tolerance.

artículo científico publicado en 2014

Malt1 ubiquitination triggers NF-kappaB signaling upon T-cell activation

artículo científico publicado en 2007

Mechanisms and consequences of constitutive NF-κB activation in B-cell lymphoid malignancies

artículo científico publicado en 2014

Mechanisms of NF-κB deregulation in lymphoid malignancies

artículo científico publicado en 2016

Molecular architecture and regulation of BCL10-MALT1 filaments

artículo científico publicado en 2018

Molecular mechanisms of constitutive NF-kappaB/Rel activation in Hodgkin/Reed-Sternberg cells.

artículo científico publicado en 1999

NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes

artículo científico publicado en 1999

NF-κB essential modulator (NEMO) interaction with linear and lys-63 ubiquitin chains contributes to NF-κB activation

artículo científico publicado en 2011

Nuclear factor kappaB-dependent gene expression profiling of Hodgkin's disease tumor cells, pathogenetic significance, and link to constitutive signal transducer and activator of transcription 5a activity

artículo científico publicado en 2002

OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin

artículo científico publicado en 2013

Oncogenic CARMA1 couples NF-κB and β-catenin signaling in diffuse large B-cell lymphomas.

artículo científico publicado en 2016

Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling

artículo científico publicado en 2007

Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL.

artículo científico publicado en 2012

Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis.

artículo científico publicado en 2014

Progressive stages of mitochondrial destruction caused by cell toxic bile salts

artículo científico publicado en 2013

Psoriasis mutations disrupt CARD14 autoinhibition promoting BCL10-MALT1-dependent NF-κB activation.

artículo científico publicado en 2016

Purification and characterization of the human elongator complex

artículo científico publicado en 2002

Regulation of S1PR2 by the EBV oncogene LMP1 in aggressive ABC-subtype diffuse large B-cell lymphoma

artículo científico publicado en 2019

Regulation of the endosomal SNX27-retromer by OTULIN

artículo científico publicado en 2019

Requirement of Hsp90 activity for IkappaB kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF-kappaB activation.

artículo científico publicado en 2004

Role of oxidative stress in ultrafine particle-induced exacerbation of allergic lung inflammation

artículo científico publicado en 2009

S1PR1 drives a feedforward signalling loop to regulate BATF3 and the transcriptional programme of Hodgkin lymphoma cells ⬇️

artículo científico publicado en 2017

Shaping oncogenic NF-κB activity in the nucleus ⬇️

artículo científico publicado el 26 de septiembre de 2013

Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and IkappaBalpha

artículo científico publicado en 2001

Signal-dependent degradation of I B is mediated by an inducible destruction box that can be transferred to NF- B, Bcl-3 or p53 ⬇️

artículo científico publicado el 1 de abril de 1998

Signals from the Nucleus: Activation of NF- B by Cytosolic ATM in the DNA Damage Response

artículo científico publicado en 2011

Structural analysis of phenothiazine derivatives as allosteric inhibitors of the MALT1 paracaspase

artículo científico publicado en 2013

Synthesis and Evaluation of Macrocyclic Peptide Aldehydes as Potent and Selective Inhibitors of the 20S Proteasome.

artículo científico publicado en 2016

Targeting TRAF6 E3 ligase activity with a small-molecule inhibitor combats autoimmunity

artículo científico publicado en 2018

The Ca2+-dependent Phosphatase Calcineurin Controls the Formation of the Carma1-Bcl10-Malt1 Complex during T Cell Receptor-induced NF-κB Activation ⬇️

artículo científico publicado el 3 de enero de 2011

The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO

artículo científico publicado en 2013

The I kappa B kinase (IKK) complex is tripartite and contains IKK gamma but not IKAP as a regular component

artículo científico publicado en 2000

The IkappaB kinase complex and NF-kappaB act as master regulators of lipopolysaccharide-induced gene expression and control subordinate activation of AP-1.

artículo científico publicado en 2004

The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2

artículo científico publicado en 2009

Tissue-specific expression of a splicing mutation in the IKBKAP gene causes familial dysautonomia

artículo científico publicado en 2001

Ubiquitin Conjugation and Deconjugation in NF-κB Signaling

artículo científico publicado en 2010

Viral targeting of the interferon-{beta}-inducing Traf family member-associated NF-{kappa}B activator (TANK)-binding kinase-1.

artículo científico publicado en 2005

YOD1/TRAF6 association balances p62-dependent IL-1 signaling to NF-κB

artículo científico publicado en 2017

Lista de obras de Daniel Krappmann

A Linear Diubiquitin-Based Probe for Efficient and Selective Detection of the Deubiquitinating Enzyme OTULIN.

A pervasive role of ubiquitin conjugation in activation and termination of IkappaB kinase pathways

A20 and CYLD do not share significant overlapping functions during B cell development and activation

A20 negatively regulates T cell receptor signaling to NF-kappaB by cleaving Malt1 ubiquitin chains.

AIP augments CARMA1-BCL10-MALT1 complex formation to facilitate NF-κB signaling upon T cell activation.

Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B.

Activity-based probes for detection of active MALT1 paracaspase in immune cells and lymphomas

Alternative splicing of MALT1 controls signalling and activation of CD4(+) T cells

Attacking MALT1 for ABC-DLBCL therapy ⬇️

B-cell receptor-driven MALT1 activity regulates MYC signaling in mantle cell lymphoma.

BCL10 - Bridging CARDs to Immune Activation

BCL10-CARD11 Fusion Mimics an Active CARD11 Seed That Triggers Constitutive BCL10 Oligomerization and Lymphocyte Activation

Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells

CARD-Bcl10-Malt1 signalosomes: missing link to NF-kappaB.

COP9 signalosome controls the Carma1-Bcl10-Malt1 complex upon T-cell stimulation

Canonical NF-κB signaling in hepatocytes acts as a tumor-suppressor in hepatitis B virus surface antigen-driven hepatocellular carcinoma by controlling the unfolded protein response.

Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation

Combinatorial BTK and MALT1 inhibition augments killing of CD79 mutant diffuse large B cell lymphoma.

Constitutive NF-kappaB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells

Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells ⬇️

Controlling NF-kappaB activation in T cells by costimulatory receptors

Correction: S1PR1 drives a feedforward signalling loop to regulate BATF3 and the transcriptional programme of Hodgkin lymphoma cells

Critical role of PI3K signaling for NF-kappaB-dependent survival in a subset of activated B-cell-like diffuse large B-cell lymphoma cells.

Degradation of Bcl10 induced by T-cell activation negatively regulates NF-kappa B signaling

Dephosphorylation of Carma1 by PP2A negatively regulates T-cell activation

Detection of recombinant and cellular MALT1 paracaspase activity

Development of new Malt1 inhibitors and probes.

Distinct isocomplexes of the TRAPP trafficking factor coexist inside human cells

Dlg3 trafficking and apical tight junction formation is regulated by nedd4 and nedd4-2 e3 ubiquitin ligases

Essential role for IkappaB kinase beta in remodeling Carma1-Bcl10-Malt1 complexes upon T cell activation

GSK3β modulates NF-κB activation and RelB degradation through site-specific phosphorylation of BCL10.

Hectd3 promotes pathogenic Th17 lineage through Stat3 activation and Malt1 signaling in neuroinflammation

Immunoproteasome subunit deficiency has no influence on the canonical pathway of NF-κB activation.

In vitro detection of NEMO-ubiquitin binding using DELFIA and microscale thermophoresis assays

In vitro susceptibility to TRAIL-induced apoptosis of acute leukemia cells in the context of TRAIL receptor gene expression and constitutive NF-kappa B activity

Inactivation of the putative ubiquitin-E3 ligase PDLIM2 in classical Hodgkin and anaplastic large cell lymphoma

Inhibition of Canonical NF-κB Signaling by a Small Molecule Targeting NEMO-Ubiquitin Interaction

Inhibition of MALT1 protease activity is selectively toxic for activated B cell–like diffuse large B cell lymphoma cells

Lymphocyte signaling and activation by the CARMA1-BCL10-MALT1 signalosome.

Lymphotoxin and lipopolysaccharide induce NF-kappaB-p52 generation by a co-translational mechanism

MALT1 activation by TRAF6 needs neither BCL10 nor CARD11

MALT1 directs B cell receptor–induced canonical nuclear factor-κB signaling selectively to the c-Rel subunit

MALT1 protease: equilibrating immunity versus tolerance.

Malt1 ubiquitination triggers NF-kappaB signaling upon T-cell activation

Mechanisms and consequences of constitutive NF-κB activation in B-cell lymphoid malignancies

Mechanisms of NF-κB deregulation in lymphoid malignancies

Molecular architecture and regulation of BCL10-MALT1 filaments

Molecular mechanisms of constitutive NF-kappaB/Rel activation in Hodgkin/Reed-Sternberg cells.

NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes

NF-κB essential modulator (NEMO) interaction with linear and lys-63 ubiquitin chains contributes to NF-κB activation

Nuclear factor kappaB-dependent gene expression profiling of Hodgkin's disease tumor cells, pathogenetic significance, and link to constitutive signal transducer and activator of transcription 5a activity

OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin

Oncogenic CARMA1 couples NF-κB and β-catenin signaling in diffuse large B-cell lymphomas.

Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling

Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL.

Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis.

Progressive stages of mitochondrial destruction caused by cell toxic bile salts

Psoriasis mutations disrupt CARD14 autoinhibition promoting BCL10-MALT1-dependent NF-κB activation.

Purification and characterization of the human elongator complex

Regulation of S1PR2 by the EBV oncogene LMP1 in aggressive ABC-subtype diffuse large B-cell lymphoma

Regulation of the endosomal SNX27-retromer by OTULIN

Requirement of Hsp90 activity for IkappaB kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF-kappaB activation.

Role of oxidative stress in ultrafine particle-induced exacerbation of allergic lung inflammation

S1PR1 drives a feedforward signalling loop to regulate BATF3 and the transcriptional programme of Hodgkin lymphoma cells ⬇️

Shaping oncogenic NF-κB activity in the nucleus ⬇️

Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and IkappaBalpha

Signal-dependent degradation of I B is mediated by an inducible destruction box that can be transferred to NF- B, Bcl-3 or p53 ⬇️

Signals from the Nucleus: Activation of NF- B by Cytosolic ATM in the DNA Damage Response

Structural analysis of phenothiazine derivatives as allosteric inhibitors of the MALT1 paracaspase

Synthesis and Evaluation of Macrocyclic Peptide Aldehydes as Potent and Selective Inhibitors of the 20S Proteasome.

Targeting TRAF6 E3 ligase activity with a small-molecule inhibitor combats autoimmunity

The Ca2+-dependent Phosphatase Calcineurin Controls the Formation of the Carma1-Bcl10-Malt1 Complex during T Cell Receptor-induced NF-κB Activation ⬇️

The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO

The I kappa B kinase (IKK) complex is tripartite and contains IKK gamma but not IKAP as a regular component

The IkappaB kinase complex and NF-kappaB act as master regulators of lipopolysaccharide-induced gene expression and control subordinate activation of AP-1.

The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2

Tissue-specific expression of a splicing mutation in the IKBKAP gene causes familial dysautonomia

Ubiquitin Conjugation and Deconjugation in NF-κB Signaling

Viral targeting of the interferon-{beta}-inducing Traf family member-associated NF-{kappa}B activator (TANK)-binding kinase-1.