Lista de obras - Patrizia Hrelia - Dominio Público Uruguay

2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents

artículo científico publicado en 2012

A Novel MYCN-Specific Antigene Oligonucleotide Deregulates Mitochondria and Inhibits Tumor Growth in MYCN-Amplified Neuroblastoma

scientific article published on 15 October 2019

A meta-analysis of Italian and Estonian individuals shows an effect of common variants in HMGCR on blood apoB levels

scientific article published on 07 September 2018

A molecular epidemiological approach to health risk assessment of urban air pollution

artículo científico publicado en 2004

A mutated p53 status did not prevent the induction of apoptosis by sulforaphane, a promising anti-cancer drug

artículo científico publicado en 2005

Absence of mutations in the human interferon alpha-2b gene in workers chronically exposed to ionising radiation

scientific article published on 01 June 2019

An exploratory association of polymorphisms in angiogenesis-related genes with susceptibility, clinical response and toxicity in gastrointestinal stromal tumors receiving sunitinib after imatinib failure.

artículo científico publicado en 2016

An exploratory study by DMET array identifies a germline signature associated with imatinib response in gastrointestinal stromal tumor

scientific article published on 20 September 2018

Antileukemic activity of sulforaphane in primary blasts from patients affected by myelo- and lympho-proliferative disorders and in hypoxic conditions

artículo científico publicado en 2014

Antitumor activity of sustained N-myc reduction in rhabdomyosarcomas and transcriptional block by antigene therapy

artículo científico publicado en 2011

Apoptosis and modulation of cell cycle control by bile acids in human leukemia T cells

artículo científico publicado en 2009

Apoptosis induction by sulfur-containing compounds in malignant and nonmalignant human cells

artículo científico publicado en 2009

Application of the lymphocyte Cytokinesis-Block Micronucleus Assay to populations exposed to petroleum and its derivatives: Results from a systematic review and meta-analysis

artículo científico publicado en 2016

Association between imatinib transporters and metabolizing enzymes genotype and response in newly diagnosed chronic myeloid leukemia patients receiving imatinib therapy

artículo científico publicado en 2012

Castanea sativa Mill. bark extract exhibits chemopreventive properties triggering extrinsic apoptotic pathway in Jurkat cells

artículo científico publicado en 2017

Clinical relevance of circulating molecules in cancer: focus on gastrointestinal stromal tumors

artículo científico publicado en 2019

Clinical relevance of pharmacogenetics in gastrointestinal stromal tumor treatment in the era of personalized therapy

artículo científico

Combination of doxorubicin and sulforaphane for reversing doxorubicin-resistant phenotype in mouse fibroblasts with p53Ser220 mutation

artículo científico publicado en 2007

Common Protective Strategies in Neurodegenerative Disease: Focusing on Risk Factors to Target the Cellular Redox System

artículo científico publicado en 2020

Cyanidin 3-O-glucopyranoside protects and rescues SH-SY5Y cells against amyloid-beta peptide-induced toxicity

artículo científico publicado en 2008

Diet and risk of cancer

article published in 2003

Early effects of Aβ1-42 oligomers injection in mice: Involvement of PI3K/Akt/GSK3 and MAPK/ERK1/2 pathways.

artículo científico publicado en 2016

Effects of environmental benzene: micronucleus frequencies and haematological values in traffic police working in an urban area

artículo científico publicado en 2005

Electrocardiogram Alterations Associated With Psychotropic Drug Use and CACNA1C Gene Variants in Three Independent Samples.

artículo científico publicado en 2016

Environmental exposure to benzene, micronucleus formation and polymorphisms in DNA-repair genes: a pilot study

artículo científico publicado en 2012

Esculetin as a Bifunctional Antioxidant Prevents and Counteracts the Oxidative Stress and Neuronal Death Induced by Amyloid Protein in SH-SY5Y Cells

artículo científico publicado en 2020

Evaluation of chromosome aberration and micronucleus frequencies in blood lymphocytes of workers exposed to low concentrations of benzene

article

Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease

artículo científico publicado en 2011

Flow cytometry vs optical microscopy in the evaluation of the genotoxic potential of xenobiotic compounds

artículo científico publicado en 2017

Folate-related polymorphisms in gastrointestinal stromal tumours: susceptibility and correlation with tumour characteristics and clinical outcome

artículo científico publicado en 2014

Gastric Adenocarcinomas and Signet-Ring Cell Carcinoma: Unraveling Gastric Cancer Complexity through Microbiome Analysis-Deepening Heterogeneity for a Personalized Therapy

artículo científico publicado en 2020

Gastrointestinal stromal tumors (GIST): Facing cell death between autophagy and apoptosis

artículo científico publicado en 2017

Genotoxic Properties of Synthetic Cannabinoids on TK6 Human Cells by Flow Cytometry

scientific article published on 09 February 2020

Genotoxicity assessment of some cosmetic and food additives

artículo científico publicado en 2013

Hemidesmus indicus induces apoptosis via proteasome inhibition and generation of reactive oxygen species

scientific article published on 10 May 2019

Identification of a new tamoxifen-xanthene hybrid as pro-apoptotic anticancer agent

scientific article published on 10 February 2019

Immunoprevention of cancer poses a challenge to pharmacological research ⬇️

artículo científico publicado el 1 de mayo de 1997

Impact of personalized diet and probiotic supplementation on inflammation, nutritional parameters and intestinal microbiota - The "RISTOMED project": Randomized controlled trial in healthy older people

artículo científico publicado en 2014

In vitro anti-angiogenic effects of Hemidesmus indicus in hypoxic and normoxic conditions

artículo científico publicado en 2015

In vitro antitumor activity of cyanidin-3-O-beta-glucopyranoside

artículo científico publicado en 2005

Induction of differentiation in human promyelocytic cells by the isothiocyanate sulforaphane.

artículo científico publicado en 2008

Inhibition by beta-caryophyllene of ethyl methanesulfonate-induced clastogenicity in cultured human lymphocytes

artículo científico publicado en 2010

Integrating miRNA and gene expression profiling analysis revealed regulatory networks in gastrointestinal stromal tumors.

artículo científico publicado en 2016

Intra- and inter-laboratory variation in the scoring of micronuclei and nucleoplasmic bridges in binucleated human lymphocytes. Results of an international slide-scoring exercise by the HUMN project

artículo científico publicado en 2003

Investigation of the photochemical properties and in vitro phototoxic potential of bumetanide

artículo científico publicado en 2003

Isothiocyanates Are Promising Compounds against Oxidative Stress, Neuroinflammation and Cell Death that May Benefit Neurodegeneration in Parkinson's Disease

artículo científico publicado en 2016

Isothiocyanates as novel cytotoxic and cytostatic agents: molecular pathway on human transformed and non-transformed cells

artículo científico publicado en 2004

Isotopic Labeling Studies Reveal the Patulin Detoxification Pathway by the Biocontrol Yeast Rhodotorula kratochvilovae LS11

scientific article published on 21 November 2018

Italian intersociety consensus on prevention, diagnosis, and treatment of delirium in hospitalized older persons.

artículo científico publicado en 2017

Key Genetic and Epigenetic Mechanisms in Chemical Carcinogenesis

artículo científico publicado en 2015

Mechanisms of resistance to a PI3K inhibitor in gastrointestinal stromal tumors: an omic approach to identify novel druggable targets

scientific article published on 05 July 2019

Metabolic and toxicological considerations of botanicals in anticancer therapy

artículo científico publicado en 2012

Micronucleus frequency in human peripheral blood lymphocytes as a biomarker for the early detection of colorectal cancer risk

artículo científico publicado en 2014

Mitochondrial pathway mediates the antileukemic effects of Hemidesmus indicus, a promising botanical drug

artículo científico publicado en 2011

Multitarget-directed drug design strategy: a novel molecule designed to block epidermal growth factor receptor (EGFR) and to exert proapoptotic effects

artículo científico publicado en 2006

Natural isothiocyanates: genotoxic potential versus chemoprevention

artículo científico publicado en 2011

Neuroprotection by 6-(methylsulfinyl)hexyl isothiocyanate in a 6-hydroxydopamine mouse model of Parkinson׳s disease.

artículo científico publicado en 2014

Neuroprotective Effect of Caffeic Acid Phenethyl Ester in A Mouse Model of Alzheimer's Disease Involves Nrf2/HO-1 Pathway

artículo científico publicado en 2018

Neuroprotective effect of sulforaphane in 6-hydroxydopamine-lesioned mouse model of Parkinson's disease

artículo científico publicado en 2013

Neuroprotective effects of anthocyanins and their in vivo metabolites in SH-SY5Y cells

artículo científico publicado en 2007

Neuroprotective effects of cyanidin 3-O-glucopyranoside on amyloid beta (25-35) oligomer-induced toxicity

artículo científico publicado en 2010

Neuroprotective effects of erucin against 6-hydroxydopamine-induced oxidative damage in a dopaminergic-like neuroblastoma cell line

artículo científico publicado en 2012

Novel Psychoactive Phenethylamines: Impact on Genetic Material

scientific article published on 17 December 2020

Novel class of quinone-bearing polyamines as multi-target-directed ligands to combat Alzheimer's disease

artículo científico publicado en 2007

Novel polyamine analogues: from substrates towards potential inhibitors of monoamine oxidases

artículo científico publicado en 2013

P-glycoprotein (ABCB1) and Oxidative Stress: Focus on Alzheimer's Disease

artículo científico publicado en 2017

PQM130, a Novel Feruloyl-Donepezil Hybrid Compound, Effectively Ameliorates the Cognitive Impairments and Pathology in a Mouse Model of Alzheimer's Disease

scientific article published on 12 June 2019

Personalized Medicine in Gastrointestinal Stromal Tumor (GIST): Clinical Implications of the Somatic and Germline DNA Analysis

artículo científico publicado en 2015

Pharmacogenetics in the treatment of gastrointestinal stromal tumors- an updated review

artículo científico publicado en 2020

Pharmacogenetics of tyrosine kinase inhibitors in gastrointestinal stromal tumor and chronic myeloid leukemia

artículo científico publicado en 2016

Polyamine conjugation of curcumin analogues toward the discovery of mitochondria-directed neuroprotective agents

artículo científico publicado en 2010

Polymorphisms in DNA repair genes in gastrointestinal stromal tumours: susceptibility and correlation with tumour characteristics and clinical outcome.

artículo científico publicado en 2016

Polymorphisms in DNA repair genes: link with biomarkers of the CBMN cytome assay in hospital workers chronically exposed to low doses of ionising radiation.

artículo científico publicado en 2015

Polymorphisms in OCTN1 and OCTN2 transporters genes are associated with prolonged time to progression in unresectable gastrointestinal stromal tumours treated with imatinib therapy

artículo científico publicado en 2012

Prognostic Role of miR-221 and miR-222 Expression in Cancer Patients: A Systematic Review and Meta-Analysis

artículo científico publicado en 2019

Protective Effects of 6-(Methylsulfinyl)hexyl Isothiocyanate on Aβ-Induced Cognitive Deficit, Oxidative Stress, Inflammation, and Apoptosis in Mice

scholarly article by Fabiana Morroni published in July 2018

Protective effects of cyanidin-3-O-beta-glucopyranoside against UVA-induced oxidative stress in human keratinocytes.

artículo científico publicado en 2005

Rational approach to discover multipotent anti-Alzheimer drugs.

artículo científico publicado en 2005

Red chicory (Cichorium intybus L. cultivar) as a potential source of antioxidant anthocyanins for intestinal health

scientific article published on 27 August 2013

Relationship between Lipid Phenotypes, Overweight, Lipid Lowering Drug Response and KIF6 and HMG-CoA Genotypes in a Subset of the Brisighella Heart Study Population.

artículo científico publicado en 2017

Short-chain aliphatic halocompounds: "in vivo" effects on microsomal monooxygenase (P450-dependent) system

artículo científico publicado el 1 de febrero de 1992

Simultaneous Analysis of SEPT9 Promoter Methylation Status, Micronuclei Frequency, and Folate-Related Gene Polymorphisms: The Potential for a Novel Blood-Based Colorectal Cancer Biomarker

artículo científico publicado en 2015

Socio-Economic and Clinical Factors as Predictors of Disease Evolution and Acute Events in COPD Patients

artículo científico publicado en 2015

Sulforaphane as a potential protective phytochemical against neurodegenerative diseases

artículo científico publicado en 2013

Sulforaphane as a promising molecule for fighting cancer

artículo científico publicado en 2014

Sulforaphane as an inducer of glutathione prevents oxidative stress-induced cell death in a dopaminergic-like neuroblastoma cell line

artículo científico publicado en 2009

Sulforaphane from Cruciferous Vegetables: Recent Advances to Improve Glioblastoma Treatment

Sulforaphane increases the efficacy of doxorubicin in mouse fibroblasts characterized by p53 mutations

artículo científico publicado en 2006

Sulforaphane induces apoptosis in rhabdomyosarcoma and restores TRAIL-sensitivity in the aggressive alveolar subtype leading to tumor elimination in mice

artículo científico publicado en 2014

Sulforaphane potentiates RNA damage induced by different xenobiotics

artículo científico publicado en 2012

TRPM2 in the Brain: Role in Health and Disease

article

The c.480C>G polymorphism of hOCT1 influences imatinib clearance in patients affected by chronic myeloid leukemia

artículo científico publicado en 2014

The rs17084733 variant in the KIT 3' UTR disrupts a miR-221/222 binding site in gastrointestinal stromal tumour: a sponge-like mechanism conferring disease susceptibility

artículo científico publicado en 2019

Withania somnifera Induces Cytotoxic and Cytostatic Effects on Human T Leukemia Cells

artículo científico publicado en 2016

Lista de obras de Patrizia Hrelia

2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents

A Novel MYCN-Specific Antigene Oligonucleotide Deregulates Mitochondria and Inhibits Tumor Growth in MYCN-Amplified Neuroblastoma

A meta-analysis of Italian and Estonian individuals shows an effect of common variants in HMGCR on blood apoB levels

A molecular epidemiological approach to health risk assessment of urban air pollution

A mutated p53 status did not prevent the induction of apoptosis by sulforaphane, a promising anti-cancer drug

Absence of mutations in the human interferon alpha-2b gene in workers chronically exposed to ionising radiation

An exploratory association of polymorphisms in angiogenesis-related genes with susceptibility, clinical response and toxicity in gastrointestinal stromal tumors receiving sunitinib after imatinib failure.

An exploratory study by DMET array identifies a germline signature associated with imatinib response in gastrointestinal stromal tumor

Antileukemic activity of sulforaphane in primary blasts from patients affected by myelo- and lympho-proliferative disorders and in hypoxic conditions

Antitumor activity of sustained N-myc reduction in rhabdomyosarcomas and transcriptional block by antigene therapy

Apoptosis and modulation of cell cycle control by bile acids in human leukemia T cells

Apoptosis induction by sulfur-containing compounds in malignant and nonmalignant human cells

Application of the lymphocyte Cytokinesis-Block Micronucleus Assay to populations exposed to petroleum and its derivatives: Results from a systematic review and meta-analysis

Association between imatinib transporters and metabolizing enzymes genotype and response in newly diagnosed chronic myeloid leukemia patients receiving imatinib therapy

Castanea sativa Mill. bark extract exhibits chemopreventive properties triggering extrinsic apoptotic pathway in Jurkat cells

Clinical relevance of circulating molecules in cancer: focus on gastrointestinal stromal tumors

Clinical relevance of pharmacogenetics in gastrointestinal stromal tumor treatment in the era of personalized therapy

Combination of doxorubicin and sulforaphane for reversing doxorubicin-resistant phenotype in mouse fibroblasts with p53Ser220 mutation

Common Protective Strategies in Neurodegenerative Disease: Focusing on Risk Factors to Target the Cellular Redox System

Cyanidin 3-O-glucopyranoside protects and rescues SH-SY5Y cells against amyloid-beta peptide-induced toxicity

Diet and risk of cancer

Early effects of Aβ1-42 oligomers injection in mice: Involvement of PI3K/Akt/GSK3 and MAPK/ERK1/2 pathways.

Effects of environmental benzene: micronucleus frequencies and haematological values in traffic police working in an urban area

Electrocardiogram Alterations Associated With Psychotropic Drug Use and CACNA1C Gene Variants in Three Independent Samples.

Environmental exposure to benzene, micronucleus formation and polymorphisms in DNA-repair genes: a pilot study

Esculetin as a Bifunctional Antioxidant Prevents and Counteracts the Oxidative Stress and Neuronal Death Induced by Amyloid Protein in SH-SY5Y Cells

Evaluation of chromosome aberration and micronucleus frequencies in blood lymphocytes of workers exposed to low concentrations of benzene

Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease

Flow cytometry vs optical microscopy in the evaluation of the genotoxic potential of xenobiotic compounds

Folate-related polymorphisms in gastrointestinal stromal tumours: susceptibility and correlation with tumour characteristics and clinical outcome

Gastric Adenocarcinomas and Signet-Ring Cell Carcinoma: Unraveling Gastric Cancer Complexity through Microbiome Analysis-Deepening Heterogeneity for a Personalized Therapy

Gastrointestinal stromal tumors (GIST): Facing cell death between autophagy and apoptosis

Genotoxic Properties of Synthetic Cannabinoids on TK6 Human Cells by Flow Cytometry

Genotoxicity assessment of some cosmetic and food additives

Hemidesmus indicus induces apoptosis via proteasome inhibition and generation of reactive oxygen species

Identification of a new tamoxifen-xanthene hybrid as pro-apoptotic anticancer agent

Immunoprevention of cancer poses a challenge to pharmacological research ⬇️

Impact of personalized diet and probiotic supplementation on inflammation, nutritional parameters and intestinal microbiota - The "RISTOMED project": Randomized controlled trial in healthy older people

In vitro anti-angiogenic effects of Hemidesmus indicus in hypoxic and normoxic conditions

In vitro antitumor activity of cyanidin-3-O-beta-glucopyranoside

Induction of differentiation in human promyelocytic cells by the isothiocyanate sulforaphane.

Inhibition by beta-caryophyllene of ethyl methanesulfonate-induced clastogenicity in cultured human lymphocytes

Integrating miRNA and gene expression profiling analysis revealed regulatory networks in gastrointestinal stromal tumors.

Intra- and inter-laboratory variation in the scoring of micronuclei and nucleoplasmic bridges in binucleated human lymphocytes. Results of an international slide-scoring exercise by the HUMN project

Investigation of the photochemical properties and in vitro phototoxic potential of bumetanide

Isothiocyanates Are Promising Compounds against Oxidative Stress, Neuroinflammation and Cell Death that May Benefit Neurodegeneration in Parkinson's Disease

Isothiocyanates as novel cytotoxic and cytostatic agents: molecular pathway on human transformed and non-transformed cells

Isotopic Labeling Studies Reveal the Patulin Detoxification Pathway by the Biocontrol Yeast Rhodotorula kratochvilovae LS11

Italian intersociety consensus on prevention, diagnosis, and treatment of delirium in hospitalized older persons.

Key Genetic and Epigenetic Mechanisms in Chemical Carcinogenesis

Mechanisms of resistance to a PI3K inhibitor in gastrointestinal stromal tumors: an omic approach to identify novel druggable targets

Metabolic and toxicological considerations of botanicals in anticancer therapy

Micronucleus frequency in human peripheral blood lymphocytes as a biomarker for the early detection of colorectal cancer risk

Mitochondrial pathway mediates the antileukemic effects of Hemidesmus indicus, a promising botanical drug

Multitarget-directed drug design strategy: a novel molecule designed to block epidermal growth factor receptor (EGFR) and to exert proapoptotic effects

Natural isothiocyanates: genotoxic potential versus chemoprevention

Neuroprotection by 6-(methylsulfinyl)hexyl isothiocyanate in a 6-hydroxydopamine mouse model of Parkinson׳s disease.

Neuroprotective Effect of Caffeic Acid Phenethyl Ester in A Mouse Model of Alzheimer's Disease Involves Nrf2/HO-1 Pathway

Neuroprotective effect of sulforaphane in 6-hydroxydopamine-lesioned mouse model of Parkinson's disease

Neuroprotective effects of anthocyanins and their in vivo metabolites in SH-SY5Y cells

Neuroprotective effects of cyanidin 3-O-glucopyranoside on amyloid beta (25-35) oligomer-induced toxicity

Neuroprotective effects of erucin against 6-hydroxydopamine-induced oxidative damage in a dopaminergic-like neuroblastoma cell line

Novel Psychoactive Phenethylamines: Impact on Genetic Material

Novel class of quinone-bearing polyamines as multi-target-directed ligands to combat Alzheimer's disease

Novel polyamine analogues: from substrates towards potential inhibitors of monoamine oxidases

P-glycoprotein (ABCB1) and Oxidative Stress: Focus on Alzheimer's Disease

PQM130, a Novel Feruloyl-Donepezil Hybrid Compound, Effectively Ameliorates the Cognitive Impairments and Pathology in a Mouse Model of Alzheimer's Disease

Personalized Medicine in Gastrointestinal Stromal Tumor (GIST): Clinical Implications of the Somatic and Germline DNA Analysis

Pharmacogenetics in the treatment of gastrointestinal stromal tumors- an updated review

Pharmacogenetics of tyrosine kinase inhibitors in gastrointestinal stromal tumor and chronic myeloid leukemia

Polyamine conjugation of curcumin analogues toward the discovery of mitochondria-directed neuroprotective agents

Polymorphisms in DNA repair genes in gastrointestinal stromal tumours: susceptibility and correlation with tumour characteristics and clinical outcome.

Polymorphisms in DNA repair genes: link with biomarkers of the CBMN cytome assay in hospital workers chronically exposed to low doses of ionising radiation.

Polymorphisms in OCTN1 and OCTN2 transporters genes are associated with prolonged time to progression in unresectable gastrointestinal stromal tumours treated with imatinib therapy

Prognostic Role of miR-221 and miR-222 Expression in Cancer Patients: A Systematic Review and Meta-Analysis

Protective Effects of 6-(Methylsulfinyl)hexyl Isothiocyanate on Aβ-Induced Cognitive Deficit, Oxidative Stress, Inflammation, and Apoptosis in Mice

Protective effects of cyanidin-3-O-beta-glucopyranoside against UVA-induced oxidative stress in human keratinocytes.

Rational approach to discover multipotent anti-Alzheimer drugs.

Red chicory (Cichorium intybus L. cultivar) as a potential source of antioxidant anthocyanins for intestinal health