Lista de obras - Paul Johnston - Dominio Público Uruguay

2-Guanidinoquinazolines as new inhibitors of the STAT3 pathway

artículo científico publicado en 2014

A case study from the chemistry core of the Pittsburgh Molecular Library Screening Center: the Polo-like kinase polo-box domain (Plk1-PBD).

artículo científico publicado en 2009

Assay development and case history of a 32K-biased library high-content MK2-EGFP translocation screen to identify p38 mitogen-activated protein kinase inhibitors on the ArrayScan 3.1 imaging platform

artículo científico publicado en 2006

Assays to Interrogate the Ability of Compounds to Inhibit the AF-2 or AF-1 Transactivation Domains of the Androgen Receptor

scientific article published on 06 September 2019

Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin α1-antitrypsin Z

artículo científico publicado en 2010

Cdc25B dual-specificity phosphatase inhibitors identified in a high-throughput screen of the NIH compound library

artículo científico publicado en 2009

Cellular platforms for HTS: three case studies

artículo científico publicado en 2002

Characterization of inhibitors of glucocorticoid receptor nuclear translocation: a model of cytoplasmic dynein-mediated cargo transport.

artículo científico publicado en 2011

Computational design, synthesis and biological evaluation of para-quinone-based inhibitors for redox regulation of the dual-specificity phosphatase Cdc25B.

scientific article published on 15 July 2008

Confirmation of Selected Synergistic Cancer Drug Combinations Identified in an HTS Campaign and Exploration of Drug Efflux Transporter Contributions to the Mode of Synergy

artículo científico publicado en 2019

Design and activity of AP endonuclease-1 inhibitors

artículo científico publicado en 2015

Development and Implementation of a High-Throughput High-Content Screening Assay to Identify Inhibitors of Androgen Receptor Nuclear Localization in Castration-Resistant Prostate Cancer Cells

artículo científico publicado en 2016

Development and implementation of a 384-well homogeneous fluorescence intensity high-throughput screening assay to identify mitogen-activated protein kinase phosphatase-1 dual-specificity protein phosphatase inhibitors

artículo científico publicado en 2007

Development and optimization of high-throughput in vitro protein phosphatase screening assays

artículo científico publicado en 2007

Drug resistance in the fission yeast Schizosaccharomyces pombe: pleiotropic mutations affecting the oleic acid and sterol composition of cell membranes

article

Effector kinase coupling enables high-throughput screens for direct HIV-1 Nef antagonists with antiretroviral activity

artículo científico publicado en 2013

Erratum to: High Content Screening

artículo científico publicado en 2018

Fc-receptor mediated protein phosphorylation in murine peritoneal macrophages

artículo científico publicado en 1984

Genomic Correlate of Exceptional Erlotinib Response in Head and Neck Squamous Cell Carcinoma

artículo científico publicado en 2015

HCS campaign to identify selective inhibitors of IL-6-induced STAT3 pathway activation in head and neck cancer cell lines

artículo científico publicado en 2015

HTS identifies novel and specific uncompetitive inhibitors of the two-component NS2B-NS3 proteinase of West Nile virus

artículo científico publicado en 2007

High Content Positional Biosensor Assay to Screen for Compounds that Prevent or Disrupt Androgen Receptor and Transcription Intermediary Factor 2 Protein-Protein Interactions.

artículo científico publicado en 2018

High Content Screening Characterization of Head and Neck Squamous Cell Carcinoma Multicellular Tumor Spheroid Cultures Generated in 384-Well Ultra-Low Attachment Plates to Screen for Better Cancer Drug Leads

scientific article published on 28 December 2018

High content screening biosensor assay to identify disruptors of p53-hDM2 protein-protein interactions.

artículo científico publicado en 2015

High-Content Screening Campaign to Identify Compounds That Inhibit or Disrupt Androgen Receptor-Transcriptional Intermediary Factor 2 Protein-Protein Interactions for the Treatment of Prostate Cancer

scientific article published on 15 August 2018

High-Content Screening Comparison of Cancer Drug Accumulation and Distribution in Two-Dimensional and Three-Dimensional Culture Models of Head and Neck Cancer

artículo científico publicado en 2017

High-content positional biosensor screening assay for compounds to prevent or disrupt androgen receptor and transcriptional intermediary factor 2 protein-protein interactions.

artículo científico publicado en 2014

High-throughput automated confocal microscopy imaging screen of a kinase-focused library to identify p38 mitogen-activated protein kinase inhibitors using the GE InCell 3000 analyzer

artículo científico publicado en 2009

Homologous and heterologous desensitization of proto-oncogene cfos expression in murine peritoneal macrophages

article

Identifying actives from HTS data sets: practical approaches for the selection of an appropriate HTS data-processing method and quality control review

artículo científico publicado en 2010

Implementation of a 220,000-compound HCS campaign to identify disruptors of the interaction between p53 and hDM2 and characterization of the confirmed hits

artículo científico publicado en 2010

Implementation of the NCI-60 Human Tumor Cell Line Panel to Screen 2260 Cancer Drug Combinations to Generate >3 Million Data Points Used to Populate a Large Matrix of Anti-Neoplastic Agent Combinations (ALMANAC) Database

artículo científico publicado en 2018

Inhibition of Androgen Receptor Function and Level in Castration-Resistant Prostate Cancer Cells by 2-[(isoxazol-4-ylmethyl)thio]-1-(4-phenylpiperazin-1-yl)ethanone.

artículo científico publicado en 2017

Inhibition of Androgen Receptor Nuclear Localization and Castration-Resistant Prostate Tumor Growth by Pyrroloimidazole-based Small Molecules.

artículo científico publicado en 2017

Introduction and Welcome to the Society of Biomolecular Imaging and Informatics (SBI2)

artículo científico publicado en 2014

Mechanism of action of selective inhibitors of IL-6 induced STAT3 pathway in head and neck cancer cell lines

artículo científico publicado en 2017

Multiple drug resistance in the fission yeast Schizosaccharomyces pombe: Correlation between drug and amino acid uptake and membrane ATPase activities

artículo científico publicado en 1983

Multiple drug resistance in the fission yeast Schizosaccharomyces pombe: Evidence for the existence of pleiotropic mutations affecting energy dependent transport systems

article

Optimization of pyrazole-containing 1,2,4-triazolo-[3,4-b]thiadiazines, a new class of STAT3 pathway inhibitors

artículo científico publicado en 2016

Potentiation of Antibiotic Therapy for Bovine Mastitis by Recombinant Bovine Interleukin-2

artículo científico publicado en 1992

Production of Uniform 3D Microtumors in Hydrogel Microwell Arrays for Measurement of Viability, Morphology, and Signaling Pathway Activation

artículo científico publicado en 2015

Profiling the NIH Small Molecule Repository for compounds that generate H2O2 by redox cycling in reducing environments

artículo científico publicado en 2010

Reconfiguring the AR-TIF2 Protein-Protein Interaction HCS Assay in Prostate Cancer Cells and Characterizing the Hits from a LOPAC Screen.

artículo científico publicado en 2016

Redox cycling compounds generate H2O2 in HTS buffers containing strong reducing reagents--real hits or promiscuous artifacts?

artículo científico publicado en 2010

STAT3 signaling: anticancer strategies and challenges.

artículo científico publicado en 2011

Standardization of high content imaging and informatics

artículo científico publicado en 2015

Synthesis and biological activity of a focused library of mitogen-activated protein kinase phosphatase inhibitors

artículo científico publicado en 2007

Synthesis and biological evaluation of 3-aminoisoquinolin-1(2H)-one based inhibitors of the dual-specificity phosphatase Cdc25B.

artículo científico publicado en 2015

Targeting subcellular localization through the polo-box domain: non-ATP competitive inhibitors recapitulate a PLK1 phenotype

artículo científico publicado en 2012

The Generation of Three-Dimensional Head and Neck Cancer Models for Drug Discovery in 384-Well Ultra-Low Attachment Microplates.

artículo científico publicado en 2018

The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites

artículo científico publicado en 2005

The production of 3D tumor spheroids for cancer drug discovery

artículo científico publicado en 2017

Toxicity, pharmacokinetics and metabolism of a novel inhibitor of IL-6-induced STAT3 activation

artículo científico publicado en 2016

Lista de obras de Paul Johnston

2-Guanidinoquinazolines as new inhibitors of the STAT3 pathway

A case study from the chemistry core of the Pittsburgh Molecular Library Screening Center: the Polo-like kinase polo-box domain (Plk1-PBD).

Assay development and case history of a 32K-biased library high-content MK2-EGFP translocation screen to identify p38 mitogen-activated protein kinase inhibitors on the ArrayScan 3.1 imaging platform

Assays to Interrogate the Ability of Compounds to Inhibit the AF-2 or AF-1 Transactivation Domains of the Androgen Receptor

Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin α1-antitrypsin Z

Cdc25B dual-specificity phosphatase inhibitors identified in a high-throughput screen of the NIH compound library

Cellular platforms for HTS: three case studies

Characterization of inhibitors of glucocorticoid receptor nuclear translocation: a model of cytoplasmic dynein-mediated cargo transport.

Computational design, synthesis and biological evaluation of para-quinone-based inhibitors for redox regulation of the dual-specificity phosphatase Cdc25B.

Confirmation of Selected Synergistic Cancer Drug Combinations Identified in an HTS Campaign and Exploration of Drug Efflux Transporter Contributions to the Mode of Synergy

Design and activity of AP endonuclease-1 inhibitors

Development and Implementation of a High-Throughput High-Content Screening Assay to Identify Inhibitors of Androgen Receptor Nuclear Localization in Castration-Resistant Prostate Cancer Cells

Development and implementation of a 384-well homogeneous fluorescence intensity high-throughput screening assay to identify mitogen-activated protein kinase phosphatase-1 dual-specificity protein phosphatase inhibitors

Development and optimization of high-throughput in vitro protein phosphatase screening assays

Drug resistance in the fission yeast Schizosaccharomyces pombe: pleiotropic mutations affecting the oleic acid and sterol composition of cell membranes

Effector kinase coupling enables high-throughput screens for direct HIV-1 Nef antagonists with antiretroviral activity

Erratum to: High Content Screening

Fc-receptor mediated protein phosphorylation in murine peritoneal macrophages

Genomic Correlate of Exceptional Erlotinib Response in Head and Neck Squamous Cell Carcinoma

HCS campaign to identify selective inhibitors of IL-6-induced STAT3 pathway activation in head and neck cancer cell lines

HTS identifies novel and specific uncompetitive inhibitors of the two-component NS2B-NS3 proteinase of West Nile virus

High Content Positional Biosensor Assay to Screen for Compounds that Prevent or Disrupt Androgen Receptor and Transcription Intermediary Factor 2 Protein-Protein Interactions.

High Content Screening Characterization of Head and Neck Squamous Cell Carcinoma Multicellular Tumor Spheroid Cultures Generated in 384-Well Ultra-Low Attachment Plates to Screen for Better Cancer Drug Leads

High content screening biosensor assay to identify disruptors of p53-hDM2 protein-protein interactions.

High-Content Screening Campaign to Identify Compounds That Inhibit or Disrupt Androgen Receptor-Transcriptional Intermediary Factor 2 Protein-Protein Interactions for the Treatment of Prostate Cancer

High-Content Screening Comparison of Cancer Drug Accumulation and Distribution in Two-Dimensional and Three-Dimensional Culture Models of Head and Neck Cancer

High-content positional biosensor screening assay for compounds to prevent or disrupt androgen receptor and transcriptional intermediary factor 2 protein-protein interactions.

High-throughput automated confocal microscopy imaging screen of a kinase-focused library to identify p38 mitogen-activated protein kinase inhibitors using the GE InCell 3000 analyzer

Homologous and heterologous desensitization of proto-oncogene cfos expression in murine peritoneal macrophages

Identifying actives from HTS data sets: practical approaches for the selection of an appropriate HTS data-processing method and quality control review

Implementation of a 220,000-compound HCS campaign to identify disruptors of the interaction between p53 and hDM2 and characterization of the confirmed hits

Implementation of the NCI-60 Human Tumor Cell Line Panel to Screen 2260 Cancer Drug Combinations to Generate >3 Million Data Points Used to Populate a Large Matrix of Anti-Neoplastic Agent Combinations (ALMANAC) Database

Inhibition of Androgen Receptor Function and Level in Castration-Resistant Prostate Cancer Cells by 2-[(isoxazol-4-ylmethyl)thio]-1-(4-phenylpiperazin-1-yl)ethanone.

Inhibition of Androgen Receptor Nuclear Localization and Castration-Resistant Prostate Tumor Growth by Pyrroloimidazole-based Small Molecules.

Introduction and Welcome to the Society of Biomolecular Imaging and Informatics (SBI2)

Mechanism of action of selective inhibitors of IL-6 induced STAT3 pathway in head and neck cancer cell lines

Multiple drug resistance in the fission yeast Schizosaccharomyces pombe: Correlation between drug and amino acid uptake and membrane ATPase activities

Multiple drug resistance in the fission yeast Schizosaccharomyces pombe: Evidence for the existence of pleiotropic mutations affecting energy dependent transport systems

Optimization of pyrazole-containing 1,2,4-triazolo-[3,4-b]thiadiazines, a new class of STAT3 pathway inhibitors

Potentiation of Antibiotic Therapy for Bovine Mastitis by Recombinant Bovine Interleukin-2

Production of Uniform 3D Microtumors in Hydrogel Microwell Arrays for Measurement of Viability, Morphology, and Signaling Pathway Activation

Profiling the NIH Small Molecule Repository for compounds that generate H2O2 by redox cycling in reducing environments

Reconfiguring the AR-TIF2 Protein-Protein Interaction HCS Assay in Prostate Cancer Cells and Characterizing the Hits from a LOPAC Screen.

Redox cycling compounds generate H2O2 in HTS buffers containing strong reducing reagents--real hits or promiscuous artifacts?

STAT3 signaling: anticancer strategies and challenges.

Standardization of high content imaging and informatics

Synthesis and biological activity of a focused library of mitogen-activated protein kinase phosphatase inhibitors

Synthesis and biological evaluation of 3-aminoisoquinolin-1(2H)-one based inhibitors of the dual-specificity phosphatase Cdc25B.

Targeting subcellular localization through the polo-box domain: non-ATP competitive inhibitors recapitulate a PLK1 phenotype

The Generation of Three-Dimensional Head and Neck Cancer Models for Drug Discovery in 384-Well Ultra-Low Attachment Microplates.

The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites

The production of 3D tumor spheroids for cancer drug discovery

Toxicity, pharmacokinetics and metabolism of a novel inhibitor of IL-6-induced STAT3 activation