Lista de obras - Hiroki Oguri - Dominio Público Uruguay

A fully synthetic 6-aza-artemisinin bearing an amphiphilic chain generates aggregates and exhibits anti-cancer activities

artículo científico publicado en 2020

Allosteric regulation of epoxide opening cascades by a pair of epoxide hydrolases in monensin biosynthesis

artículo científico publicado en 2014

An anti-tetraamination of a 1,3-diene unit via cascade annulations of the azulenone scaffold with dicarbonyl azo-compounds

artículo científico publicado en 2010

Biogenetically inspired synthesis and skeletal diversification of indole alkaloids

artículo científico publicado en 2013

Biomimetic Assembly Lines Producing Natural Product Analogs: Strategies from a Versatile Manifold to Skeletally Diverse Scaffolds

artículo científico publicado en 2016

Bioorganic Studies Utilizing Rationally Designed Synthetic Molecules: Absolute Configuration of Ciguatoxin and Development of Immunoassay Systems

article

Biosynthetic machinery of ionophore polyether lasalocid: enzymatic construction of polyether skeleton.

artículo científico

Chemo-enzymatic Total Syntheses of Jorunnamycin A, Saframycin A, and N-Fmoc Saframycin Y3

artículo científico publicado en 2018

Chiroptical Inversion of Europium(III) Complexes by Changing a Remote Stereogenic Center of a C2-Symmetric Bispyrrolidinoindoline Manifold

artículo científico publicado en 2018

Complete sequence of biosynthetic gene cluster responsible for producing triostin A and evaluation of quinomycin-type antibiotics from Streptomyces triostinicus ⬇️

artículo científico publicado en 2008

Concise synthesis of ciguatoxin ABC-ring fragments and surface plasmon resonance study of the interaction of their BSA conjugates with monoclonal antibodies

artículo científico publicado en 2001

Construction of the benzylic quaternary carbon center of zoanthenol by intramolecular Mizoroki-Heck reaction of enone

artículo científico publicado en 2002

Core assembly mechanism of quinocarcin/SF-1739: bimodular complex nonribosomal peptide synthetases for sequential mannich-type reactions

artículo científico publicado en 2013

Critical contribution of aromatic rings to specific recognition of polyether rings. The case of ciguatoxin CTX3C-ABC and its specific antibody 1C49

artículo científico publicado en 2008

Design and De Novo Synthesis of 6-Aza-artemisinins

artículo científico publicado en 2018

Divergent and expeditious access to fused skeletons inspired by indole alkaloids and transtaganolides

artículo científico publicado en 2009

Diversification of echinomycin molecular structure by way of chemoenzymatic synthesis and heterologous expression of the engineered echinomycin biosynthetic pathway

artículo científico publicado en 2009

Enantioselective synthesis of the fully functionalized ABC ring of zoanthenol

scientific article published on 01 September 2008

Enzymatic epoxide-opening cascades catalyzed by a pair of epoxide hydrolases in the ionophore polyether biosynthesis

artículo científico publicado en 2011

Enzymatic macrolactonization in the presence of DNA leading to triostin A analogs

artículo científico publicado en 2008

Epoxide hydrolase Lsd19 for polyether formation in the biosynthesis of lasalocid A: direct experimental evidence on polyene-polyepoxide hypothesis in polyether biosynthesis

artículo científico publicado en 2008

Generation of Anti-trypanosomal Agents through Concise Synthesis and Structural Diversification of Sesquiterpene Analogues ⬇️

artículo científico publicado el 17 de marzo de 2011

Heterologous expression of highly reducing polyketide synthase involved in betaenone biosynthesis

artículo científico publicado en 2015

Hg(OTf)(2)-catalyzed direct vinylation of tryptamines and versatile applications for tandem reactions

artículo científico publicado en 2012

Identification and stereochemical assignment of the beta-hydroxytryptophan intermediate in the echinomycin biosynthetic pathway

artículo científico publicado en 2006

Impact of the E540V Amino Acid Substitution in GyrB of Mycobacterium tuberculosis on Quinolone Resistance ⬇️

artículo científico publicado el 6 de junio de 2011

Intriguing substrate tolerance of epoxide hydrolase Lsd19 involved in biosynthesis of the ionophore antibiotic lasalocid A.

artículo científico publicado en 2010

Involvement of common intermediate 3-hydroxy-L-kynurenine in chromophore biosynthesis of quinomycin family antibiotics.

artículo científico publicado en 2010

Nickel-catalyzed dimerization of pyrrolidinoindoline scaffolds: systematic access to chimonanthines, folicanthines and (+)-WIN 64821

scientific article published on 01 January 2014

Parallel and four-step synthesis of natural-product-inspired scaffolds through modular assembly and divergent cyclization

artículo científico publicado en 2012

Phage-display selection of antibodies to the left end of CTX3C using synthetic fragments.

artículo científico publicado en 2004

Pictet-Spenglerase involved in tetrahydroisoquinoline antibiotic biosynthesis.

artículo científico

Rationally engineered total biosynthesis of a synthetic analogue of a natural quinomycin depsipeptide in Escherichia coli

artículo científico publicado en 2009

Reconstruction of the saframycin core scaffold defines dual Pictet-Spengler mechanisms.

artículo científico publicado en 2010

Relative and absolute configuration of antitumor agent SW-163D.

artículo científico publicado en 2007

Sequential [6+2], [2+2], and [3+2] annulations for rapid assembly of multiple fragments

artículo científico publicado en 2013

Sequential enzymatic epoxidation involved in polyether lasalocid biosynthesis

artículo científico publicado en 2012

Skeletal and stereochemical diversification of tricyclic frameworks inspired by Ca(2+)-ATPase inhibitors, artemisinin and transtaganolide D

artículo científico publicado en 2009

Skeletal diversity via a folding pathway: synthesis of indole alkaloid-like skeletons

scientific article published on 01 January 2005

Solanapyrone synthase, a possible Diels-Alderase and iterative type I polyketide synthase encoded in a biosynthetic gene cluster from Alternaria solani

artículo científico publicado en 2010

Stereodivergent Synthesis of Bispyrrolidinoindoline Alkaloidal Scaffolds and Generation of a Lead Candidate with Stereospecific Antiproliferative Activity

scientific article published on 28 March 2019

Synthesis of multiply substituted 1,6-dihydropyridines through Cu(I)-catalyzed 6-endo cyclization

artículo científico publicado en 2015

Synthesis of the fully functionalized ABCDE ring moiety of ciguatoxin

artículo científico publicado en 2004

Synthesis-based approach toward direct sandwich immunoassay for ciguatoxin CTX3C.

artículo científico publicado en 2003

The Pictet-Spengler mechanism involved in the biosynthesis of tetrahydroisoquinoline antitumor antibiotics: a novel function for a nonribosomal peptide synthetase.

artículo científico publicado en 2012

Total biosynthesis of antitumor nonribosomal peptides in Escherichia coli.

artículo científico publicado en 2006

Total synthesis of alkaloids using both chemical and biochemical methods

scientific article published on 06 March 2020

Total synthesis of ciguatoxin CTX3C.

artículo científico publicado en 2001

Zn(OTf)2-mediated annulations of N-propargylated tetrahydrocarbolines: divergent synthesis of four distinct alkaloidal scaffolds

scientific article published on 01 May 2019

Lista de obras de Hiroki Oguri

A fully synthetic 6-aza-artemisinin bearing an amphiphilic chain generates aggregates and exhibits anti-cancer activities

Allosteric regulation of epoxide opening cascades by a pair of epoxide hydrolases in monensin biosynthesis

An anti-tetraamination of a 1,3-diene unit via cascade annulations of the azulenone scaffold with dicarbonyl azo-compounds

Biogenetically inspired synthesis and skeletal diversification of indole alkaloids

Biomimetic Assembly Lines Producing Natural Product Analogs: Strategies from a Versatile Manifold to Skeletally Diverse Scaffolds

Bioorganic Studies Utilizing Rationally Designed Synthetic Molecules: Absolute Configuration of Ciguatoxin and Development of Immunoassay Systems

Biosynthetic machinery of ionophore polyether lasalocid: enzymatic construction of polyether skeleton.

Chemo-enzymatic Total Syntheses of Jorunnamycin A, Saframycin A, and N-Fmoc Saframycin Y3

Chiroptical Inversion of Europium(III) Complexes by Changing a Remote Stereogenic Center of a C2-Symmetric Bispyrrolidinoindoline Manifold

Complete sequence of biosynthetic gene cluster responsible for producing triostin A and evaluation of quinomycin-type antibiotics from Streptomyces triostinicus ⬇️

Concise synthesis of ciguatoxin ABC-ring fragments and surface plasmon resonance study of the interaction of their BSA conjugates with monoclonal antibodies

Construction of the benzylic quaternary carbon center of zoanthenol by intramolecular Mizoroki-Heck reaction of enone

Core assembly mechanism of quinocarcin/SF-1739: bimodular complex nonribosomal peptide synthetases for sequential mannich-type reactions

Critical contribution of aromatic rings to specific recognition of polyether rings. The case of ciguatoxin CTX3C-ABC and its specific antibody 1C49

Design and De Novo Synthesis of 6-Aza-artemisinins

Divergent and expeditious access to fused skeletons inspired by indole alkaloids and transtaganolides

Diversification of echinomycin molecular structure by way of chemoenzymatic synthesis and heterologous expression of the engineered echinomycin biosynthetic pathway

Enantioselective synthesis of the fully functionalized ABC ring of zoanthenol

Enzymatic epoxide-opening cascades catalyzed by a pair of epoxide hydrolases in the ionophore polyether biosynthesis

Enzymatic macrolactonization in the presence of DNA leading to triostin A analogs

Epoxide hydrolase Lsd19 for polyether formation in the biosynthesis of lasalocid A: direct experimental evidence on polyene-polyepoxide hypothesis in polyether biosynthesis

Generation of Anti-trypanosomal Agents through Concise Synthesis and Structural Diversification of Sesquiterpene Analogues ⬇️

Heterologous expression of highly reducing polyketide synthase involved in betaenone biosynthesis

Hg(OTf)(2)-catalyzed direct vinylation of tryptamines and versatile applications for tandem reactions

Identification and stereochemical assignment of the beta-hydroxytryptophan intermediate in the echinomycin biosynthetic pathway

Impact of the E540V Amino Acid Substitution in GyrB of Mycobacterium tuberculosis on Quinolone Resistance ⬇️

Intriguing substrate tolerance of epoxide hydrolase Lsd19 involved in biosynthesis of the ionophore antibiotic lasalocid A.

Involvement of common intermediate 3-hydroxy-L-kynurenine in chromophore biosynthesis of quinomycin family antibiotics.

Nickel-catalyzed dimerization of pyrrolidinoindoline scaffolds: systematic access to chimonanthines, folicanthines and (+)-WIN 64821

Parallel and four-step synthesis of natural-product-inspired scaffolds through modular assembly and divergent cyclization

Phage-display selection of antibodies to the left end of CTX3C using synthetic fragments.

Pictet-Spenglerase involved in tetrahydroisoquinoline antibiotic biosynthesis.

Rationally engineered total biosynthesis of a synthetic analogue of a natural quinomycin depsipeptide in Escherichia coli

Reconstruction of the saframycin core scaffold defines dual Pictet-Spengler mechanisms.

Relative and absolute configuration of antitumor agent SW-163D.

Sequential [6+2], [2+2], and [3+2] annulations for rapid assembly of multiple fragments

Sequential enzymatic epoxidation involved in polyether lasalocid biosynthesis

Skeletal and stereochemical diversification of tricyclic frameworks inspired by Ca(2+)-ATPase inhibitors, artemisinin and transtaganolide D

Skeletal diversity via a folding pathway: synthesis of indole alkaloid-like skeletons

Solanapyrone synthase, a possible Diels-Alderase and iterative type I polyketide synthase encoded in a biosynthetic gene cluster from Alternaria solani

Stereodivergent Synthesis of Bispyrrolidinoindoline Alkaloidal Scaffolds and Generation of a Lead Candidate with Stereospecific Antiproliferative Activity

Synthesis of multiply substituted 1,6-dihydropyridines through Cu(I)-catalyzed 6-endo cyclization

Synthesis of the fully functionalized ABCDE ring moiety of ciguatoxin

Synthesis-based approach toward direct sandwich immunoassay for ciguatoxin CTX3C.

The Pictet-Spengler mechanism involved in the biosynthesis of tetrahydroisoquinoline antitumor antibiotics: a novel function for a nonribosomal peptide synthetase.

Total biosynthesis of antitumor nonribosomal peptides in Escherichia coli.

Total synthesis of alkaloids using both chemical and biochemical methods

Total synthesis of ciguatoxin CTX3C.

Zn(OTf)2-mediated annulations of N-propargylated tetrahydrocarbolines: divergent synthesis of four distinct alkaloidal scaffolds