Lista de obras - Wei-Shuo Fang - Dominio Público Uruguay

A Series of Enthalpically Optimized Docetaxel Analogues Exhibiting Enhanced Antitumor Activity and Water Solubility

artículo científico publicado en 2018

A new triglucosylated naphthalene glycoside from Aloe vera L.

artículo científico publicado en 2009

A novel C,D-spirodioxene taxoid synthesized through an unexpected Pd-mediated ring cyclization

artículo científico publicado en 2015

A semisynthetic taxane Yg-3-46a effectively evades P-glycoprotein and β-III tubulin mediated tumor drug resistance in vitro.

artículo científico publicado en 2013

A structure-based design of new C2- and C13-substituted taxanes: tubulin binding affinities and extended quantitative structure-activity relationships using comparative binding energy (COMBINE) analysis.

artículo científico publicado en 2013

An efficient semi-synthesis and structure revision of a cytotoxic triterpenoid 25-acetoxy-3alpha-hydroxyolean-12-en-28-oic acid from Liquidamber styraciflua

artículo científico publicado en 2008

An efficient semi-synthesis of 1-hydroxyl oleanolic acid analogs

artículo científico publicado en 2017

Anti-inflammatory and analgesic effects of ethanol and aqueous extracts of Pterocephalus hookeri (C.B. Clarke) Höeck.

artículo científico publicado en 2009

Anti-tumor activity of a 3-oxo derivative of oleanolic acid

artículo científico publicado en 2005

BACE inhibitory flavanones from Balanophora involucrata Hook. f

artículo científico publicado en 2012

BACE1 (beta-secretase) inhibitory chromone glycosides from Aloe vera and Aloe nobilis

artículo científico publicado en 2008

BACE1 (beta-secretase) inhibitory phenolic acids and a novel sesquiterpenoid from Homalomena occulta

artículo científico publicado en 2010

Biotransformation of 3-oxo-oleanolic acid by Absidia glauca

artículo científico publicado en 2010

Design and synthesis of a dual linker for solid phase synthesis of oleanolic acid derivatives.

artículo científico publicado en 2011

Discovery of Farnesoid X Receptor Antagonists Based on a Library of Oleanolic Acid 3-O-Esters through Diverse Substituent Design and Molecular Docking Methods.

artículo científico publicado en 2017

Distribution of paclitaxel and its congeners in Taxus mairei

artículo científico publicado en 2001

Effects of C7 substitutions in a high affinity microtubule-binding taxane on antitumor activity and drug transport.

artículo científico publicado en 2011

Free Energy Profile and Kinetics Studies of Paclitaxel Internalization from the Outer to the Inner Wall of Microtubules.

artículo científico publicado en 2012

High affinity and covalent-binding microtubule stabilizing agents show activity in chemotherapy-resistant acute myeloid leukemia cells

artículo científico publicado en 2015

Inhibiting the proliferation, migration and invasion of triple negative breast cancer cells through anti-tumor human serum albumin nanoparticles loading aziditaxel as a novel taxane derivative

artículo científico publicado en 2017

Isolation, identification, semi-synthesis of aziditaxel derivatives and their biological evaluation

artículo científico publicado en 2012

Jacaranone analogs from Senecio scandens

artículo científico publicado en 2009

Jacaranone glycosides from Senecio scandens

artículo científico publicado en 2006

Lx2-32c, a novel semi-synthetic taxane, exerts antitumor activity against prostate cancer cells in vitro and in vivo

artículo científico publicado en 2016

Lx2-32c, a novel taxane and its antitumor activities in vitro and in vivo.

artículo científico publicado en 2008

Lx2-32c, a novel taxane derivative, exerts anti-resistance activity by initiating intrinsic apoptosis pathway in vitro and inhibits the growth of resistant tumor in vivo.

artículo científico publicado en 2012

Lx2-32c-loaded polymeric micelles with small size for intravenous drug delivery and their inhibitory effect on tumor growth and metastasis in clinically associated 4T1 murine breast cancer.

artículo científico publicado en 2016

Microtubule stabilising agents for cancer chemotherapy.

artículo científico publicado en 2009

Modification of C-seco taxoids through ring tethering and substituent replacement leading to effective agents against tumor drug resistance mediated by βIII-Tubulin and P-glycoprotein (P-gp) overexpressions.

artículo científico publicado en 2017

Modulation of Microtubule Interprotofilament Interactions by Modified Taxanes ⬇️

artículo científico publicado el 20 de diciembre de 2011

Natural products

artículo científico publicado en 2009

New ursane-type triterpene with NO production suppressing activity from Nauclea officinalis

artículo científico publicado en 2012

On the chemical constituents of Dipsacus asper. ⬇️

artículo científico publicado en 2007

Optimization of taxane binding to microtubules: binding affinity dissection and incremental construction of a high-affinity analog of paclitaxel.

artículo científico publicado en 2008

Overcoming tumor drug resistance with high-affinity taxanes: a SAR study of C2-modified 7-acyl-10-deacetyl cephalomannines.

artículo científico publicado en 2007

Preparation, pharmacokinetics, biodistribution, antitumor efficacy and safety of Lx2-32c-containing liposome

artículo científico publicado en 2014

Probing the pore drug binding site of microtubules with fluorescent taxanes: evidence of two binding poses

artículo científico publicado en 2010

Restoration of Microtubule Interaction and Cytotoxicity in D-seco Taxanes upon Incorporation of 20-Hydroxymethyl-4-allyloxy Groups

artículo científico publicado en 2015

Structural studies of taxol analogues for drug discovery.

artículo científico

Synthesis and Biological Evaluations of Cytotoxic and Antiangiogenic Triterpenoids-Jacaranone Conjugates

artículo científico publicado en 2016

Synthesis and Cytotoxicity of 7,9-O-Linked Macrocyclic C-Seco Taxoids

artículo científico publicado en 2019

Synthesis and biological activities of high affinity taxane-based fluorescent probes

artículo científico publicado en 2008

Synthesis and biological evaluation of colchicine B-ring analogues tethered with halogenated benzyl moieties

artículo científico publicado en 2012

Synthesis and biological evaluations of chalcones, flavones and chromenes as farnesoid x receptor (FXR) antagonists

artículo científico publicado en 2017

Synthesis, biological evaluations, and tubulin binding poses of C-2alpha sulfur linked taxol analogues

artículo científico publicado en 2007

Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.

artículo científico publicado en 2014

Three new antioxidant C-glucosylanthrones from Aloe nobilis

artículo científico publicado en 2010

Two novel tetrairidoid glucosides from Dipsacus asper

artículo científico publicado en 2006

[Chemical constituents from Sambucus chinensis]

artículo científico publicado en 2012

Lista de obras de Wei-Shuo Fang

A Series of Enthalpically Optimized Docetaxel Analogues Exhibiting Enhanced Antitumor Activity and Water Solubility

A new triglucosylated naphthalene glycoside from Aloe vera L.

A novel C,D-spirodioxene taxoid synthesized through an unexpected Pd-mediated ring cyclization

A semisynthetic taxane Yg-3-46a effectively evades P-glycoprotein and β-III tubulin mediated tumor drug resistance in vitro.

A structure-based design of new C2- and C13-substituted taxanes: tubulin binding affinities and extended quantitative structure-activity relationships using comparative binding energy (COMBINE) analysis.

An efficient semi-synthesis and structure revision of a cytotoxic triterpenoid 25-acetoxy-3alpha-hydroxyolean-12-en-28-oic acid from Liquidamber styraciflua

An efficient semi-synthesis of 1-hydroxyl oleanolic acid analogs

Anti-inflammatory and analgesic effects of ethanol and aqueous extracts of Pterocephalus hookeri (C.B. Clarke) Höeck.

Anti-tumor activity of a 3-oxo derivative of oleanolic acid

BACE inhibitory flavanones from Balanophora involucrata Hook. f

BACE1 (beta-secretase) inhibitory chromone glycosides from Aloe vera and Aloe nobilis

BACE1 (beta-secretase) inhibitory phenolic acids and a novel sesquiterpenoid from Homalomena occulta

Biotransformation of 3-oxo-oleanolic acid by Absidia glauca

Design and synthesis of a dual linker for solid phase synthesis of oleanolic acid derivatives.

Discovery of Farnesoid X Receptor Antagonists Based on a Library of Oleanolic Acid 3-O-Esters through Diverse Substituent Design and Molecular Docking Methods.

Distribution of paclitaxel and its congeners in Taxus mairei

Effects of C7 substitutions in a high affinity microtubule-binding taxane on antitumor activity and drug transport.

Free Energy Profile and Kinetics Studies of Paclitaxel Internalization from the Outer to the Inner Wall of Microtubules.

High affinity and covalent-binding microtubule stabilizing agents show activity in chemotherapy-resistant acute myeloid leukemia cells

Inhibiting the proliferation, migration and invasion of triple negative breast cancer cells through anti-tumor human serum albumin nanoparticles loading aziditaxel as a novel taxane derivative

Isolation, identification, semi-synthesis of aziditaxel derivatives and their biological evaluation

Jacaranone analogs from Senecio scandens

Jacaranone glycosides from Senecio scandens

Lx2-32c, a novel semi-synthetic taxane, exerts antitumor activity against prostate cancer cells in vitro and in vivo

Lx2-32c, a novel taxane and its antitumor activities in vitro and in vivo.

Lx2-32c, a novel taxane derivative, exerts anti-resistance activity by initiating intrinsic apoptosis pathway in vitro and inhibits the growth of resistant tumor in vivo.

Lx2-32c-loaded polymeric micelles with small size for intravenous drug delivery and their inhibitory effect on tumor growth and metastasis in clinically associated 4T1 murine breast cancer.

Microtubule stabilising agents for cancer chemotherapy.

Modification of C-seco taxoids through ring tethering and substituent replacement leading to effective agents against tumor drug resistance mediated by βIII-Tubulin and P-glycoprotein (P-gp) overexpressions.

Modulation of Microtubule Interprotofilament Interactions by Modified Taxanes ⬇️

Natural products

New ursane-type triterpene with NO production suppressing activity from Nauclea officinalis

On the chemical constituents of Dipsacus asper. ⬇️

Optimization of taxane binding to microtubules: binding affinity dissection and incremental construction of a high-affinity analog of paclitaxel.

Overcoming tumor drug resistance with high-affinity taxanes: a SAR study of C2-modified 7-acyl-10-deacetyl cephalomannines.

Preparation, pharmacokinetics, biodistribution, antitumor efficacy and safety of Lx2-32c-containing liposome

Probing the pore drug binding site of microtubules with fluorescent taxanes: evidence of two binding poses

Restoration of Microtubule Interaction and Cytotoxicity in D-seco Taxanes upon Incorporation of 20-Hydroxymethyl-4-allyloxy Groups

Structural studies of taxol analogues for drug discovery.

Synthesis and Biological Evaluations of Cytotoxic and Antiangiogenic Triterpenoids-Jacaranone Conjugates

Synthesis and Cytotoxicity of 7,9-O-Linked Macrocyclic C-Seco Taxoids

Synthesis and biological activities of high affinity taxane-based fluorescent probes

Synthesis and biological evaluation of colchicine B-ring analogues tethered with halogenated benzyl moieties

Synthesis and biological evaluations of chalcones, flavones and chromenes as farnesoid x receptor (FXR) antagonists

Synthesis, biological evaluations, and tubulin binding poses of C-2alpha sulfur linked taxol analogues

Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.

Three new antioxidant C-glucosylanthrones from Aloe nobilis

Two novel tetrairidoid glucosides from Dipsacus asper

[Chemical constituents from Sambucus chinensis]