Lista de obras - Erick Strauss - Dominio Público Uruguay

3-Fluoroaspartate and pyruvoyl-dependant aspartate decarboxylase: exploiting the unique characteristics of fluorine to probe reactivity and binding

artículo científico publicado en 2010

A miniaturized assay for measuring small molecule phosphorylation in the presence of complex matrices

artículo científico publicado en 2013

A pantetheinase-resistant pantothenamide with potent, on-target, and selective antiplasmodial activity

artículo científico publicado en 2015

An enzyme-initiated Smiles rearrangement enables the development of an assay of MshB, the GlcNAc-Ins deacetylase of mycothiol biosynthesis

artículo científico publicado en 2012

Antiplasmodial Mode of Action of Pantothenamides: Pantothenate Kinase Serves as a Metabolic Activator Not as a Target

artículo científico publicado en 2017

Biocatalytic Production of Coenzyme A Analogues

article

Characterization of a new pantothenate kinase isoform from Helicobacter pylori

artículo científico publicado en 2005

Coenzyme A: to make it or uptake it?

artículo científico publicado en 2016

Complex stability and dynamic subunit interchange modulates the disparate activities of the yeast moonlighting proteins Hal3 and Vhs3

artículo científico publicado en 2015

Creating Cellulose-Binding Domain Fusions of the Coenzyme A Biosynthetic Enzymes to Enable Reactor-Based Biotransformations

Crystal structure of a type III pantothenate kinase: insight into the mechanism of an essential coenzyme A biosynthetic enzyme universally distributed in bacteria

artículo científico publicado en 2006

Developing Pantetheinase-Resistant Pantothenamide Antibacterials: Structural Modification Impacts on PanK Interaction and Mode of Action.

artículo científico publicado en 2018

Development of a method for the parallel synthesis and purification of N-substituted pantothenamides, known inhibitors of coenzyme A biosynthesis and utilization

artículo científico publicado en 2008

Discovery of Potent Pantothenamide Inhibitors of Staphylococcus aureus Pantothenate Kinase through a Minimal SAR Study: Inhibition Is Due to Trapping of the Product

artículo científico publicado en 2016

Functional copper at the acetyl-CoA synthase active site

artículo científico publicado en 2003

Functional mapping of the disparate activities of the yeast moonlighting protein Hal3.

artículo científico publicado en 2012

Grand Challenge Commentary: Exploiting single-cell variation for new antibiotics ⬇️

artículo científico publicado el 1 de diciembre de 2010

Mechanistic studies on phosphopantothenoylcysteine decarboxylase

artículo científico publicado en 2001

Mechanistic studies on phosphopantothenoylcysteine decarboxylase: trapping of an enethiolate intermediate with a mechanism-based inactivating agent

artículo científico publicado en 2004

Metabolism: Jump-starting CoA biosynthesis

artículo científico publicado en 2015

Michael acceptor-containing coenzyme A analogues as inhibitors of the atypical coenzyme A disulfide reductase from Staphylococcus aureus

artículo científico publicado en 2010

Modular Enzymatic Cascade Synthesis of Vitamin B5 and Its Derivatives

scientific article published on 30 October 2018

Moonlighting proteins Hal3 and Vhs3 form a heteromeric PPCDC with Ykl088w in yeast CoA biosynthesis

artículo científico publicado en 2009

Mutations at the hydrophobic core affect Hal3 trimer stability, reducing its Ppz1 inhibitory capacity but not its PPCDC moonlighting function

artículo científico publicado en 2018

Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues

artículo científico publicado en 2018

One-pot preparation of coenzyme A analogues via an improved chemo-enzymatic synthesis of pre-CoA thioester synthons

artículo científico publicado en 2006

Overcoming synthetic challenges in targeting coenzyme A biosynthesis with the antimicrobial natural product CJ-15,801

scientific article published on 17 October 2019

Pantothenamides are potent, on-target inhibitors of Plasmodium falciparum growth when serum pantetheinase is inactivated

artículo científico publicado en 2013

Probing the ligand preferences of the three types of bacterial pantothenate kinase

scientific article published on 02 November 2018

Recent advances in targeting coenzyme A biosynthesis and utilization for antimicrobial drug development

artículo científico publicado en 2014

Role of allosteric switches and adaptor domains in long-distance cross-talk and transient tunnel formation

scientific article published on 03 April 2020

Stereochemical studies on phosphopantothenoylcysteine decarboxylase from Escherichia coli

artículo científico publicado en 2003

Structural basis for substrate binding and the catalytic mechanism of type III pantothenate kinase

artículo científico publicado en 2008

Structural modification of pantothenamides counteracts degradation by pantetheinase and improves antiplasmodial activity

artículo científico publicado en 2013

Structure of human phosphopantothenoylcysteine synthetase at 2.3 A resolution

artículo científico publicado en 2003

The Schizosaccharomyces pombe fusion gene hal3 encodes three distinct activities.

artículo científico publicado en 2013

The antibiotic CJ-15,801 is an antimetabolite that hijacks and then inhibits CoA biosynthesis

artículo científico publicado en 2012

The antibiotic activity of N-pentylpantothenamide results from its conversion to ethyldethia-coenzyme a, a coenzyme a antimetabolite

artículo científico publicado en 2002

The selectivity for cysteine over serine in coenzyme A biosynthesis

artículo científico publicado en 2005

Top down characterization of larger proteins (45 kDa) by electron capture dissociation mass spectrometry

artículo científico publicado en 2002

Turnover-Dependent Covalent Inactivation of Staphylococcus aureus Coenzyme A-Disulfide Reductase by Coenzyme A-Mimetics: Mechanistic and Structural Insights

artículo científico publicado en 2012

Variation in pantothenate kinase type determines the pantothenamide mode of action and impacts on coenzyme A salvage biosynthesis

artículo científico publicado en 2014

Vnn1 pantetheinase limits the Warburg effect and sarcoma growth by rescuing mitochondrial activity

scientific article published on 23 July 2018

Lista de obras de Erick Strauss

3-Fluoroaspartate and pyruvoyl-dependant aspartate decarboxylase: exploiting the unique characteristics of fluorine to probe reactivity and binding

A miniaturized assay for measuring small molecule phosphorylation in the presence of complex matrices

A pantetheinase-resistant pantothenamide with potent, on-target, and selective antiplasmodial activity

An enzyme-initiated Smiles rearrangement enables the development of an assay of MshB, the GlcNAc-Ins deacetylase of mycothiol biosynthesis

Antiplasmodial Mode of Action of Pantothenamides: Pantothenate Kinase Serves as a Metabolic Activator Not as a Target

Biocatalytic Production of Coenzyme A Analogues

Characterization of a new pantothenate kinase isoform from Helicobacter pylori

Coenzyme A: to make it or uptake it?

Complex stability and dynamic subunit interchange modulates the disparate activities of the yeast moonlighting proteins Hal3 and Vhs3

Creating Cellulose-Binding Domain Fusions of the Coenzyme A Biosynthetic Enzymes to Enable Reactor-Based Biotransformations

Crystal structure of a type III pantothenate kinase: insight into the mechanism of an essential coenzyme A biosynthetic enzyme universally distributed in bacteria

Developing Pantetheinase-Resistant Pantothenamide Antibacterials: Structural Modification Impacts on PanK Interaction and Mode of Action.

Development of a method for the parallel synthesis and purification of N-substituted pantothenamides, known inhibitors of coenzyme A biosynthesis and utilization

Discovery of Potent Pantothenamide Inhibitors of Staphylococcus aureus Pantothenate Kinase through a Minimal SAR Study: Inhibition Is Due to Trapping of the Product

Functional copper at the acetyl-CoA synthase active site

Functional mapping of the disparate activities of the yeast moonlighting protein Hal3.

Grand Challenge Commentary: Exploiting single-cell variation for new antibiotics ⬇️

Mechanistic studies on phosphopantothenoylcysteine decarboxylase

Mechanistic studies on phosphopantothenoylcysteine decarboxylase: trapping of an enethiolate intermediate with a mechanism-based inactivating agent

Metabolism: Jump-starting CoA biosynthesis

Michael acceptor-containing coenzyme A analogues as inhibitors of the atypical coenzyme A disulfide reductase from Staphylococcus aureus

Modular Enzymatic Cascade Synthesis of Vitamin B5 and Its Derivatives

Moonlighting proteins Hal3 and Vhs3 form a heteromeric PPCDC with Ykl088w in yeast CoA biosynthesis

Mutations at the hydrophobic core affect Hal3 trimer stability, reducing its Ppz1 inhibitory capacity but not its PPCDC moonlighting function

Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues

One-pot preparation of coenzyme A analogues via an improved chemo-enzymatic synthesis of pre-CoA thioester synthons

Overcoming synthetic challenges in targeting coenzyme A biosynthesis with the antimicrobial natural product CJ-15,801

Pantothenamides are potent, on-target inhibitors of Plasmodium falciparum growth when serum pantetheinase is inactivated

Probing the ligand preferences of the three types of bacterial pantothenate kinase

Recent advances in targeting coenzyme A biosynthesis and utilization for antimicrobial drug development

Role of allosteric switches and adaptor domains in long-distance cross-talk and transient tunnel formation

Stereochemical studies on phosphopantothenoylcysteine decarboxylase from Escherichia coli

Structural basis for substrate binding and the catalytic mechanism of type III pantothenate kinase

Structural modification of pantothenamides counteracts degradation by pantetheinase and improves antiplasmodial activity

Structure of human phosphopantothenoylcysteine synthetase at 2.3 A resolution

The Schizosaccharomyces pombe fusion gene hal3 encodes three distinct activities.

The antibiotic CJ-15,801 is an antimetabolite that hijacks and then inhibits CoA biosynthesis

The antibiotic activity of N-pentylpantothenamide results from its conversion to ethyldethia-coenzyme a, a coenzyme a antimetabolite

The selectivity for cysteine over serine in coenzyme A biosynthesis

Top down characterization of larger proteins (45 kDa) by electron capture dissociation mass spectrometry

Turnover-Dependent Covalent Inactivation of Staphylococcus aureus Coenzyme A-Disulfide Reductase by Coenzyme A-Mimetics: Mechanistic and Structural Insights

Variation in pantothenate kinase type determines the pantothenamide mode of action and impacts on coenzyme A salvage biosynthesis

Vnn1 pantetheinase limits the Warburg effect and sarcoma growth by rescuing mitochondrial activity