Lista de obras - Marie Ranson - Dominio Público Uruguay

5′-Substituted Amiloride Derivatives as Allosteric Modulators Binding in the Sodium Ion Pocket of the Adenosine A2A Receptor

artículo científico publicado en 2016

A key role for the urokinase plasminogen activator (uPA) in invasive Group A streptococcal infection

artículo científico publicado en 2013

A structural basis for differential cell signalling by PAI-1 and PAI-2 in breast cancer cells

artículo científico publicado en 2007

Allelic variants of streptokinase from Streptococcus pyogenes display functional differences in plasminogen activation

scientific article published on 29 May 2008

Amorphous protein aggregates stimulate plasminogen activation, leading to release of cytotoxic fragments that are clients for extracellular chaperones

artículo científico publicado en 2017

An investigation into the cytotoxicity and mode of action of some novel N-alkyl-substituted isatins.

artículo científico publicado en 2007

Anti-tumour/metastasis effects of the potassium-sparing diuretic amiloride: an orally active anti-cancer drug waiting for its call-of-duty?

artículo científico publicado en 2011

Assessing the Role of Pharyngeal Cell Surface Glycans in Group A Streptococcus Biofilm Formation

scientific article published on 04 November 2020

Bacterial plasminogen receptors: mediators of a multifaceted relationship.

artículo científico

Breast Tumor Cell Invasion and Pro-Invasive Activity of Cancer-Associated Fibroblasts Co-Targeted by Novel Urokinase-Derived Decapeptides

artículo científico publicado en 2020

Cell surface antigens of Mycoplasma species bovine group 7 bind to and activate plasminogen

artículo científico publicado en 2003

Circulating tumour cells in regionally metastatic cutaneous squamous cell carcinoma: A pilot study

artículo científico publicado en 2016

Comprehensive Mutational and Phenotypic Characterization of New Metastatic Cutaneous Squamous Cell Carcinoma Cell Lines Reveal Novel Drug Susceptibilities

scientific article published on 15 December 2020

Conformational rearrangements of plasminogen activator inhibitor type 2.

artículo científico publicado en 2009

Cryopreservation for delayed circulating tumor cell isolation is a valid strategy for prognostic association of circulating tumor cells in gastroesophageal cancer

artículo científico publicado en 2018

Dependence on endocytic receptor binding via a minimal binding motif underlies the differential prognostic profiles of SerpinE1 and SerpinB2 in cancer

artículo científico publicado en 2011

Differential endocytosis of tissue plasminogen activator by serpins PAI-1 and PAI-2 on human peripheral blood monocytes

artículo científico publicado en 2010

Divergence in the plasminogen-binding group a streptococcal M protein family: functional conservation of binding site and potential role for immune selection of variants

artículo científico publicado en 2006

Editorial [Hot Topic: The Plasminogen Activation System in Pathology: Use in Prognosis and Therapy (Guest Editor: Marie Ranson)]

artículo científico publicado en 2011

Effects of estrogens on human melanocytes in vitro

artículo científico publicado en 1994

Effects on human plasminogen conformation and activation rate caused by interaction with VEK-30, a peptide derived from the group A streptococcal M-like protein (PAM).

artículo científico publicado en 2010

Extracellular matrix modulates the function of human melanocytes but not melanoma cells

artículo científico publicado en 1988

First-in-human phase I study of infusional and bolus schedules of Deflexifol, a novel 5-fluorouracil and leucovorin formulation, after failure of standard treatment

scientific article published on 06 March 2019

Forty years later and the role of plasminogen activator inhibitor type 2/SERPINB2 is still an enigma.

artículo científico

Gastric cancer stem cells: evidence, potential markers, and clinical implications

artículo científico publicado en 2015

Gene expression profiling of perineural invasion in head and neck cutaneous squamous cell carcinoma

artículo científico publicado en 2021

Gnot1, a member of a new homeobox gene subfamily, is expressed in a dynamic, region-specific domain along the proximodistal axis of the developing limb

artículo científico publicado en 1995

HER2 and uPAR cooperativity contribute to metastatic phenotype of HER2-positive breast cancer

artículo científico publicado en 2015

High-Dimensional and Spatial Analysis Reveals Immune Landscape–Dependent Progression in Cutaneous Squamous Cell Carcinoma

Identification of the 49-kDa autoantigen associated with lymphocytic hypophysitis as alpha-enolase

artículo científico publicado en 2002

Improved pharmacokinetic and biodistribution properties of the selective urokinase inhibitor PAI-2 (SerpinB2) by site-specific PEGylation: implications for drug delivery.

artículo científico publicado en 2014

In vitro and preclinical targeted alpha therapy for melanoma, breast, prostate and colorectal cancers

artículo científico publicado en 2001

In vitro cytotoxicity evaluation of some substituted isatin derivatives.

artículo científico publicado en 2006

In vitro cytotoxicity of bismuth-213 (213Bi)-labeled-plasminogen activator inhibitor type 2 (alpha-PAI-2) on human breast cancer cells

artículo científico publicado en 2002

Interaction between the P14 residue and strand 2 of beta-sheet B is critical for reactive center loop insertion in plasminogen activator inhibitor-2.

artículo científico publicado en 2001

Is plasminogen deployed as a Streptococcus pyogenes virulence factor?

artículo científico publicado en 2005

Kinetic analysis of plasminogen activator inhibitor type-2: urokinase complex formation and subsequent internalisation by carcinoma cell lines

artículo científico publicado en 2004

Molecular competition between plasminogen activator inhibitors type -1 and -2 for urokinase: Implications for cellular proteolysis and adhesion in cancer.

artículo científico publicado en 2011

Mutational Patterns in Metastatic Cutaneous Squamous Cell Carcinoma

scientific article published on 23 January 2019

N-alkylated isatins evade P-gp mediated efflux and retain potency in MDR cancer cell lines

scientific article published on 21 January 2016

N-phenethyl and N-naphthylmethyl isatins and analogues as in vitro cytotoxic agents.

artículo científico publicado en 2008

Neuroserpin and transthyretin are extracellular chaperones that preferentially inhibit amyloid formation

artículo científico publicado en 2021

P2X7 receptor activation induces cell death and CD23 shedding in human RPMI 8226 multiple myeloma cells

artículo científico publicado en 2010

PD-L1 expression predicts longer disease free survival in high risk head and neck cutaneous squamous cell carcinoma.

artículo científico publicado en 2017

PZP and PAI-2: Structurally-diverse, functionally similar pregnancy proteins?

artículo científico publicado en 2016

Plasmin(ogen) acquisition by group A Streptococcus protects against C3b-mediated neutrophil killing.

artículo científico publicado en 2013

Plasminogen activator inhibitor type 2 inhibits cell surface associated tissue plasminogen activator in vitro

artículo científico publicado en 2008

Plasminogen binding and activation at the breast cancer cell surface: the integral role of urokinase activity

artículo científico publicado en 2007

Plasminogen binding and cancer: promises and pitfalls

artículo científico publicado en 2003

Plasminogen binding by group A streptococcal isolates from a region of hyperendemicity for streptococcal skin infection and a high incidence of invasive infection

artículo científico publicado en 2004

Preclinical evaluation of 213Bi-labeled plasminogen activator inhibitor type 2 in an orthotopic murine xenogenic model of human breast carcinoma

artículo científico publicado en 2007

Preclinical evaluation of novel, all-in-one formulations of 5-fluorouracil and folinic acid with reduced toxicity profiles ⬇️

artículo científico publicado el 1 de enero de 2011

Revisiting the biological roles of PAI2 (SERPINB2) in cancer

artículo científico publicado en 2008

Roles of the Na+/H+ Exchanger Isoform 1 and Urokinase in Prostate Cancer Cell Migration and Invasion

artículo científico publicado en 2021

Selective targeting of 2'-deoxy-5-fluorouridine to urokinase positive malignant cells in vitro.

artículo científico publicado en 2010

SerpinB2 (PAI-2) Modulates Proteostasis via Binding Misfolded Proteins and Promotion of Cytoprotective Inclusion Formation

artículo científico publicado en 2015

Small molecule antagonists of the urokinase (uPA): urokinase receptor (uPAR) interaction with high reported potencies show only weak effects in cell-based competition assays employing the native uPAR ligand.

artículo científico publicado en 2011

Synthesis and hydrolytic evaluation of acid-labile imine-linked cytotoxic isatin model systems.

artículo científico publicado en 2011

Synthesis and preliminary evaluation of 5,7-dimethyl-2-aryl-3H-pyrrolizin-3-ones as angiogenesis inhibitors

artículo científico publicado en 2016

Synthesis and preliminary evaluation of amiloride analogs as inhibitors of the urokinase-type plasminogen activator (uPA)

artículo científico publicado en 2011

Targeting urokinase and the transferrin receptor with novel, anti-mitotic N-alkylisatin cytotoxin conjugates causes selective cancer cell death and reduces tumor growth.

artículo científico publicado en 2012

The Maintenance of High Affinity Plasminogen Binding by Group A Streptococcal Plasminogen-binding M-like Protein Is Mediated by Arginine and Histidine Residues within the a1 and a2 Repeat Domains

artículo científico publicado en 2006

The Urokinase/PAI-2 Complex

artículo científico publicado en 2006

The human ENO1 gene product (recombinant human α-enolase) displays characteristics required for a plasminogen binding protein

artículo científico publicado en 1997

The organizer-associated chick homeobox gene, Gnot1, is expressed before gastrulation and regulated synergistically by activin and retinoic acid

artículo científico publicado en 1995

The plasminogen-binding group A streptococcal M protein-related protein Prp binds plasminogen via arginine and histidine residues

artículo científico publicado en 2006

The topology of plasminogen binding and activation on the surface of human breast cancer cells

artículo científico publicado en 2001

Thulium oxide nanoparticles as radioenhancers for the treatment of metastatic cutaneous squamous cell carcinoma

artículo científico publicado en 2020

Towards clinical translation of ligand-functionalized liposomes in targeted cancer therapy: Challenges and opportunities.

artículo científico publicado en 2018

Trigger for group A streptococcal M1T1 invasive disease

artículo científico publicado en 2006

p16 expression in cutaneous squamous cell carcinoma of the head and neck is not associated with integration of high risk HPV DNA or prognosis.

artículo científico publicado en 2017

Lista de obras de Marie Ranson

5′-Substituted Amiloride Derivatives as Allosteric Modulators Binding in the Sodium Ion Pocket of the Adenosine A2A Receptor

A key role for the urokinase plasminogen activator (uPA) in invasive Group A streptococcal infection

A structural basis for differential cell signalling by PAI-1 and PAI-2 in breast cancer cells

Allelic variants of streptokinase from Streptococcus pyogenes display functional differences in plasminogen activation

Amorphous protein aggregates stimulate plasminogen activation, leading to release of cytotoxic fragments that are clients for extracellular chaperones

An investigation into the cytotoxicity and mode of action of some novel N-alkyl-substituted isatins.

Anti-tumour/metastasis effects of the potassium-sparing diuretic amiloride: an orally active anti-cancer drug waiting for its call-of-duty?

Assessing the Role of Pharyngeal Cell Surface Glycans in Group A Streptococcus Biofilm Formation

Bacterial plasminogen receptors: mediators of a multifaceted relationship.

Breast Tumor Cell Invasion and Pro-Invasive Activity of Cancer-Associated Fibroblasts Co-Targeted by Novel Urokinase-Derived Decapeptides

Cell surface antigens of Mycoplasma species bovine group 7 bind to and activate plasminogen

Circulating tumour cells in regionally metastatic cutaneous squamous cell carcinoma: A pilot study

Comprehensive Mutational and Phenotypic Characterization of New Metastatic Cutaneous Squamous Cell Carcinoma Cell Lines Reveal Novel Drug Susceptibilities

Conformational rearrangements of plasminogen activator inhibitor type 2.

Cryopreservation for delayed circulating tumor cell isolation is a valid strategy for prognostic association of circulating tumor cells in gastroesophageal cancer

Dependence on endocytic receptor binding via a minimal binding motif underlies the differential prognostic profiles of SerpinE1 and SerpinB2 in cancer

Differential endocytosis of tissue plasminogen activator by serpins PAI-1 and PAI-2 on human peripheral blood monocytes

Divergence in the plasminogen-binding group a streptococcal M protein family: functional conservation of binding site and potential role for immune selection of variants

Editorial [Hot Topic: The Plasminogen Activation System in Pathology: Use in Prognosis and Therapy (Guest Editor: Marie Ranson)]

Effects of estrogens on human melanocytes in vitro

Effects on human plasminogen conformation and activation rate caused by interaction with VEK-30, a peptide derived from the group A streptococcal M-like protein (PAM).

Extracellular matrix modulates the function of human melanocytes but not melanoma cells

First-in-human phase I study of infusional and bolus schedules of Deflexifol, a novel 5-fluorouracil and leucovorin formulation, after failure of standard treatment

Forty years later and the role of plasminogen activator inhibitor type 2/SERPINB2 is still an enigma.

Gastric cancer stem cells: evidence, potential markers, and clinical implications

Gene expression profiling of perineural invasion in head and neck cutaneous squamous cell carcinoma

Gnot1, a member of a new homeobox gene subfamily, is expressed in a dynamic, region-specific domain along the proximodistal axis of the developing limb

HER2 and uPAR cooperativity contribute to metastatic phenotype of HER2-positive breast cancer

High-Dimensional and Spatial Analysis Reveals Immune Landscape–Dependent Progression in Cutaneous Squamous Cell Carcinoma

Identification of the 49-kDa autoantigen associated with lymphocytic hypophysitis as alpha-enolase

Improved pharmacokinetic and biodistribution properties of the selective urokinase inhibitor PAI-2 (SerpinB2) by site-specific PEGylation: implications for drug delivery.

In vitro and preclinical targeted alpha therapy for melanoma, breast, prostate and colorectal cancers

In vitro cytotoxicity evaluation of some substituted isatin derivatives.

In vitro cytotoxicity of bismuth-213 (213Bi)-labeled-plasminogen activator inhibitor type 2 (alpha-PAI-2) on human breast cancer cells

Interaction between the P14 residue and strand 2 of beta-sheet B is critical for reactive center loop insertion in plasminogen activator inhibitor-2.

Is plasminogen deployed as a Streptococcus pyogenes virulence factor?

Kinetic analysis of plasminogen activator inhibitor type-2: urokinase complex formation and subsequent internalisation by carcinoma cell lines

Molecular competition between plasminogen activator inhibitors type -1 and -2 for urokinase: Implications for cellular proteolysis and adhesion in cancer.

Mutational Patterns in Metastatic Cutaneous Squamous Cell Carcinoma

N-alkylated isatins evade P-gp mediated efflux and retain potency in MDR cancer cell lines

N-phenethyl and N-naphthylmethyl isatins and analogues as in vitro cytotoxic agents.

Neuroserpin and transthyretin are extracellular chaperones that preferentially inhibit amyloid formation

P2X7 receptor activation induces cell death and CD23 shedding in human RPMI 8226 multiple myeloma cells

PD-L1 expression predicts longer disease free survival in high risk head and neck cutaneous squamous cell carcinoma.

PZP and PAI-2: Structurally-diverse, functionally similar pregnancy proteins?

Plasmin(ogen) acquisition by group A Streptococcus protects against C3b-mediated neutrophil killing.

Plasminogen activator inhibitor type 2 inhibits cell surface associated tissue plasminogen activator in vitro

Plasminogen binding and activation at the breast cancer cell surface: the integral role of urokinase activity

Plasminogen binding and cancer: promises and pitfalls

Plasminogen binding by group A streptococcal isolates from a region of hyperendemicity for streptococcal skin infection and a high incidence of invasive infection

Preclinical evaluation of 213Bi-labeled plasminogen activator inhibitor type 2 in an orthotopic murine xenogenic model of human breast carcinoma

Preclinical evaluation of novel, all-in-one formulations of 5-fluorouracil and folinic acid with reduced toxicity profiles ⬇️

Revisiting the biological roles of PAI2 (SERPINB2) in cancer

Roles of the Na+/H+ Exchanger Isoform 1 and Urokinase in Prostate Cancer Cell Migration and Invasion

Selective targeting of 2'-deoxy-5-fluorouridine to urokinase positive malignant cells in vitro.

SerpinB2 (PAI-2) Modulates Proteostasis via Binding Misfolded Proteins and Promotion of Cytoprotective Inclusion Formation

Small molecule antagonists of the urokinase (uPA): urokinase receptor (uPAR) interaction with high reported potencies show only weak effects in cell-based competition assays employing the native uPAR ligand.

Synthesis and hydrolytic evaluation of acid-labile imine-linked cytotoxic isatin model systems.

Synthesis and preliminary evaluation of 5,7-dimethyl-2-aryl-3H-pyrrolizin-3-ones as angiogenesis inhibitors

Synthesis and preliminary evaluation of amiloride analogs as inhibitors of the urokinase-type plasminogen activator (uPA)

Targeting urokinase and the transferrin receptor with novel, anti-mitotic N-alkylisatin cytotoxin conjugates causes selective cancer cell death and reduces tumor growth.

The Maintenance of High Affinity Plasminogen Binding by Group A Streptococcal Plasminogen-binding M-like Protein Is Mediated by Arginine and Histidine Residues within the a1 and a2 Repeat Domains

The Urokinase/PAI-2 Complex

The human ENO1 gene product (recombinant human α-enolase) displays characteristics required for a plasminogen binding protein

The organizer-associated chick homeobox gene, Gnot1, is expressed before gastrulation and regulated synergistically by activin and retinoic acid

The plasminogen-binding group A streptococcal M protein-related protein Prp binds plasminogen via arginine and histidine residues

The topology of plasminogen binding and activation on the surface of human breast cancer cells

Thulium oxide nanoparticles as radioenhancers for the treatment of metastatic cutaneous squamous cell carcinoma

Towards clinical translation of ligand-functionalized liposomes in targeted cancer therapy: Challenges and opportunities.

Trigger for group A streptococcal M1T1 invasive disease

p16 expression in cutaneous squamous cell carcinoma of the head and neck is not associated with integration of high risk HPV DNA or prognosis.