Lista de obras - Diego Muñoz-Torrero - Dominio Público Uruguay

1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: synthesis, pharmacological evaluation and mechanistic studies

artículo científico publicado en 2013

3D structure of Torpedo californica acetylcholinesterase complexed with huprine X at 2.1 A resolution: kinetic and molecular dynamic correlates

artículo científico publicado en 2002

A fast and specific method to screen for intracellular amyloid inhibitors using bacterial model systems

artículo científico publicado en 2015

A synthesis of levetiracetam based on (S)-N-phenylpantolactam as a chiral auxiliary

AVCRI104P3, a novel multitarget compound with cognition-enhancing and anxiolytic activities: studies in cognitively poor middle-aged mice

artículo científico publicado en 2015

Acetylcholinesterase inhibitors as disease-modifying therapies for Alzheimer's disease.

scientific article published on January 2008

Acetylcholinesterase triggers the aggregation of PrP 106-126

artículo científico publicado en 2006

Amyloid Pan-inhibitors: One Family of Compounds To Cope with All Conformational Diseases

Behavioural effects and regulation of PKCalpha and MAPK by huprine X in middle aged mice

artículo científico publicado en 2010

Binding of 13-Amidohuprines to Acetylcholinesterase: Exploring the Ligand-Induced Conformational Change of the Gly117-Gly118 Peptide Bond in the Oxyanion Hole

artículo científico publicado en 2006

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-2.

artículo científico publicado en 2017

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-3

scientific article published on 30 June 2018

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-5

scientific article published on 30 June 2019

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-6

scientific article published on 28 December 2019

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes⁻4

scientific article published on 31 December 2018

Characterisation of the anticholinesterase activity of two new tacrine-huperzine A hybrids

artículo científico publicado en 2003

Combined in Vitro Cell-Based/in Silico Screening of Naturally Occurring Flavonoids and Phenolic Compounds as Potential Anti-Alzheimer Drugs.

artículo científico publicado en 2017

Complexity against complexity: multitarget drugs

artículo científico publicado en 2013

Corrigendum to “Straightforward preparation of enantiopure 3-amino-4,4-dimethylpyrrolidin-2-one and derivatives” [Tetrahedron: Asymmetry 21 (2010) 2124]

scholarly article published in Tetrahedron: Asymmetry

Design, synthesis and biological evaluation of N-methyl-N-[(1,2,3-triazol-4-yl)alkyl]propargylamines as novel monoamine oxidase B inhibitors

artículo científico publicado en 2016

Diastereoselective preparation of (S)-(1,4,4-trimethylpyrrolidin-3-yl)amine, a new chiral 1,2-diamine for thiourea-type organocatalysts

Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease

artículo científico publicado en 2022

Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice

artículo científico publicado en 2020

EASY ACCESS TO 4-SUBSTITUTED (±)-HUPERZINE A ANALOGUES

article by Pelayo Camps et al published January 2001 in Synthetic Communications

Effect of acetylcholinesterase inhibitors on AChE-induced PrP106-126 aggregation

artículo científico publicado en 2006

Effect of huprine X on β-amyloid, synaptophysin and α7 neuronal nicotinic acetylcholine receptors in the brain of 3xTg-AD and APPswe transgenic mice

artículo científico publicado en 2010

Effects of (+/-)-huprine Y and (+/-)-huprine Z, two new anticholinesterasic drugs, on muscarinic receptors

artículo científico publicado en 2005

Expanding the multipotent profile of huprine-tacrine heterodimers as disease-modifying anti-Alzheimer agents

artículo científico publicado en 2012

Exploiting multivalency in drug design

artículo científico publicado en 2009

Highly diastereoselective one-pot synthesis of spiro[cyclopenta[a]indene-2,2'-indene]diones from 1-indanones and aromatic aldehydes

artículo científico publicado en 2006

Human disease and drug pharmacology, complex as real life.

artículo científico

Huprine X and huperzine A improve cognition and regulate some neurochemical processes related with Alzheimer's disease in triple transgenic mice (3xTg-AD).

artículo científico publicado en 2012

Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and prion diseases

artículo científico publicado en 2012

Huprines as a new family of dual acting trypanocidal-antiplasmodial agents

artículo científico publicado en 2011

Huprines for Alzheimer's disease drug development ⬇️

artículo científico publicado el 1 de enero de 2008

Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis.

artículo científico publicado en 2018

Insertion of Isocyanides into N-Si Bonds: Multicomponent Reactions with Azines Leading to Potent Antiparasitic Compounds

artículo científico publicado en 2016

Multicomponent reaction-based synthesis and biological evaluation of tricyclic heterofused quinolines with multi-trypanosomatid activity

artículo científico publicado en 2015

Multigram synthesis and in vivo efficacy studies of a novel multitarget anti-Alzheimer's compound.

artículo científico publicado en 2015

Neuroprotective Effects of the Multitarget Agent AVCRI104P3 in Brain of Middle-Aged Mice

artículo científico publicado en 2018

Neuroprotective effects of (+/-)-huprine Y on in vitro and in vivo models of excitoxicity damage

artículo científico publicado en 2003

Nicotinic-receptor potentiator drugs, huprine X and galantamine, increase ACh release by blocking AChE activity but not acting on nicotinic receptors

artículo científico publicado en 2005

Novel Levetiracetam Derivatives That Are Effective against the Alzheimer-like Phenotype in Mice: Synthesis, in Vitro, ex Vivo, and in Vivo Efficacy Studies

artículo científico publicado en 2015

Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.

artículo científico publicado en 2008

Novel huprine derivatives with inhibitory activity toward β-amyloid aggregation and formation as disease-modifying anti-Alzheimer drug candidates

artículo científico publicado en 2010

One-pot synthesis of N-substituted pantolactams from pantolactone

Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds

artículo científico publicado en 2009

Shogaol-huprine hybrids: dual antioxidant and anticholinesterase agents with β-amyloid and tau anti-aggregating properties.

artículo científico publicado en 2014

Special Issue: "Molecules against Alzheimer".

artículo científico publicado en 2016

Straightforward preparation of enantiopure 3-amino-4,4-dimethylpyrrolidin-2-one and its derivatives

Synthesis and absolute configuration of novel N,O-psiconucleosides using (R)-N-phenylpantolactam as a resolution agent

artículo científico publicado en 2008

Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines

artículo científico publicado en 2014

Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents.

artículo científico publicado en 2016

Synthesis and evaluation of tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease

artículo científico publicado en 1998

Synthesis and evaluation of tacrine-related compounds for the treatment of Alzheimer's disease

scholarly article by F Aguado et al published January 1994 in European Journal of Medicinal Chemistry

Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents.

artículo científico publicado en 2014

Synthesis and pharmacological evaluation of huprine-tacrine heterodimers: subnanomolar dual binding site acetylcholinesterase inhibitors

scientific article published on 01 March 2005

Synthesis of both enantiomers of baclofen using (R)- and (S)-N-phenylpantolactam as chiral auxiliaries

Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity

artículo científico publicado en 2015

Synthesis, in Vitro Pharmacology, and Molecular Modeling of Very Potent Tacrine−Huperzine A Hybrids as Acetylcholinesterase Inhibitors of Potential Interest for the Treatment of Alzheimer's Disease

artículo científico publicado en 1999

Synthesis, in vitro pharmacology, and molecular modeling of syn-huprines as acetylcholinesterase inhibitors.

artículo científico publicado en 2001

Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates.

artículo científico publicado en 2010

Tetrahydrobenzo[h][1,6]naphthyridine-6-chlorotacrine hybrids as a new family of anti-Alzheimer agents targeting β-amyloid, tau, and cholinesterase pathologies.

artículo científico publicado en 2014

Tetrasubstituted Imidazolium Salts as Potent Antiparasitic Agents against African and American Trypanosomiases.

artículo científico publicado en 2018

Thioflavin-S staining of bacterial inclusion bodies for the fast, simple, and inexpensive screening of amyloid aggregation inhibitors

artículo científico publicado en 2014

Ultra rapid in vivo screening for anti-Alzheimer anti-amyloid drugs

artículo científico publicado en 2016

Undifferentiated and differentiated PC12 cells protected by huprines against injury induced by hydrogen peroxide

artículo científico publicado en 2013

Unveiling a novel transient druggable pocket in BACE-1 through molecular simulations: Conformational analysis and binding mode of multisite inhibitors.

artículo científico publicado en 2017

Lista de obras de Diego Muñoz-Torrero

1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: synthesis, pharmacological evaluation and mechanistic studies

3D structure of Torpedo californica acetylcholinesterase complexed with huprine X at 2.1 A resolution: kinetic and molecular dynamic correlates

A fast and specific method to screen for intracellular amyloid inhibitors using bacterial model systems

A synthesis of levetiracetam based on (S)-N-phenylpantolactam as a chiral auxiliary

AVCRI104P3, a novel multitarget compound with cognition-enhancing and anxiolytic activities: studies in cognitively poor middle-aged mice

Acetylcholinesterase inhibitors as disease-modifying therapies for Alzheimer's disease.

Acetylcholinesterase triggers the aggregation of PrP 106-126

Amyloid Pan-inhibitors: One Family of Compounds To Cope with All Conformational Diseases

Behavioural effects and regulation of PKCalpha and MAPK by huprine X in middle aged mice

Binding of 13-Amidohuprines to Acetylcholinesterase: Exploring the Ligand-Induced Conformational Change of the Gly117-Gly118 Peptide Bond in the Oxyanion Hole

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-2.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-3

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-5

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-6

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes⁻4

Characterisation of the anticholinesterase activity of two new tacrine-huperzine A hybrids

Combined in Vitro Cell-Based/in Silico Screening of Naturally Occurring Flavonoids and Phenolic Compounds as Potential Anti-Alzheimer Drugs.

Complexity against complexity: multitarget drugs

Corrigendum to “Straightforward preparation of enantiopure 3-amino-4,4-dimethylpyrrolidin-2-one and derivatives” [Tetrahedron: Asymmetry 21 (2010) 2124]

Design, synthesis and biological evaluation of N-methyl-N-[(1,2,3-triazol-4-yl)alkyl]propargylamines as novel monoamine oxidase B inhibitors

Diastereoselective preparation of (S)-(1,4,4-trimethylpyrrolidin-3-yl)amine, a new chiral 1,2-diamine for thiourea-type organocatalysts

Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease

Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice

EASY ACCESS TO 4-SUBSTITUTED (±)-HUPERZINE A ANALOGUES

Effect of acetylcholinesterase inhibitors on AChE-induced PrP106-126 aggregation

Effect of huprine X on β-amyloid, synaptophysin and α7 neuronal nicotinic acetylcholine receptors in the brain of 3xTg-AD and APPswe transgenic mice

Effects of (+/-)-huprine Y and (+/-)-huprine Z, two new anticholinesterasic drugs, on muscarinic receptors

Expanding the multipotent profile of huprine-tacrine heterodimers as disease-modifying anti-Alzheimer agents

Exploiting multivalency in drug design

Highly diastereoselective one-pot synthesis of spiro[cyclopenta[a]indene-2,2'-indene]diones from 1-indanones and aromatic aldehydes

Human disease and drug pharmacology, complex as real life.

Huprine X and huperzine A improve cognition and regulate some neurochemical processes related with Alzheimer's disease in triple transgenic mice (3xTg-AD).

Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and prion diseases

Huprines as a new family of dual acting trypanocidal-antiplasmodial agents

Huprines for Alzheimer's disease drug development ⬇️

Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis.

Insertion of Isocyanides into N-Si Bonds: Multicomponent Reactions with Azines Leading to Potent Antiparasitic Compounds

Multicomponent reaction-based synthesis and biological evaluation of tricyclic heterofused quinolines with multi-trypanosomatid activity

Multigram synthesis and in vivo efficacy studies of a novel multitarget anti-Alzheimer's compound.

Neuroprotective Effects of the Multitarget Agent AVCRI104P3 in Brain of Middle-Aged Mice

Neuroprotective effects of (+/-)-huprine Y on in vitro and in vivo models of excitoxicity damage

Nicotinic-receptor potentiator drugs, huprine X and galantamine, increase ACh release by blocking AChE activity but not acting on nicotinic receptors

Novel Levetiracetam Derivatives That Are Effective against the Alzheimer-like Phenotype in Mice: Synthesis, in Vitro, ex Vivo, and in Vivo Efficacy Studies

Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.

Novel huprine derivatives with inhibitory activity toward β-amyloid aggregation and formation as disease-modifying anti-Alzheimer drug candidates

One-pot synthesis of N-substituted pantolactams from pantolactone

Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds

Shogaol-huprine hybrids: dual antioxidant and anticholinesterase agents with β-amyloid and tau anti-aggregating properties.

Special Issue: "Molecules against Alzheimer".

Straightforward preparation of enantiopure 3-amino-4,4-dimethylpyrrolidin-2-one and its derivatives

Synthesis and absolute configuration of novel N,O-psiconucleosides using (R)-N-phenylpantolactam as a resolution agent

Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines

Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents.

Synthesis and evaluation of tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease

Synthesis and evaluation of tacrine-related compounds for the treatment of Alzheimer's disease

Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents.

Synthesis and pharmacological evaluation of huprine-tacrine heterodimers: subnanomolar dual binding site acetylcholinesterase inhibitors

Synthesis of both enantiomers of baclofen using (R)- and (S)-N-phenylpantolactam as chiral auxiliaries

Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity

Synthesis, in Vitro Pharmacology, and Molecular Modeling of Very Potent Tacrine−Huperzine A Hybrids as Acetylcholinesterase Inhibitors of Potential Interest for the Treatment of Alzheimer's Disease

Synthesis, in vitro pharmacology, and molecular modeling of syn-huprines as acetylcholinesterase inhibitors.

Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates.

Tetrahydrobenzo[h][1,6]naphthyridine-6-chlorotacrine hybrids as a new family of anti-Alzheimer agents targeting β-amyloid, tau, and cholinesterase pathologies.

Tetrasubstituted Imidazolium Salts as Potent Antiparasitic Agents against African and American Trypanosomiases.

Thioflavin-S staining of bacterial inclusion bodies for the fast, simple, and inexpensive screening of amyloid aggregation inhibitors

Ultra rapid in vivo screening for anti-Alzheimer anti-amyloid drugs

Undifferentiated and differentiated PC12 cells protected by huprines against injury induced by hydrogen peroxide

Unveiling a novel transient druggable pocket in BACE-1 through molecular simulations: Conformational analysis and binding mode of multisite inhibitors.