Lista de obras - Richard D. Unwin - Dominio Público Uruguay

A HPLC-SRM-MS based method for the detection and quantification of methotrexate in urine at doses used in clinical practice for patients with rheumatological disease: a potential measure of adherence

artículo científico publicado en 2015

A label-free selected reaction monitoring workflow identifies a subset of pregnancy specific glycoproteins as potential predictive markers of early-onset pre-eclampsia

artículo científico publicado en 2013

A sensitive mass spectrometric method for hypothesis-driven detection of peptide post-translational modifications: multiple reaction monitoring-initiated detection and sequencing (MIDAS).

artículo científico publicado en 2009

A specific PTPRC/CD45 phosphorylation event governed by stem cell chemokine CXCL12 regulates primitive hematopoietic cell motility

artículo científico publicado en 2013

Adipocyte NR1D1 dictates adipose tissue expansion during obesity

artículo científico publicado en 2021

An assessment of peptide enrichment methods employing mTRAQ quantification approaches

artículo científico publicado en 2012

Application of the MIDAS Approach for Analysis of Lysine Acetylation Sites

article

Assessment of downstream effectors of BCR/ABL protein tyrosine kinase using combined proteomic approaches

artículo científico publicado en 2010

Association of plasma trace element levels with neovascular age-related macular degeneration

scientific article published on 21 October 2020

Cerebral Vitamin B5 (D-Pantothenic Acid) Deficiency as a Potential Cause of Metabolic Perturbation and Neurodegeneration in Huntington's Disease

scientific article published on 11 June 2019

Cognitive dysfunction in diabetic rats is prevented by pyridoxamine treatment. A multidisciplinary investigation

artículo científico publicado en 2019

Correction: Identification of Nuclear Protein Targets for Six Leukemogenic Tyrosine Kinases Governed by Post-Translational Regulation.

artículo científico publicado en 2013

Deficient copper concentrations in dried-defatted hepatic tissue from ob/ob mice: A potential model for study of defective copper regulation in metabolic liver disease.

artículo científico publicado en 2015

Development and validation of a methotrexate adherence assay

scientific article published on 05 June 2019

Development of a selected reaction monitoring mass spectrometry-based assay to detect asparaginyl endopeptidase activity in biological fluids

artículo científico publicado en 2016

Developmental fate determination and marker discovery in hematopoietic stem cell biology using proteomic fingerprinting

artículo científico publicado en 2007

EVI1 carboxy-terminal phosphorylation is ATM-mediated and sustains transcriptional modulation and self-renewal via enhanced CtBP1 association

artículo científico publicado en 2018

Effects of Alterations of Post-Mortem Delay and Other Tissue-Collection Variables on Metabolite Levels in Human and Rat Brain

artículo científico publicado en 2020

Effects of Obesity on Perivascular Adipose Tissue Vasorelaxant Function: Nitric Oxide, Inflammation and Elevated Systemic Blood Pressure

artículo científico publicado en 2016

Eight-channel iTRAQ enables comparison of the activity of six leukemogenic tyrosine kinases

artículo científico publicado en 2007

Elevation of brain glucose and polyol-pathway intermediates with accompanying brain-copper deficiency in patients with Alzheimer's disease: metabolic basis for dementia.

artículo científico publicado en 2016

Evidence for widespread, severe brain copper deficiency in Alzheimer's dementia.

artículo científico publicado en 2017

Evidence that levels of nine essential metals in post-mortem human-Alzheimer's-brain and ex vivo rat-brain tissues are unaffected by differences in post-mortem delay, age, disease staging, and brain bank location

scientific article published on 06 May 2020

Global effects of BCR/ABL and TEL/PDGFRbeta expression on the proteome and phosphoproteome: identification of the Rho pathway as a target of BCR/ABL.

artículo científico publicado en 2004

Graded perturbations of metabolism in multiple regions of human brain in Alzheimer's disease: Snapshot of a pervasive metabolic disorder

artículo científico publicado en 2016

How will haematologists use proteomics?

artículo científico publicado en 2007

Identification of elevated urea as a severe, ubiquitous metabolic defect in the brain of patients with Huntington's disease.

artículo científico publicado en 2015

Identification of nuclear protein targets for six leukemogenic tyrosine kinases governed by post-translational regulation

artículo científico publicado en 2012

Mapping the differential distribution of proteoglycan core proteins in the adult human retina, choroid, and sclera

artículo científico publicado en 2012

Mass spectrometry‐based proteomics reveals the distinct nature of the skin proteomes of photoaged compared to intrinsically aged skin

artículo científico publicado en 2019

Metabolic Dysfunction Is Restricted to the Sciatic Nerve in Experimental Diabetic Neuropathy

artículo científico publicado en 2015

Metabolite mapping reveals severe widespread perturbation of multiple metabolic processes in Huntington's disease human brain

artículo científico publicado en 2016

Multiple Reaction Monitoring to Identify Sites of Protein Phosphorylation with High Sensitivity

article

Peptide quantification using 8-plex isobaric tags and electron transfer dissociation tandem mass spectrometry

artículo científico publicado en 2009

Phosphodiesterase 5 inhibition improves contractile function and restores transverse tubule loss and catecholamine responsiveness in heart failure

artículo científico publicado en 2019

Phosphorylation of the leukemic oncoprotein EVI1 on serine 196 modulates DNA binding, transcriptional repression and transforming ability

artículo científico publicado en 2013

Plasma metals as potential biomarkers in dementia: a case-control study in patients with sporadic Alzheimer's disease.

artículo científico publicado en 2018

Proteomic analysis of primary cell lines identifies protein changes present in renal cell carcinoma

artículo científico publicado en 2006

Proteomic analysis reveals a novel mechanism induced by the leukemic oncogene Tel/PDGFRβ in stem cells: activation of the interferon response pathways

artículo científico publicado en 2010

Proteomic changes in renal cancer and co-ordinate demonstration of both the glycolytic and mitochondrial aspects of the Warburg effect

artículo científico publicado en 2003

Quantification of Proteins by iTRAQ ⬇️

artículo científico publicado el 1 de enero de 2010

Quantitative analysis of biomarkers by LC–MS/MS

Quantitative data describing the impact of the flavonol rutin on in-vivo blood-glucose and fluid-intake profiles, and survival of human-amylin transgenic mice

artículo científico publicado en 2016

Quantitative proteomic analysis using isobaric protein tags enables rapid comparison of changes in transcript and protein levels in transformed cells

artículo científico publicado en 2005

Quantitative proteomics analysis demonstrates post-transcriptional regulation of embryonic stem cell differentiation to hematopoiesis

artículo científico publicado en 2007

Quantitative proteomics reveals posttranslational control as a regulatory factor in primary hematopoietic stem cells

scientific article published on 28 February 2006

Regional protein expression in human Alzheimer's brain correlates with disease severity

Relative quantification in proteomics: new approaches for biochemistry

artículo científico publicado en 2006

Ribosome-associated nucleophosmin 1: increased expression and shuttling activity distinguishes prognostic subtypes in chronic lymphocytic leukaemia

article

Rutin suppresses human-amylin/hIAPP misfolding and oligomer formation in-vitro, and ameliorates diabetes and its impacts in human-amylin/hIAPP transgenic mice

artículo científico publicado en 2016

Serological and proteomic evaluation of antibody responses in the identification of tumor antigens in renal cell carcinoma

artículo científico publicado en 2003

Simultaneous analysis of relative protein expression levels across multiple samples using iTRAQ isobaric tags with 2D nano LC–MS/MS ⬇️

artículo científico publicado el 26 de agosto de 2010

Statistical considerations of optimal study design for human plasma proteomics and biomarker discovery

artículo científico publicado en 2012

Streaming visualisation of quantitative mass spectrometry data based on a novel raw signal decomposition method

artículo científico publicado en 2015

Systematic proteome and transcriptome analysis of stem cell populations

artículo científico publicado en 2006

Systems-level dynamic analyses of fate change in murine embryonic stem cells

artículo científico publicado en 2009

The application of a hypothesis-driven strategy to the sensitive detection and location of acetylated lysine residues.

artículo científico publicado en 2007

The application of targeted mass spectrometry-based strategies to the detection and localization of post-translational modifications

artículo científico

The potential for proteomic definition of stem cell populations

artículo científico publicado en 2003

The use of isobaric tag peptide labeling (iTRAQ) and mass spectrometry to examine rare, primitive hematopoietic cells from patients with chronic myeloid leukemia

artículo científico publicado en 2007

The use of missing values in proteomic data-independent acquisition mass spectrometry to enable disease activity discrimination

scientific article published on 01 April 2020

Urological malignancies and the proteomic-genomic interface

artículo científico publicado en 1999

Vitamin B5 (d-pantothenic acid) localizes in myelinated structures of the rat brain: Potential role for cerebral vitamin B5 stores in local myelin homeostasis

artículo científico publicado en 2019

Wellcome Trust/EBI 2009 Meeting Report - Perspectives in Stem Cell Proteomics: 22-23 March 2009, Wellcome Trust Conference Centre, Hinxton, UK.

artículo científico publicado en 2009

Lista de obras de Richard D. Unwin

A HPLC-SRM-MS based method for the detection and quantification of methotrexate in urine at doses used in clinical practice for patients with rheumatological disease: a potential measure of adherence

A label-free selected reaction monitoring workflow identifies a subset of pregnancy specific glycoproteins as potential predictive markers of early-onset pre-eclampsia

A sensitive mass spectrometric method for hypothesis-driven detection of peptide post-translational modifications: multiple reaction monitoring-initiated detection and sequencing (MIDAS).

A specific PTPRC/CD45 phosphorylation event governed by stem cell chemokine CXCL12 regulates primitive hematopoietic cell motility

Adipocyte NR1D1 dictates adipose tissue expansion during obesity

An assessment of peptide enrichment methods employing mTRAQ quantification approaches

Application of the MIDAS Approach for Analysis of Lysine Acetylation Sites

Assessment of downstream effectors of BCR/ABL protein tyrosine kinase using combined proteomic approaches

Association of plasma trace element levels with neovascular age-related macular degeneration

Cerebral Vitamin B5 (D-Pantothenic Acid) Deficiency as a Potential Cause of Metabolic Perturbation and Neurodegeneration in Huntington's Disease

Cognitive dysfunction in diabetic rats is prevented by pyridoxamine treatment. A multidisciplinary investigation

Correction: Identification of Nuclear Protein Targets for Six Leukemogenic Tyrosine Kinases Governed by Post-Translational Regulation.

Deficient copper concentrations in dried-defatted hepatic tissue from ob/ob mice: A potential model for study of defective copper regulation in metabolic liver disease.

Development and validation of a methotrexate adherence assay

Development of a selected reaction monitoring mass spectrometry-based assay to detect asparaginyl endopeptidase activity in biological fluids

Developmental fate determination and marker discovery in hematopoietic stem cell biology using proteomic fingerprinting

EVI1 carboxy-terminal phosphorylation is ATM-mediated and sustains transcriptional modulation and self-renewal via enhanced CtBP1 association

Effects of Alterations of Post-Mortem Delay and Other Tissue-Collection Variables on Metabolite Levels in Human and Rat Brain

Effects of Obesity on Perivascular Adipose Tissue Vasorelaxant Function: Nitric Oxide, Inflammation and Elevated Systemic Blood Pressure

Eight-channel iTRAQ enables comparison of the activity of six leukemogenic tyrosine kinases

Elevation of brain glucose and polyol-pathway intermediates with accompanying brain-copper deficiency in patients with Alzheimer's disease: metabolic basis for dementia.

Evidence for widespread, severe brain copper deficiency in Alzheimer's dementia.

Evidence that levels of nine essential metals in post-mortem human-Alzheimer's-brain and ex vivo rat-brain tissues are unaffected by differences in post-mortem delay, age, disease staging, and brain bank location

Global effects of BCR/ABL and TEL/PDGFRbeta expression on the proteome and phosphoproteome: identification of the Rho pathway as a target of BCR/ABL.

Graded perturbations of metabolism in multiple regions of human brain in Alzheimer's disease: Snapshot of a pervasive metabolic disorder

How will haematologists use proteomics?

Identification of elevated urea as a severe, ubiquitous metabolic defect in the brain of patients with Huntington's disease.

Identification of nuclear protein targets for six leukemogenic tyrosine kinases governed by post-translational regulation

Mapping the differential distribution of proteoglycan core proteins in the adult human retina, choroid, and sclera

Mass spectrometry‐based proteomics reveals the distinct nature of the skin proteomes of photoaged compared to intrinsically aged skin

Metabolic Dysfunction Is Restricted to the Sciatic Nerve in Experimental Diabetic Neuropathy

Metabolite mapping reveals severe widespread perturbation of multiple metabolic processes in Huntington's disease human brain

Multiple Reaction Monitoring to Identify Sites of Protein Phosphorylation with High Sensitivity

Peptide quantification using 8-plex isobaric tags and electron transfer dissociation tandem mass spectrometry

Phosphodiesterase 5 inhibition improves contractile function and restores transverse tubule loss and catecholamine responsiveness in heart failure

Phosphorylation of the leukemic oncoprotein EVI1 on serine 196 modulates DNA binding, transcriptional repression and transforming ability

Plasma metals as potential biomarkers in dementia: a case-control study in patients with sporadic Alzheimer's disease.

Proteomic analysis of primary cell lines identifies protein changes present in renal cell carcinoma

Proteomic analysis reveals a novel mechanism induced by the leukemic oncogene Tel/PDGFRβ in stem cells: activation of the interferon response pathways

Proteomic changes in renal cancer and co-ordinate demonstration of both the glycolytic and mitochondrial aspects of the Warburg effect

Quantification of Proteins by iTRAQ ⬇️

Quantitative analysis of biomarkers by LC–MS/MS

Quantitative data describing the impact of the flavonol rutin on in-vivo blood-glucose and fluid-intake profiles, and survival of human-amylin transgenic mice

Quantitative proteomic analysis using isobaric protein tags enables rapid comparison of changes in transcript and protein levels in transformed cells

Quantitative proteomics analysis demonstrates post-transcriptional regulation of embryonic stem cell differentiation to hematopoiesis

Quantitative proteomics reveals posttranslational control as a regulatory factor in primary hematopoietic stem cells

Regional protein expression in human Alzheimer's brain correlates with disease severity

Relative quantification in proteomics: new approaches for biochemistry

Ribosome-associated nucleophosmin 1: increased expression and shuttling activity distinguishes prognostic subtypes in chronic lymphocytic leukaemia

Rutin suppresses human-amylin/hIAPP misfolding and oligomer formation in-vitro, and ameliorates diabetes and its impacts in human-amylin/hIAPP transgenic mice

Serological and proteomic evaluation of antibody responses in the identification of tumor antigens in renal cell carcinoma

Simultaneous analysis of relative protein expression levels across multiple samples using iTRAQ isobaric tags with 2D nano LC–MS/MS ⬇️

Statistical considerations of optimal study design for human plasma proteomics and biomarker discovery

Streaming visualisation of quantitative mass spectrometry data based on a novel raw signal decomposition method

Systematic proteome and transcriptome analysis of stem cell populations

Systems-level dynamic analyses of fate change in murine embryonic stem cells

The application of a hypothesis-driven strategy to the sensitive detection and location of acetylated lysine residues.

The application of targeted mass spectrometry-based strategies to the detection and localization of post-translational modifications

The potential for proteomic definition of stem cell populations

The use of isobaric tag peptide labeling (iTRAQ) and mass spectrometry to examine rare, primitive hematopoietic cells from patients with chronic myeloid leukemia

The use of missing values in proteomic data-independent acquisition mass spectrometry to enable disease activity discrimination

Urological malignancies and the proteomic-genomic interface

Vitamin B5 (d-pantothenic acid) localizes in myelinated structures of the rat brain: Potential role for cerebral vitamin B5 stores in local myelin homeostasis

Wellcome Trust/EBI 2009 Meeting Report - Perspectives in Stem Cell Proteomics: 22-23 March 2009, Wellcome Trust Conference Centre, Hinxton, UK.