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Lista de obras de Paul M Stewart

11Beta-hydroxysteroid dehydrogenase type 1 and its role in the hypothalamus-pituitary-adrenal axis, metabolic syndrome, and inflammation

artículo científico publicado en 2009

11Beta-hydroxysteroid dehydrogenase type 1 in differentiating omental human preadipocytes: from de-activation to generation of cortisol

artículo científico publicado en 2002

11beta-hydroxysteroid dehydrogenase and the pre-receptor regulation of corticosteroid hormone action

artículo científico publicado en 2005

11beta-hydroxysteroid dehydrogenase type 1 activity predicts the effects of glucocorticoids on bone

artículo científico publicado en 2003

11beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle ⬇️

artículo científico publicado en 2009

11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response

artículo científico publicado en 2004

11beta-hydroxysteroid dehydrogenase: unexpected connections

artículo científico publicado en 2003

11β-HSD1 Modulates the Set Point of Brown Adipose Tissue Response to Glucocorticoids in Male Mice ⬇️

artículo científico publicado en 2017

11β-HSD1 is the major regulator of the tissue-specific effects of circulating glucocorticoid excess

artículo científico publicado en 2014

11β-Hydroxysteroid dehydrogenase 1: translational and therapeutic aspects

artículo científico

11β-Hydroxysteroid dehydrogenase blockade prevents age-induced skin structure and function defects

artículo científico publicado en 2013

11β-Hydroxysteroid dehydrogenase type 1 within muscle protects against the adverse effects of local inflammation ⬇️

artículo científico publicado en 2016

17-Hydroxylase/C17,20-lyase (CYP17) is not the enzyme responsible for side-chain cleavage of cortisol and its metabolites

artículo científico publicado en 2008

25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 exert distinct effects on human skeletal muscle function and gene expression ⬇️

artículo científico publicado en 2017

A comparative quality assessment of evidence-based clinical guidelines in endocrinology

artículo científico

A male twin infant with skull deformity and elevated neonatal 17-hydroxyprogesterone: a prismatic case of P450 oxidoreductase deficiency

artículo científico publicado en 2004

A paradigm shift in the monitoring of patients with acromegaly: last available growth hormone may overestimate risk

artículo científico publicado en 2013

A pilot randomized, single-blind, placebo-controlled trial of traditional acupuncture for vasomotor symptoms and mechanistic pathways of menopause

artículo científico publicado en 2012

A switch in dehydrogenase to reductase activity of 11 beta-hydroxysteroid dehydrogenase type 1 upon differentiation of human omental adipose stromal cells

artículo científico publicado en 2002

A switch in hepatic cortisol metabolism across the spectrum of non alcoholic fatty liver disease ⬇️

artículo científico publicado en 2012

Absence of Cushingoid phenotype in a patient with Cushing's disease due to defective cortisone to cortisol conversion

artículo científico publicado en 2002

Academic medicine: a faltering engine

artículo científico publicado en 2002

Acromegaly databases--time for European unification

artículo científico publicado en 2004

Adrenal corticosteroid biosynthesis, metabolism, and action

artículo científico publicado en 2005

Adrenal insufficiency: review of clinical outcomes with current glucocorticoid replacement therapy

artículo científico

Adrenal suppression in patients taking inhaled glucocorticoids is highly prevalent and management can be guided by morning cortisol ⬇️

artículo científico publicado en 2015

Altered SMRT levels disrupt vitamin D3 receptor signalling in prostate cancer cells

artículo científico publicado en 2004

Altered nuclear receptor corepressor expression attenuates vitamin D receptor signaling in breast cancer cells

artículo científico publicado en 2006

Analysis of the 11beta-hydroxysteroid dehydrogenase type 2 gene (HSD11B2) in human essential hypertension

artículo científico publicado en 2005

Androgen generation in adipose tissue in women with simple obesity--a site-specific role for 17beta-hydroxysteroid dehydrogenase type 5.

artículo científico publicado en 2004

Androgen receptor-mediated regulation of the alpha-subunit of the epithelial sodium channel in human kidney

artículo científico publicado en 2005

Antiproliferative signalling by 1,25(OH)2D3 in prostate and breast cancer is suppressed by a mechanism involving histone deacetylation

artículo científico publicado en 2003

Apparent mineralocorticoid excess syndrome: an overview

artículo científico publicado en 2004

Assessing the HPA axis in patients with pituitary disease: a UK survey

artículo científico publicado en 2006

Association studies between the HSD11B2 gene (encoding human 11beta-hydroxysteroid dehydrogenase type 2), type 1 diabetes mellitus and diabetic nephropathy

artículo científico publicado en 2002

Autocrine metabolism of vitamin D in normal and malignant breast tissue

artículo científico publicado en 2005

Biochemistry and physiology of hexose-6-phosphate knockout mice

artículo científico publicado en 2010

Biomarkers of hypothalamic-pituitary-adrenal axis activity in mice lacking 11β-HSD1 and H6PDH ⬇️

artículo científico publicado en 2012

Can licorice lick colon cancer?

artículo científico publicado en 2009

Case for the wider adoption of mass spectrometry-based adrenal steroid testing, and beyond.

artículo científico publicado en 2014

Cell-intrinsic regulation of murine dendritic cell function and survival by prereceptor amplification of glucocorticoid

artículo científico publicado en 2013

Cerebrospinal fluid corticosteroid levels and cortisol metabolism in patients with idiopathic intracranial hypertension: a link between 11beta-HSD1 and intracranial pressure regulation?

artículo científico publicado en 2010

Characterisation of 11beta-hydroxysteroid dehydrogenase 1 in human orbital adipose tissue: a comparison with subcutaneous and omental fat. ⬇️

artículo científico publicado en 2007

Characterisation of fibroblast-like synoviocytes from a murine model of joint inflammation ⬇️

artículo científico publicado en 2013

Characterisation of the prereceptor regulation of glucocorticoids in the anterior segment of the rabbit eye

scientific article published on 01 August 2006

Circulating cortisone levels are associated with biochemical markers of bone formation and lumbar spine BMD: the Hertfordshire Cohort Study

artículo científico publicado en 2005

Congenital adrenal hyperplasia caused by mutant P450 oxidoreductase and human androgen synthesis: analytical study

artículo científico publicado en 2004

Corticosteroid insufficiency in acutely ill patients

artículo científico publicado en 2003

Cortisol metabolism in hypertension

artículo científico publicado en 2006

Cortisol, 11 beta-hydroxysteroid dehydrogenase type 1 and central obesity

artículo científico publicado en 2002

Cortisone-reductase deficiency associated with heterozygous mutations in 11beta-hydroxysteroid dehydrogenase type 1.

artículo científico publicado en 2011

Cushing's syndrome in women with polycystic ovaries and hyperandrogenism

artículo científico publicado en 2007

Dehydroepiandrosterone exerts antiglucocorticoid action on human preadipocyte proliferation, differentiation, and glucose uptake ⬇️

artículo científico publicado en 2013

Deletion of hexose-6-phosphate dehydrogenase activates the unfolded protein response pathway and induces skeletal myopathy

artículo científico publicado en 2008

Demonstration of proof of mechanism and pharmacokinetics and pharmacodynamic relationship with 4'-cyano-biphenyl-4-sulfonic acid (6-amino-pyridin-2-yl)-amide (PF-915275), an inhibitor of 11 -hydroxysteroid dehydrogenase type 1, in cynomolgus monkeys

artículo científico publicado en 2007

Depot-specific prostaglandin synthesis in human adipose tissue: a novel possible mechanism of adipogenesis

artículo científico publicado en 2006

Diagnosis and treatment of ACTH deficiency

artículo científico publicado en 2005

Diagnosis of primary aldosteronism: from screening to subtype differentiation

artículo científico publicado en 2005

Differential expression, function and response to inflammatory stimuli of 11beta-hydroxysteroid dehydrogenase type 1 in human fibroblasts: a mechanism for tissue-specific regulation of inflammation ⬇️

artículo científico publicado en 2006

Differential glucocorticoid metabolism in patients with persistent versus resolving inflammatory arthritis ⬇️

artículo científico publicado en 2015

Diminished 11β-hydroxysteroid dehydrogenase type 2 activity is associated with decreased weight and weight gain across the first year of life

artículo científico publicado en 2014

Dissociation of serum dehydroepiandrosterone and dehydroepiandrosterone sulfate in septic shock

artículo científico publicado en 2006

Effect of spironolactone on left ventricular mass and aortic stiffness in early-stage chronic kidney disease: a randomized controlled trial.

artículo científico publicado en 2009

Effect of spironolactone on left ventricular systolic and diastolic function in patients with early stage chronic kidney disease

artículo científico publicado en 2010

Efficacy of Sandostatin LAR (long-acting somatostatin analogue) is similar in patients with untreated acromegaly and in those previously treated with surgery and/or radiotherapy

artículo científico publicado en 2004

Exploring Inpatient Hospitalizations and Morbidity in Patients With Adrenal Insufficiency

artículo científico publicado en 2016

Exploring the pathogenesis of IIH: an inflammatory perspective

scientific article published on 03 August 2008

Expression and distribution of the serum and glucocorticoid regulated kinase and the epithelial sodium channel subunits in the human cornea

artículo científico publicado en 2003

Expression and functional consequences of oestrogen and progesterone receptors in human insulinomas

artículo científico

Expression of 11β-hydroxysteroid dehydrogenase enzymes in human osteosarcoma: potential role in pathogenesis and as targets for treatments

artículo científico publicado en 2012

Expression of renal 11beta-hydroxysteroid dehydrogenase type 2 is decreased in patients with impaired renal function

artículo científico publicado en 2005

Expression profiles for steroidogenic enzymes in adrenocortical disease

artículo científico publicado en 2005

Extensive experience in the management of macroprolactinomas

artículo científico publicado en 2014

Gas chromatography/mass spectrometry (GC/MS) remains a pre-eminent discovery tool in clinical steroid investigations even in the era of fast liquid chromatography tandem mass spectrometry (LC/MS/MS).

artículo científico publicado en 2010

Gender-Specific Differences in Skeletal Muscle 11β-HSD1 Expression Across Healthy Aging

artículo científico publicado en 2015

Genotype at the P554L variant of the hexose-6 phosphate dehydrogenase gene is associated with carotid intima-medial thickness ⬇️

artículo científico publicado en 2011

Glucocorticoid modulation of insulin signaling in human subcutaneous adipose tissue

artículo científico publicado en 2007

Glucocorticoid regulation of p450 aromatase activity in human adipose tissue: gender and site differences

artículo científico publicado en 2002

Glucocorticoid-induced apoptosis in human decidua: a novel role for 11beta-hydroxysteroid dehydrogenase in late gestation

artículo científico publicado en 2007

Glucocorticoids and 11β-HSD1 are major regulators of intramyocellular protein metabolism ⬇️

artículo científico publicado en 2016

Glucocorticoids and bone mineral content in the childhood nephrotic syndrome

artículo científico publicado en 2004

Glucocorticoids fail to cause insulin resistance in human subcutaneous adipose tissue in vivo

artículo científico publicado en 2013

Health Care Burden in Patients With Adrenal Insufficiency

artículo científico publicado en 2017

Hepatic 11beta-HSD1 mRNA expression in fatty liver and nonalcoholic steatohepatitis

artículo científico publicado en 2009

Hexose-6-Phosphate Dehydrogenase Contributes to Skeletal Muscle Homeostasis Independent of 11β-Hydroxysteroid Dehydrogenase Type 1 ⬇️

artículo científico publicado el 24 de noviembre de 2010

Hexose-6-phosphate dehydrogenase confers oxo-reductase activity upon 11 beta-hydroxysteroid dehydrogenase type 1.

artículo científico publicado en 2005

Hexose-6-phosphate dehydrogenase knock-out mice lack 11 beta-hydroxysteroid dehydrogenase type 1-mediated glucocorticoid generation

artículo científico publicado en 2005

High throughput LC-MS/MS method for the simultaneous analysis of multiple vitamin D analytes in serum

artículo científico publicado en 2016

How should we rate research?

artículo científico publicado en 2006

Human Delta4-3-oxosteroid 5beta-reductase (AKR1D1) deficiency and steroid metabolism

artículo científico publicado en 2007

Hyperandrogenemia predicts metabolic phenotype in polycystic ovary syndrome: the utility of serum androstenedione

artículo científico publicado en 2014

Hypertension and the cortisol-cortisone shuttle

artículo científico publicado en 2003

Hypoglycemia with enhanced hepatic glycogen synthesis in recombinant mice lacking hexose-6-phosphate dehydrogenase

artículo científico publicado en 2007

Hypopituitarism: clinical features, diagnosis, and management

artículo científico publicado en 2008

IGF-1, IGFBP-3 and ALS in adult patients with chronic kidney disease

artículo científico publicado en 2009

Identification of VDR-responsive gene signatures in breast cancer cells

artículo científico publicado en 2006

Immediate versus modified release hydrocortisone in mitotane-treated patients with adrenocortical cancer

artículo científico publicado en 2017

Immunofluorescent visualisation of focal adhesion kinase in human skeletal muscle and its associated microvasculature.

artículo científico publicado en 2012

Impaired glucose tolerance and insulin resistance are associated with increased adipose 11beta-hydroxysteroid dehydrogenase type 1 expression and elevated hepatic 5alpha-reductase activity ⬇️

artículo científico publicado en 2008

Improving clinical research ⬇️

artículo científico publicado el 1 de noviembre de 2003

Improving outcomes in patients with adrenal insufficiency: a review of current and future treatments

artículo científico

Increased 5 alpha-reductase activity and adrenocortical drive in women with polycystic ovary syndrome

artículo científico publicado en 2009

Increased expression of mineralocorticoid effector mechanisms in kidney biopsies of patients with heavy proteinuria

artículo científico publicado en 2005

Induction of hepatic 11beta-hydroxysteroid dehydrogenase type 1 in patients with alcoholic liver disease

artículo científico publicado en 2007

Inflammatory regulation of glucocorticoid metabolism in mesenchymal stromal cells ⬇️

artículo científico publicado en 2012

Inherited forms of mineralocorticoid hypertension

artículo científico publicado en 2011

Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 activity in vivo limits glucocorticoid exposure to human adipose tissue and decreases lipolysis.

artículo científico publicado en 2007

Inhibition of 11β-HSD1 with RO5093151 for non-alcoholic fatty liver disease: a multicentre, randomised, double-blind, placebo-controlled trial

artículo científico publicado en 2014

Investigating hypertension in a young person

artículo científico publicado en 2009

Is subclinical Cushing's syndrome an entity or a statistical fallout from diagnostic testing? Consensus surrounding the diagnosis is required before optimal treatment can be defined

artículo científico publicado en 2010

Is there sufficient evidence to consider the use of 11β-hydroxysteroid dehydrogenase type 1 inhibition in children?

artículo científico

Lack of hexose-6-phosphate dehydrogenase impairs lipid mobilization from mouse adipose tissue

artículo científico publicado en 2008

Lack of significant metabolic abnormalities in mice with liver-specific disruption of 11β-hydroxysteroid dehydrogenase type 1.

artículo científico publicado en 2012

Late-onset apparent mineralocorticoid excess caused by novel compound heterozygous mutations in the HSD11B2 gene

artículo científico publicado en 2003

Long-term safety and efficacy of depot long-acting somatostatin analogs for the treatment of acromegaly

artículo científico publicado en 2002

Longitudinal changes in glucocorticoid metabolism are associated with later development of adverse metabolic phenotype

artículo científico publicado en 2014

Low energy diet and intracranial pressure in women with idiopathic intracranial hypertension: prospective cohort study ⬇️

artículo científico publicado en 2010

Low-dose growth hormone inhibits 11 beta-hydroxysteroid dehydrogenase type 1 but has no effect upon fat mass in patients with simple obesity

artículo científico publicado en 2003

Male 11β-HSD1 Knockout Mice Fed Trans-Fats and Fructose Are Not Protected From Metabolic Syndrome or Nonalcoholic Fatty Liver Disease ⬇️

artículo científico publicado en 2016

Mechanisms of disease: Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 as a novel treatment for the metabolic syndrome

artículo científico publicado en 2005

MicroRNA-24 is a novel regulator of aldosterone and cortisol production in the human adrenal cortex

artículo científico publicado en 2013

Minireview: hexose-6-phosphate dehydrogenase and redox control of 11{beta}-hydroxysteroid dehydrogenase type 1 activity

artículo científico publicado en 2005

Mitotane Therapy in Adrenocortical Cancer Induces CYP3A4 and Inhibits 5α-Reductase, Explaining the Need for Personalized Glucocorticoid and Androgen Replacement

scientific article published on 16 November 2012

Modified-Release Hydrocortisone: Is It Time to Change Clinical Practice?

artículo científico publicado en 2019

Modulation of 11beta-hydroxysteroid dehydrogenase (11betaHSD) activity biomarkers and pharmacokinetics of PF-00915275, a selective 11betaHSD1 inhibitor

artículo científico publicado en 2007

Modulation of glucocorticoid action and the treatment of type-2 diabetes

artículo científico publicado en 2007

Mortality and pituitary disease

artículo científico publicado en 2012

Mortality following pituitary radiotherapy

artículo científico publicado en 2009

Mortality in patients with Cushing's disease more than 10 years after remission: a multicentre, multinational, retrospective cohort study

artículo científico publicado en 2016

Mortality in patients with pituitary disease

artículo científico publicado en 2010

Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency

artículo científico publicado en 2003

Mutations of key hydrophobic surface residues of 11β-hydroxysteroid dehydrogenase type 1 increase solubility and monodispersity in a bacterial expression system

artículo científico publicado en 2009

No evidence for hepatic conversion of dehydroepiandrosterone (DHEA) sulfate to DHEA: in vivo and in vitro studies

artículo científico publicado en 2005

Osteoblastic 11beta-hydroxysteroid dehydrogenase type 1 activity increases with age and glucocorticoid exposure

artículo científico publicado en 2002

Outcome of Cushing's disease following transsphenoidal surgery in a single center over 20 years

artículo científico publicado en 2012

Pegvisomant: an advance in clinical efficacy in acromegaly

artículo científico publicado en 2003

Premature adrenarche: novel lessons from early onset androgen excess

artículo científico publicado en 2011

Prereceptor regulation of glucocorticoid action by 11beta-hydroxysteroid dehydrogenase: a novel determinant of cell proliferation

artículo científico publicado en 2002

Rationale for treatment and therapeutic options in Cushing's disease

scientific article published on December 2009

Reduced 11beta-hydroxysteroid dehydrogenase type 1 activity in obese boys.

artículo científico publicado en 2007

Reduced glucocorticoid production rate, decreased 5alpha-reductase activity, and adipose tissue insulin sensitization after weight loss

artículo científico publicado en 2008

Reduction of the vitamin D hormonal system in kidney disease is associated with increased renal inflammation

artículo científico publicado en 2008

Regulation of lipid metabolism by glucocorticoids and 11β-HSD1 in skeletal muscle

artículo científico publicado en 2013

Regulation of lipogenesis by glucocorticoids and insulin in human adipose tissue ⬇️

artículo científico publicado en 2011

Regulation--the real threat to clinical research.

artículo científico publicado en 2008

Renal PPARγ mRNA expression increases with impairment of renal function in patients with chronic kidney disease

artículo científico publicado en 2010

Renal TLR4 mRNA expression correlates with inflammatory marker MCP-1 and profibrotic molecule TGF-β₁ in patients with chronic kidney disease.

artículo científico publicado en 2011

SFRP2 Is Associated with Increased Adiposity and VEGF Expression ⬇️

artículo científico publicado en 2016

Saving lives of patients with adrenal insufficiency: a pan-European initiative?

artículo científico publicado en 2014

Selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 for patients with metabolic syndrome: is the target liver, fat, or both? ⬇️

artículo científico publicado en 2009

Serum- and glucocorticoid-regulated kinase isoform-1 and epithelial sodium channel subunits in human ocular ciliary epithelium

artículo científico publicado en 2003

Sex steroid metabolism in human peripheral blood mononuclear cells changes with aging

artículo científico publicado en 2005

Steroid biomarkers and genetic studies reveal inactivating mutations in hexose-6-phosphate dehydrogenase in patients with cortisone reductase deficiency

artículo científico publicado en 2008

Synovial DKK1 expression is regulated by local glucocorticoid metabolism in inflammatory arthritis ⬇️

artículo científico publicado en 2012

TNFα-mediated Hsd11b1 binding of NF-κB p65 is associated with suppression of 11β-HSD1 in muscle ⬇️

artículo científico publicado en 2014

Targeting the pre-receptor metabolism of cortisol as a novel therapy in obesity and diabetes

artículo científico publicado en 2010

The diagnosis of Cushing's syndrome: an Endocrine Society Clinical Practice Guideline

artículo científico publicado en 2008

The effect of spironolactone upon corticosteroid hormone metabolism in patients with early stage chronic kidney disease

artículo científico publicado en 2010

The hypertensiogenetic steroid 19-nor-progesterone does not influence cortisol inactivation by 11beta-hydroxysteroid dehydrogenase type 2.

artículo científico publicado en 2009

The long-term predictive accuracy of the short synacthen (corticotropin) stimulation test for assessment of the hypothalamic-pituitary-adrenal axis

artículo científico publicado en 2005

The modulation of corticosteroid metabolism by hydrocortisone therapy in patients with hypopituitarism increases tissue glucocorticoid exposure

artículo científico publicado en 2015

The ontogeny of 25-hydroxyvitamin D(3) 1alpha-hydroxylase expression in human placenta and decidua

artículo científico publicado en 2002

The pituitary-adrenal axis and body composition

artículo científico publicado en 2009

The role of 11beta-hydroxysteroid dehydrogenase 1 in adipogenesis in thyroid-associated ophthalmopathy

artículo científico publicado en 2009

The safety and tolerability of spironolactone in patients with mild to moderate chronic kidney disease

artículo científico publicado en 2012

Tissue-specific Cushing's syndrome uncovers a new target in treating the metabolic syndrome--11beta-hydroxysteroid dehydrogenase type 1.

artículo científico publicado en 2005

Tissue-specific Cushing's syndrome, 11beta-hydroxysteroid dehydrogenases and the redefinition of corticosteroid hormone action

artículo científico publicado en 2003

Treatment of primary aldosteronism

artículo científico publicado en 2010

Updates in growth hormone treatment and mortality

artículo científico publicado en 2013

Weight loss increases 11beta-hydroxysteroid dehydrogenase type 1 expression in human adipose tissue

artículo científico publicado en 2004

What happens to clinical training fellows? A retrospective study of the 20 years outcome of a Medical Research Council UK cohort ⬇️

artículo científico publicado en 2012

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