Lista de obras - Zoe Hughes - Dominio Público Uruguay

3-(Pyridin-2-yl-ethynyl)benzamide metabotropic glutamate receptor 5 negative allosteric modulators: Hit to lead studies

article

5-HT(1A) receptor antagonism reverses and prevents fluoxetine-induced sexual dysfunction in rats

artículo científico publicado en 2009

5-Piperazinyl-3-sulfonylindazoles as potent and selective 5-hydroxytryptamine-6 antagonists

artículo científico publicado en 2010

A partial noradrenergic lesion induced by DSP-4 increases extracellular noradrenaline concentration in rat frontal cortex: a microdialysis study in vivo

artículo científico publicado en 1998

Ablation of the locus coeruleus increases oxidative stress in tg-2576 transgenic but not wild-type mice.

artículo científico publicado en 2010

Altered functional brain network connectivity and glutamate system function in transgenic mice expressing truncated Disrupted-in-Schizophrenia 1

artículo científico publicado en 2015

BACE1 (beta-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes

artículo científico publicado en 2003

Central effects of urotensin-II following ICV administration in rats

artículo científico publicado en 2001

Characterisation of the selective 5-HT1B receptor antagonist SB-616234-A (1-[6-(cis-3,5-dimethylpiperazin-1-yl)-2,3-dihydro-5-methoxyindol-1-yl]-1-[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methanone hydrochloride): in vivo neurochem

artículo científico publicado en 2006

Comparison of changes in the extracellular concentration of noradrenaline in rat frontal cortex induced by sibutramine or d-amphetamine: modulation by alpha2-adrenoceptors

artículo científico publicado en 1999

Correlating efficacy in rodent cognition models with in vivo 5-hydroxytryptamine1a receptor occupancy by a novel antagonist, (R)-N-(2-methyl-(4-indolyl-1-piperazinyl)ethyl)-N-(2-pyridinyl)-cyclohexane carboxamide (WAY-101405).

artículo científico publicado en 2008

Critical data-based re-evaluation of minocycline as a putative specific microglia inhibitor.

artículo científico publicado en 2016

Development of a liquid chromatography/tandem mass spectrometry method for the quantitation of acetylcholine and related neurotransmitters in brain microdialysis samples

artículo científico publicado en 2007

Differential autoreceptor control of extracellular 5-HT in guinea pig and rat: species and regional differences

artículo científico publicado en 2003

Differentiating antidepressants of the future: efficacy and safety

artículo científico publicado en 2006

Effects of a Balanced Translocation between Chromosomes 1 and 11 Disrupting the DISC1 Locus on White Matter Integrity

artículo científico publicado en 2015

Effects of atomoxetine and methylphenidate on attention and impulsivity in the 5-choice serial reaction time test

artículo científico publicado en 2007

Evidence for sustained elevation of IL-6 in the CNS as a key contributor of depressive-like phenotypes.

artículo científico publicado en 2012

Evidence from microdialysis and synaptosomal studies of rat cortex for noradrenaline uptake sites with different sensitivities to SSRIs ⬇️

artículo científico publicado el 1 de julio de 1998

Flow cytometric analysis of BrdU incorporation as a high-throughput method for measuring adult neurogenesis in the mouse

artículo científico publicado en 2008

Future Viable Models of Psychiatry Drug Discovery in Pharma ⬇️

artículo científico publicado el 7 de febrero de 2013

High-performance liquid chromatography/tandem mass spectrometry assay for the rapid high sensitivity measurement of basal acetylcholine from microdialysates

artículo científico publicado en 2002

Histidine decarboxylase deficiency causes tourette syndrome: parallel findings in humans and mice

artículo científico publicado en 2014

In vivo characterization of basal amino acid levels in subregions of the rat nucleus accumbens: effect of a dopamine D(3)/D(2) agonist

artículo científico publicado en 2001

Increased noradrenaline efflux induced by local infusion of fluoxetine in the rat frontal cortex

artículo científico publicado en 1996

Increased responsiveness of dopamine to atypical, but not typical antipsychotics in the medial prefrontal cortex of rats reared in isolation

artículo científico publicado en 2001

Innovations in CNS drug discovery: differentiating strategies to treat depression ⬇️

artículo científico publicado el 1 de octubre de 2007

Innovative approaches for the development of antidepressant drugs: current and future strategies

artículo científico publicado en 2005

LPA1 receptor-deficient mice have phenotypic changes observed in psychiatric disease

artículo científico publicado en 2003

Negative allosteric modulation of metabotropic glutamate receptor 5 results in broad spectrum activity relevant to treatment resistant depression.

artículo científico publicado en 2012

Neurochemical changes in LPA1 receptor deficient mice--a putative model of schizophrenia

artículo científico publicado en 2005

Neurochemical evaluation of the novel 5-HT1A receptor partial agonist/serotonin reuptake inhibitor, vilazodone.

artículo científico publicado en 2005

PDE4B as a microglia target to reduce neuroinflammation.

artículo científico publicado en 2016

Pharmacological disruption of mouse social approach behavior: relevance to negative symptoms of schizophrenia

artículo científico publicado en 2013

Prefrontal Cortical Kappa Opioid Receptors Attenuate Responses to Amygdala Inputs.

artículo científico publicado en 2015

Receptor and behavioral pharmacology of WAY-267464, a non-peptide oxytocin receptor agonist

artículo científico publicado en 2010

Simultaneous blockade of 5-HT1A/B receptors and 5-HT transporters results in acute increases in extracellular 5-HT in both rats and guinea pigs: in vivo characterization of the novel 5-HT1A/B receptor antagonist/5-HT transport inhibitor SB-649915-B.

artículo científico publicado en 2007

Temporal dysregulation of cortical gene expression in the isolation reared Wistar rat.

artículo científico publicado en 2010

The BTBR Mouse Model of Autism Spectrum Disorders Has Learning and Attentional Impairments and Alterations in Acetylcholine and Kynurenic Acid in Prefrontal Cortex ⬇️

artículo científico publicado el 24 de abril de 2013

The metabotropic glutamate receptor 7 allosteric modulator AMN082: a monoaminergic agent in disguise?

artículo científico publicado en 2011

The orphan GPCR, GPR88, modulates function of the striatal dopamine system: a possible therapeutic target for psychiatric disorders?

artículo científico publicado en 2009

The synthesis and biological evaluation of quinolyl-piperazinyl piperidines as potent serotonin 5-HT1A antagonists

artículo científico publicado en 2010

Use of Arc expression as a molecular marker of increased postsynaptic 5-HT function after SSRI/5-HT1A receptor antagonist co-administration

artículo científico publicado en 2003

WAY-200070, a selective agonist of estrogen receptor beta as a potential novel anxiolytic/antidepressant agent

artículo científico publicado en 2008

WAY-318068: a novel, potent and selective noradrenaline re-uptake inhibitor with activity in rodent models of pain and depression

artículo científico publicado en 2010

WS-50030 [7-{4-[3-(1H-inden-3-yl)propyl]piperazin-1-yl}-1,3-benzoxazol-2(3H)-one]: a novel dopamine D2 receptor partial agonist/serotonin reuptake inhibitor with preclinical antipsychotic-like and antidepressant-like activity

artículo científico publicado en 2009

Lista de obras de Zoe Hughes

3-(Pyridin-2-yl-ethynyl)benzamide metabotropic glutamate receptor 5 negative allosteric modulators: Hit to lead studies

5-HT(1A) receptor antagonism reverses and prevents fluoxetine-induced sexual dysfunction in rats

5-Piperazinyl-3-sulfonylindazoles as potent and selective 5-hydroxytryptamine-6 antagonists

A partial noradrenergic lesion induced by DSP-4 increases extracellular noradrenaline concentration in rat frontal cortex: a microdialysis study in vivo

Ablation of the locus coeruleus increases oxidative stress in tg-2576 transgenic but not wild-type mice.

Altered functional brain network connectivity and glutamate system function in transgenic mice expressing truncated Disrupted-in-Schizophrenia 1

BACE1 (beta-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes

Central effects of urotensin-II following ICV administration in rats

Characterisation of the selective 5-HT1B receptor antagonist SB-616234-A (1-[6-(cis-3,5-dimethylpiperazin-1-yl)-2,3-dihydro-5-methoxyindol-1-yl]-1-[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methanone hydrochloride): in vivo neurochem

Comparison of changes in the extracellular concentration of noradrenaline in rat frontal cortex induced by sibutramine or d-amphetamine: modulation by alpha2-adrenoceptors

Correlating efficacy in rodent cognition models with in vivo 5-hydroxytryptamine1a receptor occupancy by a novel antagonist, (R)-N-(2-methyl-(4-indolyl-1-piperazinyl)ethyl)-N-(2-pyridinyl)-cyclohexane carboxamide (WAY-101405).

Critical data-based re-evaluation of minocycline as a putative specific microglia inhibitor.

Development of a liquid chromatography/tandem mass spectrometry method for the quantitation of acetylcholine and related neurotransmitters in brain microdialysis samples

Differential autoreceptor control of extracellular 5-HT in guinea pig and rat: species and regional differences

Differentiating antidepressants of the future: efficacy and safety

Effects of a Balanced Translocation between Chromosomes 1 and 11 Disrupting the DISC1 Locus on White Matter Integrity

Effects of atomoxetine and methylphenidate on attention and impulsivity in the 5-choice serial reaction time test

Evidence for sustained elevation of IL-6 in the CNS as a key contributor of depressive-like phenotypes.

Evidence from microdialysis and synaptosomal studies of rat cortex for noradrenaline uptake sites with different sensitivities to SSRIs ⬇️

Flow cytometric analysis of BrdU incorporation as a high-throughput method for measuring adult neurogenesis in the mouse

Future Viable Models of Psychiatry Drug Discovery in Pharma ⬇️

High-performance liquid chromatography/tandem mass spectrometry assay for the rapid high sensitivity measurement of basal acetylcholine from microdialysates

Histidine decarboxylase deficiency causes tourette syndrome: parallel findings in humans and mice

In vivo characterization of basal amino acid levels in subregions of the rat nucleus accumbens: effect of a dopamine D(3)/D(2) agonist

Increased noradrenaline efflux induced by local infusion of fluoxetine in the rat frontal cortex

Increased responsiveness of dopamine to atypical, but not typical antipsychotics in the medial prefrontal cortex of rats reared in isolation

Innovations in CNS drug discovery: differentiating strategies to treat depression ⬇️

Innovative approaches for the development of antidepressant drugs: current and future strategies

LPA1 receptor-deficient mice have phenotypic changes observed in psychiatric disease

Negative allosteric modulation of metabotropic glutamate receptor 5 results in broad spectrum activity relevant to treatment resistant depression.

Neurochemical changes in LPA1 receptor deficient mice--a putative model of schizophrenia

Neurochemical evaluation of the novel 5-HT1A receptor partial agonist/serotonin reuptake inhibitor, vilazodone.

PDE4B as a microglia target to reduce neuroinflammation.

Pharmacological disruption of mouse social approach behavior: relevance to negative symptoms of schizophrenia

Prefrontal Cortical Kappa Opioid Receptors Attenuate Responses to Amygdala Inputs.

Receptor and behavioral pharmacology of WAY-267464, a non-peptide oxytocin receptor agonist

Simultaneous blockade of 5-HT1A/B receptors and 5-HT transporters results in acute increases in extracellular 5-HT in both rats and guinea pigs: in vivo characterization of the novel 5-HT1A/B receptor antagonist/5-HT transport inhibitor SB-649915-B.

Temporal dysregulation of cortical gene expression in the isolation reared Wistar rat.

The BTBR Mouse Model of Autism Spectrum Disorders Has Learning and Attentional Impairments and Alterations in Acetylcholine and Kynurenic Acid in Prefrontal Cortex ⬇️

The metabotropic glutamate receptor 7 allosteric modulator AMN082: a monoaminergic agent in disguise?

The orphan GPCR, GPR88, modulates function of the striatal dopamine system: a possible therapeutic target for psychiatric disorders?

The synthesis and biological evaluation of quinolyl-piperazinyl piperidines as potent serotonin 5-HT1A antagonists

Use of Arc expression as a molecular marker of increased postsynaptic 5-HT function after SSRI/5-HT1A receptor antagonist co-administration

WAY-200070, a selective agonist of estrogen receptor beta as a potential novel anxiolytic/antidepressant agent

WAY-318068: a novel, potent and selective noradrenaline re-uptake inhibitor with activity in rodent models of pain and depression

WS-50030 [7-{4-[3-(1H-inden-3-yl)propyl]piperazin-1-yl}-1,3-benzoxazol-2(3H)-one]: a novel dopamine D2 receptor partial agonist/serotonin reuptake inhibitor with preclinical antipsychotic-like and antidepressant-like activity