Lista de obras - Manuel D. Gahete - Dominio Público Uruguay

A Somatostatin Receptor Subtype-3 (SST3) Peptide Agonist Shows Antitumor Effects in Experimental Models of Nonfunctioning Pituitary Tumors

scientific article published on 17 October 2019

A cellular and molecular basis for the selective desmopressin-induced ACTH release in Cushing disease patients: key role of AVPR1b receptor and potential therapeutic implications

artículo científico publicado en 2013

A novel human ghrelin variant (In1-ghrelin) and ghrelin-O-acyltransferase are overexpressed in breast cancer: potential pathophysiological relevance

artículo científico publicado en 2011

A potential inhibitory role for the new truncated variant of somatostatin receptor 5, sst5TMD4, in pituitary adenomas poorly responsive to somatostatin analogs

artículo científico publicado en 2010

Adiponectin in mice with altered GH action: links to insulin sensitivity and longevity?

scientific article published on 25 February 2013

Association between radiological parameters and clinical and molecular characteristics in human somatotropinomas

artículo científico publicado en 2018

BIM-23A760 influences key functional endpoints in pituitary adenomas and normal pituitaries: molecular mechanisms underlying the differential response in adenomas

artículo científico publicado en 2017

Biguanides exert antitumoral actions in pituitary tumor cells through AMPK-dependent and -independent mechanisms

artículo científico publicado en 2019

Breast cancer is associated to impaired glucose/insulin homeostasis in premenopausal obese/overweight patients.

artículo científico publicado en 2017

Changes in Splicing Machinery Components Influence, Precede, and Early Predict the Development of Type 2 Diabetes: From the CORDIOPREV Study

artículo científico publicado en 2018

Clinical Utility of Ghrelin-O-Acyltransferase (GOAT) Enzyme as a Diagnostic Tool and Potential Therapeutic Target in Prostate Cancer

scientific article published on 22 November 2019

Clinical and functional implication of the components of somatostatin system in gastroenteropancreatic neuroendocrine tumors.

artículo científico publicado en 2017

Cortistatin is not a somatostatin analogue but stimulates prolactin release and inhibits GH and ACTH in a gender-dependent fashion: potential role of ghrelin.

artículo científico publicado en 2011

Dietary Intervention Modulates the Expression of Splicing Machinery in Cardiovascular Patients at High Risk of Type 2 Diabetes Development: From the CORDIOPREV Study

artículo científico publicado en 2020

Dietary fat alters the expression of cortistatin and ghrelin systems in the PBMCs of elderly subjects: putative implications in the postprandial inflammatory response

artículo científico publicado en 2014

Differential impact of selective GH deficiency and endogenous GH excess on insulin-mediated actions in muscle and liver of male mice.

artículo científico publicado en 2014

Does the pituitary somatotrope play a primary role in regulating GH output in metabolic extremes?

artículo científico publicado en 2011

Dysregulated splicing factor SF3B1 unveils a dual therapeutic vulnerability to target pancreatic cancer cells and cancer stem cells with an anti-splicing drug

artículo científico publicado en 2021

Dysregulation of the Splicing Machinery Is Associated to the Development of Nonalcoholic Fatty Liver Disease

artículo científico publicado en 2019

Dysregulation of the splicing machinery is directly associated to aggressiveness of prostate cancer

scientific article published on 03 January 2020

Elevated GH/IGF-I promotes mammary tumors in high-fat, but not low-fat, fed mice

artículo científico publicado en 2014

Elevated GH/IGF-I, due to somatotrope-specific loss of both IGF-I and insulin receptors, alters glucose homeostasis and insulin sensitivity in a diet-dependent manner

artículo científico publicado en 2011

Endogenous somatostatin is critical in regulating the acute effects of L-arginine on growth hormone and insulin release in mice.

artículo científico publicado en 2013

Evidence that endogenous SST inhibits ACTH and ghrelin expression by independent pathways.

artículo científico publicado en 2006

Examination of the direct effects of metabolic factors on somatotrope function in a non-human primate model, Papio anubis.

artículo científico publicado en 2006

Expression of Somatostatin, cortistatin, and their receptors, as well as dopamine receptors, but not of neprilysin, are reduced in the temporal lobe of Alzheimer's disease patients.

artículo científico publicado en 2010

Expression of functional KISS1 and KISS1R system is altered in human pituitary adenomas: evidence for apoptotic action of kisspeptin-10

artículo científico publicado en 2010

Expression of the ghrelin and neurotensin systems is altered in the temporal lobe of Alzheimer's disease patients.

artículo científico publicado en 2010

Fasting modulates GH/IGF-I axis and its regulatory systems in the mammary gland of female mice: Influence of endogenous cortistatin.

artículo científico publicado en 2016

Ghrelin O-acyltransferase (GOAT) enzyme is overexpressed in prostate cancer, and its levels are associated with patient's metabolic status: Potential value as a non-invasive biomarker.

artículo científico publicado en 2016

Ghrelin gene products, receptors, and GOAT enzyme: biological and pathophysiological insight.

artículo científico

Ghrelin-O-Acyltransferase (GOAT) Enzyme as a Novel Potential Biomarker in Gastroenteropancreatic Neuroendocrine Tumors

scientific article published on 08 October 2018

Homologous and heterologous in vitro regulation of pituitary receptors for somatostatin, growth hormone (GH)-releasing hormone, and ghrelin in a nonhuman primate (Papio anubis).

artículo científico publicado en 2011

Identification and characterization of two novel truncated but functional isoforms of the somatostatin receptor subtype 5 differentially present in pituitary tumors

artículo científico publicado en 2009

Identification of a mouse ghrelin gene transcript that contains intron 2 and is regulated in the pituitary and hypothalamus in response to metabolic stress.

artículo científico publicado en 2007

In1-ghrelin splicing variant is associated with reduced disease-free survival of breast cancer patients and increases malignancy of breast cancer cells lines

artículo científico publicado en 2017

In1-ghrelin splicing variant is overexpressed in pituitary adenomas and increases their aggressive features.

artículo científico publicado en 2015

In1-ghrelin, a splice variant of ghrelin gene, is associated with the evolution and aggressiveness of human neuroendocrine tumors: Evidence from clinical, cellular and molecular parameters

artículo científico publicado en 2015

Insulin and IGF-I inhibit GH synthesis and release in vitro and in vivo by separate mechanisms.

artículo científico publicado en 2013

Islet insulin content and release are increased in male mice with elevated endogenous GH and IGF-I, without evidence of systemic insulin resistance or alterations in β-cell mass.

artículo científico publicado en 2015

Kisspeptin regulates gonadotroph and somatotroph function in nonhuman primate pituitary via common and distinct signaling mechanisms

artículo científico publicado en 2011

Lack of cortistatin or somatostatin differentially influences DMBA-induced mammary gland tumorigenesis in mice in an obesity-dependent mode.

artículo científico publicado en 2016

Long- but not short-term adult-onset, isolated GH deficiency in male mice leads to deterioration of β-cell function, which cannot be accounted for by changes in β-cell mass.

artículo científico publicado en 2013

Melatonin regulates somatotrope and lactotrope function through common and distinct signaling pathways in cultured primary pituitary cells from female primates

artículo científico publicado en 2014

Metabolic regulation of ghrelin O-acyl transferase (GOAT) expression in the mouse hypothalamus, pituitary, and stomach.

artículo científico publicado en 2009

Metformin Reduces Prostate Tumor Growth, in a Diet-Dependent Manner, by Modulating Multiple Signaling Pathways

artículo científico publicado en 2017

Mitochondrial-driven ubiquinone enhances extracellular calcium-dependent nitric oxide production and reduces glycochenodeoxycholic acid-induced cell death in hepatocytes

artículo científico publicado en 2009

Models of GH deficiency in animal studies.

artículo científico publicado en 2016

Mouse models in endocrine tumors

scientific article published on 01 November 2018

Multilayered heterogeneity as an intrinsic hallmark of neuroendocrine tumors

article

Multiple signaling pathways convey central and peripheral signals to regulate pituitary function: Lessons from human and non-human primate models.

artículo científico publicado en 2017

Not So Giants: Mice Lacking Both Somatostatin and Cortistatin Have High GH Levels but Show No Changes in Growth Rate or IGF-1 Levels

artículo científico publicado en 2015

Obesity alters gene expression for GH/IGF-I axis in mouse mammary fat pads: differential role of cortistatin and somatostatin

artículo científico publicado en 2015

Obesity and metabolic dysfunction severely influence prostate cell function: role of insulin and IGF1.

artículo científico publicado en 2017

Obesity- and gender-dependent role of endogenous somatostatin and cortistatin in the regulation of endocrine and metabolic homeostasis in mice

artículo científico publicado en 2016

Obestatin plays an opposite role in the regulation of pituitary somatotrope and corticotrope function in female primates and male/female mice.

artículo científico publicado en 2014

Octreotide and pasireotide (dis)similarly inhibit pituitary tumor cells in vitro.

artículo científico publicado en 2016

Oncogenic Role of Secreted Engrailed Homeobox 2 (EN2) in Prostate Cancer

scientific article published on 06 September 2019

Peptides derived from the extracellular domain of the somatostatin receptor splicing variant SST5TMD4 increase malignancy in multiple cancer cell types

artículo científico publicado en 2019

Peripubertal-onset but not adult-onset obesity increases IGF-I and drives development of lean mass, which may lessen the metabolic impairment in adult obesity ⬇️

artículo científico publicado el 28 de agosto de 2012

Plasma ghrelin O-acyltransferase (GOAT) enzyme levels: A novel non-invasive diagnosis tool for patients with significant prostate cancer

artículo científico publicado en 2018

Porcine sst1 can physically interact with other somatostatin receptors, and its expression is regulated by metabolic/inflammatory sensors.

artículo científico publicado en 2013

Presence of sst5TMD4, a truncated splice variant of the somatostatin receptor subtype 5, is associated to features of increased aggressiveness in pancreatic neuroendocrine tumors.

artículo científico publicado en 2015

Resistin regulates pituitary somatotrope cell function through the activation of multiple signaling pathways.

artículo científico publicado en 2009

Role of endogenous cortistatin in the regulation of ghrelin system expression at pancreatic level under normal and obese conditions

artículo científico publicado en 2013

Role of ghrelin system in neuroprotection and cognitive functions: implications in Alzheimer's disease.

artículo científico publicado en 2011

Role of the Kiss1/Kiss1r system in the regulation of pituitary cell function.

artículo científico publicado en 2016

SF3B1 inhibition disrupts malignancy and prolongs survival in glioblastoma patients through BCL2L1 splicing and mTOR/ß-catenin pathways imbalances

artículo científico publicado en 2022

Somatostatin and its receptors contribute in a tissue-specific manner to the sex-dependent metabolic (fed/fasting) control of growth hormone axis in mice ⬇️

artículo científico publicado el 13 de octubre de 2010

Somatostatin and its receptors from fish to mammals.

artículo científico publicado en 2010

Somatostatin dramatically stimulates growth hormone release from primate somatotrophs acting at low doses via somatostatin receptor 5 and cyclic AMP.

artículo científico publicado en 2012

Somatostatin receptor subtype 1 as a potential diagnostic marker and therapeutic target in prostate cancer.

artículo científico publicado en 2017

Somatotroph tumor progression during pegvisomant therapy: a clinical and molecular study.

artículo científico publicado en 2010

Spliceosome component SF3B1 as novel prognostic biomarker and therapeutic target for prostate cancer

artículo científico publicado en 2019

Splicing Machinery is Dysregulated in Pituitary Neuroendocrine Tumors and is Associated with Aggressiveness Features

scientific article published on 26 September 2019

Statins directly regulate pituitary cell function and exert antitumor effects in pituitary tumors

artículo científico publicado en 2020

The Pituitary Gland is a Novel Major Site of Action of Metformin in Non-Human Primates: a Potential Path to Expand and Integrate Its Metabolic Actions

artículo científico publicado en 2018

The components of somatostatin and ghrelin systems are altered in neuroendocrine lung carcinoids and associated to clinical-histological features.

artículo científico publicado en 2017

The expression of the truncated isoform of somatostatin receptor subtype 5 associates with aggressiveness in medullary thyroid carcinoma cells

artículo científico publicado en 2015

The long non-coding RNA GHSROS reprograms prostate cancer cell lines toward a more aggressive phenotype

artículo científico publicado en 2021

The oncogenic role of the In1-ghrelin splicing variant in prostate cancer aggressiveness

artículo científico publicado en 2017

The oncogenic role of the spliced somatostatin receptor sst5TMD4 variant in prostate cancer.

artículo científico publicado en 2017

The rise in growth hormone during starvation does not serve to maintain glucose levels or lean mass but is required for appropriate adipose tissue response in female mice

artículo científico publicado en 2012

The truncated isoform of somatostatin receptor5 (sst5TMD4) is associated with poorly differentiated thyroid cancer

artículo científico publicado en 2014

The truncated somatostatin receptor sst5TMD4 stimulates the angiogenic process and is associated to lymphatic metastasis and disease-free survival in breast cancer patients

artículo científico publicado en 2016

Truncated somatostatin receptor variant sst5TMD4 confers aggressive features (proliferation, invasion and reduced octreotide response) to somatotropinomas

artículo científico publicado en 2015

Truncated somatostatin receptors as new players in somatostatin–cortistatin pathophysiology ⬇️

artículo científico publicado el 1 de marzo de 2011

Truncated variants of pig somatostatin receptor subtype 5 (sst5) act as dominant-negative modulators for sst2-mediated signaling.

artículo científico publicado en 2012

Type 2 Diabetes in Neuroendocrine Tumors: Are Biguanides and Statins Part of the Solution?

artículo científico publicado en 2019

Understanding the multifactorial control of growth hormone release by somatotropes: lessons from comparative endocrinology.

artículo científico publicado en 2009

Unleashing the Diagnostic, Prognostic and Therapeutic Potential of the Neuronostatin/GPR107 System in Prostate Cancer

scientific article published on 02 June 2020

Urotensin II and urotensin II-related peptide activate somatostatin receptor subtypes 2 and 5.

artículo científico publicado en 2008

Lista de obras de Manuel D. Gahete

A Somatostatin Receptor Subtype-3 (SST3) Peptide Agonist Shows Antitumor Effects in Experimental Models of Nonfunctioning Pituitary Tumors

A cellular and molecular basis for the selective desmopressin-induced ACTH release in Cushing disease patients: key role of AVPR1b receptor and potential therapeutic implications

A novel human ghrelin variant (In1-ghrelin) and ghrelin-O-acyltransferase are overexpressed in breast cancer: potential pathophysiological relevance

A potential inhibitory role for the new truncated variant of somatostatin receptor 5, sst5TMD4, in pituitary adenomas poorly responsive to somatostatin analogs

Adiponectin in mice with altered GH action: links to insulin sensitivity and longevity?

Association between radiological parameters and clinical and molecular characteristics in human somatotropinomas

BIM-23A760 influences key functional endpoints in pituitary adenomas and normal pituitaries: molecular mechanisms underlying the differential response in adenomas

Biguanides exert antitumoral actions in pituitary tumor cells through AMPK-dependent and -independent mechanisms

Breast cancer is associated to impaired glucose/insulin homeostasis in premenopausal obese/overweight patients.

Changes in Splicing Machinery Components Influence, Precede, and Early Predict the Development of Type 2 Diabetes: From the CORDIOPREV Study

Clinical Utility of Ghrelin-O-Acyltransferase (GOAT) Enzyme as a Diagnostic Tool and Potential Therapeutic Target in Prostate Cancer

Clinical and functional implication of the components of somatostatin system in gastroenteropancreatic neuroendocrine tumors.

Cortistatin is not a somatostatin analogue but stimulates prolactin release and inhibits GH and ACTH in a gender-dependent fashion: potential role of ghrelin.

Dietary Intervention Modulates the Expression of Splicing Machinery in Cardiovascular Patients at High Risk of Type 2 Diabetes Development: From the CORDIOPREV Study

Dietary fat alters the expression of cortistatin and ghrelin systems in the PBMCs of elderly subjects: putative implications in the postprandial inflammatory response

Differential impact of selective GH deficiency and endogenous GH excess on insulin-mediated actions in muscle and liver of male mice.

Does the pituitary somatotrope play a primary role in regulating GH output in metabolic extremes?

Dysregulated splicing factor SF3B1 unveils a dual therapeutic vulnerability to target pancreatic cancer cells and cancer stem cells with an anti-splicing drug

Dysregulation of the Splicing Machinery Is Associated to the Development of Nonalcoholic Fatty Liver Disease

Dysregulation of the splicing machinery is directly associated to aggressiveness of prostate cancer

Elevated GH/IGF-I promotes mammary tumors in high-fat, but not low-fat, fed mice

Elevated GH/IGF-I, due to somatotrope-specific loss of both IGF-I and insulin receptors, alters glucose homeostasis and insulin sensitivity in a diet-dependent manner

Endogenous somatostatin is critical in regulating the acute effects of L-arginine on growth hormone and insulin release in mice.

Evidence that endogenous SST inhibits ACTH and ghrelin expression by independent pathways.

Examination of the direct effects of metabolic factors on somatotrope function in a non-human primate model, Papio anubis.

Expression of Somatostatin, cortistatin, and their receptors, as well as dopamine receptors, but not of neprilysin, are reduced in the temporal lobe of Alzheimer's disease patients.

Expression of functional KISS1 and KISS1R system is altered in human pituitary adenomas: evidence for apoptotic action of kisspeptin-10

Expression of the ghrelin and neurotensin systems is altered in the temporal lobe of Alzheimer's disease patients.

Fasting modulates GH/IGF-I axis and its regulatory systems in the mammary gland of female mice: Influence of endogenous cortistatin.

Ghrelin O-acyltransferase (GOAT) enzyme is overexpressed in prostate cancer, and its levels are associated with patient's metabolic status: Potential value as a non-invasive biomarker.

Ghrelin gene products, receptors, and GOAT enzyme: biological and pathophysiological insight.

Ghrelin-O-Acyltransferase (GOAT) Enzyme as a Novel Potential Biomarker in Gastroenteropancreatic Neuroendocrine Tumors

Homologous and heterologous in vitro regulation of pituitary receptors for somatostatin, growth hormone (GH)-releasing hormone, and ghrelin in a nonhuman primate (Papio anubis).

Identification and characterization of two novel truncated but functional isoforms of the somatostatin receptor subtype 5 differentially present in pituitary tumors

Identification of a mouse ghrelin gene transcript that contains intron 2 and is regulated in the pituitary and hypothalamus in response to metabolic stress.

In1-ghrelin splicing variant is associated with reduced disease-free survival of breast cancer patients and increases malignancy of breast cancer cells lines

In1-ghrelin splicing variant is overexpressed in pituitary adenomas and increases their aggressive features.

In1-ghrelin, a splice variant of ghrelin gene, is associated with the evolution and aggressiveness of human neuroendocrine tumors: Evidence from clinical, cellular and molecular parameters

Insulin and IGF-I inhibit GH synthesis and release in vitro and in vivo by separate mechanisms.

Islet insulin content and release are increased in male mice with elevated endogenous GH and IGF-I, without evidence of systemic insulin resistance or alterations in β-cell mass.

Kisspeptin regulates gonadotroph and somatotroph function in nonhuman primate pituitary via common and distinct signaling mechanisms

Lack of cortistatin or somatostatin differentially influences DMBA-induced mammary gland tumorigenesis in mice in an obesity-dependent mode.

Long- but not short-term adult-onset, isolated GH deficiency in male mice leads to deterioration of β-cell function, which cannot be accounted for by changes in β-cell mass.

Melatonin regulates somatotrope and lactotrope function through common and distinct signaling pathways in cultured primary pituitary cells from female primates

Metabolic regulation of ghrelin O-acyl transferase (GOAT) expression in the mouse hypothalamus, pituitary, and stomach.

Metformin Reduces Prostate Tumor Growth, in a Diet-Dependent Manner, by Modulating Multiple Signaling Pathways

Mitochondrial-driven ubiquinone enhances extracellular calcium-dependent nitric oxide production and reduces glycochenodeoxycholic acid-induced cell death in hepatocytes

Models of GH deficiency in animal studies.

Mouse models in endocrine tumors

Multilayered heterogeneity as an intrinsic hallmark of neuroendocrine tumors

Multiple signaling pathways convey central and peripheral signals to regulate pituitary function: Lessons from human and non-human primate models.

Not So Giants: Mice Lacking Both Somatostatin and Cortistatin Have High GH Levels but Show No Changes in Growth Rate or IGF-1 Levels

Obesity alters gene expression for GH/IGF-I axis in mouse mammary fat pads: differential role of cortistatin and somatostatin

Obesity and metabolic dysfunction severely influence prostate cell function: role of insulin and IGF1.

Obesity- and gender-dependent role of endogenous somatostatin and cortistatin in the regulation of endocrine and metabolic homeostasis in mice

Obestatin plays an opposite role in the regulation of pituitary somatotrope and corticotrope function in female primates and male/female mice.

Octreotide and pasireotide (dis)similarly inhibit pituitary tumor cells in vitro.

Oncogenic Role of Secreted Engrailed Homeobox 2 (EN2) in Prostate Cancer

Peptides derived from the extracellular domain of the somatostatin receptor splicing variant SST5TMD4 increase malignancy in multiple cancer cell types

Peripubertal-onset but not adult-onset obesity increases IGF-I and drives development of lean mass, which may lessen the metabolic impairment in adult obesity ⬇️

Plasma ghrelin O-acyltransferase (GOAT) enzyme levels: A novel non-invasive diagnosis tool for patients with significant prostate cancer

Porcine sst1 can physically interact with other somatostatin receptors, and its expression is regulated by metabolic/inflammatory sensors.

Presence of sst5TMD4, a truncated splice variant of the somatostatin receptor subtype 5, is associated to features of increased aggressiveness in pancreatic neuroendocrine tumors.

Resistin regulates pituitary somatotrope cell function through the activation of multiple signaling pathways.

Role of endogenous cortistatin in the regulation of ghrelin system expression at pancreatic level under normal and obese conditions

Role of ghrelin system in neuroprotection and cognitive functions: implications in Alzheimer's disease.

Role of the Kiss1/Kiss1r system in the regulation of pituitary cell function.

SF3B1 inhibition disrupts malignancy and prolongs survival in glioblastoma patients through BCL2L1 splicing and mTOR/ß-catenin pathways imbalances

Somatostatin and its receptors contribute in a tissue-specific manner to the sex-dependent metabolic (fed/fasting) control of growth hormone axis in mice ⬇️

Somatostatin and its receptors from fish to mammals.

Somatostatin dramatically stimulates growth hormone release from primate somatotrophs acting at low doses via somatostatin receptor 5 and cyclic AMP.

Somatostatin receptor subtype 1 as a potential diagnostic marker and therapeutic target in prostate cancer.

Somatotroph tumor progression during pegvisomant therapy: a clinical and molecular study.

Spliceosome component SF3B1 as novel prognostic biomarker and therapeutic target for prostate cancer

Splicing Machinery is Dysregulated in Pituitary Neuroendocrine Tumors and is Associated with Aggressiveness Features

Statins directly regulate pituitary cell function and exert antitumor effects in pituitary tumors

The Pituitary Gland is a Novel Major Site of Action of Metformin in Non-Human Primates: a Potential Path to Expand and Integrate Its Metabolic Actions

The components of somatostatin and ghrelin systems are altered in neuroendocrine lung carcinoids and associated to clinical-histological features.

The expression of the truncated isoform of somatostatin receptor subtype 5 associates with aggressiveness in medullary thyroid carcinoma cells