Lista de obras - Pavel Gershkovich - Dominio Público Uruguay

A novel nucleoside rescue metabolic pathway may be responsible for therapeutic effect of orally administered cordycepin

artículo científico publicado en 2019

A novel tropically stable oral amphotericin B formulation (iCo-010) exhibits efficacy against visceral Leishmaniasis in a murine model.

artículo científico publicado en 2010

A review of the application of lipid-based systems in systemic, dermal/ transdermal, and ocular drug delivery.

scientific article published on January 2008

A simple and sensitive method for determination of vitamins D3 and K1 in rat plasma: application for an in vivo pharmacokinetic study.

artículo científico publicado en 2013

Analytical ultracentrifugation in saliva research: Impact of green tea astringency and its significance on the in-vivo aroma release

artículo científico publicado en 2018

Application of biorelevant saliva-based dissolution for optimisation of orally disintegrating formulations of felodipine

artículo científico publicado en 2018

Assessment of cholesterol absorption inhibitors nanostructured aluminosilicate and cholestyramine using in vitro lipolysis model

artículo científico publicado en 2011

Assessment of novel oral lipid-based formulations of amphotericin B using an in vitro lipolysis model.

artículo científico publicado en 2012

Biodistribution and tissue toxicity of amphotericin B in mice following multiple dose administration of a novel oral lipid-based formulation (iCo-009).

artículo científico publicado en 2010

Cardiac glycoside cerberin exerts anticancer activity through PI3K/AKT/mTOR signal transduction inhibition

scientific article published on 28 March 2019

Chain length affects pancreatic lipase activity and the extent and pH-time profile of triglyceride lipolysis.

artículo científico publicado en 2015

Characterisation of human saliva as a platform for oral dissolution medium development.

artículo científico publicado en 2015

Codrug Approach for the Potential Treatment of EML4-ALK Positive Lung Cancer

artículo científico publicado en 2019

Delivery of Temozolomide and N3-Propargyl Analog to Brain Tumors Using an Apoferritin Nanocage

scientific article published on 04 March 2020

Development and characterization of oral lipid-based amphotericin B formulations with enhanced drug solubility, stability and antifungal activity in rats infected with Aspergillus fumigatus or Candida albicans

artículo científico publicado en 2009

Development and validation of a cost-effective and sensitive bioanalytical HPLC-UV method for determination of lopinavir in rat and human plasma

artículo científico publicado en 2020

Development of Cordycepin Formulations for Preclinical and Clinical Studies

artículo científico

Development of a simple and sensitive HPLC-UV method for the simultaneous determination of cannabidiol and Δ(9)-tetrahydrocannabinol in rat plasma.

artículo científico publicado en 2015

Dietary fats and pharmaceutical lipid excipients increase systemic exposure to orally administered cannabis and cannabis-based medicines

artículo científico publicado en 2016

Different impacts of intestinal lymphatic transport on the oral bioavailability of structurally similar synthetic lipophilic cannabinoids: dexanabinol and PRS-211,220

scientific article published on 05 May 2007

Dissolution methodology for taste masked oral dosage forms.

artículo científico publicado en 2013

Dual physiologically based pharmacokinetic model of liposomal and nonliposomal amphotericin B disposition

artículo científico publicado en 2013

Effect of a high-fat meal on absorption and disposition of lipophilic compounds: the importance of degree of association with triglyceride-rich lipoproteins

artículo científico publicado en 2007

Effect of abdominal surgery on the intestinal absorption of lipophilic drugs: possible role of the lymphatic transport.

artículo científico publicado en 2009

Effect of hypertriglyceridemia on the pharmacokinetics and blood-brain barrier penetration of clozapine and norclozapine following administration to rats

artículo científico publicado en 2010

Effect of variations in treatment regimen and liver cirrhosis on exposure to benzodiazepines during treatment of alcohol withdrawal syndrome.

artículo científico publicado en 2015

Efficacy and toxicity of a tropically stable lipid-based formulation of amphotericin B (iCo-010) in a rat model of invasive candidiasis

artículo científico publicado en 2012

Evaluation of the effect of plant sterols on the intestinal processing of cholesterol using an in vitro lipolysis model.

artículo científico publicado en 2012

Highly effective oral amphotericin B formulation against murine visceral leishmaniasis

artículo científico publicado en 2009

Hyperlipidaemia alone and in combination with acidosis can increase the incidence and severity of statin-induced myotoxicity

artículo científico publicado en 2017

In vitro anticancer properties and biological evaluation of novel natural alkaloid jerantinine B.

artículo científico publicado en 2015

In vitro cytotoxicity of two novel oral formulations of Amphotericin B (iCo-009 and iCo-010) against Candida albicans, human monocytic and kidney cell lines

artículo científico publicado en 2011

Inhibition of cholesterol absorption: targeting the intestine.

artículo científico

Inhibition of intestinal absorption of cholesterol by surface-modified nanostructured aluminosilicate compounds

artículo científico publicado en 2009

Is rat a good model for assessment of particulate-based taste-masked formulations?

scientific article published on 11 November 2019

Linking in Vitro Lipolysis and Microsomal Metabolism for the Quantitative Prediction of Oral Bioavailability of BCS II Drugs Administered in Lipidic Formulations

artículo científico publicado en 2016

Lipid-lowering Activity of Natural and Semi-Synthetic Sterols and Stanols

artículo científico publicado en 2015

Lipophilic activated ester prodrug approach for drug delivery to the intestinal lymphatic system

artículo científico publicado en 2018

Long-circulating non-toxic blood pool imaging agent based on hyperbranched polyglycerols

artículo científico publicado en 2011

Novel oral amphotericin B formulation (iCo-010) remains highly effective against murine systemic candidiasis following exposure to tropical temperature.

artículo científico publicado en 2014

Oral administration of cannabis with lipids leads to high levels of cannabinoids in the intestinal lymphatic system and prominent immunomodulation.

artículo científico publicado en 2017

Pharmacokinetics and biodistribution of amphotericin B in rats following oral administration in a novel lipid-based formulation.

artículo científico publicado en 2009

Pharmacokinetics and tissue distribution of amphotericin B following oral administration of three lipid-based formulations to rats

artículo científico publicado en 2012

Physiologically based pharmacokinetic model of amphotericin B disposition in rats following administration of deoxycholate formulation (Fungizone®): pooled analysis of published data.

artículo científico publicado en 2011

Protonated nanostructured aluminosilicate (NSAS) reduces plasma cholesterol concentrations and atherosclerotic lesions in Apolipoprotein E deficient mice fed a high cholesterol and high fat diet

artículo científico publicado en 2009

Quantitative Prediction of Oral Bioavailability of a Lipophilic Antineoplastic Drug Bexarotene Administered in Lipidic Formulation Using a Combined In Vitro Lipolysis/Microsomal Metabolism Approach

scientific article published on 28 September 2018

Quantitative analysis of lab-to-lab variability in Caco-2 permeability assays.

artículo científico publicado en 2017

Reduced variability in tacrolimus pharmacokinetics following intramuscular injection compared to oral administration in cynomolgus monkeys: Investigating optimal dosing regimens

artículo científico publicado en 2018

Rifampicin-induced CYP3A4 activation in CTX patients cannot replace chenodeoxycholic acid treatment

artículo científico publicado en 2007

Self-Assembling Benzothiazole-Based Gelators: A Mechanistic Understanding of in Vitro Bioactivation and Gelation.

artículo científico publicado en 2018

Simple and sensitive HPLC-UV method for determination of bexarotene in rat plasma.

artículo científico publicado en 2016

Simultaneous determination of a novel antitrypanosomal compound (OSU-36) and its ester derivative (OSU-40) in plasma by HPLC: application to first pharmacokinetic study in rats.

artículo científico publicado en 2011

Solid lipid nanoparticles self-assembled from spray dried microparticles

scientific article published on 30 October 2019

Synthesis and antitrypanosomal evaluation of derivatives of N-benzyl-1,2-dihydroquinolin-6-ols: Effect of core substitutions and salt formation

scientific article published in 2011

Synthesis of micellar-like terpolymer nanoparticles with reductively-cleavable cross-links and evaluation of efficacy in 2D and 3D models of triple negative breast cancer

scientific article published on 01 May 2020

Targeted delivery of lopinavir to HIV reservoirs in the mesenteric lymphatic system by lipophilic ester prodrug approach

artículo científico publicado en 2020

The effect of a high-fat meal on the pharmacodynamics of a model lipophilic compound that binds extensively to triglyceride-rich lipoproteins

artículo científico publicado en 2007

The role of acid-base imbalance in statin-induced myotoxicity

artículo científico publicado en 2016

The role of molecular physicochemical properties and apolipoproteins in association of drugs with triglyceride-rich lipoproteins: in-silico prediction of uptake by chylomicrons

artículo científico publicado en 2009

The role of the lymphatic system in subcutaneous absorption of macromolecules in the rat model

artículo científico publicado en 2007

The use of the United States FDA programs as a strategy to advance the development of drug products for neglected tropical diseases

artículo científico

Translational insight into statin-induced muscle toxicity: from cell culture to clinical studies.

artículo científico

Tropically stable novel oral lipid formulation of amphotericin B (iCo-010): biodistribution and toxicity in a mouse model

artículo científico publicado en 2011

Uptake of lipophilic drugs by plasma derived isolated chylomicrons: linear correlation with intestinal lymphatic bioavailability

artículo científico publicado en 2005

Visceral leishmaniasis affects liver and spleen concentrations of amphotericin B following administration to mice

artículo científico publicado en 2009

Lista de obras de Pavel Gershkovich

A novel nucleoside rescue metabolic pathway may be responsible for therapeutic effect of orally administered cordycepin

A novel tropically stable oral amphotericin B formulation (iCo-010) exhibits efficacy against visceral Leishmaniasis in a murine model.

A review of the application of lipid-based systems in systemic, dermal/ transdermal, and ocular drug delivery.

A simple and sensitive method for determination of vitamins D3 and K1 in rat plasma: application for an in vivo pharmacokinetic study.

Analytical ultracentrifugation in saliva research: Impact of green tea astringency and its significance on the in-vivo aroma release

Application of biorelevant saliva-based dissolution for optimisation of orally disintegrating formulations of felodipine

Assessment of cholesterol absorption inhibitors nanostructured aluminosilicate and cholestyramine using in vitro lipolysis model

Assessment of novel oral lipid-based formulations of amphotericin B using an in vitro lipolysis model.

Biodistribution and tissue toxicity of amphotericin B in mice following multiple dose administration of a novel oral lipid-based formulation (iCo-009).

Cardiac glycoside cerberin exerts anticancer activity through PI3K/AKT/mTOR signal transduction inhibition

Chain length affects pancreatic lipase activity and the extent and pH-time profile of triglyceride lipolysis.

Characterisation of human saliva as a platform for oral dissolution medium development.

Codrug Approach for the Potential Treatment of EML4-ALK Positive Lung Cancer

Delivery of Temozolomide and N3-Propargyl Analog to Brain Tumors Using an Apoferritin Nanocage

Development and characterization of oral lipid-based amphotericin B formulations with enhanced drug solubility, stability and antifungal activity in rats infected with Aspergillus fumigatus or Candida albicans

Development and validation of a cost-effective and sensitive bioanalytical HPLC-UV method for determination of lopinavir in rat and human plasma

Development of Cordycepin Formulations for Preclinical and Clinical Studies

Development of a simple and sensitive HPLC-UV method for the simultaneous determination of cannabidiol and Δ(9)-tetrahydrocannabinol in rat plasma.

Dietary fats and pharmaceutical lipid excipients increase systemic exposure to orally administered cannabis and cannabis-based medicines

Different impacts of intestinal lymphatic transport on the oral bioavailability of structurally similar synthetic lipophilic cannabinoids: dexanabinol and PRS-211,220

Dissolution methodology for taste masked oral dosage forms.

Dual physiologically based pharmacokinetic model of liposomal and nonliposomal amphotericin B disposition

Effect of a high-fat meal on absorption and disposition of lipophilic compounds: the importance of degree of association with triglyceride-rich lipoproteins

Effect of abdominal surgery on the intestinal absorption of lipophilic drugs: possible role of the lymphatic transport.

Effect of hypertriglyceridemia on the pharmacokinetics and blood-brain barrier penetration of clozapine and norclozapine following administration to rats

Effect of variations in treatment regimen and liver cirrhosis on exposure to benzodiazepines during treatment of alcohol withdrawal syndrome.

Efficacy and toxicity of a tropically stable lipid-based formulation of amphotericin B (iCo-010) in a rat model of invasive candidiasis

Evaluation of the effect of plant sterols on the intestinal processing of cholesterol using an in vitro lipolysis model.

Highly effective oral amphotericin B formulation against murine visceral leishmaniasis

Hyperlipidaemia alone and in combination with acidosis can increase the incidence and severity of statin-induced myotoxicity

In vitro anticancer properties and biological evaluation of novel natural alkaloid jerantinine B.

In vitro cytotoxicity of two novel oral formulations of Amphotericin B (iCo-009 and iCo-010) against Candida albicans, human monocytic and kidney cell lines

Inhibition of cholesterol absorption: targeting the intestine.

Inhibition of intestinal absorption of cholesterol by surface-modified nanostructured aluminosilicate compounds

Is rat a good model for assessment of particulate-based taste-masked formulations?

Linking in Vitro Lipolysis and Microsomal Metabolism for the Quantitative Prediction of Oral Bioavailability of BCS II Drugs Administered in Lipidic Formulations

Lipid-lowering Activity of Natural and Semi-Synthetic Sterols and Stanols

Lipophilic activated ester prodrug approach for drug delivery to the intestinal lymphatic system

Long-circulating non-toxic blood pool imaging agent based on hyperbranched polyglycerols

Novel oral amphotericin B formulation (iCo-010) remains highly effective against murine systemic candidiasis following exposure to tropical temperature.

Oral administration of cannabis with lipids leads to high levels of cannabinoids in the intestinal lymphatic system and prominent immunomodulation.

Pharmacokinetics and biodistribution of amphotericin B in rats following oral administration in a novel lipid-based formulation.

Pharmacokinetics and tissue distribution of amphotericin B following oral administration of three lipid-based formulations to rats

Physiologically based pharmacokinetic model of amphotericin B disposition in rats following administration of deoxycholate formulation (Fungizone®): pooled analysis of published data.

Protonated nanostructured aluminosilicate (NSAS) reduces plasma cholesterol concentrations and atherosclerotic lesions in Apolipoprotein E deficient mice fed a high cholesterol and high fat diet

Quantitative Prediction of Oral Bioavailability of a Lipophilic Antineoplastic Drug Bexarotene Administered in Lipidic Formulation Using a Combined In Vitro Lipolysis/Microsomal Metabolism Approach

Quantitative analysis of lab-to-lab variability in Caco-2 permeability assays.

Reduced variability in tacrolimus pharmacokinetics following intramuscular injection compared to oral administration in cynomolgus monkeys: Investigating optimal dosing regimens

Rifampicin-induced CYP3A4 activation in CTX patients cannot replace chenodeoxycholic acid treatment

Self-Assembling Benzothiazole-Based Gelators: A Mechanistic Understanding of in Vitro Bioactivation and Gelation.

Simple and sensitive HPLC-UV method for determination of bexarotene in rat plasma.

Simultaneous determination of a novel antitrypanosomal compound (OSU-36) and its ester derivative (OSU-40) in plasma by HPLC: application to first pharmacokinetic study in rats.

Solid lipid nanoparticles self-assembled from spray dried microparticles

Synthesis and antitrypanosomal evaluation of derivatives of N-benzyl-1,2-dihydroquinolin-6-ols: Effect of core substitutions and salt formation

Synthesis of micellar-like terpolymer nanoparticles with reductively-cleavable cross-links and evaluation of efficacy in 2D and 3D models of triple negative breast cancer

Targeted delivery of lopinavir to HIV reservoirs in the mesenteric lymphatic system by lipophilic ester prodrug approach

The effect of a high-fat meal on the pharmacodynamics of a model lipophilic compound that binds extensively to triglyceride-rich lipoproteins

The role of acid-base imbalance in statin-induced myotoxicity

The role of molecular physicochemical properties and apolipoproteins in association of drugs with triglyceride-rich lipoproteins: in-silico prediction of uptake by chylomicrons

The role of the lymphatic system in subcutaneous absorption of macromolecules in the rat model

The use of the United States FDA programs as a strategy to advance the development of drug products for neglected tropical diseases

Translational insight into statin-induced muscle toxicity: from cell culture to clinical studies.

Tropically stable novel oral lipid formulation of amphotericin B (iCo-010): biodistribution and toxicity in a mouse model

Uptake of lipophilic drugs by plasma derived isolated chylomicrons: linear correlation with intestinal lymphatic bioavailability

Visceral leishmaniasis affects liver and spleen concentrations of amphotericin B following administration to mice