Lista de obras - Julien Hanson - Dominio Público Uruguay

7-Phenoxy-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency

artículo científico publicado en 2017

A dynamic and screening-compatible nanoluciferase-based complementation assay enables profiling of individual GPCR-G protein interactions

scientific article published on 28 December 2018

Activation of the Orphan G Protein-Coupled Receptor GPR27 by Surrogate Ligands Promotes β-Arrestin 2 Recruitment

artículo científico publicado en 2017

Alternative glycosylation controls endoplasmic reticulum dynamics and tubular extension in mammalian cells

artículo científico publicado en 2021

An autocrine lactate loop mediates insulin-dependent inhibition of lipolysis through GPR81.

artículo científico publicado en 2010

BM-520, an original TXA2 modulator, inhibits the action of thromboxane A2 and 8-iso-prostaglandin F2alphain vitro and in vivo on human and rodent platelets, and aortic vascular smooth muscles from rodents

artículo científico publicado en 2007

BM-573 inhibits the development of early atherosclerotic lesions in Apo E deficient mice by blocking TP receptors and thromboxane synthase

artículo científico publicado en 2011

Capillary electrophoretic mobility shift displacement assay for the assessment of weak drug-protein interactions

artículo científico publicado en 2018

Cardiovascular haemodynamics and ventriculo-arterial coupling in an acute pig model of coronary ischaemia-reperfusion

artículo científico publicado en 2006

Characterization of an original model of myocardial infarction provoked by coronary artery thrombosis induced by ferric chloride in pig.

artículo científico publicado en 2005

Chemokine neutralization as an innovative therapeutic strategy for atopic dermatitis.

artículo científico publicado en 2016

Coxibs and cardiovascular side-effects: from light to shadow.

artículo científico publicado en 2006

Deorphanization of GPR109B as a receptor for the beta-oxidation intermediate 3-OH-octanoic acid and its role in the regulation of lipolysis

artículo científico publicado en 2009

Design, synthesis, and SAR study of a series of N-alkyl-N'-[2-(aryloxy)-5-nitrobenzenesulfonyl]ureas and -cyanoguanidine as selective antagonists of the TPalpha and TPbeta isoforms of the human thromboxane A2 receptor.

artículo científico publicado en 2007

Different contribution of chemokine N-terminal features attest a different ligand binding mode and a bias towards activation of the atypical chemokine receptor ACKR3/CXCR7 compared to CXCR4 and CXCR3.

artículo científico publicado en 2017

Effect of BM-573 [N-terbutyl-N'-[2-(4'-methylphenylamino)-5-nitro-benzenesulfonyl]urea], a dual thromboxane synthase inhibitor and thromboxane receptor antagonist, in a porcine model of acute pulmonary embolism

artículo científico publicado en 2004

Effects of BM-573, a thromboxane A2 modulator on systemic hemodynamics perturbations induced by U-46619 in the pig.

artículo científico publicado en 2005

Effects of dobutamine on left ventriculoarterial coupling and mechanical efficiency in acutely ischemic pigs

artículo científico publicado en 2005

Enhancing Action of Positive Allosteric Modulators through the Design of Dimeric Compounds

artículo científico publicado en 2018

Evaluation of BM-573, a novel TXA2 synthase inhibitor and receptor antagonist, in a porcine model of myocardial ischemia-reperfusion

artículo científico publicado en 2005

Forskolin-free cAMP assay for Gi-coupled receptors.

artículo científico publicado en 2015

From the design to the clinical application of thromboxane modulators

artículo científico publicado en 2006

GPCRs in immunity: Atypical receptors and novel concepts.

artículo científico publicado en 2016

GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11

scientific article published on 21 September 2020

Heterologously expressed formyl peptide receptor 2 (FPR2/ALX) does not respond to lipoxin A₄.

artículo científico publicado en 2013

Human herpesvirus 8-encoded chemokine vCCL2/vMIP-II is an agonist of the atypical chemokine receptor ACKR3/CXCR7.

artículo científico publicado en 2016

Identification and pharmacological characterization of succinate receptor agonists

artículo científico publicado en 2017

In vitro and in vivo pharmacological characterization of BM-613 [N-n-pentyl-N'-[2-(4'-methylphenylamino)-5-nitrobenzenesulfonyl]urea], a novel dual thromboxane synthase inhibitor and thromboxane receptor antagonist.

artículo científico publicado en 2004

Insight into SUCNR1 (GPR91) structure and function.

artículo científico publicado en 2016

Mutational analysis of the extracellular disulphide bridges of the atypical chemokine receptor ACKR3/CXCR7 uncovers multiple binding and activation modes for its chemokine and endogenous non-chemokine agonists.

artículo científico publicado en 2018

New developments on thromboxane modulators.

artículo científico publicado en 2004

Nicotinic acid (niacin): new lipid-independent mechanisms of action and therapeutic potentials

artículo científico publicado en 2011

Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice

artículo científico publicado en 2010

Partial filling affinity capillary electrophoresis as a useful tool for fragment-based drug discovery: A proof of concept on thrombin.

artículo científico publicado en 2017

Pharmacological characterization of N-tert-butyl-N'-[2-(4'-methylphenylamino)-5-nitrobenzenesulfonyl]urea (BM-573), a novel thromboxane, etc.

artículo científico publicado en 2004

Pharmacological evaluation of both enantiomers of (R,S)-BM-591 as thromboxane A2 receptor antagonists and thromboxane synthase inhibitors

artículo científico publicado en 2004

Progress in the field of GPIIb/IIIa antagonists

artículo científico publicado en 2004

Role of HCA₂ (GPR109A) in nicotinic acid and fumaric acid ester-induced effects on the skin

artículo científico

Synthesis and pharmacological evaluation of 2-aryloxy/arylamino-5-cyanobenzenesulfonylureas as novel thromboxane A₂ receptor antagonists.

artículo científico publicado en 2013

Synthesis and pharmacological evaluation of novel nitrobenzenic thromboxane modulators as antiplatelet agents acting on both the alpha and beta isoforms of the human thromboxane receptor

scientific article published on 01 June 2006

The Distinct Roles of CXCR3 Variants and Their Ligands in the Tumor Microenvironment

scientific article published on 18 June 2019

The G Protein-Coupled Receptors deorphanization landscape

artículo científico publicado en 2018

The causes and consequences of pituitary gigantism

scientific article published on 01 December 2018

Therapeutic applications of prostaglandins and thromboxane A2 inhibitors in abdominal aortic aneurysms

artículo científico publicado en 2017

Thromboxane, prostacyclin and isoprostanes: therapeutic targets in atherogenesis

artículo científico publicado en 2005

Lista de obras de Julien Hanson

7-Phenoxy-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency

A dynamic and screening-compatible nanoluciferase-based complementation assay enables profiling of individual GPCR-G protein interactions

Activation of the Orphan G Protein-Coupled Receptor GPR27 by Surrogate Ligands Promotes β-Arrestin 2 Recruitment

Alternative glycosylation controls endoplasmic reticulum dynamics and tubular extension in mammalian cells

An autocrine lactate loop mediates insulin-dependent inhibition of lipolysis through GPR81.

BM-520, an original TXA2 modulator, inhibits the action of thromboxane A2 and 8-iso-prostaglandin F2alphain vitro and in vivo on human and rodent platelets, and aortic vascular smooth muscles from rodents

BM-573 inhibits the development of early atherosclerotic lesions in Apo E deficient mice by blocking TP receptors and thromboxane synthase

Capillary electrophoretic mobility shift displacement assay for the assessment of weak drug-protein interactions

Cardiovascular haemodynamics and ventriculo-arterial coupling in an acute pig model of coronary ischaemia-reperfusion

Characterization of an original model of myocardial infarction provoked by coronary artery thrombosis induced by ferric chloride in pig.

Chemokine neutralization as an innovative therapeutic strategy for atopic dermatitis.

Coxibs and cardiovascular side-effects: from light to shadow.

Deorphanization of GPR109B as a receptor for the beta-oxidation intermediate 3-OH-octanoic acid and its role in the regulation of lipolysis

Design, synthesis, and SAR study of a series of N-alkyl-N'-[2-(aryloxy)-5-nitrobenzenesulfonyl]ureas and -cyanoguanidine as selective antagonists of the TPalpha and TPbeta isoforms of the human thromboxane A2 receptor.

Different contribution of chemokine N-terminal features attest a different ligand binding mode and a bias towards activation of the atypical chemokine receptor ACKR3/CXCR7 compared to CXCR4 and CXCR3.

Effect of BM-573 [N-terbutyl-N'-[2-(4'-methylphenylamino)-5-nitro-benzenesulfonyl]urea], a dual thromboxane synthase inhibitor and thromboxane receptor antagonist, in a porcine model of acute pulmonary embolism

Effects of BM-573, a thromboxane A2 modulator on systemic hemodynamics perturbations induced by U-46619 in the pig.

Effects of dobutamine on left ventriculoarterial coupling and mechanical efficiency in acutely ischemic pigs

Enhancing Action of Positive Allosteric Modulators through the Design of Dimeric Compounds

Evaluation of BM-573, a novel TXA2 synthase inhibitor and receptor antagonist, in a porcine model of myocardial ischemia-reperfusion

Forskolin-free cAMP assay for Gi-coupled receptors.

From the design to the clinical application of thromboxane modulators

GPCRs in immunity: Atypical receptors and novel concepts.

GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11

Heterologously expressed formyl peptide receptor 2 (FPR2/ALX) does not respond to lipoxin A₄.

Human herpesvirus 8-encoded chemokine vCCL2/vMIP-II is an agonist of the atypical chemokine receptor ACKR3/CXCR7.

Identification and pharmacological characterization of succinate receptor agonists

In vitro and in vivo pharmacological characterization of BM-613 [N-n-pentyl-N'-[2-(4'-methylphenylamino)-5-nitrobenzenesulfonyl]urea], a novel dual thromboxane synthase inhibitor and thromboxane receptor antagonist.

Insight into SUCNR1 (GPR91) structure and function.

Mutational analysis of the extracellular disulphide bridges of the atypical chemokine receptor ACKR3/CXCR7 uncovers multiple binding and activation modes for its chemokine and endogenous non-chemokine agonists.

New developments on thromboxane modulators.

Nicotinic acid (niacin): new lipid-independent mechanisms of action and therapeutic potentials

Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice

Partial filling affinity capillary electrophoresis as a useful tool for fragment-based drug discovery: A proof of concept on thrombin.

Pharmacological characterization of N-tert-butyl-N'-[2-(4'-methylphenylamino)-5-nitrobenzenesulfonyl]urea (BM-573), a novel thromboxane, etc.

Pharmacological evaluation of both enantiomers of (R,S)-BM-591 as thromboxane A2 receptor antagonists and thromboxane synthase inhibitors

Progress in the field of GPIIb/IIIa antagonists

Role of HCA₂ (GPR109A) in nicotinic acid and fumaric acid ester-induced effects on the skin

Synthesis and pharmacological evaluation of 2-aryloxy/arylamino-5-cyanobenzenesulfonylureas as novel thromboxane A₂ receptor antagonists.

Synthesis and pharmacological evaluation of novel nitrobenzenic thromboxane modulators as antiplatelet agents acting on both the alpha and beta isoforms of the human thromboxane receptor

The Distinct Roles of CXCR3 Variants and Their Ligands in the Tumor Microenvironment

The G Protein-Coupled Receptors deorphanization landscape

The causes and consequences of pituitary gigantism

Therapeutic applications of prostaglandins and thromboxane A2 inhibitors in abdominal aortic aneurysms

Thromboxane, prostacyclin and isoprostanes: therapeutic targets in atherogenesis