Lista de obras - Anne Blangy - Dominio Público Uruguay

A cell active chemical GEF inhibitor selectively targets the Trio/RhoG/Rac1 signaling pathway

artículo científico publicado en 2009

A murine sequence-specific DNA binding protein shows extensive local similarities to the amyloid precursor protein

artículo científico publicado el 30 de diciembre de 1992

A receptor-interacting protein 1 (RIP1)-independent necrotic death under the control of protein phosphatase PP2A that involves the reorganization of actin cytoskeleton and the action of cofilin-1.

artículo científico publicado en 2014

Allosteric inhibition of the guanine nucleotide exchange factor DOCK5 by a small molecule

artículo científico publicado en 2017

Biogenesis of N-cadherin-dependent cell-cell contacts in living fibroblasts is a microtubule-dependent kinesin-driven mechanism

artículo científico publicado en 2002

Characterization of TCL, a new GTPase of the rho family related to TC10 andCcdc42

artículo científico publicado en 2000

Cibler l’activité de l’ostéoclaste

Cofilin activation during podosome belt formation in osteoclasts

artículo científico publicado en 2012

Combined strategy of siRNA and osteoclast actin cytoskeleton automated imaging to identify novel regulators of bone resorption shows a non-mitotic function for anillin

scientific article published on 31 October 2018

Dock-family exchange factors in cell migration and disease

artículo científico

Dock5 is a new regulator of microtubule dynamic instability in osteoclasts

scientific article published on 06 September 2019

Dynamic changes in nuclear architecture during mitosis: on the role of protein phosphorylation in spindle assembly and chromosome segregation.

artículo científico publicado en 1996

Expression profile of RhoGTPases and RhoGEFs during RANKL-stimulated osteoclastogenesis: identification of essential genes in osteoclasts

artículo científico publicado en 2006

Identification of TRIO-GEFD1 chemical inhibitors using the yeast exchange assay

artículo científico publicado en 2006

Identification of a bipartite focal adhesion localization signal in RhoU/Wrch-1, a Rho family GTPase that regulates cell adhesion and migration

artículo científico publicado en 2007

Induction of lamellipodia by Kalirin does not require its guanine nucleotide exchange factor activity

artículo científico publicado en 2005

Interaction of ezrin with the novel guanine nucleotide exchange factor PLEKHG6 promotes RhoG-dependent apical cytoskeleton rearrangements in epithelial cells

artículo científico publicado en 2007

Interaction of the mitotic inhibitor monastrol with human kinesin Eg5.

artículo científico publicado en 2003

Interferon-alpha and -beta differentially regulate osteoclastogenesis: role of differential induction of chemokine CXCL11 expression.

artículo científico publicado en 2005

Kinectin is a key effector of RhoG microtubule-dependent cellular activity

artículo científico publicado en 2001

Mammalian and viral DNA sequences which interfere with the maintenance of a centromeric vector in yeast

artículo científico publicado en 1992

Methods to Investigate the Role of Rho GTPases in Osteoclast Function

artículo científico publicado en 2018

Modulation of osteoclast differentiation and bone resorption by Rho GTPases

artículo científico publicado en 2014

N-cadherin-dependent cell-cell contact regulates Rho GTPases and beta-catenin localization in mouse C2C12 myoblasts

artículo científico publicado en 2002

Novel 2,7-Diazaspiro[4,4]nonane Derivatives to Inhibit Mouse and Human Osteoclast Activities and Prevent Bone Loss in Ovariectomized Mice without Affecting Bone Formation

artículo científico publicado en 2020

Osteoclast Biology and Mechanosensing

Phagocytosis of apoptotic cells is regulated by a UNC-73/TRIO-MIG-2/RhoG signaling module and armadillo repeats of CED-12/ELMO

artículo científico publicado en 2004

Pharmacological inhibition of Dock5 prevents osteolysis by affecting osteoclast podosome organization while preserving bone formation

scientific article published in Nature Communications

Phosphorylation by p34cdc2 protein kinase regulates binding of the kinesin-related motor HsEg5 to the dynactin subunit p150

artículo científico publicado en 1997

Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo

artículo científico publicado en 1995

Podosome organization drives osteoclast-mediated bone resorption.

artículo científico publicado en 2014

Podosomes are dispensable for osteoclast differentiation and migration

artículo científico publicado en 2013

Primary myeloid cell proteomics and transcriptomics: importance of ß tubulin isotypes for osteoclast function

scientific article published on 07 April 2020

Promyelocytic leukemia zinc-finger induction signs mesenchymal stem cell commitment: identification of a key marker for stemness maintenance?

artículo científico publicado en 2014

Recognition of the CDEl motif GTCACATG by mouse nuclear proteins and interference with the early development of the mouse embryo ⬇️

artículo científico publicado el 1 de diciembre de 1991

Rho GTPases in osteoclasts: orchestrators of podosome arrangement

artículo científico publicado en 2008

RhoA GTPase regulates M-cadherin activity and myoblast fusion

artículo científico publicado en 2005

RhoE controls myoblast alignment prior fusion through RhoA and ROCK.

artículo científico publicado en 2008

Rigor-type mutation in the kinesin-related protein HsEg5 changes its subcellular localization and induces microtubule bundling

artículo científico publicado en 1998

Signalling pathways controlled by the GTPase RhoG

Targeting the Dbl and dock-family RhoGEFs: a yeast-based assay to identify cell-active inhibitors of Rho-controlled pathways

artículo científico

Tensin 3 is a new partner of Dock5 that controls osteoclast podosome organization and activity

artículo científico publicado en 2016

Tensins are versatile regulators of Rho GTPase signalling and cell adhesion

artículo científico publicado en 2016

The Beta-Tubulin Isotype TUBB6 Controls Microtubule and Actin Dynamics in Osteoclasts

artículo científico publicado en 2021

The DH-PH region of the giant protein UNC-89 activates RHO-1 GTPase in Caenorhabditis elegans body wall muscle

artículo científico publicado en 2008

The Evolutionary Landscape of Dbl-Like RhoGEF Families: Adapting Eukaryotic Cells to Environmental Signals

artículo científico publicado en 2017

The GTP/GDP cycling of rho GTPase TCL is an essential regulator of the early endocytic pathway

artículo científico publicado en 2003

The Human Rho-GEF trio and its target GTPase RhoG are involved in the NGF pathway, leading to neurite outgrowth

artículo científico publicado en 2002

The Rac1 exchange factor Dock5 is essential for bone resorption by osteoclasts

artículo científico publicado en 2011

The Rho GTPase Wrch1 regulates osteoclast precursor adhesion and migration

artículo científico publicado en 2008

The RhoE/ROCK/ARHGAP25 signaling pathway controls cell invasion by inhibition of Rac activity

artículo científico publicado en 2016

The atypical Rac activator Dock180 (Dock1) regulates myoblast fusion in vivo

artículo científico publicado en 2008

The atypical Rho GTPase RhoU interacts with intersectin-2 to regulate endosomal recycling pathways

artículo científico publicado en 2020

The atypical RhoU/Wrch1 Rho GTPase controls cell proliferation and apoptosis in the gut epithelium

artículo científico publicado en 2019

The gene for a new brain specific RhoA exchange factor maps to the highly unstable chromosomal region 1p36.2-1p36.3.

artículo científico publicado en 2001

The mineral dissolution function of osteoclasts is dispensable for hypertrophic cartilage degradation during long bone development and growth

artículo científico publicado en 2014

The osteoclast cytoskeleton - current understanding and therapeutic perspectives for osteoporosis

artículo científico publicado en 2020

The yeast exchange assay, a new complementary method to screen for Dbl-like protein specificity: identification of a novel RhoA exchange factor

artículo científico publicado en 2000

Using a Modified Yeast Two-Hybrid System to Screen for Chemical GEF Inhibitors ⬇️

artículo científico publicado el 1 de enero de 2012

Lista de obras de Anne Blangy

A cell active chemical GEF inhibitor selectively targets the Trio/RhoG/Rac1 signaling pathway

A murine sequence-specific DNA binding protein shows extensive local similarities to the amyloid precursor protein

A receptor-interacting protein 1 (RIP1)-independent necrotic death under the control of protein phosphatase PP2A that involves the reorganization of actin cytoskeleton and the action of cofilin-1.

Allosteric inhibition of the guanine nucleotide exchange factor DOCK5 by a small molecule

Biogenesis of N-cadherin-dependent cell-cell contacts in living fibroblasts is a microtubule-dependent kinesin-driven mechanism

Characterization of TCL, a new GTPase of the rho family related to TC10 andCcdc42

Cibler l’activité de l’ostéoclaste

Cofilin activation during podosome belt formation in osteoclasts

Combined strategy of siRNA and osteoclast actin cytoskeleton automated imaging to identify novel regulators of bone resorption shows a non-mitotic function for anillin

Combined strategy of siRNA and osteoclast actin cytoskeleton automated imaging to identify novel regulators of bone resorption shows a non-mitotic function for anillin

Dock-family exchange factors in cell migration and disease

Dock5 is a new regulator of microtubule dynamic instability in osteoclasts

Dynamic changes in nuclear architecture during mitosis: on the role of protein phosphorylation in spindle assembly and chromosome segregation.

Expression profile of RhoGTPases and RhoGEFs during RANKL-stimulated osteoclastogenesis: identification of essential genes in osteoclasts

Identification of TRIO-GEFD1 chemical inhibitors using the yeast exchange assay

Identification of a bipartite focal adhesion localization signal in RhoU/Wrch-1, a Rho family GTPase that regulates cell adhesion and migration

Induction of lamellipodia by Kalirin does not require its guanine nucleotide exchange factor activity

Interaction of ezrin with the novel guanine nucleotide exchange factor PLEKHG6 promotes RhoG-dependent apical cytoskeleton rearrangements in epithelial cells

Interaction of the mitotic inhibitor monastrol with human kinesin Eg5.

Interferon-alpha and -beta differentially regulate osteoclastogenesis: role of differential induction of chemokine CXCL11 expression.

Kinectin is a key effector of RhoG microtubule-dependent cellular activity

Mammalian and viral DNA sequences which interfere with the maintenance of a centromeric vector in yeast

Methods to Investigate the Role of Rho GTPases in Osteoclast Function

Modulation of osteoclast differentiation and bone resorption by Rho GTPases

N-cadherin-dependent cell-cell contact regulates Rho GTPases and beta-catenin localization in mouse C2C12 myoblasts

Novel 2,7-Diazaspiro[4,4]nonane Derivatives to Inhibit Mouse and Human Osteoclast Activities and Prevent Bone Loss in Ovariectomized Mice without Affecting Bone Formation

Osteoclast Biology and Mechanosensing

Phagocytosis of apoptotic cells is regulated by a UNC-73/TRIO-MIG-2/RhoG signaling module and armadillo repeats of CED-12/ELMO

Pharmacological inhibition of Dock5 prevents osteolysis by affecting osteoclast podosome organization while preserving bone formation

Phosphorylation by p34cdc2 protein kinase regulates binding of the kinesin-related motor HsEg5 to the dynactin subunit p150

Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo

Podosome organization drives osteoclast-mediated bone resorption.

Podosomes are dispensable for osteoclast differentiation and migration

Primary myeloid cell proteomics and transcriptomics: importance of ß tubulin isotypes for osteoclast function

Promyelocytic leukemia zinc-finger induction signs mesenchymal stem cell commitment: identification of a key marker for stemness maintenance?

Recognition of the CDEl motif GTCACATG by mouse nuclear proteins and interference with the early development of the mouse embryo ⬇️

Rho GTPases in osteoclasts: orchestrators of podosome arrangement

RhoA GTPase regulates M-cadherin activity and myoblast fusion

RhoE controls myoblast alignment prior fusion through RhoA and ROCK.

Rigor-type mutation in the kinesin-related protein HsEg5 changes its subcellular localization and induces microtubule bundling

Signalling pathways controlled by the GTPase RhoG

Targeting the Dbl and dock-family RhoGEFs: a yeast-based assay to identify cell-active inhibitors of Rho-controlled pathways

Tensin 3 is a new partner of Dock5 that controls osteoclast podosome organization and activity

Tensins are versatile regulators of Rho GTPase signalling and cell adhesion

The Beta-Tubulin Isotype TUBB6 Controls Microtubule and Actin Dynamics in Osteoclasts

The DH-PH region of the giant protein UNC-89 activates RHO-1 GTPase in Caenorhabditis elegans body wall muscle

The Evolutionary Landscape of Dbl-Like RhoGEF Families: Adapting Eukaryotic Cells to Environmental Signals

The GTP/GDP cycling of rho GTPase TCL is an essential regulator of the early endocytic pathway

The Human Rho-GEF trio and its target GTPase RhoG are involved in the NGF pathway, leading to neurite outgrowth

The Rac1 exchange factor Dock5 is essential for bone resorption by osteoclasts

The Rho GTPase Wrch1 regulates osteoclast precursor adhesion and migration

The RhoE/ROCK/ARHGAP25 signaling pathway controls cell invasion by inhibition of Rac activity

The atypical Rac activator Dock180 (Dock1) regulates myoblast fusion in vivo

The atypical Rho GTPase RhoU interacts with intersectin-2 to regulate endosomal recycling pathways

The atypical RhoU/Wrch1 Rho GTPase controls cell proliferation and apoptosis in the gut epithelium

The gene for a new brain specific RhoA exchange factor maps to the highly unstable chromosomal region 1p36.2-1p36.3.

The mineral dissolution function of osteoclasts is dispensable for hypertrophic cartilage degradation during long bone development and growth

The osteoclast cytoskeleton - current understanding and therapeutic perspectives for osteoporosis

The yeast exchange assay, a new complementary method to screen for Dbl-like protein specificity: identification of a novel RhoA exchange factor

Using a Modified Yeast Two-Hybrid System to Screen for Chemical GEF Inhibitors ⬇️