Lista de obras - Andrew Grierson - Dominio Público Uruguay

C9ORF72-derived poly-GA DPRs undergo endocytic uptake in iAstrocytes and spread to motor neurons

artículo científico publicado en 2022

AAV9-mediated central nervous system-targeted gene delivery via cisterna magna route in mice

artículo científico publicado en 2016

ALG-2 interacting protein AIP1: a novel link between D1 and D3 signalling

artículo científico publicado en 2008

Abnormalities in whisking behaviour are associated with lesions in brain stem nuclei in a mouse model of amyotrophic lateral sclerosis

artículo científico publicado en 2013

Adipose-derived stem cells protect motor neurons and reduce glial activation in both in vitro and in vivo models of ALS

artículo científico publicado en 2021

Altered age-related changes in bioenergetic properties and mitochondrial morphology in fibroblasts from sporadic amyotrophic lateral sclerosis patients

artículo científico publicado en 2015

An integrated map of chromosome 18 CAG trinucleotide repeat loci

artículo científico publicado en 1999

Androgen induced cell death in SHSY5Y neuroblastoma cells expressing wild-type and spinal bulbar muscular atrophy mutant androgen receptors.

artículo científico publicado en 2001

Axonal Transport Defects in a Mitofusin 2 Loss of Function Model of Charcot-Marie-Tooth Disease in Zebrafish.

artículo científico publicado en 2013

Axonal transport of neurofilaments in normal and disease states

artículo científico publicado en 2002

Characterization of the caspase cascade in a cell culture model of SOD1-related familial amyotrophic lateral sclerosis: expression, activation and therapeutic effects of inhibition.

artículo científico publicado en 2005

Charcot-Marie-Tooth disease neurofilament mutations disrupt neurofilament assembly and axonal transport

artículo científico publicado en 2002

Cyclin D2 interacts with cdk-5 and modulates cellular cdk-5/p35 activity

artículo científico publicado en 1998

Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients

scientific journal article

Discovery of Western European R1b1a2 Y chromosome variants in 1000 genomes project data: an online community approach

artículo científico publicado en 2012

Early detection of motor dysfunction in the SOD1G93A mouse model of Amyotrophic Lateral Sclerosis (ALS) using home cage running wheels

artículo científico publicado en 2014

Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content

artículo científico publicado en 2007

Gestational choriocarcinoma of the ovary diagnosed by analysis of tumour DNA

artículo científico publicado en 1996

Hereditary spastic paraparesis: disrupted intracellular transport associated with spastin mutation

artículo científico publicado en 2003

Impairment of the tRNA-splicing endonuclease subunit 54 (tsen54) gene causes neurological abnormalities and larval death in zebrafish models of pontocerebellar hypoplasia

artículo científico publicado en 2011

Investigation of the RB-1 tumour suppressor gene in a United Kingdom series of non-Hodgkin's lymphomas

artículo científico publicado en 1996

Mitochondrial function and actin regulate dynamin-related protein 1-dependent mitochondrial fission

artículo científico publicado en 2005

Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis ⬇️

artículo científico publicado el 1 de noviembre de 2011

Mutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS).

artículo científico publicado en 2010

Neurofilament heavy chain side arm phosphorylation regulates axonal transport of neurofilaments.

artículo científico publicado en 2003

Neutrophils use selective autophagy receptor Sqstm1/p62 to target Staphylococcus aureus for degradation in vivo in zebrafish

scientific article published on 19 June 2020

New pedigrees and novel mutation expand the phenotype of REEP1-associated hereditary spastic paraplegia (HSP)

artículo científico publicado en 2008

No evidence for cardiac dysfunction in Kif6 mutant mice

artículo científico publicado en 2013

Optimised and rapid pre-clinical screening in the SOD1(G93A) transgenic mouse model of amyotrophic lateral sclerosis (ALS).

artículo científico publicado en 2011

Parkinson's disease alpha-synuclein mutations exhibit defective axonal transport in cultured neurons

artículo científico publicado en 2004

Phosphorylation of thr(668) in the cytoplasmic domain of the Alzheimer's disease amyloid precursor protein by stress-activated protein kinase 1b (Jun N-terminal kinase-3).

artículo científico publicado en 2001

Polyglutamine repeat length influences human androgen receptor/c-Jun mediated transcription

scientific article published on 01 December 1999

Review: The role of mitochondria in the pathogenesis of amyotrophic lateral sclerosis.

artículo científico publicado en 2011

Role of axonal transport in neurodegenerative diseases

artículo científico publicado en 2008

S[+] Apomorphine is a CNS penetrating activator of the Nrf2-ARE pathway with activity in mouse and patient fibroblast models of amyotrophic lateral sclerosis

artículo científico publicado en 2013

Selective loss of neurofilament expression in Cu/Zn superoxide dismutase (SOD1) linked amyotrophic lateral sclerosis

artículo científico publicado en 2002

Superoxide dismutase 1 mutation in a cellular model of amyotrophic lateral sclerosis shifts energy generation from oxidative phosphorylation to glycolysis

artículo científico publicado en 2013

Systemic delivery of scAAV9 expressing SMN prolongs survival in a model of spinal muscular atrophy

artículo científico publicado en 2010

Tardbpl splicing rescues motor neuron and axonal development in a mutant tardbp zebrafish

artículo científico publicado en 2013

The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy

artículo científico publicado en 2016

The effect of SOD1 mutation on cellular bioenergetic profile and viability in response to oxidative stress and influence of mutation-type.

artículo científico publicado en 2013

The gene for the human Src-like adaptor protein (hSLAP) is located within the 64-kb intron of the thyroglobulin gene

artículo científico publicado en 1998

Three different human tau isoforms and rat neurofilament light, middle and heavy chain proteins are cellular substrates for transglutaminase

artículo científico publicado en 2001

Use of zebrafish models to investigate rare human disease

artículo científico publicado en 2018

p38alpha stress-activated protein kinase phosphorylates neurofilaments and is associated with neurofilament pathology in amyotrophic lateral sclerosis.

artículo científico publicado en 2004

Lista de obras de Andrew Grierson

<i>C9ORF72</i>-derived poly-GA DPRs undergo endocytic uptake in iAstrocytes and spread to motor neurons

AAV9-mediated central nervous system-targeted gene delivery via cisterna magna route in mice

ALG-2 interacting protein AIP1: a novel link between D1 and D3 signalling

Abnormalities in whisking behaviour are associated with lesions in brain stem nuclei in a mouse model of amyotrophic lateral sclerosis

Adipose-derived stem cells protect motor neurons and reduce glial activation in both <i>in vitro</i> and <i>in vivo</i> models of ALS

Altered age-related changes in bioenergetic properties and mitochondrial morphology in fibroblasts from sporadic amyotrophic lateral sclerosis patients

An integrated map of chromosome 18 CAG trinucleotide repeat loci

Androgen induced cell death in SHSY5Y neuroblastoma cells expressing wild-type and spinal bulbar muscular atrophy mutant androgen receptors.

Axonal Transport Defects in a Mitofusin 2 Loss of Function Model of Charcot-Marie-Tooth Disease in Zebrafish.

Axonal transport of neurofilaments in normal and disease states

Characterization of the caspase cascade in a cell culture model of SOD1-related familial amyotrophic lateral sclerosis: expression, activation and therapeutic effects of inhibition.

Charcot-Marie-Tooth disease neurofilament mutations disrupt neurofilament assembly and axonal transport

Cyclin D2 interacts with cdk-5 and modulates cellular cdk-5/p35 activity

Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients

Discovery of Western European R1b1a2 Y chromosome variants in 1000 genomes project data: an online community approach

Early detection of motor dysfunction in the SOD1G93A mouse model of Amyotrophic Lateral Sclerosis (ALS) using home cage running wheels

Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content

Gestational choriocarcinoma of the ovary diagnosed by analysis of tumour DNA

Hereditary spastic paraparesis: disrupted intracellular transport associated with spastin mutation

Impairment of the tRNA-splicing endonuclease subunit 54 (tsen54) gene causes neurological abnormalities and larval death in zebrafish models of pontocerebellar hypoplasia

Investigation of the RB-1 tumour suppressor gene in a United Kingdom series of non-Hodgkin's lymphomas

Mitochondrial function and actin regulate dynamin-related protein 1-dependent mitochondrial fission

Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis ⬇️

Mutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS).

Neurofilament heavy chain side arm phosphorylation regulates axonal transport of neurofilaments.

Neutrophils use selective autophagy receptor Sqstm1/p62 to target Staphylococcus aureus for degradation in vivo in zebrafish

New pedigrees and novel mutation expand the phenotype of REEP1-associated hereditary spastic paraplegia (HSP)

No evidence for cardiac dysfunction in Kif6 mutant mice

Optimised and rapid pre-clinical screening in the SOD1(G93A) transgenic mouse model of amyotrophic lateral sclerosis (ALS).

Parkinson's disease alpha-synuclein mutations exhibit defective axonal transport in cultured neurons

Phosphorylation of thr(668) in the cytoplasmic domain of the Alzheimer's disease amyloid precursor protein by stress-activated protein kinase 1b (Jun N-terminal kinase-3).

Polyglutamine repeat length influences human androgen receptor/c-Jun mediated transcription

Review: The role of mitochondria in the pathogenesis of amyotrophic lateral sclerosis.

Role of axonal transport in neurodegenerative diseases

S[+] Apomorphine is a CNS penetrating activator of the Nrf2-ARE pathway with activity in mouse and patient fibroblast models of amyotrophic lateral sclerosis

Selective loss of neurofilament expression in Cu/Zn superoxide dismutase (SOD1) linked amyotrophic lateral sclerosis

Superoxide dismutase 1 mutation in a cellular model of amyotrophic lateral sclerosis shifts energy generation from oxidative phosphorylation to glycolysis

Systemic delivery of scAAV9 expressing SMN prolongs survival in a model of spinal muscular atrophy

Tardbpl splicing rescues motor neuron and axonal development in a mutant tardbp zebrafish

The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy

The effect of SOD1 mutation on cellular bioenergetic profile and viability in response to oxidative stress and influence of mutation-type.

The gene for the human Src-like adaptor protein (hSLAP) is located within the 64-kb intron of the thyroglobulin gene

Three different human tau isoforms and rat neurofilament light, middle and heavy chain proteins are cellular substrates for transglutaminase

Use of zebrafish models to investigate rare human disease

p38alpha stress-activated protein kinase phosphorylates neurofilaments and is associated with neurofilament pathology in amyotrophic lateral sclerosis.