Lista de obras - Frédéric Lynen - Dominio Público Uruguay

3D-LC-MS with <sup>2</sup>D Multimethod Option for Fully Automated Assessment of Multiple Attributes of Monoclonal Antibodies Directly from Cell Culture Supernatants

artículo científico publicado en 2022

A novel UPLC-MS-MS method for simultaneous determination of seven uremic retention toxins with cardiovascular relevance in chronic kidney disease patients

artículo científico publicado en 2013

Analysis of bacterial fatty acids by flow modulated comprehensive two-dimensional gas chromatography with parallel flame ionization detector/mass spectrometry

artículo científico publicado en 2010

Application of the isopycnic kinetic plot method for elucidating the potential of sub-2 µm and core-shell particles in SFC.

artículo científico publicado en 2013

Capillary liquid chromatography separations using non-porous pillar array columns

artículo científico publicado en 2012

Chemical profiling of the major components in natural waxes to elucidate their role in liquid oil structuring.

artículo científico publicado en 2016

Chip-Based Multicapillary Column with Maximal Interconnectivity to Combine Maximum Efficiency and Maximum Loadability

artículo científico publicado en 2017

Chiral stationary phase optimized selectivity supercritical fluid chromatography: A strategy for the separation of mixtures of chiral isomers

artículo científico publicado en 2018

Combining liquid chromatography with multiplexed capillary gel electrophoresis for offline comprehensive analysis of complex oligonucleotide samples

artículo científico publicado en 2014

Comparative evaluation of ICP sample introduction systems to be used in the metabolite profiling of chlorine-containing pharmaceuticals via HPLC-ICP-MS

artículo científico publicado en 2018

Comparison between polymerized ionic liquids synthesized using chain-growth and step-growth mechanisms used as stationary phase in gas chromatography.

artículo científico publicado en 2016

Comparison of the quantitative performance of constant pressure versus constant flow rate gradient elution separations using concentration-sensitive detectors

artículo científico publicado en 2011

Comprehensive hydrophilic interaction and ion-pair reversed-phase liquid chromatography for analysis of di- to deca-oligonucleotides

artículo científico publicado en 2011

Comprehensive two-dimensional liquid chromatography coupled to the ABTS radical scavenging assay: a powerful method for the analysis of phenolic antioxidants.

artículo científico publicado en 2014

Construction of a new interface for comprehensive supercritical fluid chromatography x reversed phase liquid chromatography (SFC x RPLC).

artículo científico publicado en 2008

Deconvolution of overlapping spectral polymer signals in size exclusion separation-diode array detection separations by implementing a multivariate curve resolution method optimized by alternating least square

artículo científico publicado en 2014

Design and evaluation of a multi-detection system composed of ultraviolet, evaporative light scattering and inductively coupled plasma mass spectrometry detection for the analysis of pharmaceuticals by liquid chromatography

artículo científico publicado en 2008

Design and evaluation of various methods for the construction of kinetic performance limit plots for supercritical fluid chromatography

artículo científico publicado en 2012

Detailed characterisation of the flow resistance of commercial sub-2 micrometer reversed-phase columns

artículo científico publicado en 2007

Determination of cyclic guanosine- and cyclic adenosine monophosphate (cGMP and cAMP) in human plasma and animal tissues by solid phase extraction on silica and liquid chromatography-triple quadrupole mass spectrometry

artículo científico publicado en 2012

Determination of in Vitro and in Silico Indexes for the Modeling of Blood-Brain Barrier Partitioning of Drugs via Micellar and Immobilized Artificial Membrane Liquid Chromatography.

artículo científico publicado en 2017

Determination of the total drug-related chlorine and bromine contents in human blood plasma using high performance liquid chromatography-tandem ICP-mass spectrometry (HPLC-ICP-MS/MS).

artículo científico publicado en 2016

Development of the first sphingomyelin biomimetic stationary phase for immobilized artificial membrane (IAM) chromatography

artículo científico publicado en 2011

Effect of analyte properties on the kinetic performance of liquid chromatographic separations

artículo científico publicado en 2008

Effects of the water-soluble fraction of a crude oil on estuarine meiofauna: A microcosm approach

scientific article published on 25 April 2019

Elution behavior of short dsDNA strands in silicon micropillar array columns in ion pair reversed-phase chromatography mode

artículo científico publicado en 2012

Enantioseparation of pharmaceutical compounds by multiplexed capillary electrophoresis using highly sulphated alpha-, beta- and gamma-cyclodextrins

artículo científico publicado en 2008

Enhancing the Possibilities of Comprehensive Two-Dimensional Liquid Chromatography through Hyphenation of Purely Aqueous Temperature-Responsive and Reversed-Phase Liquid Chromatography.

artículo científico publicado en 2018

Errors involved in the existing B-term expressions for the longitudinal diffusion in fully porous chromatographic media Part II: experimental data in packed columns and surface diffusion measurements.

artículo científico publicado en 2008

Evaluation of a molecularly imprinted polymer as in-line concentrator in capillary electrophoresis.

artículo científico publicado en 2008

Evaluation of a multiarray system for pharmaceutical analysis by microemulsion electrokinetic chromatography

artículo científico publicado en 2011

Evaluation of automated sample preparation, retention time locked gas chromatography-mass spectrometry and data analysis methods for the metabolomic study of Arabidopsis species

artículo científico publicado en 2011

Evaluation of ionic liquid stationary phases for one dimensional gas chromatography-mass spectrometry and comprehensive two dimensional gas chromatographic analyses of fatty acids in marine biota

artículo científico publicado en 2011

Evaluation of sphingomyelin, cholester, and phosphatidylcholine-based immobilized artificial membrane liquid chromatography to predict drug penetration across the blood-brain barrier.

artículo científico publicado en 2014

Evaluation of the Temperature Responsive Stationary Phase Poly(N-isopropylacrylamide) in Aqueous LC for the Analysis of Small Molecules

article by Frédéric Lynen et al published 19 June 2007 in Chromatographia

Gradient stationary phase optimized selectivity liquid chromatography with conventional columns.

artículo científico publicado en 2013

High efficiency liquid chromatography on conventional columns and instrumentation by using temperature as a variable. Kinetic plots and experimental verification.

artículo científico publicado en 2006

High performance liquid chromatography analysis of wine anthocyanins revisited: effect of particle size and temperature.

artículo científico publicado en 2009

High-efficiency high performance liquid chromatographic analysis of red wine anthocyanins

artículo científico publicado en 2011

High-efficiency hydrophilic interaction chromatography by coupling 25 cm x 4.6mm ID x 5 microm silica columns and operation at 80 degrees C.

artículo científico publicado en 2009

Hyphenation of a Deoxyribonuclease I immobilized enzyme reactor with liquid chromatography for the online stability evaluation of oligonucleotides

artículo científico publicado en 2015

Implementing stationary-phase optimized selectivity in supercritical fluid chromatography

artículo científico publicado en 2014

Improving the universal response of evaporative light scattering detection by mobile phase compensation

artículo científico publicado en 2007

In vitro prediction of human intestinal absorption and blood-brain barrier partitioning: development of a lipid analog for micellar liquid chromatography

artículo científico publicado en 2015

Investigation of poly(styrene-divinylbenzene-vinylsulfonic acid) as retentive and electroosmotic flow generating phase in open-tubular electrochromatography

artículo científico publicado en 2015

Investigation of the validity of the kinetic plot method to predict the performance of coupled column systems operated at very high pressures under different thermal conditions.

artículo científico publicado en 2009

Kinetic performance evaluation and perspectives of contemporary packed column capillary electrochromatography

artículo científico publicado en 2014

Kinetic plot and particle size distribution analysis to discuss the performance limits of sub-2 microm and supra-2 microm particle columns.

artículo científico publicado en 2008

Kinetic plot method as a tool to design coupled column systems producing 100,000 theoretical plates in the shortest possible time.

artículo científico publicado en 2008

Kinetic plots for gas chromatography: theory and experimental verification.

artículo científico publicado en 2015

Kinetic plots for programmed temperature gas chromatography.

artículo científico publicado en 2016

Migration of photoinitiators from cardboard into dry food: evaluation of Tenax® as a food simulant.

artículo científico publicado en 2016

Mn-salen@MIL101(Al): a heterogeneous, enantioselective catalyst synthesized using a 'bottle around the ship' approach

artículo científico publicado en 2013

Model-based determination of the influence of textile fabric on bioassay analysis and the effectiveness of a textile slow-release system of DEET in mosquito control

artículo científico publicado en 2014

Near-infrared luminescence and RNA cleavage ability of lanthanide Schiff base complexes derived from N,N'-bis(3-methoxysalicylidene)ethylene-1,2-diamine ligands

artículo científico publicado en 2016

Nontargeted Pattern Recognition in the Search for Pyrolysis Gas Chromatography/Mass Spectrometry Resin Markers in Historic Lacquered Objects

artículo científico publicado en 2019

Nontargeted quantitation of lipid classes using hydrophilic interaction liquid chromatography-electrospray ionization mass spectrometry with single internal standard and response factor approach

artículo científico publicado en 2012

Offline comprehensive liquid chromatography in combination with a Deoxyribonuclease I immobilized enzymatic reactor for selective screening of oligonucleotide mixtures

artículo científico publicado en 2016

On-column sample enrichment for the high-sensitivity sheath-flow CE-MS analysis of peptides

artículo científico publicado en 2006

Optimization of a high-resolution radical scavenging assay coupled on-line to reversed-phase liquid chromatography for antioxidant detection in complex natural extracts

artículo científico publicado en 2015

Performance evaluation of long monolithic silica capillary columns in gradient liquid chromatography using peptide mixtures

scientific article published on 15 October 2010

Pharmaceutical impurity analysis by comprehensive two-dimensional temperature responsive × reversed phase liquid chromatography

artículo científico publicado en 2020

Predicting drug penetration across the blood-brain barrier: comparison of micellar liquid chromatography and immobilized artificial membrane liquid chromatography.

artículo científico publicado en 2013

Quantification aspects of constant pressure (ultra) high pressure liquid chromatography using mass-sensitive detectors with a nebulizing interface

artículo científico publicado en 2012

Quantification of silanol sites for the most common mesoporous ordered silicas and organosilicas: total versus accessible silanols

artículo científico publicado en 2012

Quantitation of triacylglycerols from plant oils using charged aerosol detection with gradient compensation

artículo científico publicado en 2007

Removal of atrazine in water by combination of activated carbon and dielectric barrier discharge.

artículo científico publicado en 2015

Response to Tsikas et al. Comments on Boelaert et al. Determination of Asymmetric and Symmetric Dimethylarginine in Serum from Patients with Chronic Kidney Disease: UPLC-MS/MS versus ELISA. Toxins 2016, 8, 149.

artículo científico publicado en 2016

Screening therapeutics according to their uptake across the blood-brain barrier: A high throughput method based on immobilized artificial membrane liquid chromatography-diode-array-detection coupled to electrospray-time-of-flight mass spectrometry.

artículo científico publicado en 2018

Selectivity optimization in green chromatography by gradient stationary phase optimized selectivity liquid chromatography

artículo científico publicado en 2010

Serial coupling of reversed-phase and hydrophilic interaction liquid chromatography to broaden the elution window for the analysis of pharmaceutical compounds.

artículo científico publicado en 2008

Solid-phase extraction based on hydrophilic interaction liquid chromatography with acetone as eluent for eliminating matrix effects in the analysis of biological fluids by LC-MS.

artículo científico publicado en 2013

Stationary-phase optimized selectivity liquid chromatography: development of a linear gradient prediction algorithm

artículo científico publicado en 2010

Stir bar sorptive extraction combined with GC-MS analysis and chemometric methods for the classification of South African Wines according to the volatile composition

artículo científico publicado en 2008

The kinetic plot method applied to gradient chromatography: theoretical framework and experimental validation.

artículo científico publicado en 2010

Total pore blocking as an alternative method for the on-column determination of the external porosity of packed and monolithic reversed-phase columns

artículo científico publicado en 2007

Tryptic digest analysis by comprehensive reversed phasextwo reversed phase liquid chromatography (RP-LCx2RP-LC) at different pH's.

artículo científico publicado en 2009

Tunable temperature responsive liquid chromatography through thiolactone-based immobilization of poly(N-isopropylacrylamide).

artículo científico publicado en 2015

Turbulence as a source of excessive baseline noise during high-speed isocratic and gradient separations using absorption detection.

artículo científico publicado en 2008

Universal response in liquid chromatography using charged aerosol detection.

artículo científico publicado en 2006

Variable column length method development strategy for amino acid analysis in serum samples of neonates with metabolic disorders.

artículo científico publicado en 2013

Variation in volatile leaf oils of five Eucalyptus species harvested from Jbel Abderrahman arboreta (Tunisia).

artículo científico publicado en 2011

Wounding stress causes rapid increase in concentration of the naturally occurring 2',3'-isomers of cyclic guanosine- and cyclic adenosine monophosphate (cGMP and cAMP) in plant tissues

artículo científico publicado en 2014

Lista de obras de Frédéric Lynen

3D-LC-MS with <sup>2</sup>D Multimethod Option for Fully Automated Assessment of Multiple Attributes of Monoclonal Antibodies Directly from Cell Culture Supernatants

A novel UPLC-MS-MS method for simultaneous determination of seven uremic retention toxins with cardiovascular relevance in chronic kidney disease patients

Analysis of bacterial fatty acids by flow modulated comprehensive two-dimensional gas chromatography with parallel flame ionization detector/mass spectrometry

Application of the isopycnic kinetic plot method for elucidating the potential of sub-2 µm and core-shell particles in SFC.

Capillary liquid chromatography separations using non-porous pillar array columns

Chemical profiling of the major components in natural waxes to elucidate their role in liquid oil structuring.

Chip-Based Multicapillary Column with Maximal Interconnectivity to Combine Maximum Efficiency and Maximum Loadability

Chiral stationary phase optimized selectivity supercritical fluid chromatography: A strategy for the separation of mixtures of chiral isomers

Combining liquid chromatography with multiplexed capillary gel electrophoresis for offline comprehensive analysis of complex oligonucleotide samples

Comparative evaluation of ICP sample introduction systems to be used in the metabolite profiling of chlorine-containing pharmaceuticals via HPLC-ICP-MS

Comparison between polymerized ionic liquids synthesized using chain-growth and step-growth mechanisms used as stationary phase in gas chromatography.

Comparison of the quantitative performance of constant pressure versus constant flow rate gradient elution separations using concentration-sensitive detectors

Comprehensive hydrophilic interaction and ion-pair reversed-phase liquid chromatography for analysis of di- to deca-oligonucleotides

Comprehensive two-dimensional liquid chromatography coupled to the ABTS radical scavenging assay: a powerful method for the analysis of phenolic antioxidants.

Construction of a new interface for comprehensive supercritical fluid chromatography x reversed phase liquid chromatography (SFC x RPLC).

Deconvolution of overlapping spectral polymer signals in size exclusion separation-diode array detection separations by implementing a multivariate curve resolution method optimized by alternating least square

Design and evaluation of a multi-detection system composed of ultraviolet, evaporative light scattering and inductively coupled plasma mass spectrometry detection for the analysis of pharmaceuticals by liquid chromatography

Design and evaluation of various methods for the construction of kinetic performance limit plots for supercritical fluid chromatography

Detailed characterisation of the flow resistance of commercial sub-2 micrometer reversed-phase columns

Determination of cyclic guanosine- and cyclic adenosine monophosphate (cGMP and cAMP) in human plasma and animal tissues by solid phase extraction on silica and liquid chromatography-triple quadrupole mass spectrometry

Determination of in Vitro and in Silico Indexes for the Modeling of Blood-Brain Barrier Partitioning of Drugs via Micellar and Immobilized Artificial Membrane Liquid Chromatography.

Determination of the total drug-related chlorine and bromine contents in human blood plasma using high performance liquid chromatography-tandem ICP-mass spectrometry (HPLC-ICP-MS/MS).

Development of the first sphingomyelin biomimetic stationary phase for immobilized artificial membrane (IAM) chromatography

Effect of analyte properties on the kinetic performance of liquid chromatographic separations

Effects of the water-soluble fraction of a crude oil on estuarine meiofauna: A microcosm approach

Elution behavior of short dsDNA strands in silicon micropillar array columns in ion pair reversed-phase chromatography mode

Enantioseparation of pharmaceutical compounds by multiplexed capillary electrophoresis using highly sulphated alpha-, beta- and gamma-cyclodextrins

Enhancing the Possibilities of Comprehensive Two-Dimensional Liquid Chromatography through Hyphenation of Purely Aqueous Temperature-Responsive and Reversed-Phase Liquid Chromatography.

Errors involved in the existing B-term expressions for the longitudinal diffusion in fully porous chromatographic media Part II: experimental data in packed columns and surface diffusion measurements.

Evaluation of a molecularly imprinted polymer as in-line concentrator in capillary electrophoresis.

Evaluation of a multiarray system for pharmaceutical analysis by microemulsion electrokinetic chromatography

Evaluation of automated sample preparation, retention time locked gas chromatography-mass spectrometry and data analysis methods for the metabolomic study of Arabidopsis species

Evaluation of ionic liquid stationary phases for one dimensional gas chromatography-mass spectrometry and comprehensive two dimensional gas chromatographic analyses of fatty acids in marine biota

Evaluation of sphingomyelin, cholester, and phosphatidylcholine-based immobilized artificial membrane liquid chromatography to predict drug penetration across the blood-brain barrier.

Evaluation of the Temperature Responsive Stationary Phase Poly(N-isopropylacrylamide) in Aqueous LC for the Analysis of Small Molecules

Gradient stationary phase optimized selectivity liquid chromatography with conventional columns.

High efficiency liquid chromatography on conventional columns and instrumentation by using temperature as a variable. Kinetic plots and experimental verification.

High performance liquid chromatography analysis of wine anthocyanins revisited: effect of particle size and temperature.

High-efficiency high performance liquid chromatographic analysis of red wine anthocyanins

High-efficiency hydrophilic interaction chromatography by coupling 25 cm x 4.6mm ID x 5 microm silica columns and operation at 80 degrees C.

Hyphenation of a Deoxyribonuclease I immobilized enzyme reactor with liquid chromatography for the online stability evaluation of oligonucleotides

Implementing stationary-phase optimized selectivity in supercritical fluid chromatography

Improving the universal response of evaporative light scattering detection by mobile phase compensation

In vitro prediction of human intestinal absorption and blood-brain barrier partitioning: development of a lipid analog for micellar liquid chromatography

Investigation of poly(styrene-divinylbenzene-vinylsulfonic acid) as retentive and electroosmotic flow generating phase in open-tubular electrochromatography

Investigation of the validity of the kinetic plot method to predict the performance of coupled column systems operated at very high pressures under different thermal conditions.

Kinetic performance evaluation and perspectives of contemporary packed column capillary electrochromatography

Kinetic plot and particle size distribution analysis to discuss the performance limits of sub-2 microm and supra-2 microm particle columns.

Kinetic plot method as a tool to design coupled column systems producing 100,000 theoretical plates in the shortest possible time.

Kinetic plots for gas chromatography: theory and experimental verification.

Kinetic plots for programmed temperature gas chromatography.

Migration of photoinitiators from cardboard into dry food: evaluation of Tenax® as a food simulant.

Mn-salen@MIL101(Al): a heterogeneous, enantioselective catalyst synthesized using a 'bottle around the ship' approach

Model-based determination of the influence of textile fabric on bioassay analysis and the effectiveness of a textile slow-release system of DEET in mosquito control

Near-infrared luminescence and RNA cleavage ability of lanthanide Schiff base complexes derived from N,N'-bis(3-methoxysalicylidene)ethylene-1,2-diamine ligands

Nontargeted Pattern Recognition in the Search for Pyrolysis Gas Chromatography/Mass Spectrometry Resin Markers in Historic Lacquered Objects

Nontargeted quantitation of lipid classes using hydrophilic interaction liquid chromatography-electrospray ionization mass spectrometry with single internal standard and response factor approach

Offline comprehensive liquid chromatography in combination with a Deoxyribonuclease I immobilized enzymatic reactor for selective screening of oligonucleotide mixtures

On-column sample enrichment for the high-sensitivity sheath-flow CE-MS analysis of peptides

Optimization of a high-resolution radical scavenging assay coupled on-line to reversed-phase liquid chromatography for antioxidant detection in complex natural extracts

Performance evaluation of long monolithic silica capillary columns in gradient liquid chromatography using peptide mixtures

Pharmaceutical impurity analysis by comprehensive two-dimensional temperature responsive × reversed phase liquid chromatography

Predicting drug penetration across the blood-brain barrier: comparison of micellar liquid chromatography and immobilized artificial membrane liquid chromatography.

Quantification aspects of constant pressure (ultra) high pressure liquid chromatography using mass-sensitive detectors with a nebulizing interface

Quantification of silanol sites for the most common mesoporous ordered silicas and organosilicas: total versus accessible silanols

Quantitation of triacylglycerols from plant oils using charged aerosol detection with gradient compensation

Removal of atrazine in water by combination of activated carbon and dielectric barrier discharge.

Response to Tsikas et al. Comments on Boelaert et al. Determination of Asymmetric and Symmetric Dimethylarginine in Serum from Patients with Chronic Kidney Disease: UPLC-MS/MS versus ELISA. Toxins 2016, 8, 149.

Screening therapeutics according to their uptake across the blood-brain barrier: A high throughput method based on immobilized artificial membrane liquid chromatography-diode-array-detection coupled to electrospray-time-of-flight mass spectrometry.

Selectivity optimization in green chromatography by gradient stationary phase optimized selectivity liquid chromatography

Serial coupling of reversed-phase and hydrophilic interaction liquid chromatography to broaden the elution window for the analysis of pharmaceutical compounds.

Solid-phase extraction based on hydrophilic interaction liquid chromatography with acetone as eluent for eliminating matrix effects in the analysis of biological fluids by LC-MS.

Stationary-phase optimized selectivity liquid chromatography: development of a linear gradient prediction algorithm

Stir bar sorptive extraction combined with GC-MS analysis and chemometric methods for the classification of South African Wines according to the volatile composition

The kinetic plot method applied to gradient chromatography: theoretical framework and experimental validation.

Total pore blocking as an alternative method for the on-column determination of the external porosity of packed and monolithic reversed-phase columns

Tryptic digest analysis by comprehensive reversed phasextwo reversed phase liquid chromatography (RP-LCx2RP-LC) at different pH's.

Tunable temperature responsive liquid chromatography through thiolactone-based immobilization of poly(N-isopropylacrylamide).

Turbulence as a source of excessive baseline noise during high-speed isocratic and gradient separations using absorption detection.