Lista de obras - Carlotta Granchi - Dominio Público Uruguay

4-Aryliden-2-methyloxazol-5(4H)-one as a new scaffold for selective reversible MAGL inhibitors

artículo científico publicado en 2015

A Guide to PIN1 Function and Mutations Across Cancers

artículo científico publicado en 2018

A Virtual Screening Study for Lactate Dehydrogenase 5 Inhibitors by Using a Pharmacophore-based Approach.

artículo científico publicado en 2016

A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).

artículo científico publicado en 2017

ATP citrate lyase (ACLY) inhibitors: An anti-cancer strategy at the crossroads of glucose and lipid metabolism

scientific article published on 01 September 2018

Activators of Sirtuin-1 and their Involvement in Cardioprotection

artículo científico publicado en 2018

An Update on Patents Covering Agents That Interfere with the Cancer Glycolytic Cascade

artículo científico publicado en 2018

An update on therapeutic opportunities offered by cancer glycolytic metabolism

artículo científico

An updated patent review of monoacylglycerol lipase (MAGL) inhibitors (2018-present)

scientific article published on 21 October 2020

Anticancer agents interacting with membrane glucose transporters

artículo científico publicado en 2016

Anticancer agents that counteract tumor glycolysis.

artículo científico publicado en 2012

Application of MM-PBSA Methods in Virtual Screening

artículo científico publicado en 2020

Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds

scientific article published on 29 August 2013

BACE1 inhibitory activities of enantiomerically pure, variously substituted N-(3-(4-benzhydrylpiperazin-1-yl)-2-hydroxypropyl) arylsulfonamides

artículo científico publicado en 2010

Binding investigation and preliminary optimisation of the 3-amino-1,2,4-triazin-5(2H)-one core for the development of new Fyn inhibitors.

artículo científico publicado en 2018

Bioactive heterocycles containing endocyclic N-hydroxy groups

artículo científico publicado en 2015

Bioreductively activated lysyl oxidase inhibitors against hypoxic tumours

artículo científico publicado en 2009

Biphenyl-Derivatives Possessing Tertiary Amino Groups as β-Secretase (BACE1) Inhibitors

scholarly article by Simone Bertini et al published 1 August 2010 in Letters in drug design & discovery

Carbazole-containing arylcarboxamides as BACE1 inhibitors

artículo científico publicado en 2011

Characterization of the Saffron Derivative Crocetin as an Inhibitor of Human Lactate Dehydrogenase 5 in the Antiglycolytic Approach against Cancer.

artículo científico publicado en 2017

Computationally driven discovery of phenyl(piperazin-1-yl)methanone derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors

artículo científico publicado en 2019

Constituents of Polygala flavescens ssp. flavescens and Their Activity as Inhibitors of Human Lactate Dehydrogenase.

artículo científico

Correction to Constituents of Polygala flavescens ssp. flavescens and Their Activity as Inhibitors of Human Lactate Dehydrogenase.

artículo científico publicado en 2017

Cyclic Ketoximes as Estrogen Receptor β Selective Agonists.

artículo científico publicado en 2016

Design, Synthesis, and Evaluation of GLUT Inhibitors.

artículo científico publicado en 2018

Development and validation of a docking-based virtual screening platform for the identification of new lactate dehydrogenase inhibitors.

artículo científico publicado en 2015

Development of terphenyl-2-methyloxazol-5(4H)-one derivatives as selective reversible MAGL inhibitors.

artículo científico publicado en 2017

Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors.

artículo científico publicado en 2018

Discovery of Allosteric Inhibition of Human ATP-Citrate Lyase

scientific article published on 06 May 2019

Discovery of Monoacylglycerol Lipase (MAGL) Inhibitors Based on a Pharmacophore-Guided Virtual Screening Study

artículo científico publicado en 2020

Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells.

artículo científico publicado en 2011

Discovery of a new ATP-citrate lyase (ACLY) inhibitor identified by a pharmacophore-based virtual screening study

artículo científico publicado en 2020

Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors

scientific article published on 16 August 2018

Dual targeting of the Warburg effect with a glucose-conjugated lactate dehydrogenase inhibitor.

artículo científico publicado en 2013

Effect of Tumor Relevant Acidic Environment in the Interaction of a N-hydroxyindole-2-Carboxylic Derivative with the Phospholipid Bilayer

artículo científico publicado en 2018

Estrogen receptor ligands: a patent review update

artículo científico publicado en 2013

Estrogen receptors alpha (ERα) and beta (ERβ): subtype-selective ligands and clinical potential.

artículo científico publicado en 2014

First Examples of H2S-Releasing Glycoconjugates: Stereoselective Synthesis and Anticancer Activities

artículo científico publicado en 2019

First-of-its-kind STARD3 Inhibitor: In Silico Identification and Biological Evaluation as Anticancer Agent

scientific article published on 20 February 2019

Highly selective salicylketoxime-based estrogen receptor β agonists display antiproliferative activities in a glioma model

artículo científico publicado en 2015

Identification and characterization of a new reversible MAGL inhibitor

artículo científico publicado en 2014

Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53-independent pathways

artículo científico publicado en 2014

Identification of new Fyn kinase inhibitors using a FLAP-based approach.

artículo científico publicado en 2013

Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies

artículo científico publicado en 2018

Inhibitors of lactate dehydrogenase isoforms and their therapeutic potentials

artículo científico publicado en 2010

Lactate dehydrogenase-A inhibition induces human glioblastoma multiforme stem cell differentiation and death

artículo científico publicado en 2015

Liposomal delivery of a Pin1 inhibitor complexed with cyclodextrins as new therapy for high-grade serous ovarian cancer

scientific article published on 08 May 2018

N-Hydroxyindole-based inhibitors of lactate dehydrogenase against cancer cell proliferation

artículo científico publicado en 2011

New Phenylethanoid Glycosides from Cistanche phelypaea and Their Activity as Inhibitors of Monoacylglycerol Lipase (MAGL).

artículo científico publicado en 2018

New diterpenes from Salvia pseudorosmarinus and their activity as inhibitors of monoacylglycerol lipase (MAGL)

artículo científico publicado en 2018

Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor

artículo científico publicado en 2019

Oxime-based inhibitors of glucose transporter 1 displaying antiproliferative effects in cancer cells.

artículo científico publicado en 2013

Phenylpropanoids and flavonoids from Phlomis kurdica as inhibitors of human lactate dehydrogenase.

artículo científico publicado en 2015

Phospho-Akt overexpression is prognostic and can be used to tailor the synergistic interaction of Akt inhibitors with gemcitabine in pancreatic cancer

artículo científico publicado en 2017

Rational Development of MAGL Inhibitors

artículo científico publicado en 2018

Reactive Oxygen Species Synergize To Potently and Selectively Induce Cancer Cell Death

artículo científico publicado en 2017

Receptor-based virtual screening evaluation for the identification of estrogen receptorβligands

artículo científico publicado en 2014

Risks and benefits related to alimentary exposure to xenoestrogens

artículo científico publicado en 2016

Salicylaldoxime derivatives as new leads for the development of carbonic anhydrase inhibitors.

artículo científico publicado en 2012

Salicylketoximes That Target Glucose Transporter 1 Restrict Energy Supply to Lung Cancer Cells

artículo científico publicado en 2015

Selective and potent agonists for estrogen receptor beta derived from molecular refinements of salicylaldoximes.

artículo científico publicado en 2011

Small-molecule inhibitors of human LDH5.

scientific article published on October 2013

Structural Optimization of 4-Chlorobenzoylpiperidine Derivatives for the Development of Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors.

artículo científico publicado en 2016

Structural evolutions of salicylaldoximes as selective agonists for estrogen receptor beta

artículo científico publicado en 2009

Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcitabine against pancreatic cancer cells in hypoxia

artículo científico publicado en 2013

Synthesis and Biological Evaluation of New Glycoconjugated LDH Inhibitors as Anticancer Agents

artículo científico publicado en 2019

Synthesis and biological evaluation of non-glucose glycoconjugated N-hydroyxindole class LDH inhibitors as anticancer agents.

artículo científico publicado en 2015

Synthesis of sulfonamide-containing N-hydroxyindole-2-carboxylates as inhibitors of human lactate dehydrogenase-isoform 5

artículo científico publicado en 2011

The dichotomous role of the glycolytic metabolism pathway in cancer metastasis: Interplay with the complex tumor microenvironment and novel therapeutic strategies

scientific article published on 21 August 2019

The influence of Echinacea purpurea leaf microbiota on chicoric acid level

scientific article published on 26 July 2019

Three-Dimensional Analysis of the Interactions between hLDH5 and Its Inhibitors.

artículo científico publicado en 2017

Triazole-substituted N-hydroxyindol-2-carboxylates as inhibitors of isoform 5 of human lactate dehydrogenase (hLDH5)

Virtual screening identifies a PIN1 inhibitor with possible antiovarian cancer effects

scientific article published on 29 January 2019

alpha-Naphthylaminopropan-2-ol Derivatives as BACE1 Inhibitors

artículo científico publicado en 2008

Lista de obras de Carlotta Granchi

4-Aryliden-2-methyloxazol-5(4H)-one as a new scaffold for selective reversible MAGL inhibitors

A Guide to PIN1 Function and Mutations Across Cancers

A Virtual Screening Study for Lactate Dehydrogenase 5 Inhibitors by Using a Pharmacophore-based Approach.

A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).

ATP citrate lyase (ACLY) inhibitors: An anti-cancer strategy at the crossroads of glucose and lipid metabolism

Activators of Sirtuin-1 and their Involvement in Cardioprotection

An Update on Patents Covering Agents That Interfere with the Cancer Glycolytic Cascade

An update on therapeutic opportunities offered by cancer glycolytic metabolism

An updated patent review of monoacylglycerol lipase (MAGL) inhibitors (2018-present)

Anticancer agents interacting with membrane glucose transporters

Anticancer agents that counteract tumor glycolysis.

Application of MM-PBSA Methods in Virtual Screening

Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds

BACE1 inhibitory activities of enantiomerically pure, variously substituted N-(3-(4-benzhydrylpiperazin-1-yl)-2-hydroxypropyl) arylsulfonamides

Binding investigation and preliminary optimisation of the 3-amino-1,2,4-triazin-5(2H)-one core for the development of new Fyn inhibitors.

Bioactive heterocycles containing endocyclic N-hydroxy groups

Bioreductively activated lysyl oxidase inhibitors against hypoxic tumours

Biphenyl-Derivatives Possessing Tertiary Amino Groups as β-Secretase (BACE1) Inhibitors

Carbazole-containing arylcarboxamides as BACE1 inhibitors

Characterization of the Saffron Derivative Crocetin as an Inhibitor of Human Lactate Dehydrogenase 5 in the Antiglycolytic Approach against Cancer.

Computationally driven discovery of phenyl(piperazin-1-yl)methanone derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors

Constituents of Polygala flavescens ssp. flavescens and Their Activity as Inhibitors of Human Lactate Dehydrogenase.

Correction to Constituents of Polygala flavescens ssp. flavescens and Their Activity as Inhibitors of Human Lactate Dehydrogenase.

Cyclic Ketoximes as Estrogen Receptor β Selective Agonists.

Design, Synthesis, and Evaluation of GLUT Inhibitors.

Development and validation of a docking-based virtual screening platform for the identification of new lactate dehydrogenase inhibitors.

Development of terphenyl-2-methyloxazol-5(4H)-one derivatives as selective reversible MAGL inhibitors.

Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors.

Discovery of Allosteric Inhibition of Human ATP-Citrate Lyase

Discovery of Monoacylglycerol Lipase (MAGL) Inhibitors Based on a Pharmacophore-Guided Virtual Screening Study

Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells.

Discovery of a new ATP-citrate lyase (ACLY) inhibitor identified by a pharmacophore-based virtual screening study

Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors

Dual targeting of the Warburg effect with a glucose-conjugated lactate dehydrogenase inhibitor.

Effect of Tumor Relevant Acidic Environment in the Interaction of a N-hydroxyindole-2-Carboxylic Derivative with the Phospholipid Bilayer

Estrogen receptor ligands: a patent review update

Estrogen receptors alpha (ERα) and beta (ERβ): subtype-selective ligands and clinical potential.

First Examples of H2S-Releasing Glycoconjugates: Stereoselective Synthesis and Anticancer Activities

First-of-its-kind STARD3 Inhibitor: In Silico Identification and Biological Evaluation as Anticancer Agent

Highly selective salicylketoxime-based estrogen receptor β agonists display antiproliferative activities in a glioma model

Identification and characterization of a new reversible MAGL inhibitor

Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53-independent pathways

Identification of new Fyn kinase inhibitors using a FLAP-based approach.

Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies

Inhibitors of lactate dehydrogenase isoforms and their therapeutic potentials

Lactate dehydrogenase-A inhibition induces human glioblastoma multiforme stem cell differentiation and death

Liposomal delivery of a Pin1 inhibitor complexed with cyclodextrins as new therapy for high-grade serous ovarian cancer

N-Hydroxyindole-based inhibitors of lactate dehydrogenase against cancer cell proliferation

New Phenylethanoid Glycosides from Cistanche phelypaea and Their Activity as Inhibitors of Monoacylglycerol Lipase (MAGL).

New diterpenes from Salvia pseudorosmarinus and their activity as inhibitors of monoacylglycerol lipase (MAGL)

Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor

Oxime-based inhibitors of glucose transporter 1 displaying antiproliferative effects in cancer cells.

Phenylpropanoids and flavonoids from Phlomis kurdica as inhibitors of human lactate dehydrogenase.

Phospho-Akt overexpression is prognostic and can be used to tailor the synergistic interaction of Akt inhibitors with gemcitabine in pancreatic cancer

Rational Development of MAGL Inhibitors

Reactive Oxygen Species Synergize To Potently and Selectively Induce Cancer Cell Death

Receptor-based virtual screening evaluation for the identification of estrogen receptorβligands

Risks and benefits related to alimentary exposure to xenoestrogens

Salicylaldoxime derivatives as new leads for the development of carbonic anhydrase inhibitors.

Salicylketoximes That Target Glucose Transporter 1 Restrict Energy Supply to Lung Cancer Cells

Selective and potent agonists for estrogen receptor beta derived from molecular refinements of salicylaldoximes.

Small-molecule inhibitors of human LDH5.

Structural Optimization of 4-Chlorobenzoylpiperidine Derivatives for the Development of Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors.

Structural evolutions of salicylaldoximes as selective agonists for estrogen receptor beta

Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcitabine against pancreatic cancer cells in hypoxia

Synthesis and Biological Evaluation of New Glycoconjugated LDH Inhibitors as Anticancer Agents

Synthesis and biological evaluation of non-glucose glycoconjugated N-hydroyxindole class LDH inhibitors as anticancer agents.

Synthesis of sulfonamide-containing N-hydroxyindole-2-carboxylates as inhibitors of human lactate dehydrogenase-isoform 5

The dichotomous role of the glycolytic metabolism pathway in cancer metastasis: Interplay with the complex tumor microenvironment and novel therapeutic strategies

The influence of Echinacea purpurea leaf microbiota on chicoric acid level

Three-Dimensional Analysis of the Interactions between hLDH5 and Its Inhibitors.

Triazole-substituted N-hydroxyindol-2-carboxylates as inhibitors of isoform 5 of human lactate dehydrogenase (hLDH5)

Virtual screening identifies a PIN1 inhibitor with possible antiovarian cancer effects

alpha-Naphthylaminopropan-2-ol Derivatives as BACE1 Inhibitors