Lista de obras - David Tscharke - Dominio Público Uruguay

A consensus epitope prediction approach identifies the breadth of murine T(CD8+)-cell responses to vaccinia virus

artículo científico publicado en 2006

Altered CD8(+) T cell immunodominance after vaccinia virus infection and the naive repertoire in inbred and F(1) mice.

artículo científico publicado en 2009

An intact signal peptide on dengue virus E protein enhances immunogenicity for CD8(+) T cells and antibody when expressed from modified vaccinia Ankara

artículo científico publicado en 2014

An intradermal model for vaccinia virus pathogenesis in mice.

artículo científico publicado en 2012

An ultrastructural investigation of tumors undergoing regression mediated by immunotherapy

artículo científico publicado en 2017

Analysis of A47, an immunoprevalent protein of vaccinia virus, leads to a reevaluation of the total antiviral CD8+ T cell response.

artículo científico publicado en 2010

Analyzing CD8 T cells in mouse models of poxvirus infection

artículo científico publicado en 2012

Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasome ⬇️

artículo científico publicado en 2020

Benchmarking predictions of MHC class I restricted T cell epitopes in a comprehensively studied model system

scientific article published on 26 May 2020

CRISPR/Cas9-Based Genome Editing of HSV

artículo científico publicado en 2020

Comparative analysis of the complete genome sequence of the California MSW strain of myxoma virus reveals potential host adaptations

artículo científico publicado en 2013

Definition of epitopes and antigens recognized by vaccinia specific immune responses: their conservation in variola virus sequences, and use as a model system to study complex pathogens

artículo científico publicado en 2009

Delayed control of herpes simplex virus infection and impaired CD4(+) T-cell migration to the skin in mouse models of DOCK8 deficiency

artículo científico publicado en 2015

Deletion of gene A41L enhances vaccinia virus immunogenicity and vaccine efficacy.

artículo científico publicado en 2006

Dissociation between epitope hierarchy and immunoprevalence in CD8 responses to vaccinia virus western reserve

artículo científico publicado en 2008

Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting.

artículo científico publicado en 2016

Ectromelia virus N1L is essential for virulence but not dissemination in a classical model of mousepox.

artículo científico publicado en 2016

Effective Priming of Herpes Simplex Virus-Specific CD8+ T Cells In Vivo Does Not Require Infected Dendritic Cells ⬇️

artículo científico publicado en 2017

Engineering herpes simplex viruses by infection-transfection methods including recombination site targeting by CRISPR/Cas9 nucleases.

artículo científico publicado en 2014

Engineering recombinant poxviruses using a compact GFP-blasticidin resistance fusion gene for selection.

artículo científico publicado en 2010

Evolutionary history and attenuation of myxoma virus on two continents

artículo científico publicado en 2012

Extent of Systemic Spread Determines CD8+ T Cell Immunodominance for Laboratory Strains, Smallpox Vaccines, and Zoonotic Isolates of Vaccinia Virus.

artículo científico publicado en 2015

From mice to humans - murine intelligence for human CD8+ T cell vaccine design

artículo científico publicado en 2005

Functional analysis of the short isoform of orf virus protein OV20.0.

artículo científico publicado en 2015

Functional paralysis of human natural killer cells by alphaherpesviruses.

artículo científico publicado en 2019

Genome scale evolution of myxoma virus reveals host-pathogen adaptation and rapid geographic spread

artículo científico publicado en 2013

HLA class I-restricted responses to vaccinia recognize a broad array of proteins mainly involved in virulence and viral gene regulation

artículo científico publicado en 2005

HLA-A0201, HLA-A1101, and HLA-B*0702 transgenic mice recognize numerous poxvirus determinants from a wide variety of viral gene products.

artículo científico publicado en 2005

Herpes Simplex Virus Latency Is Noisier the Closer We Look

scientific article published on 31 January 2020

IL-4 and IL-13 mediated down-regulation of CD8 expression levels can dampen anti-viral CD8⁺ T cell avidity following HIV-1 recombinant pox viral vaccination.

artículo científico publicado en 2013

Identification of poxvirus CD8+ T cell determinants to enable rational design and characterization of smallpox vaccines

artículo científico publicado en 2004

Immunodomination during peripheral vaccinia virus infection.

artículo científico publicado en 2013

Immunology by numbers: quantitation of antigen presentation completes the quantitative milieu of systems immunology!

artículo científico publicado en 2016

Increasing antigen presentation on HSV-1-infected cells increases lesion size but does not alter neural infection or latency.

artículo científico publicado en 2018

Influenza A Virus Infection Induces Viral and Cellular Defective Ribosomal Products Encoded by Alternative Reading Frames

scientific article published on 15 May 2019

Inside the professionals

artículo científico publicado en 2002

Kinetic analysis of a complete poxvirus transcriptome reveals an immediate-early class of genes

artículo científico publicado en 2008

Kinetics of antigen expression and epitope presentation during virus infection.

artículo científico publicado en 2013

Linear fidelity in quantification of anti-viral CD8+ T cells

artículo científico publicado en 2012

Local proliferation maintains a stable pool of tissue-resident memory T cells after antiviral recall responses

artículo científico publicado en 2018

Lytic Promoters Express Protein during Herpes Simplex Virus Latency.

artículo científico publicado en 2016

Lytic gene expression is frequent in HSV-1 latent infection and correlates with the engagement of a cell-intrinsic transcriptional response

artículo científico publicado en 2014

Modified Vaccinia Virus Ankara Can Induce Optimal CD8+ T Cell Responses to Directly Primed Antigens Depending on Vaccine Design

artículo científico publicado en 2019

Most viral peptides displayed by class I MHC on infected cells are immunogenic

artículo científico publicado en 2019

Overlapping Peptides Elicit Distinct CD8+ T Cell Responses following Influenza A Virus Infection

scientific article published on 31 August 2020

Poxvirus CD8+ T-cell determinants and cross-reactivity in BALB/c mice

artículo científico publicado en 2006

Quantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responses

artículo científico publicado en 2019

Quantifying epitope presentation using mass spectrometry

artículo científico

Rapid poxvirus engineering using CRISPR/Cas9 as a selection tool

artículo científico publicado en 2020

Reduced interleukin-4 receptor α expression on CD8+ T cells correlates with higher quality anti-viral immunity

artículo científico publicado en 2013

Reduction of vector gene expression increases foreign antigen-specific CD8+ T-cell priming

artículo científico publicado en 2007

Redundancy complicates the definition of essential genes for vaccinia virus

artículo científico publicado en 2015

Regulation of protein translation through mRNA structure influences MHC class I loading and T cell recognition.

artículo científico publicado en 2008

Regulatory T cells suppress CD8+ T cell responses induced by direct priming and cross-priming and moderate immunodominance disparities.

artículo científico publicado en 2005

Reply to Satheshkumar and Moss: Poxvirus transcriptome analysis.

artículo científico publicado en 2008

Simultaneous Quantification of Viral Antigen Expression Kinetics Using Data-Independent (DIA) Mass Spectrometry.

artículo científico publicado en 2015

Sizing up the key determinants of the CD8(+) T cell response

artículo científico

Strikingly poor CD8+ T-cell immunogenicity of vaccinia virus strain MVA in BALB/c mice.

artículo científico publicado en 2014

Surprisingly Effective Priming of CD8+ T cells by Heat-Inactivated Vaccinia Virus Virions

artículo científico publicado en 2020

Systemic toll-like receptor ligation and selective killing of dendritic cell subsets fail to dissect priming pathways for anti-vaccinia virus CD8⁺ T cells

artículo científico publicado en 2013

T cells bite the hand that feeds them

artículo científico publicado en 2003

The Epstein-Barr Virus Glycoprotein gp150 Forms an Immune-Evasive Glycan Shield at the Surface of Infected Cells

artículo científico publicado en 2016

The cellular redox environment alters antigen presentation

artículo científico publicado en 2014

The developmental pathway for CD103(+)CD8+ tissue-resident memory T cells of skin.

artículo científico publicado en 2013

The ectromelia virus SPI-2 protein causes lethal mousepox by preventing NK cell responses

artículo científico publicado en 2011

The primary immune response to Vaccinia virus vaccination includes cells with a distinct cytotoxic effector CD4 T-cell phenotype.

artículo científico publicado en 2016

The vaccinia virus kelch-like protein C2L affects calcium-independent adhesion to the extracellular matrix and inflammation in a murine intradermal model

artículo científico publicado en 2003

Tissue-resident memory T cells in tissue homeostasis, persistent infection, and cancer surveillance.

artículo científico publicado en 2018

Truncation of gene F5L partially masks rescue of vaccinia virus strain MVA growth on mammalian cells by restricting plaque size.

artículo científico publicado en 2013

Uncovering the interplay between CD8, CD4 and antibody responses to complex pathogens.

artículo científico publicado en 2010

Use of CD107-based cell sorting ex vivo to enrich subdominant CD8+ T cells in culture.

artículo científico publicado en 2007

Vaccinia virus CD8+ T-cell dominance hierarchies cannot be altered by prior immunization with individual peptides.

artículo científico publicado en 2009

Vaccinia virus F5 is required for normal plaque morphology in multiple cell lines but not replication in culture or virulence in mice

artículo científico publicado en 2014

Lista de obras de David Tscharke

A consensus epitope prediction approach identifies the breadth of murine T(CD8+)-cell responses to vaccinia virus

Altered CD8(+) T cell immunodominance after vaccinia virus infection and the naive repertoire in inbred and F(1) mice.

An intact signal peptide on dengue virus E protein enhances immunogenicity for CD8(+) T cells and antibody when expressed from modified vaccinia Ankara

An intradermal model for vaccinia virus pathogenesis in mice.

An ultrastructural investigation of tumors undergoing regression mediated by immunotherapy

Analysis of A47, an immunoprevalent protein of vaccinia virus, leads to a reevaluation of the total antiviral CD8+ T cell response.

Analyzing CD8 T cells in mouse models of poxvirus infection

Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasome ⬇️

Benchmarking predictions of MHC class I restricted T cell epitopes in a comprehensively studied model system

CRISPR/Cas9-Based Genome Editing of HSV

Comparative analysis of the complete genome sequence of the California MSW strain of myxoma virus reveals potential host adaptations

Definition of epitopes and antigens recognized by vaccinia specific immune responses: their conservation in variola virus sequences, and use as a model system to study complex pathogens

Delayed control of herpes simplex virus infection and impaired CD4(+) T-cell migration to the skin in mouse models of DOCK8 deficiency

Deletion of gene A41L enhances vaccinia virus immunogenicity and vaccine efficacy.

Dissociation between epitope hierarchy and immunoprevalence in CD8 responses to vaccinia virus western reserve

Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting.

Ectromelia virus N1L is essential for virulence but not dissemination in a classical model of mousepox.

Effective Priming of Herpes Simplex Virus-Specific CD8+ T Cells In Vivo Does Not Require Infected Dendritic Cells ⬇️

Engineering herpes simplex viruses by infection-transfection methods including recombination site targeting by CRISPR/Cas9 nucleases.

Engineering recombinant poxviruses using a compact GFP-blasticidin resistance fusion gene for selection.

Evolutionary history and attenuation of myxoma virus on two continents

Extent of Systemic Spread Determines CD8+ T Cell Immunodominance for Laboratory Strains, Smallpox Vaccines, and Zoonotic Isolates of Vaccinia Virus.

From mice to humans - murine intelligence for human CD8+ T cell vaccine design

Functional analysis of the short isoform of orf virus protein OV20.0.

Functional paralysis of human natural killer cells by alphaherpesviruses.

Genome scale evolution of myxoma virus reveals host-pathogen adaptation and rapid geographic spread

HLA class I-restricted responses to vaccinia recognize a broad array of proteins mainly involved in virulence and viral gene regulation

HLA-A*0201, HLA-A*1101, and HLA-B*0702 transgenic mice recognize numerous poxvirus determinants from a wide variety of viral gene products.

Herpes Simplex Virus Latency Is Noisier the Closer We Look

IL-4 and IL-13 mediated down-regulation of CD8 expression levels can dampen anti-viral CD8⁺ T cell avidity following HIV-1 recombinant pox viral vaccination.

Identification of poxvirus CD8+ T cell determinants to enable rational design and characterization of smallpox vaccines

Immunodomination during peripheral vaccinia virus infection.

Immunology by numbers: quantitation of antigen presentation completes the quantitative milieu of systems immunology!

Increasing antigen presentation on HSV-1-infected cells increases lesion size but does not alter neural infection or latency.

Influenza A Virus Infection Induces Viral and Cellular Defective Ribosomal Products Encoded by Alternative Reading Frames

Inside the professionals

Kinetic analysis of a complete poxvirus transcriptome reveals an immediate-early class of genes

Kinetics of antigen expression and epitope presentation during virus infection.

Linear fidelity in quantification of anti-viral CD8+ T cells

Local proliferation maintains a stable pool of tissue-resident memory T cells after antiviral recall responses

Lytic Promoters Express Protein during Herpes Simplex Virus Latency.

Lytic gene expression is frequent in HSV-1 latent infection and correlates with the engagement of a cell-intrinsic transcriptional response

Modified Vaccinia Virus Ankara Can Induce Optimal CD8+ T Cell Responses to Directly Primed Antigens Depending on Vaccine Design

Most viral peptides displayed by class I MHC on infected cells are immunogenic

Overlapping Peptides Elicit Distinct CD8+ T Cell Responses following Influenza A Virus Infection

Poxvirus CD8+ T-cell determinants and cross-reactivity in BALB/c mice

Quantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responses

Quantifying epitope presentation using mass spectrometry

Rapid poxvirus engineering using CRISPR/Cas9 as a selection tool

Reduced interleukin-4 receptor α expression on CD8+ T cells correlates with higher quality anti-viral immunity

Reduction of vector gene expression increases foreign antigen-specific CD8+ T-cell priming

Redundancy complicates the definition of essential genes for vaccinia virus

Regulation of protein translation through mRNA structure influences MHC class I loading and T cell recognition.

Regulatory T cells suppress CD8+ T cell responses induced by direct priming and cross-priming and moderate immunodominance disparities.

Reply to Satheshkumar and Moss: Poxvirus transcriptome analysis.

Simultaneous Quantification of Viral Antigen Expression Kinetics Using Data-Independent (DIA) Mass Spectrometry.

Sizing up the key determinants of the CD8(+) T cell response

Strikingly poor CD8+ T-cell immunogenicity of vaccinia virus strain MVA in BALB/c mice.

Surprisingly Effective Priming of CD8+ T cells by Heat-Inactivated Vaccinia Virus Virions

Systemic toll-like receptor ligation and selective killing of dendritic cell subsets fail to dissect priming pathways for anti-vaccinia virus CD8⁺ T cells

T cells bite the hand that feeds them

The Epstein-Barr Virus Glycoprotein gp150 Forms an Immune-Evasive Glycan Shield at the Surface of Infected Cells

The cellular redox environment alters antigen presentation

The developmental pathway for CD103(+)CD8+ tissue-resident memory T cells of skin.

The ectromelia virus SPI-2 protein causes lethal mousepox by preventing NK cell responses

The primary immune response to Vaccinia virus vaccination includes cells with a distinct cytotoxic effector CD4 T-cell phenotype.

The vaccinia virus kelch-like protein C2L affects calcium-independent adhesion to the extracellular matrix and inflammation in a murine intradermal model

Tissue-resident memory T cells in tissue homeostasis, persistent infection, and cancer surveillance.

Truncation of gene F5L partially masks rescue of vaccinia virus strain MVA growth on mammalian cells by restricting plaque size.

Uncovering the interplay between CD8, CD4 and antibody responses to complex pathogens.

Use of CD107-based cell sorting ex vivo to enrich subdominant CD8+ T cells in culture.

Vaccinia virus CD8+ T-cell dominance hierarchies cannot be altered by prior immunization with individual peptides.

Vaccinia virus F5 is required for normal plaque morphology in multiple cell lines but not replication in culture or virulence in mice

HLA-A0201, HLA-A1101, and HLA-B*0702 transgenic mice recognize numerous poxvirus determinants from a wide variety of viral gene products.